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1. 发明申请

US20110172400A1 COMPOSITIONS MONOVALENT FOR CD40L BINDING AND METHODS OF USE 审中-公开
标题翻译： CD40L结合物的组合物单一使用方法和使用方法
公开(公告)号：US20110172400A1
公开(公告)日：2011-07-14
申请号：US12941870
申请日：2010-11-08
申请人： Steven Grant , Haiqun Liu , Kevin Moulder
发明人： Steven Grant , Haiqun Liu , Kevin Moulder
IPC分类号： C07K16/18
CPC分类号： C07K16/2875 , C07K2317/565 , C07K2317/569 , C07K2317/76
摘要： The invention relates to antibody polypeptides that monovalently bind CD4OL. Antibody polypeptides that are monovalent for binding of CD4OL can inhibit CD4OL activity while avoiding potential undesirable effects that can occur with antibodies capable of divalent or multivalent binding of DC4OL. in one aspect, a monovalent anti-CD4OL antibody polypeptide consists of or comprises a single immunoglobulin variable domain that specifically binds and antagonizes the activity of DC4OL, preferably without substantially agonizing CD40 activity. In another aspect, the monovalent anti-CD4OL antibody polypeptide is a human antibody polypeptide. The invention further encompasses methods of antagonizing CD40/CD4OL interactions in an individual and methods of treating diseases or disorders involving CD40/DC4OL interactions, the methods involving administering a monovalent anti-CD4OL antibody polypeptide to the individual.
摘要翻译：本发明涉及单价结合CD4OL的抗体多肽。用于结合CD4OL的单价抗体多肽可以抑制CD4OL活性，同时避免可能与能够进行DC4OL的二价或多价结合的抗体发生的不良反应。在一个方面，单价抗-T1OL抗体多肽由特异性结合并拮抗DC4OL的活性的单个免疫球蛋白可变区组成或包含，优选不具有实质上激动的CD40活性。另一方面，单价抗-TOLOL抗体多肽是人抗体多肽。本发明还包括拮抗个体中CD40 / CD4OL相互作用的拮抗作用的方法以及治疗涉及CD40 / DC4OL相互作用的疾病或病症的方法，所述方法包括对个体施用单价抗-TOLOL抗体多肽。

2. 发明申请

US20100234570A1 Ligand 审中-公开
标题翻译：配体
公开(公告)号：US20100234570A1
公开(公告)日：2010-09-16
申请号：US11501546
申请日：2006-08-08
申请人： Kevin Moulder , Ian Tomlinson
发明人： Kevin Moulder , Ian Tomlinson
IPC分类号： C07K16/00
CPC分类号： C07K16/18 , C07K16/241 , C07K16/2875 , C07K16/2878 , C07K16/40 , C07K16/42 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/53 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/622 , C07K2317/626 , C07K2317/92 , C07K2318/20
摘要： The invention provides a dual-specific ligand comprising a first immunoglobulin variable domain having a first binding specificity and a complementary or non-complementary immunoglobulin variable domain having a second binding specificity.
摘要翻译：本发明提供了包含具有第一结合特异性的第一免疫球蛋白可变结构域和具有第二结合特异性的互补或非互补免疫球蛋白可变结构域的双重特异性配体。

