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1. 发明申请

US20090297479A1 DC-HIL CONJUGATES FOR TREATMENT OF T-CELL DISORDERS 审中-公开
标题翻译： DC-HIL联合治疗T细胞疾病
公开(公告)号：US20090297479A1
公开(公告)日：2009-12-03
申请号：US12411898
申请日：2009-03-26
申请人： Kiyoshi Ariizumi , Ponciano D. Cruz
发明人： Kiyoshi Ariizumi , Ponciano D. Cruz
IPC分类号： A61K38/21 , A61K39/395 , C12N9/00 , C07K19/00
CPC分类号： C07K16/2827 , C07K2319/30
摘要： The present invention relates to the use of DC-HIL and fragments and variants thereof to selectively target toxins to activated T-cells expressing a unique form of syndecan-4 that is not found on other cells. Thus, the toxin is delivered only to activated T-cells, and not to other syndecan-4 expressing cells. Such toxin-DC-HIL conjugates are useful in the treatment of T-cell inflammatory disorders such as dermatitis, autoimmune disease, and graft rejection, as well as T-cell lymphomas.
摘要翻译：本发明涉及DC-HIL及其片段和变体的选择性靶向靶向表达在其他细胞上未发现的syndecan-4独特形式的活化T细胞的毒素。因此，毒素仅被递送到活化的T细胞，而不传递给其他的syndecan-4表达细胞。这种毒素-DC-HIL缀合物可用于治疗T细胞炎症性疾病如皮炎，自身免疫性疾病和移植排斥反应以及T细胞淋巴瘤。

2. 发明授权

US07071171B1 Unique dendritic cell-associated c-type lectins, dectin-1 and dectin-2 compositions and uses thereof 失效
标题翻译：独特的树突状细胞相关c型凝集素，dectin-1和dectin-2组合物及其用途
公开(公告)号：US07071171B1
公开(公告)日：2006-07-04
申请号：US09396492
申请日：1999-09-14
申请人： Kiyoshi Ariizumi , Akira Takashima
发明人： Kiyoshi Ariizumi , Akira Takashima
IPC分类号： A61K48/00 , C07H21/04
CPC分类号： C07K16/2851
摘要： Novel genes expressed selectively by long-term dendritic cell (DC) lines (XS series) from murine epidermis which retain important features of resident epidermal Langerhans cells (LC) are provided. These genes encode distinct type II membrane-integrated polypeptides, each consisting of a cytoplasmic domain, a transmembrane domain, an extracellular connecting domain, and a C-terminal extracellular domain that exhibits significant homology to the carbohydrate recognition domains (CRD)) of C-type lectins. Expression of both genes is highly restricted to cells of DC lineage (including epidermal LC). Thus, these genes encode new, DC-specific members of the C-type lectin family, now termed “DC-associated C-type lectin-1 and -2” (dectin-1 and dectin-2). Two isoforms of the dectin-1 molecule and five isoforms of the dectin-2 molecule have also been identified. The invention further provides His-tagged fusion proteins comprising 6x histidine and the extracellular domain of dectin-1 or dectin-2. Also provided are antibodies raised to synthetic peptides designed from the dectin-1 sequence or to the His-tagged fusion proteins described.
摘要翻译：提供了保留常驻表皮朗格汉斯细胞（LC）的重要特征的来自鼠表皮的长期树突细胞（DC）系（XS系列）选择性表达的新基因。这些基因编码不同的II型膜整合多肽，每个多肽由细胞质结构域，跨膜结构域，细胞外连接结构域和与碳水化合物识别结构域（CRD）显示显着同源性的C-末端胞外结构域）组成C- 型凝集素。两种基因的表达高度限于DC谱系细胞（包括表皮LC）。因此，这些基因编码C型凝集素家族的新的DC特异性成员，现在称为“DC-相关C型凝集素-1和-2”（果胶-1和果胶-2）。还鉴定了果胶-1分子的两种同工型和果胶-2分子的五种同种型。本发明还提供包含6x组氨酸和dectin-1或dectin-2的细胞外结构域的His-标记的融合蛋白。还提供了针对由所述dectin-1序列或所述His标记的融合蛋白设计的合成肽产生的抗体。

3. 发明申请

US20200206343A1 ANTI-DC-HIL ANTIBODIES FOR CANCER DIAGNOSIS, PROGNOSIS AND THERAPY 审中-公开
公开(公告)号：US20200206343A1
公开(公告)日：2020-07-02
申请号：US16731285
申请日：2019-12-31
申请人： Kiyoshi ARIIZUMI , Ponciano CRUZ
发明人： Kiyoshi ARIIZUMI , Ponciano CRUZ
IPC分类号： A61K39/395 , C07K16/28 , A61K35/15 , A61K45/06 , C12Q1/6886 , G01N33/574 , C12Q1/68 , C07K16/30
摘要： The present disclosure is directed to antibodies that bind to DC-HIL on the surface of myeloid-derived suppressor cells, and thus antagonize the T cell suppressor function of these cells, as well as their use in diagnosing and treating cancers such as melanoma.

