专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08153816B2 Process for production of 3-[5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-OXO-2-substituted-2,3-dihydro-1,2-benzisoxazol-6-yl)methoxy]phenyl]propionate ester and intermediate for the process 有权
标题翻译：制备3- [5- [4-（环戊氧基）-2-羟基苯甲酰基] -2 - [（3-氧代-2-取代-2,3-二氢-1,2-苯并异恶唑-6-基）甲氧基 ]苯基]丙酸酯和中间体
公开(公告)号：US08153816B2
公开(公告)日：2012-04-10
申请号：US13177744
申请日：2011-07-07
申请人： Kenji Yonezawa , Tamotsu Takamatsu , Naokatu Aoki , Tomohiro Hashimoto , Masahiro Takebayashi , Yoshiaki Suzuki , Yuji Oonishi
发明人： Kenji Yonezawa , Tamotsu Takamatsu , Naokatu Aoki , Tomohiro Hashimoto , Masahiro Takebayashi , Yoshiaki Suzuki , Yuji Oonishi
IPC分类号： C07D261/20
CPC分类号： C07D261/20 , C07C67/03 , C07C67/303 , C07C69/738 , C07C2601/08 , C07D311/14
摘要： A 6-(halomethyl)-1,2-benzisoxazol-3(2H)-one derivative represented by the formula: wherein R5 is a methyl group that is substituted with one or more optionally substituted phenyl groups, or an optionally substituted oxygen-containing heterocyclic group; and X is a halogen atom.
摘要翻译：一种由下式表示的6-（卤代甲基）-1,2-苯并异恶唑-3（2H） - 酮衍生物：其中R5是被一个或多个任选取代的苯基取代的甲基或任选取代的含氧杂环基; X为卤素原子。

2. 发明申请

US20110263866A1 PROCESS FOR PRODUCTION OF 3-[5-[4-(CYCLOPENTYLOXY)-2-HYDROXYBENZOYL]-2-[(3-OXO-2-SUBSTITUTED-2,3-DIHYDRO-1,2-BENZISOXAZOL-6-YL)METHOXY]PHENYL]PROPIONATE ESTER AND INTERMEDIATE FOR THE PROCESS 有权
标题翻译：制备3- [5- [4-（环戊氧基）-2-羟基苯甲酰基] -2 - [（3-氧代-2-取代-2,3-二氢-1,2-苯并咪唑-6-基）甲氧基] ] PHENYL]丙酸酯和中间体的方法
公开(公告)号：US20110263866A1
公开(公告)日：2011-10-27
申请号：US13177744
申请日：2011-07-07
申请人： Kenji YONEZAWA , Tamotsu Takamatsu , Naokatu Aoki , Tomohiro Hashimoto , Masahiro Takebayashi , Yoshiaki Suzuki , Yuji Oonishi
发明人： Kenji YONEZAWA , Tamotsu Takamatsu , Naokatu Aoki , Tomohiro Hashimoto , Masahiro Takebayashi , Yoshiaki Suzuki , Yuji Oonishi
IPC分类号： C07D261/20 , C07D407/04
CPC分类号： C07D261/20 , C07C67/03 , C07C67/303 , C07C69/738 , C07C2601/08 , C07D311/14
摘要： A 6-(halomethyl)-1,2-benzisoxazol-3(2H)-one derivative represented by the formula: wherein R5 is a methyl group that is substituted with one or more optionally substituted phenyl groups, or an optionally substituted oxygen-containing heterocyclic group; and X is a halogen atom.
摘要翻译：一种由下式表示的6-（卤代甲基）-1,2-苯并异恶唑-3（2H） - 酮衍生物：其中R5是被一个或多个任选取代的苯基取代的甲基或任选取代的含氧杂环基; X为卤素原子。

