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1. 发明公开

EP2763563A2 MOBILE DEVICE CASE WITH RETRACTOR REEL ASSEMBLY FOR USER-PROVIDED HEADPHONES 有权
标题翻译：住房与用户的卷筒组装耳机移动设备
公开(公告)号：EP2763563A2
公开(公告)日：2014-08-13
申请号：EP12838154.8
申请日：2012-09-24
申请人： Koenig, Scott , Conroy, David
发明人： Koenig, Scott , Conroy, David
IPC分类号： A45C11/00 , H04B1/38
CPC分类号： H05K5/0247 , B65H75/4431 , B65H75/4449 , B65H2701/3919 , H01R13/72 , H02G11/02 , H04M1/15 , H04R1/1033 , H05K5/0217
摘要： A mobile device case includes a reel assembly, including a reel, a supporting plate, and a hub between the reel and the supporting plate. The hub includes a first cavity between the hub and the supporting plate for housing a spring, and a second cavity between the hub and the reel for housing a flat flexible cable (FFC). The spring is wound in a first direction, while the FFC is wound in a second direction. The FFC includes a first end for electrically coupling to a female jack connector of a device. A female connector is electrically coupled to a second end of the FFC for engaging a male jack connector of user-provided headphones. When the reel rotates in the first direction, the spring tightens and the FFC loosens. When the reel rotates in the second direction, the spring loosens and the FFC tightens.

2. 发明公开

EP3085266A1 MOBILE DEVICE CASE WITH RETRACTOR REEL ASSEMBLY FOR USER-PROVIDED HEADPHONES 无效
标题翻译：住房与用户的卷筒组装耳机移动设备
公开(公告)号：EP3085266A1
公开(公告)日：2016-10-26
申请号：EP16168493.1
申请日：2012-09-24
申请人： Koenig, Scott , Conroy, David
发明人： Koenig, Scott , Conroy, David
IPC分类号： A45C11/00 , H04B1/38 , H01R13/72 , H02G11/02 , H04M1/15 , B65H75/44
CPC分类号： H05K5/0247 , B65H75/4431 , B65H75/4449 , B65H2701/3919 , H01R13/72 , H02G11/02 , H04M1/15 , H04R1/1033 , H05K5/0217
摘要： A mobile device case (100) includes a reel assembly, including a reel (105), a supporting plate (110), and a hub (108) between the reel and the supporting plate. The hub includes a first cavity between the hub and the supporting plate for housing a spring (109), and a second cavity between the hub and the reel for housing a flat flexible cable (106) (FFC). The spring is wound in a first direction, while the FFC is wound in a second direction. The FFC includes a first end for electrically coupling to a female jack connector (119) of a device. A female connector (107) is electrically coupled to a second end of the FFC for engaging a male jack connector of user-provided headphones (116). When the reel (105) rotates in the first direction, the spring (109) tightens and the FFC loosens. When the reel (105) rotates in the second direction, the spring (109) loosens and the FFC tightens.
摘要翻译：的移动设备的情况下（100）包括一个卷轴组件，包括一个带盘（105），支撑板（110）和所述卷轴和所述支承板之间的轮毂（108）。轮毂包括毂和用于容纳弹簧（109）的支撑板，和轮毂之间的第二腔体和用于容纳扁平柔性电缆（106）的卷轴（FFC）之间的第一腔。该弹簧被卷绕在第一方向上，而FFC被在第二方向上缠绕。的FFC包括用于电耦合的第一端连接到装置的阴插座连接器（119）。的阴连接器（107）电耦合到所述FFC的第二端，用于接合用户提供的耳机（116）的阳连接器插孔。当卷轴（105）在第一方向上旋转时，弹簧（109）拧紧和松开FFC。当卷轴（105）在第二方向上旋转时，弹簧（109）松开和收紧FFC。

