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1. 发明授权

US07928038B2 Intermediates and methods for forming passivated surfaces on oxide layers and articles produced thereby 有权
标题翻译：用于在由其制造的氧化物层和制品上形成钝化表面的中间体和方法
公开(公告)号：US07928038B2
公开(公告)日：2011-04-19
申请号：US11943851
申请日：2007-11-21
申请人： Steven M. Menchen , Christina E. Inman , Meng Taing , Khai Luong , Handong Li
发明人： Steven M. Menchen , Christina E. Inman , Meng Taing , Khai Luong , Handong Li
IPC分类号： C40B60/14 , C12M1/34 , C07H21/02 , A61K38/04
CPC分类号： G01N33/54393 , G01N33/551 , Y10T428/31678
摘要： Intermediates and methods for forming passivated surfaces on oxide layers and articles produced thereby are described. Hydroxyl or hydroxide groups on the oxide surfaces are reacted with a metal reagent of the formula Y(L-Pol)m, where Y is a transition metal, magnesium or aluminum, L is oxygen, sulfur, selenium or an amine, and “Pol” represents a passivating agent such as a polyethylene glycol, a hydrocarbon, or a fluorocarbon. The resulting modified surface can be further reacted with a passivating agent having a phosphate functional group or a polyvalent reagent comprising a passivating moiety and a plurality of functional groups that are reactive with or that form complexes with Y. The passivating agent can also include a functional group such as biotin to provide surfaces with a desired functionality. The passivated surfaces exhibit minimal binding to bio-molecules and can be used in single-molecule detection schemes.
摘要翻译：描述了用于在氧化物层上形成钝化表面的中间体和方法以及由此制备的制品。氧化物表面上的羟基或氢氧基与式Y（L-Pol）m的金属试剂反应，其中Y是过渡金属，镁或铝，L是氧，硫，硒或胺，“Pol “表示钝化剂，例如聚乙二醇，烃或碳氟化合物。所得到的改性表面可以进一步与具有磷酸酯官能团的钝化剂或包含钝化部分和多个与Y形成复合物的多个官能团的多价试剂反应。钝化剂还可以包括官能团例如生物素，以提供具有所需功能的表面。被钝化的表面表现出与生物分子的最小结合，并可用于单分子检测方案。

2. 发明申请

US20090181396A1 METHODS AND SYSTEMS FOR ANALYSIS OF FLUORESCENT REACTIONS WITH MODULATED EXCITATION 有权
标题翻译：用调制激发荧光反应分析的方法与系统
公开(公告)号：US20090181396A1
公开(公告)日：2009-07-16
申请号：US12351173
申请日：2009-01-09
申请人： Khai Luong , Paul Lundquist , Ravi Dalal , John Lyle , Stephen Turner
发明人： Khai Luong , Paul Lundquist , Ravi Dalal , John Lyle , Stephen Turner
IPC分类号： C12Q1/68 , G01N21/76 , C12M1/34
CPC分类号： C12M1/34 , G01N21/6428 , G01N21/645 , G01N2021/6417 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2021/7786 , Y10T436/2525
摘要： Methods, systems and their components for monitoring fluorescent signals and particularly transient fluorescent signals from reaction mixtures of interest, which methods and systems employ modulated excitation light sources to reduce impacts of excessive illumination on the reaction components or the data obtained therefrom.
摘要翻译：用于监测来自感兴趣的反应混合物的荧光信号和特别是瞬时荧光信号的方法，系统及其组件，该方法和系统采用调制的激发光源以减少过度照明对反应组分的影响或由其获得的数据。