4. 发明授权

US07129039B2 Unique dendritic cell-associated C-type lectins, dectin-1 and dectin-2; compositions and uses thereof 失效
公开(公告)号：US07129039B2
公开(公告)日：2006-10-31
申请号：US10201060
申请日：2002-07-23
申请人： Kiyoshi Ariizumi , Akira Takashima
发明人： Kiyoshi Ariizumi , Akira Takashima
IPC分类号： C12Q1/00 , G01N33/53
CPC分类号： C07K14/7056 , A01K2217/075 , A61K38/00 , A61K2039/5154 , C07K2319/00
摘要： Novel genes expressed selectively by long-term dendritic cell (DC) lines (XS series) from murine epidermis which retain important features of resident epidermal Langerhans cells (LC) are provided. These genes encode distinct type II membrane-integrated polypeptides, each consisting of a cytoplasmic domain, a transmembrane domain, an extracellular connecting domain, and a C-terminal extracellular domain that exhibits significant homology to the carbohydrate recognition domains (CRD) of C-type lectins. Expression of both genes is highly restricted to cells of DC lineage (including epidermal LC). Thus, these genes encode new, DC-specific members of the C-type lectin family, now termed “DC-associated C-type lectin-1 and -2” (dectin-1 and dectin-2). Two isoforms of the dectin-1 molecule and five isoforms of the dectin-2 molecule have also been identified. The invention further provides His-tagged fusion proteins comprising 6× histidine and the extracellular domain of dectin-1 or dectin-2. Also provided are antibodies raised to synthetic peptides designed from the dectin-1 sequence or to the His-tagged fusion proteins described.

5. 发明申请

US20060074007A1 Unique dendritic cell-associated C-type lectins, dectin-1 and dectin-2; compositions and uses thereof 失效
公开(公告)号：US20060074007A1
公开(公告)日：2006-04-06
申请号：US10201060
申请日：2002-07-23
申请人： Kiyoshi Ariizumi , Akira Takashima
发明人： Kiyoshi Ariizumi , Akira Takashima
IPC分类号： A61K38/17 , G01N33/574
CPC分类号： C07K14/7056 , A01K2217/075 , A61K38/00 , A61K2039/5154 , C07K2319/00
摘要： Novel genes expressed selectively by long-term dendritic cell (DC) lines (XS series) from murine epidermis which retain important features of resident epidermal Langerhans cells (LC) are provided. These genes encode distinct type II membrane-integrated polypeptides, each consisting of a cytoplasmic domain, a transmembrane domain, an extracellular connecting domain, and a C-terminal extracellular domain that exhibits significant homology to the carbohydrate recognition domains (CRD) of C-type lectins. Expression of both genes is highly restricted to cells of DC lineage (including epidermal LC). Thus, these genes encode new, DC-specific members of the C-type lectin family, now termed “DC-associated C-type lectin-1 and -2” (dectin-1 and dectin-2). Two isoforms of the dectin-1 molecule and five isoforms of the dectin-2 molecule have also been identified. The invention further provides His-tagged fusion proteins comprising 6× histidine and the extracellular domain of dectin-1 or dectin-2. Also provided are antibodies raised to synthetic peptides designed from the dectin-1 sequence or to the His-tagged fusion proteins described.

6. 发明授权

US6046158A Unique dendritic cell-associated C-type lectins, dectin-1 and dectin-2; compositions and uses thereof 失效
标题翻译：独特的树突状细胞相关C型凝集素，dectin-1和dectin-2; 组合物和用途
公开(公告)号：US6046158A
公开(公告)日：2000-04-04
申请号：US772440
申请日：1996-12-20
申请人： Kiyoshi Ariizumi , Akira Takashima
发明人： Kiyoshi Ariizumi , Akira Takashima
IPC分类号： C12N15/09 , A61K38/00 , C07K14/705 , A61K38/04 , C07K7/08 , C07K19/00
CPC分类号： C07K14/7056 , A01K2217/075 , A61K2039/5154 , A61K38/00 , C07K2319/00
摘要： Novel genes expressed selectively by long-term dendritic cell (DC) lines (XS series) from murine epidermis which retain important features of resident epidermal Langerhans cells (LC) are provided. These genes encode distinct type II membrane-integrated polypeptides, each consisting of a cytoplasmic domain, a transmembrane domain, an extracellular connecting domain, and a C-terminal extracellular domain that exhibits significant homology to the carbohydrate recognition domains (CRD) of C-type lectins. Expression of both genes is highly restricted to cells of DC lineage (including epidermal LC). Thus, these genes encode new, DC-specific members of the C-type lectin family, now termed "DC-associated C-type lectin-1 and -2" (dectin-1 and dectin-2). Two isoforms of the dectin-1 molecule and five isoforms of the dectin-2 molecule have also been identified. The invention further provides His-tagged fusion proteins comprising 6.times. histidine and the extracellular domain of dectin-1 or dectin-2. Also provided are antibodies raised to synthetic peptides designed from the dectin-1 sequence or to the His-tagged fusion proteins described.
摘要翻译：提供了保留常驻表皮朗格汉斯细胞（LC）的重要特征的来自鼠表皮的长期树突细胞（DC）系（XS系列）选择性表达的新基因。这些基因编码不同的II型膜整合多肽，每个由细胞质结构域，跨膜结构域，细胞外连接结构域和与C型碳水化合物识别结构域（CRD）显示显着同源性的C-末端胞外结构域组成凝集素。两种基因的表达高度限于DC谱系细胞（包括表皮LC）。因此，这些基因编码C型凝集素家族的新的DC特异性成员，现在称为“DC-相关C型凝集素-1和-2”（果胶-1和果胶-2）。还鉴定了果胶-1分子的两种同工型和果胶-2分子的五种同种型。本发明还提供包含6x组氨酸和dectin-1或dectin-2的细胞外结构域的His-标记的融合蛋白。还提供了针对由所述dectin-1序列或所述His标记的融合蛋白设计的合成肽产生的抗体。

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