3. 发明授权

EP2763563B1 MOBILE DEVICE CASE WITH RETRACTOR REEL ASSEMBLY FOR USER-PROVIDED HEADPHONES 有权
标题翻译：用于用户提供的耳机的移动设备壳体和用于收缩器卷盘组件
公开(公告)号：EP2763563B1
公开(公告)日：2016-08-10
申请号：EP12838154.8
申请日：2012-09-24
申请人： Koenig, Scott , Conroy, David
发明人： Koenig, Scott , Conroy, David
IPC分类号： H04R1/10 , A45C11/00 , H04B1/38 , H01R13/72 , H02G11/02 , H04M1/15 , B65H75/44 , H05K5/02
CPC分类号： H05K5/0247 , B65H75/4431 , B65H75/4449 , B65H2701/3919 , H01R13/72 , H02G11/02 , H04M1/15 , H04R1/1033 , H05K5/0217

4. 发明公开

EP2763563A4 MOBILE DEVICE CASE WITH RETRACTOR REEL ASSEMBLY FOR USER-PROVIDED HEADPHONES 有权
标题翻译：住房与用户的卷筒组装耳机移动设备
公开(公告)号：EP2763563A4
公开(公告)日：2015-03-25
申请号：EP12838154
申请日：2012-09-24
申请人： KOENIG SCOTT , CONROY DAVID
发明人： KOENIG SCOTT , CONROY DAVID
IPC分类号： A45C11/00 , B65H75/44 , H01R13/72 , H02G11/02 , H04B1/38 , H04M1/15
CPC分类号： H05K5/0247 , B65H75/4431 , B65H75/4449 , B65H2701/3919 , H01R13/72 , H02G11/02 , H04M1/15 , H04R1/1033 , H05K5/0217

5. 发明申请

WO2013052303A3 MOBILE DEVICE CASE WITH RETRACTOR REEL ASSEMBLY FOR USER-PROVIDED HEADPHONES 审中-公开
标题翻译：带有退磁头组件的移动设备外壳用于用户提供的耳机
公开(公告)号：WO2013052303A3
公开(公告)日：2013-06-13
申请号：PCT/US2012056970
申请日：2012-09-24
申请人： KOENIG SCOTT , CONROY DAVID
发明人： KOENIG SCOTT , CONROY DAVID
IPC分类号： A45C11/00 , H04B1/38
CPC分类号： H05K5/0247 , B65H75/4431 , B65H75/4449 , B65H2701/3919 , H01R13/72 , H02G11/02 , H04M1/15 , H04R1/1033 , H05K5/0217
摘要： A mobile device case includes a reel assembly, including a reel, a supporting plate, and a hub between the reel and the supporting plate. The hub includes a first cavity between the hub and the supporting plate for housing a spring, and a second cavity between the hub and the reel for housing a flat flexible cable (FFC). The spring is wound in a first direction, while the FFC is wound in a second direction. The FFC includes a first end for electrically coupling to a female jack connector of a device. A female connector is electrically coupled to a second end of the FFC for engaging a male jack connector of user-provided headphones. When the reel rotates in the first direction, the spring tightens and the FFC loosens. When the reel rotates in the second direction, the spring loosens and the FFC tightens.
摘要翻译：移动设备壳体包括卷轴组件，包括卷轴，支撑板以及在卷轴和支撑板之间的轮毂。毂包括在毂和用于容纳弹簧的支撑板之间的第一空腔，以及在毂和卷轴之间的用于容纳扁平柔性电缆（FFC）的第二腔。弹簧沿第一方向缠绕，而FFC沿第二方向缠绕。 FFC包括用于电耦合到装置的母插座连接器的第一端。母连接器电耦合到FFC的第二端，用于接合用户提供的耳机的公插头连接器。当卷轴沿第一方向旋转时，弹簧拉紧，FFC松动。当卷轴沿第二个方向旋转时，弹簧松开，FFC拉紧。