3. 发明申请

US20090297524A1 Compositions monovalent for CD40L binding and methods of use 有权
标题翻译：用于CD40L结合的单价组合物和使用方法
公开(公告)号：US20090297524A1
公开(公告)日：2009-12-03
申请号：US11663247
申请日：2005-09-16
申请人： Steven Grant , Haiqun Liu , Kevin Moulder
发明人： Steven Grant , Haiqun Liu , Kevin Moulder
IPC分类号： A61K39/395 , C07K16/28 , A61P37/00
CPC分类号： C07K16/2875 , C07K2317/565 , C07K2317/569 , C07K2317/76
摘要： The invention relates to antibody polypeptides that monovalently bind CD40L. Antibody polypeptides that are monovalent for binding of CD40L can inhibit CD40L activity while avoiding potential undesirable effects that can occur with antibodies capable of divalent or multivalent binding of CD40L. In one aspect, a monovalent anti-CD40L antibody polypeptide consists of or comprises a single immunoglobulin variable domain that specifically binds and antagonizes the activity of CD40L, preferably without substantially agonizing CD40 and/or CD40L activity. In another aspect, the monovalent anti-CD40L antibody polypeptide is a human antibody polypeptide. The invention further encompasses methods of antagonizing CD40/CD40L interactions in an individual and methods of treating diseases or disorders involving CD40/CD40L interactions, the methods involving administering a monovalent anti-CD40L antibody polypeptide to the individual.
摘要翻译：本发明涉及单价结合CD40L的抗体多肽。针对CD40L结合的单价抗体多肽可以抑制CD40L活性，同时避免可能与能够进行CD40L二价或多价结合的抗体发生的不良反应。一方面，单价抗CD40L抗体多肽由特异性结合和拮抗CD40L的活性的单个免疫球蛋白可变区组成或包含，优选不具有实质上激动的CD40和/或CD40L活性。另一方面，单价抗CD40L抗体多肽是人抗体多肽。本发明还包括拮抗个体中CD40 / CD40L相互作用的拮抗作用的方法以及治疗涉及CD40 / CD40L相互作用的疾病或病症的方法，涉及向个体施用单价抗CD40L抗体多肽的方法。

4. 发明申请

US20070093651A1 Ligand 审中-公开
标题翻译：配体
公开(公告)号：US20070093651A1
公开(公告)日：2007-04-26
申请号：US11501522
申请日：2006-08-08
申请人： Kevin Moulder , Ian Tomlinson
发明人： Kevin Moulder , Ian Tomlinson
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , C07K16/241 , C07K16/2875 , C07K16/2878 , C07K16/40 , C07K16/42 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/53 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/622 , C07K2317/626 , C07K2317/92 , C07K2318/20
摘要： The invention provides a dual-specific ligand comprising a first immunoglobulin variable domain having a first binding specificity and a complementary or non-complementary immunoglobulin variable domain having a second binding specificity.
摘要翻译：本发明提供了包含具有第一结合特异性的第一免疫球蛋白可变结构域和具有第二结合特异性的互补或非互补免疫球蛋白可变结构域的双重特异性配体。

5. 发明申请

US20060063921A1 Ligand 审中-公开
公开(公告)号：US20060063921A1
公开(公告)日：2006-03-23
申请号：US11217919
申请日：2005-09-01
申请人： Kevin Moulder , Ian Tomlinson
发明人： Kevin Moulder , Ian Tomlinson
IPC分类号： A61K39/395 , C07K16/44
CPC分类号： C07K16/18 , C07K16/241 , C07K16/2875 , C07K16/2878 , C07K16/40 , C07K16/42 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/53 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/622 , C07K2317/626 , C07K2317/92 , C07K2318/20
摘要： The invention provides a dual-specific ligand comprising a first immunoglobulin variable domain having a first binding specificity and a complementary or non-complementary immunoglobulin variable domain having a second binding specificity.

6. 发明申请

US20100081792A1 Ligand 审中-公开
标题翻译：配体
公开(公告)号：US20100081792A1
公开(公告)日：2010-04-01
申请号：US11981821
申请日：2007-10-31
申请人： Steven Grant , Amrik Basran , Olga Ignatovich , Rudolph Maria T. De Wildt , Philip Jones , Neil Brewis , Ben Woolven , Elena De Angelis , Lucy J. Holt , Greg Winter , Ian Tomlinson , Kevin Moulder
发明人： Steven Grant , Amrik Basran , Olga Ignatovich , Rudolph Maria T. De Wildt , Philip Jones , Neil Brewis , Ben Woolven , Elena De Angelis , Lucy J. Holt , Greg Winter , Ian Tomlinson , Kevin Moulder
IPC分类号： C07K16/00
CPC分类号： C07K16/468 , A61K47/60 , A61K2039/505 , C07K14/415 , C07K16/18 , C07K16/22 , C07K16/241 , C07K16/2866 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/52 , C07K2317/522 , C07K2317/55 , C07K2317/569 , C07K2317/622 , C07K2319/00
摘要： The invention provides a dual-specific ligand comprising a first and second single variable domain, each having binding specificity for a antigenic target. The invention also provides for a single variable domain monomer ligand that specifically binds to an antigenic target.
摘要翻译：本发明提供了双特异性配体，其包含第一和第二单可变结构域，每一结构域对抗原靶具有结合特异性。本发明还提供了与抗原靶特异性结合的单个可变域单体配体。

