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1. 发明授权

US4445885A Insulin releasing supplier 失效
标题翻译：胰岛素释放供应商
公开(公告)号：US4445885A
公开(公告)日：1984-05-01
申请号：US78630
申请日：1979-09-25
申请人： Koji Kifune
发明人： Koji Kifune
IPC分类号： A61M1/34 , A61M1/36 , A61M1/03 , B01D13/00
CPC分类号： A61M1/36 , A61M1/3427
摘要： An insulin supplier, which can be effectively used for the treatment of diabetic patients, comprising a casing and at least one tubular structure composed of a polymeric semipermeable membrane to provide an internal chamber inside of the tubular membrane and an external chamber outside of the tubular membrane, either one of the internal chamber and the external chamber having at least one fluid-inlet and at least one fluid-outlet; wherein blood or another body fluid is introduced into that chamber which has the at least one fluid-inlet and the at least one fluid-outlet and a solution of insulin is introduced into the other chamber, whereby insulin in an effective amount required for metabolism within the body is supplied to the blood or the body fluid depending on the blood glucose level through the polymeric semipermeable membrane between the internal and external chambers over a long period of time.
摘要翻译：可以有效地用于治疗糖尿病患者的胰岛素供应者，包括壳体和由聚合物半透膜组成的至少一个管状结构，以在管状膜内提供内部腔室和在管状膜外部的外部室内室和外室中的任一个具有至少一个流体入口和至少一个流体出口; 其中将血液或另一体液引入到具有所述至少一个流体入口和所述至少一个流体出口的所述腔室中，并且将胰岛素溶液引入到另一个腔室中，由此将胰岛素以有效量代入内取决于通过内部和外部室之间的聚合物半透膜在长时间内的血糖水平将身体供应到血液或体液。

2. 发明授权

US5290752A Method for preparation of a shaped chitin body containing a physiologically active substance 失效
标题翻译：含有生理活性物质的成形甲壳素的制备方法
公开(公告)号：US5290752A
公开(公告)日：1994-03-01
申请号：US963256
申请日：1992-10-19
申请人： Koji Kifune , Kenzo Motosugi , Hiroyuki Tanae
发明人： Koji Kifune , Kenzo Motosugi , Hiroyuki Tanae
IPC分类号： A01N25/10 , A61K9/20 , C08L5/08
CPC分类号： A61K9/205 , A01N25/10 , C08L5/08
摘要： A shaped chitin body containing a high content of a physiologically active substance, such as a drug to be used for the cure or prevention of disease, is prepared by incorporating said physiologically active substance into a dope comprising (a) a water-insoluble chitin, (b) lithium chloride, and (c) N-methylpyrrolidone and/or dimethylacetamide, with the amount of said physiologically active substance incorporated being 0.5 wt. % or more with respect to the amount of the chitin contained in said dope, and thereafter coagulating the resulting mixture with a coagulant to obtain a shaped body.The high content of the physiologically active substance thus incorporated in the shaped chitin can be slowly released therefrom over a long period of time. The shaped-chitin of the present invention is characterized by long duration of the physiological activity of the active substance contained therein.
摘要翻译：通过将所述生理活性物质掺入到包含（a）不溶于水的几丁质中，制备含有高含量生理活性物质（例如用于治愈或预防疾病的药物）的成形甲壳质，（b）氯化锂，和（c）N-甲基吡咯烷酮和/或二甲基乙酰胺，其中加入的所述生理活性物质的量为0.5wt。相对于所述涂料中所含的几丁质的量，然后用凝结剂使所得混合物凝结，得到成形体。因此，结合在成形甲壳质中的生理活性物质的高含量可以长时间缓慢释放。本发明的成形几丁质的特征在于其中含有活性物质的生理活性持续时间长。

3. 发明授权

US4932404A Chitin fibers and process for the production of the same 失效
标题翻译：几丁质纤维和生产过程相同
公开(公告)号：US4932404A
公开(公告)日：1990-06-12
申请号：US368952
申请日：1989-06-13
申请人： Koji Kifune , Katsuhiro Inoue , Shigeru Mori
发明人： Koji Kifune , Katsuhiro Inoue , Shigeru Mori
IPC分类号： A61L17/08 , D01F9/00
CPC分类号： A61L17/08 , D01F9/00
摘要： A fiber comprised of chitin having a single yarn denier of 0.5 to 20 and a dry tensile strength of 2 g/d or more, and a process for the production thereof are described. The use of such chitin fibers permits the production of surgical sutures having high tensile strength and flexibility, and good absorption properties.

