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1. 发明授权

US5776711A Simultaneous human ABO and RH(D) blood typing or antibody screening by flow cytometry 失效
标题翻译：通过流式细胞术同时进行人ABO和RH（D）血型或抗体筛选
公开(公告)号：US5776711A
公开(公告)日：1998-07-07
申请号：US747558
申请日：1996-11-12
申请人： Girish N. Vyas , Kodumudi Venkateswaran
发明人： Girish N. Vyas , Kodumudi Venkateswaran
IPC分类号： G01N33/80 , G01N33/53 , G01N33/555
CPC分类号： G01N33/80
摘要： Flow cytometric methodology is provided for simultaneous determination of (1) ABO and Rh(D) typing of human red cells, (2) natural isoantibodies in plasma, and (3) screening for alloantibodies in plasma. The method includes (a) the use of a unique combination of fluorescent labelled antibodies to A, B and Rh(D) antigens to carry out (1); (b) different sized beads coated with blood group substances A & B to carry out (2); and (c) the differential fluorescent labelling of screening reagent red blood cells for flow cytometric analyses to carry out (3). The routine ABO and Rh(D) typing and antibody screening of human blood for both isoantibodies and alloantibodies can be determined in three individual reactions compared to 7 to 10 tests currently performed in blood banks.
摘要翻译：提供流式细胞术方法用于同时测定（1）人红细胞的ABO和Rh（D）分型，（2）血浆中的天然异抗体，和（3）筛选血浆中的同种抗体。该方法包括（a）使用荧光标记抗体对A，B和Rh（D）抗原的独特组合进行（1）; （b）涂有血型物质A和B的不同大小的珠子进行（2）; 和（c）筛选试剂红细胞的差异荧光标记用于流式细胞术分析进行（3）。可以在三个单独的反应中测定人类血液中同种抗体和同种异体抗体的常规ABO和Rh（D）分型和抗体筛选，与目前在血库中进行的7至10次测试相比。

2. 发明申请

US20070117110A1 Flow cytometric detection method for DNA samples 有权
标题翻译： DNA样品的流式细胞检测方法
公开(公告)号：US20070117110A1
公开(公告)日：2007-05-24
申请号：US11454478
申请日：2006-06-16
申请人： Shanavaz Nasarabadi , Richard Langlois , Kodumudi Venkateswaran
发明人： Shanavaz Nasarabadi , Richard Langlois , Kodumudi Venkateswaran
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12Q1/6851 , C12Q1/686 , C12Q2565/626 , C12Q2563/155 , C12Q2561/101 , C12Q2537/143
摘要： Disclosed herein are two methods for rapid multiplex analysis to determine the presence and identity of target DNA sequences within a DNA sample. Both methods use reporting DNA sequences, e.g., modified conventional Taqman® probes, to combine multiplex PCR amplification with microsphere-based hybridization using flow cytometry means of detection. Real-time PCR detection can also be incorporated. The first method uses a cyanine dye, such as, Cy3™, as the reporter linked to the 5′ end of a reporting DNA sequence. The second method positions a reporter dye, e.g., FAM, on the 3′ end of the reporting DNA sequence and a quencher dye, e.g., TAMRA, on the 5′ end.
摘要翻译：本文公开了用于快速多重分析以确定DNA样品中靶DNA序列的存在和身份的两种方法。两种方法使用报告DNA序列，例如修饰的常规Taqman探针，以使用流式细胞术检测方法将多重PCR扩增与基于微球的杂交组合。也可以并入实时PCR检测。第一种方法使用花青染料，例如Cy3 TM作为连接到报告DNA序列的5'末端的报告物。第二种方法将报告染料（例如FAM）置于报告DNA序列的3'末端和5'末端的猝灭剂染料（例如TAMRA）上。

