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    • 4. 发明授权
    • Process for producing acrylonitrile compound
    • 制备丙烯腈化合物的方法
    • US08138368B2
    • 2012-03-20
    • US12588251
    • 2009-10-08
    • Kenzo FukudaYasuo KondoNorio TanakaHideaki SuzukiMasatoshi OhnariKoichi Nishio
    • Kenzo FukudaYasuo KondoNorio TanakaHideaki SuzukiMasatoshi OhnariKoichi Nishio
    • C07C255/03C07C211/78
    • C07D231/12
    • There is provided a process for stereoselectively producing E-form of 3-acyloxyacrylonitrile compound (3) or Z-form which comprises reacting 3-oxopropionitrile compound (1) with an acid chloride (2), characterized in that the reaction is conducted with removal of hydrogen chloride, or by using an organic base or an inorganic base, to thereby regulate the stereostructure of the product; a process for producing the compound (1) characterized by reacting acetonitrile compound (5) with an aromatic ester compound (6) by use of an alkali metal alkoxide in a hydrocarbon solvent while removing alcohol formed as a by-product by azeotropic distillation in a separating tank; and a process for isomerizing E-form of 3-acyloxyacrylonitrile compound to Z-form thereof by use of an organic base.
    • 提供了一种用于立体选择性地生产3-酰氧基丙烯腈化合物(3)或Z-型的E-型的方法,其包括使3-氧代丙腈化合物(1)与酰氯(2)反应,其特征在于反应进行除去 的氯化氢,或通过使用有机碱或无机碱,从而调节产物的立体结构; 一种制备化合物(1)的方法,其特征在于在烃溶剂中使用碱金属醇盐使乙腈化合物(5)与芳族酯化合物(6)反应,同时通过共沸蒸馏除去形成副产物的醇 分离罐 以及通过使用有机碱将E-型3-酰氧基丙烯腈化合物异构化为Z-形式的方法。
    • 6. 发明授权
    • Process for producing acrylonitrile compound
    • 制备丙烯腈化合物的方法
    • US07649104B2
    • 2010-01-19
    • US10551041
    • 2004-03-26
    • Kenzo FukudaYasuo KondoNorio TanakaHideaki SuzukiMasatoshi OhnariKoichi Nishio
    • Kenzo FukudaYasuo KondoNorio TanakaHideaki SuzukiMasatoshi OhnariKoichi Nishio
    • C07C255/07
    • C07D231/12
    • There is provided a process for stereoselectively producing E-form of 3-acyloxyacrylonitrile compound (3) or Z-form which comprises reacting 3-oxopropionitrile compound (1) with an acid chloride (2), characterized in that the reaction is conducted with removal of hydrogen chloride, or by using an organic base or an inorganic base, to thereby regulate the stereostructure of the product; a process for producing the compound (1) characterized by reacting acetonitrile compound (5) with an aromatic ester compound (6) by use of an alkali metal alkoxide in a hydrocarbon solvent while removing alcohol formed as a by-product by azeotropic distillation in a separating tank; and a process for isomerizing E-form of 3-acyloxyacrylonitrile compound to Z-form thereof by use of an organic base.
    • 提供了一种用于立体选择性地生产3-酰氧基丙烯腈化合物(3)或Z-型的E-型的方法,其包括使3-氧代丙腈化合物(1)与酰氯(2)反应,其特征在于反应进行除去 的氯化氢,或通过使用有机碱或无机碱,从而调节产物的立体结构; 一种制备化合物(1)的方法,其特征在于在烃溶剂中使用碱金属醇盐使乙腈化合物(5)与芳族酯化合物(6)反应,同时通过共沸蒸馏除去形成副产物的醇 分离罐 以及通过使用有机碱将E-型3-酰氧基丙烯腈化合物异构化为Z-形式的方法。