4. 发明授权

US4704268A Method for manufacture of biodegradable drug donor and drug donor made thereby 失效
标题翻译：由此制造可生物降解的药物供体和药物供体的方法
公开(公告)号：US4704268A
公开(公告)日：1987-11-03
申请号：US637191
申请日：1984-08-02
申请人： Koji Kifune
发明人： Koji Kifune
IPC分类号： A61K9/18 , A61K9/20 , A61K9/22 , A61K47/36 , A61K9/00
CPC分类号： A61K9/205 , A61K47/36
摘要： A method for the manufacture of a biodegradable drug donor capable of gradually releasing a drug to a living body and the drug donor made thereby are described, said method comprising dissolving a chitin in a solvent to thereby prepare a dope, bringing said dope into contact with a liquid coagulant to thereby form a swelled mass containing said chitin, impregnating said chitin-containing swelled mass with a solution containing a drug, and subsequently drying the impregnated swelled mass.
摘要翻译：所述方法包括将几丁质溶解在溶剂中，由此制备涂料，使所述掺杂物与所述生物体接触液体凝结剂，从而形成包含所述几丁质的溶胀物质，用含有药物的溶液浸渍所述含几丁质的溶胀物质，随后干燥浸渍的膨胀物质。

5. 发明授权

US4699135A Shaped chitin body 失效
标题翻译：形状的几丁质体
公开(公告)号：US4699135A
公开(公告)日：1987-10-13
申请号：US761260
申请日：1985-08-01
申请人： Kenzo Motosugi , Koji Kifune , Yasuhiko Yamaguchi , Yasuo Nobe , Hiroyuki Tanae
发明人： Kenzo Motosugi , Koji Kifune , Yasuhiko Yamaguchi , Yasuo Nobe , Hiroyuki Tanae
IPC分类号： A61L15/28 , C08L5/08 , D01F9/00 , A61F15/00
CPC分类号： D01F9/00 , A61L15/28 , C08L5/08
摘要： A shaped chitin body prepared by treating a shaped body of chitin with an alkali solution, such that within a dilute aqueous solution of acetic acid, the volume of said shaped chitin body will increase by a factor of at least about 10 while substantially retaining its shape. This shaped chitin body has versatile capabilities comparable to those of chitosan. A nonwoven fabric made of a fibrous chitin body is particularly effective as a wound dressing.
摘要翻译：通过用碱溶液处理几丁质成形体制备的成形甲壳质体，使得在乙酸的稀水溶液中，所述成形甲壳质体的体积将增加至少约10倍，同时基本保持其形状。这种形状的几丁质体具有与壳聚糖相当的通用能力。由纤维状几丁质体制成的非织造织物作为伤口敷料是特别有效的。

6. 发明授权

US4575519A Porous chitin shaped article and production thereof 失效
标题翻译：多孔几丁质制品及其生产
公开(公告)号：US4575519A
公开(公告)日：1986-03-11
申请号：US767971
申请日：1985-08-21
申请人： Koji Kifune , Hiroyuki Tanae , Yasuhiko Yamaguchi , Kenzo Motosugi
发明人： Koji Kifune , Hiroyuki Tanae , Yasuhiko Yamaguchi , Kenzo Motosugi
IPC分类号： C08B37/08 , A61L15/28 , A61L15/42 , C08J9/26 , C08L5/08 , B32B9/00 , C08J9/00
CPC分类号： C08J9/26 , A61L15/28 , A61L15/425 , C08L5/08 , C08J2201/0462 , C08J2305/08 , Y10T428/2991 , Y10T428/31971
摘要： The present invention provides a porous chitin shaped article which has a wet strength of not less than about 1 g/mm.sup.2. The shaped article has preferably a porosity of more than 90%.The present invention also provides a process for preparing the above chitin shaped article, which comprises:dissolving chitin in a solvent to form a dope, dispersing a water-soluble polymer, which is solid at ambient temperature, in said dope to form a coagulated article, andremoving the water-soluble polymer from said coagulated article by treating with aqueous solution.
摘要翻译：本发明提供一种具有不小于约1g / mm 2的湿强度的多孔几丁质制品。成形制品优选具有大于90％的孔隙率。本发明还提供了制备上述几丁质制品的方法，其包括：将几丁质溶解在溶剂中以形成涂料，将在环境温度下为固体的水溶性聚合物分散在所述涂料中以形成凝结物品，并通过用水溶液处理从所述凝结制品中除去水溶性聚合物。