3. 发明申请

US20060277748A1 Method of mounting electro-conductive rings on a non-conductive tubular body 审中-公开
标题翻译：将导电环安装在非导电管状体上的方法
公开(公告)号：US20060277748A1
公开(公告)日：2006-12-14
申请号：US11146979
申请日：2005-06-08
申请人： Khai Luong
发明人： Khai Luong
IPC分类号： H01F7/06
CPC分类号： A61B5/042 , A61B2562/125 , A61N1/05 , A61N1/0509 , A61N1/0517 , A61N1/0519 , A61N1/0551 , A61N1/056 , Y10T29/49073 , Y10T29/49194
摘要： An inexpensive method to build thin-wall, flush-mounted, electro-conductive rings directly from the conductor leads embedded inside a non-conductive tubular body is described. Such rings, made from a combination of mechanical and chemical processes, are intended for use as cylindrical electrodes when placed inside human tubular organs.
摘要翻译：描述了一种廉价的方法来直接从嵌入在非导电管状体内的导体引线构建薄壁，嵌入式导电环。这些由机械和化学过程的组合制成的环，当放置在人体管状器官内时用作圆柱形电极。

4. 发明申请

US20110159305A1 Intermediates And Methods For Forming Passivated Surfaces On Oxide Layers And Articles Produced Thereby 审中-公开
标题翻译：中间体和方法在氧化物层和由此产生的制品上形成钝化表面
公开(公告)号：US20110159305A1
公开(公告)日：2011-06-30
申请号：US13044759
申请日：2011-03-10
申请人： Steven M. MENCHEN , Christina E. Inman , Meng Taing , Khai Luong , Handong Li
发明人： Steven M. MENCHEN , Christina E. Inman , Meng Taing , Khai Luong , Handong Li
IPC分类号： B32B15/00
CPC分类号： G01N33/54393 , G01N33/551 , Y10T428/31678
摘要： Intermediates and methods for forming passivated surfaces on oxide layers and articles produced thereby are described. Hydroxyl or hydroxide groups on the oxide surfaces are reacted with a metal reagent of the formula Y(L-Pol)m, where Y is a transition metal, magnesium or aluminum, L is oxygen, sulfur, selenium or an amine, and “Pol” represents a passivating agent such as a polyethylene glycol, a hydrocarbon, or a fluorocarbon. The resulting modified surface can be further reacted with a passivating agent having a phosphate functional group or a polyvalent reagent comprising a passivating moiety and a plurality of functional groups that are reactive with or that form complexes with Y. The passivating agent can also include a functional group such as biotin to provide surfaces with a desired functionality. The passivated surfaces exhibit minimal binding to bio-molecules and can be used in single-molecule detection schemes.
摘要翻译：描述了用于在氧化物层上形成钝化表面的中间体和方法以及由此制备的制品。氧化物表面上的羟基或氢氧基与式Y（L-Pol）m的金属试剂反应，其中Y是过渡金属，镁或铝，L是氧，硫，硒或胺，“Pol “表示钝化剂，例如聚乙二醇，烃或碳氟化合物。所得到的改性表面可以进一步与具有磷酸酯官能团的钝化剂或包含钝化部分和多个与Y形成复合物的多个官能团的多价试剂反应。钝化剂还可以包括官能团例如生物素，以提供具有所需功能的表面。被钝化的表面表现出与生物分子的最小结合，并可用于单分子检测方案。

5. 发明授权

US07486399B1 Method for mapping a natural gas leak 有权
标题翻译：绘制天然气泄漏的方法
公开(公告)号：US07486399B1
公开(公告)日：2009-02-03
申请号：US12012670
申请日：2008-02-04
申请人： Thomas A. Reichardt , Amy Khai Luong , Thomas J. Kulp , Sanjay Devdas
发明人： Thomas A. Reichardt , Amy Khai Luong , Thomas J. Kulp , Sanjay Devdas
IPC分类号： G01N21/01 , G01N21/00
CPC分类号： G01N21/314 , G01M3/20 , G01M3/38 , G01N21/53
摘要： A system is described that is suitable for use in determining the location of leaks of gases having a background concentration. The system is a point-wise backscatter absorption gas measurement system that measures absorption and distance to each point of an image. The absorption measurement provides an indication of the total amount of a gas of interest, and the distance provides an estimate of the background concentration of gas. The distance is measured from the time-of-flight of laser pulse that is generated along with the absorption measurement light. The measurements are formatted into an image of the presence of gas in excess of the background. Alternatively, an image of the scene is superimposed on the image of the gas to aid in locating leaks. By further modeling excess gas as a plume having a known concentration profile, the present system provides an estimate of the maximum concentration of the gas of interest.
摘要翻译：描述了适用于确定具有背景浓度的气体泄漏位置的系统。该系统是一个点向后向散射吸收气体测量系统，其测量到图像每个点的吸收和距离。吸收测量提供了所关注的气体总量的指示，并且距离提供了气体的背景浓度的估计。从与吸收测量光一起产生的激光脉冲的飞行时间测量距离。测量被格式化为超过背景的气体的存在的图像。或者，将场景的图像叠加在气体的图像上，以帮助定位泄漏。通过进一步建模过量气体作为具有已知浓度分布的羽流，本系统提供所关注气体的最大浓度的估计。