7. 发明申请

US20100092483A1 Compositions monovalent for CD40L binding and methods of use 有权
公开(公告)号：US20100092483A1
公开(公告)日：2010-04-15
申请号：US12387423
申请日：2009-05-01
申请人： Steven Grant , Haiqun Liu , Kevin Moulder
发明人： Steven Grant , Haiqun Liu , Kevin Moulder
IPC分类号： A61K39/395
CPC分类号： C07K16/2875 , C07K2317/565 , C07K2317/569 , C07K2317/76
摘要： The invention relates to antibody polypeptides that monovalently bind CD40L. Antibody polypeptides that are monovalent for binding of CD40L can inhibit CD40L activity while avoiding potential undesirable effects that can occur with antibodies capable of divalent or multivalent binding of DC40L. in one aspect, a monovalent anti-CD40L antibody polypeptide consists of or comprises a single immunoglobulin variable domain that specifically binds and antagonizes the activity of DC40L, preferably without substantially agonizing CD40 activity. In another aspect, the monovalent anti-CD40L antibody polypeptide is a human antibody polypeptide. The invention further encompasses methods of antagonizing CD40/CD40L interactions in an individual and methods of treating diseases or disorders involving CD40/DC40L interactions, the methods involving administering a monovalent anti-CD40L antibody polypeptide to the individual.

8. 发明申请

US20100092482A1 Compositions monovalent for CD40L binding and methods of use 有权
标题翻译：用于CD40L结合的单价组合物和使用方法
公开(公告)号：US20100092482A1
公开(公告)日：2010-04-15
申请号：US12387421
申请日：2009-05-01
申请人： Steven Grant , Haiqun Liu , Kevin Moulder
发明人： Steven Grant , Haiqun Liu , Kevin Moulder
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： C07K16/2875 , C07K2317/565 , C07K2317/569 , C07K2317/76
摘要： The invention relates to antibody polypeptides that monovalently bind CD40L. Antibody polypeptides that are monovalent for binding of CD40L can inhibit CD40L activity while avoiding potential undesirable effects that can occur with antibodies capable of divalent or multivalent binding of DC40L. in one aspect, a monovalent anti-CD40L antibody polypeptide consists of or comprises a single immunoglobulin variable domain that specifically binds and antagonizes the activity of DC40L, preferably without substantially agonizing CD40 activity. In another aspect, the monovalent anti-CD40L antibody polypeptide is a human antibody polypeptide. The invention further encompasses methods of antagonizing CD40/CD40L interactions in an individual and methods of treating diseases or disorders involving CD40/DC40L interactions, the methods involving administering a monovalent anti-CD40L antibody polypeptide to the individual.
摘要翻译：本发明涉及单价结合CD40L的抗体多肽。 CD40L结合的一价抗体多肽可以抑制CD40L活性，同时避免可能发生在能够进行DC40L二价或多价结合的抗体的潜在的不良作用。在一个方面，单价抗CD40L抗体多肽由特异性结合并拮抗DC40L的活性的单个免疫球蛋白可变区组成或包含，优选不具有实质上激动的CD40活性。另一方面，单价抗CD40L抗体多肽是人抗体多肽。本发明还包括拮抗个体中CD40 / CD40L相互作用的拮抗作用的方法以及治疗涉及CD40 / DC40L相互作用的疾病或病症的方法，涉及向个体施用单价抗CD40L抗体多肽的方法。