3. 发明申请

US20110098484A1 PROCESS FOR PRODUCTION OF 1-(3-(2-(1-BENZOTHIOPHEN-5-YL)- ETHOXY)PROPYL)AZETIDIN-3-OL OR SALTS THEREOF 有权
标题翻译： 1-（3-（2-（1-苯并噻吩-5-基） - 乙氧基）丙基）亚甲基-3-醇或其盐的生产方法
公开(公告)号：US20110098484A1
公开(公告)日：2011-04-28
申请号：US12985616
申请日：2011-01-06
申请人： Akihito SAITOH , Yoshiaki Suzuki , Kenji Yonezawa , Mitsuhide Kawamura , Takahiko Kusanagi , Takashi Nakai
发明人： Akihito SAITOH , Yoshiaki Suzuki , Kenji Yonezawa , Mitsuhide Kawamura , Takahiko Kusanagi , Takashi Nakai
IPC分类号： C07D409/12 , C07D333/54
CPC分类号： C07D333/54 , C07D333/64 , C07D409/12
摘要： A Process for production of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or salts thereof which comprises using as a starting compound as a (phenylthio)acetic acid derivative or salts thereof represented by the general formula: wherein X1 represents a halogen atom, is useful as a safe process for mass production of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or salts thereof which is useful as a remedy for disease of central and peripheral nerve.
摘要翻译：制备1-（3-（2-（1-苯并噻吩-5-基）乙氧基）丙基）氮杂环丁烷-3-醇或其盐的方法，其包括使用（苯硫基）乙酸衍生物作为起始化合物或其通式如下：其中X1表示卤原子，可用作大量生产1-（3-（2-（1-苯并噻吩-5-基）乙氧基）丙基）氮杂环丁烷-3-基）醇或其盐，其可用作中枢和周围神经疾病的补救剂。

4. 发明申请

US20090275757A1 NOVEL CRYSTAL OF 3-[5-[4-(CYCLOPENTYLOXY)-2- HYDROXYBENZOYL]-2-[(3-HYDROXY-1,2-BENZISOXAZOL-6- YL)METHOXY]PHENYL]PROPIONIC ACID 有权
标题翻译： 3- [5- [4-（环戊氧基）-2-羟基苯甲酰基] -2 - [（3-羟基-1,2-苯并咪唑-6-基）甲氧基]苯基]丙酸的新晶体
公开(公告)号：US20090275757A1
公开(公告)日：2009-11-05
申请号：US12302375
申请日：2007-05-25
申请人： Kenji Yonezawa , Hironori Kotsubo , Yasutaka Baba , Yukie Tada
发明人： Kenji Yonezawa , Hironori Kotsubo , Yasutaka Baba , Yukie Tada
IPC分类号： C07D261/20
CPC分类号： C07D261/20
摘要： The crystal of 3-{5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl}propionic acid having peaks at the position of 14.0, 16.0, 23.3, 23.7 and 26.3° and the crystal of 3-{5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl}propionic acid having peaks at the position of 14.6, 23.1, 24.7, 25.6 and 26.0° on 2θ of diffraction angle in a powder X-ray diffraction pattern have a small specific volume, are hard to be charged with electricity, are easily handled and are useful for an active pharmaceutical ingredient of excellent anti-rheumatic agents.
摘要翻译： 3- {5- [4-（环戊氧基）-2-羟基苯甲酰基] -2 - [（3-羟基-1,2-苯并异恶唑-6-基）甲氧基]苯基}丙酸的晶体在 14.0,16.0,23.3,23.7和26.3°，3- {5- [4-（环戊氧基）-2-羟基苯甲酰基] -2 - [（3-羟基-1,2-苯并异恶唑-6-基）甲氧基 ]苯基}丙酸在粉末X射线衍射图中的衍射角度为14.6,23.1,24.7,25.6和26.0°的峰具有小的比容，难以用电充电，容易并且可用于优异的抗风湿剂的活性药物成分。