6. 发明授权

US08802424B2 Methods and systems for analysis of fluorescent reactions with modulated excitation 有权
标题翻译：用调制激发分析荧光反应的方法和系统
公开(公告)号：US08802424B2
公开(公告)日：2014-08-12
申请号：US12351173
申请日：2009-01-09
申请人： Khai Luong , Paul Lundquist , Ravi Dalal , John Lyle , Stephen Turner
发明人： Khai Luong , Paul Lundquist , Ravi Dalal , John Lyle , Stephen Turner
IPC分类号： C12M1/00 , C12Q1/68 , C12M1/34 , G01N21/64 , G01N1/00
CPC分类号： C12M1/34 , G01N21/6428 , G01N21/645 , G01N2021/6417 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2021/7786 , Y10T436/2525
摘要： Methods, systems and their components for monitoring fluorescent signals and particularly transient fluorescent signals from reaction mixtures of interest, which methods and systems employ modulated excitation light sources to reduce impacts of excessive illumination on the reaction components or the data obtained therefrom.
摘要翻译：用于监测来自感兴趣的反应混合物的荧光信号和特别是瞬时荧光信号的方法，系统及其组件，该方法和系统采用调制的激发光源以减少过度照明对反应组分的影响或从其获得的数据。

7. 发明授权

US07310142B2 Fast time-correlated multi-element photon detector and method 有权
标题翻译：快速时间相关多元素光子检测器和方法
公开(公告)号：US07310142B2
公开(公告)日：2007-12-18
申请号：US11209353
申请日：2005-08-22
申请人： Carl C. Hayden , David W. Chandler , A. Khai Luong
发明人： Carl C. Hayden , David W. Chandler , A. Khai Luong
IPC分类号： G01J3/30
CPC分类号： G01J1/42 , G01J3/14 , G01J3/2889 , G01N21/6408 , G01N21/6452 , G01N21/6458 , G01N2021/6417 , G01N2021/6421 , G01N2021/6441
摘要： Photons emitted from a sample responsive to being excited by laser pulses are directed through a prism onto a photomultiplier tube having several spaced-apart anodes. The prism alters the path of each photon as a function of its wavelength so that the wavelength determines the anode to which the photon is directed. Taps of first and second delay lines that are coupled to respective alternating anodes. When an anode receives the photon, it generates a pulse that propagates through the delay line in opposite directions from its associated tap. A timer determines first and second times from the laser pulse to the pulse reaching the first and second ends of the delay line. The difference between the first and second times corresponds to the wavelength of the emitted photon and the sum of the first and second times corresponds to the emission delay of the emitted photon.
摘要翻译：响应于激光脉冲激发的样品发射的光子被引导通过棱镜到具有多个间隔开的阳极的光电倍增管上。棱镜根据其波长改变每个光子的路径，使得波长决定光子所指向的阳极。连接到各个交替阳极的第一和第二延迟线的抽头。当阳极接收到光子时，它产生一个脉冲，通过延迟线从相关的水龙头以相反的方向传播。定时器从激光脉冲到达延迟线的第一和第二端的脉冲的第一次和第二次。第一次和第二次之间的差值对应于发射光子的波长，第一次和第二次的和对应于发射的光子的发射延迟。