7. 发明授权

US5204107A Slow-releasing composition of platinum-containing anticancer agent 失效
标题翻译：含铂类抗癌剂的缓释组合物
公开(公告)号：US5204107A
公开(公告)日：1993-04-20
申请号：US794909
申请日：1991-11-20
申请人： Ryoichi Tsurutani , Koji Kifune , Yuriko Nakamura
发明人： Ryoichi Tsurutani , Koji Kifune , Yuriko Nakamura
IPC分类号： A61K9/70 , A61K31/28 , A61K31/282 , A61K31/715 , A61K33/24 , A61K47/36 , A61K47/48 , A61P35/00 , C08B37/08
CPC分类号： A61K31/28 , A61K33/24 , A61K47/36 , A61K47/4823 , A61K47/48853 , A61K9/70
摘要： A slow-releasing composition of a platinum-containing anticancer agent comprising a platinum-containing anticancer agent bound to deacetylated chitin. The release of the platinum-containing anticancer agent is sustained for a prolonged duration of several months, thereby minimizing undesirable side effects of the platinum-containing anticancer agent.

8. 发明授权

US4651725A Wound dressing 失效
标题翻译：伤口敷料
公开(公告)号：US4651725A
公开(公告)日：1987-03-24
申请号：US852246
申请日：1986-04-15
申请人： Koji Kifune , Yasuhiko Yamaguchi , Hiroyuki Tanae
发明人： Koji Kifune , Yasuhiko Yamaguchi , Hiroyuki Tanae
IPC分类号： A61L15/16 , A61L15/22 , A61L15/28 , A61L15/00
CPC分类号： A61L15/225 , A61L15/28
摘要： Disclosed is a wound dressing comprising a nonwoven fabric composed of(A) a chitin fiber having a thickness of less than one denier and a strength of not less than 2 g/d, and(b) a fibrous binder,which is suitable for dressings of skin defect wounds, which has compatibility to a living body and good fitness property to the surface of wounds and which is insoluble with exudates.
摘要翻译：公开了一种伤口敷料，其包括由（A）厚度小于1旦且强度不小于2g / d的壳多糖纤维组成的无纺织物，和（b）适合于敷料的纤维粘合剂的皮肤缺损伤口，其与活体相容性和对伤口表面的良好适应性，并且与渗出物不溶。

9. 发明授权

US4431601A Process for the production of chitin fibers 失效
标题翻译：生产几丁质纤维的方法
公开(公告)号：US4431601A
公开(公告)日：1984-02-14
申请号：US316384
申请日：1981-10-29
申请人： Koji Kifune , Katsuhiro Inoue , Shigeru Mori
发明人： Koji Kifune , Katsuhiro Inoue , Shigeru Mori
IPC分类号： A61L17/08 , D01F9/00
CPC分类号： A61L17/08 , D01F9/00
摘要： A fiber comprised of chitin having a single yarn denier of 0.5 to 20 and a dry tensile strength of 2 g/d or more, and a process for the production thereof are described. The use of such chitin fibers permits the production of surgical sutures having high tensile strength and flexibility, and good absorption properties.
摘要翻译：描述了由单丝旦数为0.5〜20，干拉伸强度为2g / d以上的几丁质构成的纤维及其制造方法。使用这种几丁质纤维允许生产具有高拉伸强度和柔韧性以及良好吸收性能的外科缝合线。

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