5. 发明申请

US20090099369A1 PROCESS FOR PRODUCTION OF 3-[5-[4-(CYCLOPENTYLOXY)-2-HYDROXYBENZOYL]-2-[(3-OXO-2-SUBSTITUTED-2,3-DIHYDRO-1,2-BENZISOXAZOL-6-YL)METHOXY]PHENYL]PROPIONATE ESTER AND INTERMEDIATE FOR THE PROCESS 有权
标题翻译：制备3- [5- [4-（环戊氧基）-2-羟基苯甲酰基] -2 - [（3-氧代-2-取代-2,3-二氢-1,2-苯并咪唑-6-基）甲氧基] ] PHENYL]丙酸酯和中间体的方法
公开(公告)号：US20090099369A1
公开(公告)日：2009-04-16
申请号：US12280098
申请日：2007-02-19
申请人： Kenji Yonezawa , Tamotsu Takamatsu , Naokatu Aoki , Tomohiro Hashimoto , Masahiro Takebayashi , Yoshiaki Suzuki , Yuji Oonishi
发明人： Kenji Yonezawa , Tamotsu Takamatsu , Naokatu Aoki , Tomohiro Hashimoto , Masahiro Takebayashi , Yoshiaki Suzuki , Yuji Oonishi
IPC分类号： C07D261/20 , C07C69/612 , C07D311/02
CPC分类号： C07D261/20 , C07C67/03 , C07C67/303 , C07C69/738 , C07C2601/08 , C07D311/14
摘要： A preparation method using as an intermediate 6-(halomethyl)-1,2-benzisoxazol-3(2H)-one derivative represented by general formula wherein R5 is a methyl group that is substituted with one or more optionally substituted phenyl groups, or an optionally substituted oxygen-containing heterocyclic group; X represents a halogen atom, can be used as a method for safely and easily preparing 3-{5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl}propionic acid, which is useful as an antirheumatic agent, with a high yield.
摘要翻译：另外，作为中间体6-（卤代甲基）-1,2-苯并异恶唑-3（2H） - 酮衍生物的制备方法，其中R5是被一个或多个任意取代的苯基取代的甲基，或任选取代的含氧杂环基; X表示卤素原子，可用作安全且容易地制备3- {5- [4-（环戊氧基）-2-羟基苯甲酰基] -2 - [（3-羟基-1,2-苯并异恶唑-6-基）吡啶-2-基）甲氧基]苯基}丙酸，其可用作抗风湿剂，产率高。

6. 发明申请

US20090069576A1 PROCESS FOR PRODUCTION OF 1-(3-(2-(1-BENZOTHIOPHEN-5-YL)-ETHOXY)PROPYL)AZETIDIN-3-OL OR SALTS THEREOF 有权
标题翻译： 1-（3-（2-（1-苯并噻吩-5-基） - 乙氧基）丙基）亚甲基-3-醇或其盐的生产方法
公开(公告)号：US20090069576A1
公开(公告)日：2009-03-12
申请号：US11909809
申请日：2006-03-27
申请人： Akihito Saitoh , Yoshiaki Suzuki , Kenji Yonezawa , Mitsuhide Kawamura , Takahiko Kusanagi , Takashi Nakai
发明人： Akihito Saitoh , Yoshiaki Suzuki , Kenji Yonezawa , Mitsuhide Kawamura , Takahiko Kusanagi , Takashi Nakai
IPC分类号： C07D205/04 , C07D333/52
CPC分类号： C07D333/54 , C07D333/64 , C07D409/12
摘要： A Process for production of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or salts thereof which comprises using as a starting compound as a (phenylthio)acetic acid derivative or salts thereof represented by the general formula: wherein X1 represents a halogen atom, is useful as a safe process for mass production of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or salts thereof which is useful as a remedy for disease of central and peripheral nerve.
摘要翻译：制备1-（3-（2-（1-苯并噻吩-5-基）乙氧基）丙基）氮杂环丁烷-3-醇或其盐的方法，其包括使用（苯硫基）乙酸衍生物作为起始化合物或其通式如下：其中X1表示卤原子，可用作大量生产1-（3-（2-（1-苯并噻吩-5-基）乙氧基）丙基）氮杂环丁烷-3-基）醇或其盐，其可用作中枢和周围神经疾病的补救剂。

