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1. 发明授权

US5788687A Compositions and devices for controlled release of active ingredients 失效
标题翻译：用于控制释放活性成分的组合物和装置
公开(公告)号：US5788687A
公开(公告)日：1998-08-04
申请号：US509120
申请日：1995-07-31
申请人： Christopher D. Batich , Marc S. Cohen , Kirk Foster , William Toreki, III
发明人： Christopher D. Batich , Marc S. Cohen , Kirk Foster , William Toreki, III
IPC分类号： A61K9/20 , A61K9/22 , A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16
CPC分类号： A61L31/10 , A61K9/2027 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/404 , A61L2300/602 , A61L2300/606
摘要： A method for the controlled release of a biologically active agent wherein the agent is released from a hydrophobic, pH-sensitive polymer matrix is disclosed and claimed. In one embodiment, the polymer matrix swells when the environment reaches pH 8.5, releasing the active agent. A polymer of hydrophobic and weakly acidic comonomers is disclosed for use in the controlled release system. In another embodiment, weakly basic comonomers are used and the active agent is released as the pH drops. Further disclosed is a specific embodiment in which the controlled release system may be used. The pH-sensitive polymer is coated onto a latex catheter used in ureteral catheterization. A common problem with catheterized patients is the infection of the urinary tract with urease-producing bacteria. In addition to the irritation caused by the presence of the bacteria, urease produced by these bacteria degrade urea in the urine, forming carbon dioxide and ammonia. The ammonia causes an increase in the pH of the urine. Minerals in the urine begin to precipitate at this high pH, forming encrustations which complicate the functioning of the catheter. A ureteral catheter coated with a pH-sensitive polymer having an antibiotic or urease inhibitor trapped within its matrix releases the active agent when exposed to the high pH urine as the polymer gel swells. Such release can be made slow enough so that the drug remains at significant levels for a clinically useful period of time. Other uses for the methods and devices of this invention include use in gastrointestinal tubes, respiratory trap lines and ventilation tubes, dye releasing pH sensitive sutures, active agent release from contact lenses, penile implants, heart pacemakers, neural shunts, food wraps, and clean room walls.
摘要翻译：公开并要求保护其中药物从疏水性，pH敏感性聚合物基质释放的生物活性剂的受控释放的方法。在一个实施方案中，当环境达到pH8.5时，聚合物基体膨胀，释放活性剂。公开了疏水和弱酸性共聚单体的聚合物用于控制释放系统。在另一个实施方案中，使用弱碱性共聚单体，并且随着pH下降，活性剂被释放。进一步公开的是其中可以使用控制释放系统的具体实施例。将pH敏感聚合物涂覆在用于输尿管导管插入术的乳胶导管上。导尿患者的常见问题是产生尿素酶的细菌导致尿路感染。除了由细菌的存在引起的刺激之外，由这些细菌产生的尿素酶会在尿液中降解尿素，形成二氧化碳和氨。氨会引起尿液的pH值增加。尿液中的矿物质在该高pH下开始沉淀，形成结垢，导致导管的功能复杂化。涂覆有pH敏感聚合物的输尿管导管，当聚合物凝胶溶胀时，当暴露于高pH值尿液时，捕获在其基质内的抗生素或脲酶抑制剂释放活性剂。这样的释放可以足够慢，使得药物在临床有用的时间段内保持在显着水平。用于本发明的方法和装置的其它用途包括用于胃肠管，呼吸陷阱线和通气管，染料释放pH敏感缝线，从隐形眼镜释放的活性剂，阴茎植入物，心脏起搏器，神经分流器，食品包装和清洁房间墙壁