8. 发明授权

US07375814B2 Natural gas leak mapper 有权
标题翻译：天然气泄漏图
公开(公告)号：US07375814B2
公开(公告)日：2008-05-20
申请号：US11078527
申请日：2005-03-11
申请人： Thomas A. Reichardt , Amy Khai Luong , Thomas J. Kulp , Sanjay Devdas
发明人： Thomas A. Reichardt , Amy Khai Luong , Thomas J. Kulp , Sanjay Devdas
IPC分类号： G01N21/01 , G01N21/00
CPC分类号： G01N21/314 , G01M3/20 , G01M3/38 , G01N21/53
摘要： A system is described that is suitable for use in determining the location of leaks of gases having a background concentration. The system is a point-wise backscatter absorption gas measurement system that measures absorption and distance to each point of an image. The absorption measurement provides an indication of the total amount of a gas of interest, and the distance provides an estimate of the background concentration of gas. The distance is measured from the time-of-flight of laser pulse that is generated along with the absorption measurement light. The measurements are formated into an image of the presence of gas in excess of the background. Alternatively, an image of the scene is superimosed on the image of the gas to aid in locating leaks. By further modeling excess gas as a plume having a known concentration profile, the present system provides an estimate of the maximum concentration of the gas of interest.
摘要翻译：描述了适用于确定具有背景浓度的气体泄漏位置的系统。该系统是一个点向后向散射吸收气体测量系统，其测量到图像每个点的吸收和距离。吸收测量提供了所关注的气体总量的指示，并且距离提供了气体的背景浓度的估计。从与吸收测量光一起产生的激光脉冲的飞行时间测量距离。测量结果形成了超过背景气体存在的图像。或者，将场景的图像叠加在气体的图像上以帮助定位泄漏。通过进一步建模过量气体作为具有已知浓度分布的羽流，本系统提供所关注气体的最大浓度的估计。

9. 发明申请

US20080176761A1 Intermediates and Methods for Forming Passivated Surfaces on Oxide Layers and Articles Produced Thereby 有权
标题翻译：中间体和氧化层上形成钝化表面的方法和由此产生的制品
公开(公告)号：US20080176761A1
公开(公告)日：2008-07-24
申请号：US11943851
申请日：2007-11-21
申请人： Steven M. Menchen , Christina E. Inman , Meng Taing , Khai Luong , Handong Li
发明人： Steven M. Menchen , Christina E. Inman , Meng Taing , Khai Luong , Handong Li
IPC分类号： C40B50/14 , C40B40/00 , C07F9/09 , C07F9/02 , C40B50/18
CPC分类号： G01N33/54393 , G01N33/551 , Y10T428/31678
摘要： Intermediates and methods for forming passivated surfaces on oxide layers and articles produced thereby are described. Hydroxyl or hydroxide groups on the oxide surfaces are reacted with a metal reagent of the formula Y(L-Pol)m, where Y is a transition metal, magnesium or aluminum, L is oxygen, sulfur, selenium or an amine, and “Pol” represents a passivating agent such as a polyethylene glycol, a hydrocarbon, or a fluorocarbon. The resulting modified surface can be further reacted with a passivating agent having a phosphate functional group or a polyvalent reagent comprising a passivating moiety and a plurality of functional groups that are reactive with or that form complexes with Y. The passivating agent can also include a functional group such as biotin to provide surfaces with a desired functionality. The passivated surfaces exhibit minimal binding to bio-molecules and can be used in single-molecule detection schemes.
摘要翻译：描述了用于在氧化物层上形成钝化表面的中间体和方法以及由此制备的制品。氧化物表面上的羟基或氢氧基与式Y（L-POL）m的金属试剂反应，其中Y是过渡金属，镁或铝，L是氧，硫，硒或胺，“Pol”表示钝化剂，例如聚乙二醇，烃或碳氟化合物。所得到的改性表面可以进一步与具有磷酸酯官能团的钝化剂或包含钝化部分和多个与Y形成复合物的多个官能团的多价试剂反应。钝化剂还可以包括官能团例如生物素，以提供具有所需功能的表面。被钝化的表面表现出与生物分子的最小结合，并可用于单分子检测方案。

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