9. 发明授权

US08524236B2 Methods of antagonizing the binding of CD40 to CD40L with CD40L-specific monovalent polypeptides in autoimmune individuals 有权
标题翻译：在自身免疫个体中拮抗CD40与CD40L与CD40L特异性单价多肽的结合的方法
公开(公告)号：US08524236B2
公开(公告)日：2013-09-03
申请号：US11663247
申请日：2005-09-16
申请人： Steven Grant , Haiqun Liu , Kevin Moulder
发明人： Steven Grant , Haiqun Liu , Kevin Moulder
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2875 , C07K2317/565 , C07K2317/569 , C07K2317/76
摘要： The invention relates to antibody polypeptides that monovalently bind CD40L. Antibody polypeptides that are monovalent for binding of CD40L can inhibit CD40L activity while avoiding potential undesirable effects that can occur with antibodies capable of divalent or multivalent binding of CD40L. In one aspect, a monovalent anti-CD40L antibody polypeptide consists of or comprises a single immunoglobulin variable domain that specifically binds and antagonizes the activity of CD40L, preferably without substantially agonizing CD40 and/or CD40L activity. In another aspect, the monovalent anti-CD40L antibody polypeptide is a human antibody polypeptide. The invention further encompasses methods of antagonizing CD40/CD40L interactions in an individual and methods of treating diseases or disorders involving CD40/CD40L interactions, the methods involving administering a monovalent anti-CD40L antibody polypeptide to the individual.
摘要翻译：本发明涉及单价结合CD40L的抗体多肽。针对CD40L结合的单价抗体多肽可以抑制CD40L活性，同时避免可能与能够进行CD40L二价或多价结合的抗体发生的不良反应。一方面，单价抗CD40L抗体多肽由特异性结合和拮抗CD40L的活性的单个免疫球蛋白可变区组成或包含，优选不具有实质上激动的CD40和/或CD40L活性。另一方面，单价抗CD40L抗体多肽是人抗体多肽。本发明还包括拮抗个体中CD40 / CD40L相互作用的拮抗作用的方法以及治疗涉及CD40 / CD40L相互作用的疾病或病症的方法，涉及向个体施用单价抗CD40L抗体多肽的方法。

10. 发明授权

US07927596B2 Methods of antagonizing binding of CD40 to CD40L with CD40L-specific monovalent polypeptides 有权
标题翻译：拮抗CD40与CD40L与CD40L特异性单价多肽的结合的方法
公开(公告)号：US07927596B2
公开(公告)日：2011-04-19
申请号：US12387423
申请日：2009-05-01
申请人： Steven Grant , Haiqun Liu , Kevin Moulder
发明人： Steven Grant , Haiqun Liu , Kevin Moulder
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2875 , C07K2317/565 , C07K2317/569 , C07K2317/76
摘要： The invention relates to antibody polypeptides that monovalently bind CD40L. Antibody polypeptides that are monovalent for binding of CD40L can inhibit CD40L activity while avoiding potential undesirable effects that can occur with antibodies capable of divalent or multivalent binding of DC40L. in one aspect, a monovalent anti-CD40L antibody polypeptide consists of or comprises a single immunoglobulin variable domain that specifically binds and antagonizes the activity of DC40L, preferably without substantially agonizing CD40 activity. In another aspect, the monovalent anti-CD40L antibody polypeptide is a human antibody polypeptide. The invention further encompasses methods of antagonizing CD40/CD40L interactions in an individual and methods of treating diseases or disorders involving CD40/DC40L interactions, the methods involving administering a monovalent anti-CD40L antibody polypeptide to the individual.
摘要翻译：本发明涉及单价结合CD40L的抗体多肽。 CD40L结合的一价抗体多肽可以抑制CD40L活性，同时避免可能发生在能够进行DC40L二价或多价结合的抗体的潜在的不良作用。在一个方面，单价抗CD40L抗体多肽由特异性结合并拮抗DC40L的活性的单个免疫球蛋白可变区组成或包含，优选不具有实质上激动的CD40活性。另一方面，单价抗CD40L抗体多肽是人抗体多肽。本发明还包括拮抗个体中CD40 / CD40L相互作用的拮抗作用的方法以及治疗涉及CD40 / DC40L相互作用的疾病或病症的方法，涉及向个体施用单价抗CD40L抗体多肽的方法。

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