2. 发明授权

US5554147A Compositions and devices for controlled release of active ingredients 失效
标题翻译：用于控制释放活性成分的组合物和装置
公开(公告)号：US5554147A
公开(公告)日：1996-09-10
申请号：US189854
申请日：1994-02-01
申请人： Christopher D. Batich , Marc S. Cohen , Kirk Foster
发明人： Christopher D. Batich , Marc S. Cohen , Kirk Foster
IPC分类号： A61K9/20 , A61K9/22 , A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/16
CPC分类号： A61K31/57 , A61K9/2027 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/404 , A61L2300/602 , A61L2300/606
摘要： A method for the controlled release of a biologically active agent wherein the agent is released from a hydrophobic, pH-sensitive polymer matrix is disclosed and claimed. The polymer matrix swells when the environment reaches pH 8.5, releasing the active agent. A polymer of hydrophobic and weakly acidic comonomers is disclosed for use in the controlled release system. Further disclosed is a specific embodiment in which the controlled release system may be used. The pH-sensitive polymer is coated onto a latex catheter used in ureteral catheterization. A common problem with catheterized patients is the infection of the urinary tract with urease-producing bacteria. In addition to the irritation caused by the presence of the bacteria, urease produced by these bacteria degrade urea in the urine, forming carbon dioxide and ammonia. The ammonia causes an increase in the pH of the urine. Minerals in the urine begin to precipitate at this high pH, forming encrustations which complicate the functioning of the catheter. A ureteral catheter coated with a pH-sensitive polymer having an antibiotic or urease inhibitor trapped within its matrix will release the active agent when exposed to the high pH urine as the polymer gel swells. Such release can be made slow enough so that the drug remains at significant levels for a clinically useful period of time.
摘要翻译：公开并要求保护其中药物从疏水性，pH敏感性聚合物基质释放的生物活性剂的受控释放的方法。当环境达到pH8.5时，聚合物基体膨胀，释放活性剂。公开了疏水和弱酸性共聚单体的聚合物用于控制释放系统。进一步公开的是其中可以使用控制释放系统的具体实施例。将pH敏感聚合物涂覆在用于输尿管导管插入术的乳胶导管上。导尿患者的常见问题是产生尿素酶的细菌导致尿路感染。除了由细菌的存在引起的刺激之外，由这些细菌产生的尿素酶会在尿液中降解尿素，形成二氧化碳和氨。氨会引起尿液的pH值增加。尿液中的矿物质在该高pH下开始沉淀，形成结垢，导致导管的功能复杂化。涂覆有pH敏感聚合物的输尿管导管，当聚合物凝胶溶胀时，当暴露于高pH值尿液时，其中具有捕获在其基质内的抗生素或脲酶抑制剂将释放活性剂。这样的释放可以足够慢，使得药物在临床有用的时间段内保持在显着水平。

3. 发明申请

US20080103623A1 FACILITY CONNECTION POSITIONING TEMPLATE 审中-公开
标题翻译：设备连接定位模板
公开(公告)号：US20080103623A1
公开(公告)日：2008-05-01
申请号：US11770546
申请日：2007-06-28
申请人： Oscar Gomez , Jeffrey Barrett Robinson , Jason Kirk Foster , Duc Dang Buckius
发明人： Oscar Gomez , Jeffrey Barrett Robinson , Jason Kirk Foster , Duc Dang Buckius
IPC分类号： G06F19/00
CPC分类号： H01L21/6719 , H01L21/67017 , H01L21/67196
摘要： One embodiment of an apparatus includes a flat, plate-shaped template adapted for facilities integration. The template defines a plurality of apertures arranged in a predetermined pattern of locations, each template aperture adapted to position a facility conduit passing through each template aperture in a predetermined location to facilitate subsequently coupling the positioned facility conduit to the wafer processing tool. Other embodiments are described and claimed.
摘要翻译：装置的一个实施例包括适于设施集成的平板的板状模板。模板限定了以预定图案的位置布置的多个孔，每个模板孔适于将设备导管定位成穿过每个模板孔在预定位置，以便于随后将定位的设备导管连接到晶片处理工具。描述和要求保护其他实施例。

