会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 8. 发明申请
    • Biocatalytic Manufacturing of (Meth) Acrylylcholine or 2-(N, N-Dimethylamino) Ethyl (Meth) Acrylate
    • (甲基)丙烯酰胆碱或2-(N,N-二甲基氨基)乙基(甲基)丙烯酸酯的生物催化制备
    • US20070238156A1
    • 2007-10-11
    • US10591775
    • 2005-03-09
    • Jonathan HughesKenneth Symes
    • Jonathan HughesKenneth Symes
    • C12P13/00A01H5/00A01K67/033C12N5/04C12N5/06
    • C12P13/00C12P7/62C12P13/001
    • A biocatalytic method for the synthesis of 2-(N,N-dimethylamino)ethanol and/or choline esters of acrylic acid and/or methacrylic acid, namely a method or process for the manufacture of acrylylcholine and/or methacrylylcholine, comprising reacting 2-(N,N-dimethylamino)ethanol and/or choline with acrylyl-CoA and/or methacrylyl-CoA in the presence of a biocatalyst with choline acetyltransferase activity, where preferably the acrylyl-CoA and/or methacrylyl-CoA is formed by reaction of acrylate and/or methacrylate with coenzyme A in the presence of an energy providing substance and a biocatalyst with S-acetyl coenzyme A synthetase activity (acetyl CoA synthetase activity); to (especially transformed, that is genetically modified) organisms having choline acetyltransferase activity and preferably in addition the acetyl CoA synthetase activity and their use in said process or method; the use of a biocatalyst with choline acetyltransferase activity to carry out the transfer of the (meth)acrylyl moiety from (meth)acrylyl CoA to 2-(N,N-dimethylamino)ethanol and/or choline, in order to manufacture 2-(N,N-dimethylamino)ethyl(meth)acrylate and/or (meth)acrylylcholine; and further uses, organisms, processes and methods as described in the specification.
    • 用于合成丙烯酸和/或甲基丙烯酸的2-(N,N-二甲基氨基)乙醇和/或胆碱酯的生物催化方法,即制备丙烯酰胆碱和/或甲基丙烯酰胆碱的方法或方法,包括使2- (N,N-二甲基氨基)乙醇和/或胆碱与丙烯酰辅酶A和/或甲基丙烯酰辅酶A在具有胆碱乙酰转移酶活性的生物催化剂存在下进行,其中优选通过以下方式形成丙烯酰辅酶A和/或甲基丙烯酰辅酶A. 丙烯酸酯和/或甲基丙烯酸酯与能量提供物质和具有S-乙酰辅酶A合成酶活性的生物催化剂(乙酰辅酶A合成酶活性)存在下的辅酶A; 具有胆碱乙酰转移酶活性(特别是经转基因,即经遗传修饰的)生物体,优选地还包括乙酰CoA合成酶活性及其在所述方法或方法中的用途; 使用具有胆碱乙酰转移酶活性的生物催化剂进行(甲基)丙烯酰部分从(甲基)丙烯酰辅酶A向2-(N,N-二甲基氨基)乙醇和/或胆碱的转移,以制备2-( N,N-二甲基氨基)乙基(甲基)丙烯酸酯和/或(甲基)丙烯酰胆碱; 以及说明书中描述的进一步的用途,生物,过程和方法。