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    • 7. 发明授权
    • Suspension of sparingly water-soluble acidic drug
    • 悬浮微量水溶性酸性药物
    • US06231890B1
    • 2001-05-15
    • US09171631
    • 1998-10-22
    • Mayumi NaitoHiroshi NakanoKazuo HasegawaToshiaki NakajimaIchiro OkudairaKenji Tsunoda
    • Mayumi NaitoHiroshi NakanoKazuo HasegawaToshiaki NakajimaIchiro OkudairaKenji Tsunoda
    • A61K914
    • A61K9/0095
    • A suspension of a sparingly water-soluble acidic drug, especially, a nonsteroidal anti-inflammatory analgesic agent, which is stable for a prolonged period of time and is highly dissolvable, and a process for simply and easily producing the suspension. This suspension has a pH value of 2 to 5 and comprises a sparingly water-soluble acidic drug whose average particle size ranges from 1 to 15 &mgr;m, a polyglycerol fatty acid ester, a water-soluble polyhydric alcohol and water, optionally, together with an inorganic powder having an average particle size of 1 to 15 &mgr;m. This process is characterized by carrying out pulverization and dispersion of a sparingly water-soluble acid drug, a polyglycerol fatty acid ester, a water-soluble polyhydric alcohol and water by means of a pulverizer comprising a main shaft adapted to rotate in a casing and a plurality of layshafts adapted to revolve in relationship interlocked with the rotation of the main shaft, each of the layshafts being fitted with a multiplicity of annular griding media.
    • 微溶水性酸性药物,特别是长时间稳定且非常可溶性的非甾体抗炎止痛剂的悬浮液,以及简单且容易地制备悬浮液的方法。 该悬浮液的pH值为2〜5,并且包含平均粒径为1〜15μm的微溶水性酸性药物,聚甘油脂肪酸酯,水溶性多元醇和水,任选地与 平均粒径为1〜15μm的无机粉末。 该方法的特征在于通过粉碎机进行微水溶性酸性药物,聚甘油脂肪酸酯,水溶性多元醇和水的粉碎和分散,所述粉碎机包括适于在壳体内旋转的主轴和 多个副轴适于以与主轴的旋转互锁的关系旋转,每个副轴装配有多个环形磨盘。
    • 9. 发明申请
    • Continuous production of foam molding from expanded polyolefine resin beads
    • 从膨胀聚烯烃树脂珠连续生产泡沫塑料
    • US20050215652A1
    • 2005-09-29
    • US11085541
    • 2005-03-22
    • Masanori TanakaKenji Tsunoda
    • Masanori TanakaKenji Tsunoda
    • B29C44/30B29C44/44C08J9/232C08J9/18
    • C08J9/232C08J2323/02
    • A process for continuously preparing a polyolefin foam molding, wherein expanded polyolefin resin beads are fed between a pair of upper and lower endless belts continuously traveling along a pair of opposing upper and lower surfaces, respectively, within a passage defined by structural members and rectangular in section, the expanded beads feed being then successively passed through a heating zone and a cooling zone within the passage. The expanded polyolefin resin beads have a core-coat structure in which the core is in an expanded state and comprises a crystalline polyolefin resin, while the coat is in a substantially unexpanded state and surrounds the core. The coat comprises a crystalline polyolefin polymer which is lower in melting point by at least 15° C. than that of the crystalline polyolefin resin or a substantially non-crystalline polyolefin polymer which is lower in Vicat softening point by at least 15° C. than that of the crystalline polyolefin resin.
    • 一种用于连续制备聚烯烃发泡成型体的方法,其中发泡聚烯烃树脂珠粒分别在由结构构件限定的通道和矩形的通道内分别沿着一对相对的上表面和下表面连续行进的一对上下环形带之间进给 然后将膨胀的珠粒进料依次通过加热区和通道内的冷却区。 发泡聚烯烃树脂珠粒具有核心层,其中核心处于膨胀状态并且包含结晶聚烯烃树脂,而涂层处于基本上未膨胀的状态并且包围芯体。 该涂层包括结晶聚烯烃聚合物,其熔点低于结晶聚烯烃树脂或维卡软化点低至少15℃的基本上非结晶的聚烯烃聚合物至少15℃以上 结晶聚烯烃树脂。