4. 发明授权

US06306422B1 Compositions and devices for controlled release of active ingredients 失效
标题翻译：用于控制释放活性成分的组合物和装置
公开(公告)号：US06306422B1
公开(公告)日：2001-10-23
申请号：US09128252
申请日：1998-08-03
申请人： Christopher D. Batich , Marc S. Cohen , Kirk Foster , William Toreki, III
发明人： Christopher D. Batich , Marc S. Cohen , Kirk Foster , William Toreki, III
IPC分类号： A61M2700
CPC分类号： A61L31/10 , A61K9/2027 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/404 , A61L2300/602 , A61L2300/606 , C08L33/02
摘要： A method for the controlled release of a biologically active agent wherein the agent is released from a hydrophobic, pH-sensitive polymer matrix is disclosed and claimed. In one embodiment, the polymer matrix swells when the environment reaches pH 8.5, releasing the active agent. A polymer of hydrophobic and weakly acidic comonomers is disclosed for use in the controlled release system. In another embodiment, weakly basic comonomers are used and the active agent is released as the pH drops. Further disclosed is a specific embodiment in which the controlled release system may be used. The pH-sensitive polymer is coated onto a latex catheter used in ureteral catheterization. A common problem with catheterized patients is the infection of the urinary tract with urease-producing bacteria. In addition to the irritation caused by the presence of the bacteria, urease produced by these bacteria degrade urea in the urine, forming carbon dioxide and ammonia. The ammonia causes an increase in the pH of the urine. Minerals in the urine begin to precipitate at this high pH, forming encrustations which complicate the functioning of the catheter. A ureteral catheter coated with a pH-sensitive polymer having an antibiotic or urease inhibitor trapped within its matrix releases the active agent when exposed to the high pH urine as the polymer gel swells. Such release can be made slow enough so that the drug remains at significant levels for a clinically useful period of time. Other uses for the methods and devices of this invention include use in gastrointestinal tubes, respiratory trap lines and ventilation tubes, dye releasing pH sensitive sutures, active agent release from contact lenses, penile implants, heart pacemakers, neural shunts, food wraps, and clean room walls.
摘要翻译：公开并要求保护其中药物从疏水性，pH敏感性聚合物基质释放的生物活性剂的受控释放的方法。在一个实施方案中，当环境达到pH8.5时，聚合物基体膨胀，释放活性剂。公开了疏水和弱酸性共聚单体的聚合物用于控制释放系统。在另一个实施方案中，使用弱碱性共聚单体，并且随着pH下降，活性剂被释放。进一步公开的是其中可以使用控制释放系统的具体实施例。将pH敏感聚合物涂覆在用于输尿管导管插入术的乳胶导管上。导尿患者的常见问题是产生尿素酶的细菌导致尿路感染。除了由细菌的存在引起的刺激之外，由这些细菌产生的尿素酶会在尿液中降解尿素，形成二氧化碳和氨。氨会引起尿液的pH值增加。尿液中的矿物质在该高pH下开始沉淀，形成结垢，导致导管的功能复杂化。涂覆有pH敏感聚合物的输尿管导管，当聚合物凝胶溶胀时，当暴露于高pH值尿液时，捕获在其基质内的抗生素或脲酶抑制剂释放活性剂。这样的释放可以足够慢，使得药物在临床有用的时间段内保持在显着水平。用于本发明的方法和装置的其它用途包括用于胃肠管，呼吸陷阱线和通气管，染料释放pH敏感缝线，从隐形眼镜释放的活性剂，阴茎植入物，心脏起搏器，神经分流器，食品包装和清洁房间墙壁