6. 发明申请

WO2007009064A3 METHODS FOR THE TREATMENT OF AUTOIMMUNE DISORDERS USING IMMUNOSUPPRESSIVE MONOCLONAL ANTIBODIES WITH REDUCED TOXICITY 审中-公开
标题翻译：使用具有降低毒性的免疫抑制性单克隆抗体治疗自身免疫性疾病的方法
公开(公告)号：WO2007009064A3
公开(公告)日：2009-04-23
申请号：PCT/US2006027386
申请日：2006-07-11
申请人： MACROGENICS INC , KOENIG SCOTT , WILDER RONALD , BONVINI EZIO , JOHNSON LESLIE S
发明人： KOENIG SCOTT , WILDER RONALD , BONVINI EZIO , JOHNSON LESLIE S
IPC分类号： A61K39/395 , A61P37/02
CPC分类号： C07K16/2809 , A61K38/28 , A61K2039/505 , C07K2317/24 , C07K2317/524 , C07K2317/53 , C07K2317/71 , A61K2300/00
摘要： The present invention provides methods of treating, preventing or ameliorating the symptoms of T cell-mediated immunological diseases, particularly autoimmune diseases, through the use of anti-CD3 antibodies. In particular, the methods of the invention provide for administration of antibodies that specifically bind the epsilon subunit within the human CD3 complex. Such antibodies modulate the T cell receptor/alloantigen interaction and, thus, regulate the T cell mediated cytotoxicity associated with autoimmune disorders. Additionally, the invention provides for modification of the anti-CD3 antibodies such that they exhibit reduced or eliminated effector function and T cell activation as compared to non- modified anti-CD3 antibodies.
摘要翻译：本发明提供了通过使用抗CD3抗体来治疗，预防或改善T细胞介导的免疫疾病，特别是自身免疫性疾病的症状的方法。特别地，本发明的方法提供了特异性结合人CD3复合物内的ε亚基的抗体的施用。这种抗体调节T细胞受体/同种异体抗原相互作用，因此调节与自身免疫疾病相关的T细胞介导的细胞毒性。另外，本发明提供抗CD3抗体的修饰，使得它们与非修饰抗CD3抗体相比表现出降低或消除的效应子功能和T细胞活化。

7. 发明申请

WO2008140603A2 METHODS FOR THE TREATMENT OF DISEASE USING IMMUNOGLOBULINS HAVING FC REGIONS WITH ALTERED AFFINITIES FOR FCγR ACTIVATING AND FCγR INHIBITING 审中-公开
标题翻译：使用具有更改功能的FC区域的免疫球蛋白治疗疾病的方法用于FC？R激活和FC？R抑制
公开(公告)号：WO2008140603A2
公开(公告)日：2008-11-20
申请号：PCT/US2007/086793
申请日：2007-12-07
申请人： MACROGENICS, INC. , STAVENHAGEN, Jeffrey, B. , KOENIG, Scott
发明人： STAVENHAGEN, Jeffrey, B. , KOENIG, Scott
IPC分类号： A61K39/395 , C07K16/28 , C07K16/24
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/2887 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734
摘要： The present invention relates to methods of treating or preventing cancer and other diseases using molecules, particularly polypeptides, more particularly immunoglobulins ( e.g ., antibodies), comprising a variant Fc region, wherein said variant Fc region comprises at least one amino acid modification relative to a wild-type Fc region, which variant Fc region binds an FcγR that activates a cellular effector ("FcγR activating ," such as FcγRIIA or FcγRIIIA) and an FcγR that inhibits a cellular effector ("FcγR inhibiting " such as FcγRIIA) with an altered Ratio of Affinities relative to the respective binding affinities of such FcγR for the Fc region of the wild-type immunoglobulin. The methods of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection where either an enhanced efficacy of effector cell function mediated by FcγR is desired ( e.g ., cancer, infectious disease) or an inhibited effector cell response mediated by FcγR is desired ( e.g ., inflammation, autoimmunde disease).
摘要翻译：本发明涉及使用分子，特别是多肽，特别是包含变体Fc区的免疫球蛋白（例如抗体）治疗或预防癌症和其它疾病的方法，其中所述变体Fc区包含至少一个相对于野生型Fc区，该变体Fc区结合激活细胞效应子（“FcγRIIA活化”，例如FcγRIIA或FcγRIIIA）的FcγR和FcγR 其具有相对于野生型Fc区的Fc区的这种FcγR的各自结合亲和力的改变的亲和力比例抑制细胞效应子（“FcαRα抑制”如FcγRIIA）型免疫球蛋白。本发明的方法特别可用于预防，治疗或改善与需要由FcγR介导的效应细胞功能的增强功效的疾病，病症或感染相关的一种或多种症状（例如，癌症，感染性疾病）或由FcγR介导的受抑制的效应细胞应答是期望的（例如炎症，自身免疫疾病）。