3. 发明申请

US20070292889A1 Immunoassay magnetic trapping device 审中-公开
标题翻译：免疫测定磁捕获装置
公开(公告)号：US20070292889A1
公开(公告)日：2007-12-20
申请号：US11455211
申请日：2006-06-16
申请人： Christopher Bailey , Perry Bell , Kodumudi Venkateswaran , Allen Christian , Elizabeth Wheeler
发明人： Christopher Bailey , Perry Bell , Kodumudi Venkateswaran , Allen Christian , Elizabeth Wheeler
IPC分类号： G01N33/53 , C12M3/00 , G01N33/551
CPC分类号： B01L3/502761 , B01L3/527 , B01L7/52 , B01L2200/0668 , B01L2200/141 , B01L2300/0867 , B01L2300/0877 , B01L2400/043
摘要： A system for immunoassaying a sample comprising providing magnetic beads, connecting signal molecules to the beads, connecting the sample to the magnetic beads with the connected signal molecules, magnetically trapping the magnetic beads with the connected signal molecules and the sample, lysising the sample, and analyzing the sample.
摘要翻译：一种用于免疫测定样品的系统，包括提供磁珠，将信号分子连接到珠，将样品连接到具有连接的信号分子的磁珠，用连接的信号分子和样品磁性捕获磁珠，裂解样品，以及分析样品。

4. 发明申请

US20060281101A1 Biobriefcase 审中-公开
标题翻译：生物百科全书
公开(公告)号：US20060281101A1
公开(公告)日：2006-12-14
申请号：US11154975
申请日：2005-06-15
申请人： John Dzenitis , William Benett , Raymond Mariella , Steven Visuri , Kodumudi Venkateswaran
发明人： John Dzenitis , William Benett , Raymond Mariella , Steven Visuri , Kodumudi Venkateswaran
IPC分类号： C12Q1/68 , G01N33/53 , C12M1/34
CPC分类号： G01N35/00 , B01L1/52 , B01L3/5027 , G01N1/28 , G01N33/543 , G01N2001/027
摘要： A bio-briefcase system for analyzing a sample for the presence of biological agents. The bio-briefcase system comprises a housing, an immunoassay section operatively connected to the housing, and/or a nucleic acid assay section operatively connected to the housing.
摘要翻译：用于分析样品存在生物制剂的生物公文包系统。生物公文包系统包括壳体，可操作地连接到壳体的免疫测定部分和/或可操作地连接到壳体的核酸测定部分。

5. 发明申请

US20060057599A1 System for autonomous monitoring of bioagents 审中-公开
标题翻译：生物制剂自主监测系统
公开(公告)号：US20060057599A1
公开(公告)日：2006-03-16
申请号：US11000491
申请日：2004-11-29
申请人： John Dzenitis , Steve Brown , Billy Colston , Dora Gutierrez , Bruce Henderer , Benjamin Hindson , Ramakrishna Madabhushi , Anthony Makarewicz , Don Masquelier , Mary McBride , Thomas Metz , Shanavaz Nasarabadi , Ujwal Setlur , Sally Smith , Kodumudi Venkateswaran
发明人： John Dzenitis , Steve Brown , Billy Colston , Dora Gutierrez , Bruce Henderer , Benjamin Hindson , Ramakrishna Madabhushi , Anthony Makarewicz , Don Masquelier , Mary McBride , Thomas Metz , Shanavaz Nasarabadi , Ujwal Setlur , Sally Smith , Kodumudi Venkateswaran
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： G01N1/2202 , G01N1/2211 , G01N15/1459 , G01N35/08 , G01N2001/2217 , Y02A90/26
摘要： An autonomous monitoring apparatus for monitoring air, water, soil, or other substance for bioagents. A collector gathers a quantity of the air, water, soil, or other substance being monitored. A sample preparation system prepares a sample of the selected potential bioagent particles. The sample is analyzed by a system for detecting said bioagents.
摘要翻译：一种用于监测用于生物制剂的空气，水，土壤或其他物质的自主监测装置。收集者收集一定数量的被监测的空气，水，土壤或其他物质。样品制备系统准备所选择的潜在生物标记颗粒的样品。通过用于检测所述生物代理的系统分析样品。

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