5. 发明授权

US5607417A Compositions and devices for controlled release of active ingredients 失效
标题翻译：用于控制释放活性成分的组合物和装置
公开(公告)号：US5607417A
公开(公告)日：1997-03-04
申请号：US382315
申请日：1995-02-01
申请人： Christopher D. Batich , Marc S. Cohen , Kirk Foster
发明人： Christopher D. Batich , Marc S. Cohen , Kirk Foster
IPC分类号： A61K9/20 , A61K9/22 , A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/16
CPC分类号： A61K31/57 , A61K9/2027 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/404 , A61L2300/602 , A61L2300/606
摘要： A method for the controlled release of a biologically active agent wherein the agent is released from a hydrophobic, pH-sensitive polymer matrix is disclosed and claimed. The polymer matrix swells when the environment reaches pH 8.5, releasing the active agent. A polymer of hydrophobic and weakly acidic comonomers is disclosed for use in the controlled release system. Further disclosed is a specific embodiment in which the controlled release system may be used. The pH-sensitive polymer is coated onto a latex catheter used in ureteral catheterization. A common problem with catheterized patients is the infection of the urinary tract with ureaseproducing bacteria. In addition to the irritation caused by the presence of the bacteria, urease produced by these bacteria degrade urea in the urine, forming carbon dioxide and ammonia. The ammonia causes an increase in the pH of the urine. Minerals in the urine begin to precipitate at this high pH, forming encrustations which complicate the functioning of the catheter. A ureteral catheter coated with a pH-sensitive polymer having an antibiotic or urease inhibitor trapped within its matrix will release the active agent when exposed to the high pH urine as the polymer gel swells. Such release can be made slow enough so that the drug remains at significant levels for a clinically useful period of time.
摘要翻译：公开并要求保护其中药物从疏水性，pH敏感性聚合物基质释放的生物活性剂的受控释放的方法。当环境达到pH8.5时，聚合物基体膨胀，释放活性剂。公开了疏水和弱酸性共聚单体的聚合物用于控制释放系统。进一步公开的是其中可以使用控制释放系统的具体实施例。将pH敏感聚合物涂覆在用于输尿管导管插入术的乳胶导管上。导尿患者的常见问题是泌尿生殖细菌感染尿道。除了由细菌的存在引起的刺激之外，由这些细菌产生的尿素酶会在尿液中降解尿素，形成二氧化碳和氨。氨会引起尿液的pH值增加。尿液中的矿物质在该高pH下开始沉淀，形成结垢，导致导管的功能复杂化。涂覆有pH敏感聚合物的输尿管导管，当聚合物凝胶溶胀时，当暴露于高pH值尿液时，其中具有捕获在其基质内的抗生素或脲酶抑制剂将释放活性剂。这样的释放可以足够慢，使得药物在临床有用的时间段内保持在显着水平。

6. 发明申请

US20050283082A1 Optical noninvasive vital sign monitor 有权
标题翻译：光学无创生命体征监测仪
公开(公告)号：US20050283082A1
公开(公告)日：2005-12-22
申请号：US11157215
申请日：2005-06-20
申请人： Leslie Geddes , Rebecca Roeder , Kirk Foster , George Graber
发明人： Leslie Geddes , Rebecca Roeder , Kirk Foster , George Graber
IPC分类号： A61B5/00 , A61B5/02 , A61B5/021
CPC分类号： A61B5/6814 , A61B5/0059 , A61B5/021 , A61B5/02225
摘要： An optical noninvasive vital sign monitor comprising a reflectance-type optical sensor within a pressurizable capsule retained by a headband, the capsule having an optically transparent or translucent inner wall adapted for placement against a subject's forehead. The optical sensor is mounted on the inside surface of the pressurizable capsule's inner wall, which contacts the subject's forehead during use, and includes a light source and a photodetector aimed toward the inside surface of the inner capsule wall. One embodiment of the vital sign monitor includes optical oscillometric circuit means responsive to an output signal from the optical sensor for determining systolic pressure, mean pressure and diastolic pressure during a transition in capsule pressure between a pressure greater than normal systolic pressure and a pressure less than normal diastolic pressure.
摘要翻译：一种光学非侵入性生命体征监测器，包括由头带保持的可加压胶囊内的反射型光学传感器，所述胶囊具有适于放置在被检者的前额上的光学透明或半透明内壁。光学传感器安装在可加压胶囊的内壁的内表面上，该内壁在使用期间接触被检者的前额，并且包括光源和瞄准内囊壁内表面的光检测器。生命体征监测器的一个实施例包括响应于来自光学传感器的输出信号的光学示波电路装置，用于确定在压力大于正常收缩压和小于压力的压力之间的胶囊压力转换期间的收缩压，平均压力和舒张压正常舒张压。

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