8. 发明申请

WO2008118324A3 COMPOSITION AND METHOD OF TREATING CANCER WITH AN ANTI-UROPLAKIN IB ANTIBODY 审中-公开
标题翻译：抗UROPLAKIN抗体治疗癌症的组合物和方法
公开(公告)号：WO2008118324A3
公开(公告)日：2008-10-02
申请号：PCT/US2008/003635
申请日：2008-03-20
申请人： MACROGENICS, INC. , FERGUSON, Stacy , KOENIG, Scott , TUAILLON, Nadine , JOHNSON, Leslie, S. , HUANG, Ling , RANKIN, Christopher
发明人： FERGUSON, Stacy , KOENIG, Scott , TUAILLON, Nadine , JOHNSON, Leslie, S. , HUANG, Ling , RANKIN, Christopher
IPC分类号： C07K16/28
摘要： This invention provides antibodies that specifically recognize and bind to UPK-Ib. Also included are diagnostic and therapeutic assays directed to diseases associated with unregulated levels of UPK-Ib using said antibodies. The antibodies and derivatives thereof can also be useful in the diagnisic and/or treatment of cancer associated with abnormal expression of UPK-Ib.
摘要翻译：本发明提供了特异性识别并结合UPK-1b的抗体。还包括使用所述抗体针对与未调节水平的UPK-Ib相关的疾病的诊断和治疗测定。所述抗体及其衍生物还可用于诊断和/或治疗与UPK-Ib异常表达相关的癌症。

9. 发明申请

WO2008118324A2 COMPOSITION AND METHOD OF TREATING CANCER WITH AN ANTI-UROPLAKIN IB ANTIBODY 审中-公开
标题翻译：抗UROPLAKIN抗体治疗癌症的组合物和方法
公开(公告)号：WO2008118324A2
公开(公告)日：2008-10-02
申请号：PCT/US2008003635
申请日：2008-03-20
申请人： MACROGENICS INC , FERGUSON STACY , KOENIG SCOTT , TUAILLON NADINE , JOHNSON LESLIE S , HUANG LING , RANKIN CHRISTOPHER
发明人： FERGUSON STACY , KOENIG SCOTT , TUAILLON NADINE , JOHNSON LESLIE S , HUANG LING , RANKIN CHRISTOPHER
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/72 , C07K2317/732 , C07K2319/30
摘要： This invention provides antibodies that specifically recognize and bind to UPK-Ib. Also included are diagnostic and therapeutic assays directed to diseases associated with unregulated levels of UPK-Ib using said antibodies. The antibodies and derivatives thereof can also be useful in the diagnisic and/or treatment of cancer associated with abnormal expression of UPK-Ib.
摘要翻译：本发明提供了特异性识别和结合UPK-1b的抗体。还包括使用所述抗体针对与未调节水平的UPK-Ib相关的疾病的诊断和治疗测定。该抗体及其衍生物也可用于诊断和/或治疗与UPK-1b异常表达相关的癌症。

10. 发明申请

WO2007117600A3 COMBINATION THERAPY FOR TREATING AUTOIMMUNE DISEASES 审中-公开
标题翻译：治疗自身免疫性疾病的组合疗法
公开(公告)号：WO2007117600A3
公开(公告)日：2008-08-14
申请号：PCT/US2007008579
申请日：2007-04-06
申请人： MACROGENICS INC , KOENIG SCOTT
发明人： KOENIG SCOTT
IPC分类号： A61K39/395
CPC分类号： C07K16/2809 , A61K2039/507 , C07K16/2887
摘要： A combination therapy comprising administering to a subject in need of an effective therapeutic treatment for an autoimmune disease, a T cell antibody that is capable of modulating the activation of a T cell response to an antigen presenting cell in combination with a B cell antibody. The combination therapy may provide improved clinical benefits to a subject in need of treatment by reducing the circulating and tissue levels of B cells while providing immunosuppression of T cell activation, thus modulating the immune response to self antigens.
摘要翻译：一种联合疗法，其包括对需要对自身免疫性疾病进行有效治疗的受治疗者，能够调节与B细胞抗体组合的抗原呈递细胞的T细胞应答活化的T细胞抗体。联合治疗可以通过减少B细胞的循环和组织水平来提供需要治疗的受试者的改善的临床益处，同时提供T细胞活化的免疫抑制，从而调节对自身抗原的免疫应答。

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