7. 发明授权

US06675843B2 Non-return valve for fuel tank 失效
标题翻译：燃油箱止回阀
公开(公告)号：US06675843B2
公开(公告)日：2004-01-13
申请号：US10166392
申请日：2002-06-11
申请人： Kenji Yonezawa , Hiroki Isobe
发明人： Kenji Yonezawa , Hiroki Isobe
IPC分类号： B65B104
CPC分类号： B60K15/04 , Y10T137/86372
摘要： A non-return valve includes a main tube to be externally inserted into and joined to a fuel filling pipe, and a valve element to be provided on a downstream end of the main tube for allowing fuel to flow into a fuel tank and inhibiting a back flow out of the fuel tank. On an upstream side of the main tube, provided is a first inner tube including a first retaining portion relevant to the fuel filling pipe, an annular sealing member abutting on an inner periphery of the main tube and on an outer periphery of the fuel filling pipe, and a second inner pipe disposed more upstream than the first inner tube so as to sandwich the annular sealing member together with the first inner tube, the second inner tube including a second retaining portion relevant to the main tube.
摘要翻译：止回阀包括外部插入并连接到燃料填充管的主管，以及设置在主管的下游端的阀元件，用于允许燃料流入燃料箱并阻止后部流出燃油箱。在主管的上游侧，设置有第一内管，其包括与燃料填充管相关的第一保持部，邻接于主管的内周的环状密封构件和燃料填充管的外周以及设置在比第一内管更上游的第二内管，以便与第一内管一起夹住环形密封构件，第二内管包括与主管相关的第二保持部。

8. 发明授权

US07032610B2 Float valve device 失效
标题翻译：浮阀装置
公开(公告)号：US07032610B2
公开(公告)日：2006-04-25
申请号：US10820153
申请日：2004-04-08
申请人： Shinichi Matsuo , Kenji Yonezawa
发明人： Shinichi Matsuo , Kenji Yonezawa
IPC分类号： F16K24/04
CPC分类号： F16K24/042 , Y10T137/0874 , Y10T137/3099
摘要： An allowable angle of a float valve member with respect to a valve case is so set that a deformed direction, as caused by a gate position at a injection molding time, of a inner circumference of a communication hole of the valve case with respect to a roundness and a deformed direction, as caused by a gate position at a injection molding time, of an outer circumference of a crest portion of the float valve member with respect to the roundness may be substantially aligned. Between the valve case and the float valve member, there is an interposed angle regulating unit for preventing the angle of the float valve member with respect to the valve case from varying over the allowable angle.
摘要翻译：浮阀构件相对于阀壳体的允许角度被设定为使得由阀壳体的连通孔的内周相对于喷嘴成型时的入口位置引起的变形方向可以基本上对准浮子阀构件的顶部的圆周方向的圆周度和由浇注模制时的浇口位置引起的变形方向。在阀壳和浮阀构件之间，设置有用于防止浮阀构件相对于阀壳的角度在允许角度上变化的插入角度调节单元。

9. 发明授权

US06857537B2 Heat insulation plate mounting structure on fuel tank 有权
标题翻译：燃油箱隔热板安装结构
公开(公告)号：US06857537B2
公开(公告)日：2005-02-22
申请号：US10407188
申请日：2003-04-07
申请人： Kenji Yonezawa
发明人： Kenji Yonezawa
IPC分类号： B60K15/063 , B60K15/067 , F02M37/00 , B65D6/00
CPC分类号： B60K15/067 , Y10T403/21
摘要： A resin member has a first barrel member 30, which can be welded to the fuel tank, and a second barrel member having a higher melting temperature than the first barrel member. The first barrel member is joined to the outer circumference of the second barrel member and protrudes at one axial end. The second barrel member protrudes at the other axial end. A bolt is inserted from one end where the first barrel member protrudes through the second barrel member out of an end face where the second barrel member protrudes. The first barrel member of the resin member is welded to the fuel tank. The bolt is inserted into a mounting hole of the heat insulation plate and securely fastened. A flange spreading diametrically is preferably formed on a protruding end face of the second barrel member.
摘要翻译：树脂构件具有能够焊接到燃料箱的第一筒构件30和具有比第一筒构件更高的熔化温度的第二筒构件。第一筒构件连接到第二筒构件的外周并且在一个轴向端部处突出。第二筒构件在另一轴向端部突出。螺栓从第一筒构件从第二筒构件突出的端面穿过第二筒构件的一端插入。树脂构件的第一桶构件焊接到燃料箱。将螺栓插入绝热板的安装孔中并牢固固定。优选地，在第二筒构件的突出端面上形成径向扩展的凸缘。

10. 发明授权

US06337399B1 Processes for producing 7-isoindolinequinolonecarboxylic derivatives and intermediates therefor, salts of 7-isoindolinequinolonecarboxylic acids, hydrates thereof, and composition containing the same as active ingredient 有权
公开(公告)号：US06337399B1
公开(公告)日：2002-01-08
申请号：US09529407
申请日：2000-04-26
申请人： Minoru Yamada , Shoichi Hamamoto , Kazuya Hayashi , Kazuko Takaoka , Hiroko Matsukura , Minako Yotsuji , Kenji Yonezawa , Katsuji Ojima , Tamotsu Takamatsu , Kyoko Taya , Hirohiko Yamamoto , Taro Kiyoto , Hironori Kotsubo
发明人： Minoru Yamada , Shoichi Hamamoto , Kazuya Hayashi , Kazuko Takaoka , Hiroko Matsukura , Minako Yotsuji , Kenji Yonezawa , Katsuji Ojima , Tamotsu Takamatsu , Kyoko Taya , Hirohiko Yamamoto , Taro Kiyoto , Hironori Kotsubo
IPC分类号： C07D21516
CPC分类号： C07D401/04 , A61K31/4709 , C07C217/48 , C07D209/44 , C07D215/56 , C07F5/025 , Y02P20/55
摘要： This invention relates to processes for producing a 7-isoindoline-quinolonecarboxylic acid derivative represented by the general formula [1] which is useful as an antibacterial agent, and an intermediate thereof: wherein R1 represents a hydrogen atom or a carboxyl-protecting group; R2 represents a substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aryl or heterocyclic group; R3 represents at least one group selected from hydrogen atom, halogen atoms, substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aryl, alkoxy or alkylthio groups, nitro group, cyano group, acyl groups, protected or unprotected hydroxyl groups and protected or unprotected or substituted or unsubstituted amino groups; R4 represents at least one group selected from hydrogen atom, halogen atoms, substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aralkyl, aryl, alkoxy or alkylthio groups, protected or unprotected hydroxyl or imino groups, protected or unprotected or substituted or unsubstituted amino groups, alkylidene groups, oxo group and groups each forming a cycloalkane group together with the carbon atom to which R4 bonds; R5 represents a hydrogen atom, an amino-protecting group, a substituted or unsubstituted alkyl, cycloalkyl, alkylsulfonyl, arylsulfonyl, acyl or aryl group; R6 represents a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl, alkoxy or alkylthio group, a protected or unprotected hydroxyl or amino group or a nitro group; and A represents CH or C—R7 in which R7 represents a halogen atom, a substituted or unsubstituted alkyl, alkoxy or alkylthio group or a protected or unprotected hydroxyl group, and to a salt of a 7-isoindoline-quinolonecarboxylic acid represented by the general formula [1], a hydrate thereof and a composition comprising them as an active ingredient.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式