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1. 发明授权

US4370415A Process for producing uroporphyrin III 失效
标题翻译：生产尿卟啉III的方法
公开(公告)号：US4370415A
公开(公告)日：1983-01-25
申请号：US204789
申请日：1980-11-07
申请人： Ichiro Kojima , Kenji Maruhashi , Yasuo Fujiwara
发明人： Ichiro Kojima , Kenji Maruhashi , Yasuo Fujiwara
IPC分类号： C07D487/22 , C12P17/18 , C12R1/06
CPC分类号： C07D487/22 , C12P17/182 , C12R1/06 , Y10S435/83
摘要： A process for producing uroporphyrin III, which comprises cultivating a uroporphyrin III-producing microorganism of the genus Arthrobacter in a culture medium containing a carbon source, a nitrogen source and a mineral, and recovering uroporphyrin III from the culture broth.
摘要翻译：一种生产尿卟啉III的方法，包括在含有碳源，氮源和矿物质的培养基中培养节杆菌属的尿卟啉III生产微生物，并从培养液中回收尿卟啉III。

2. 发明授权

US4347184A Process for separating and recovering coproporphyrin and uroporphyrin from a culture broth containing them 失效
标题翻译：从含有它们的培养液中分离和回收cop卟啉和尿卟啉的方法
公开(公告)号：US4347184A
公开(公告)日：1982-08-31
申请号：US247501
申请日：1981-03-25
申请人： Ichiro Kojima , Kenji Maruhashi , Yasuo Fujiwara
发明人： Ichiro Kojima , Kenji Maruhashi , Yasuo Fujiwara
IPC分类号： C07D487/22 , C12P17/18 , C07D207/00
CPC分类号： C07D487/22 , C12P17/182 , C12R1/06 , Y10S435/83
摘要： A process for separating and recovering coproporphyrin and uroporphyrin from a culture broth containing them, which comprises(1) adjusting the pH of the liquid phase of a cultured broth containing coproporphyrin and uroporphyrin to a range of 2.5 to 4 to form a solid precipitate containing coproporphyrin and uroporphyrin and collecting the precipitate,(2) preparing an aqueous alkaline solution of the solid precipitate obtained in step (1), adjusting the pH of the solution to a range of more than 4 but not over 6, to form a solid precipitate containing coproporphyrin, and collecting the precipitate, and(3) adjusting the pH of the residue left after collection of the precipitate in step (2) to a range of 1 to 4 to form a solid precipitate containing uroporphyrin and collecting the precipitate.The active porphyrin components thus obtained have physiological activity in regulating various organisms of the body, such as, for example, improving the function of the liver.
摘要翻译：一种从含有它们的培养液中分离和回收cop卟啉和尿卟啉的方法，其包括（1）将含有脯氨酸和尿卟啉的培养肉汤的液相的pH调节至2.5至4的范围以形成含有卟啉的固体沉淀物和铕卟啉并收集沉淀物，（2）制备步骤（1）中获得的固体沉淀物的碱性水溶液，将溶液的pH调节至大于4但不超过6的范围，以形成含有并且收集沉淀物，和（3）在步骤（2）中收集沉淀物后留下的残留物的pH调节至1至4的范围，以形成含有urop卟啉的固体沉淀并收集沉淀物。由此获得的活性卟啉组分在调节身体的各种生物体中具有生理活性，例如改善肝脏的功能。

3. 发明授权

US4334021A Process for producing coproporphyrin III 失效
标题翻译：卟啉III的制备方法
公开(公告)号：US4334021A
公开(公告)日：1982-06-08
申请号：US211057
申请日：1980-11-28
申请人： Ichiro Kojima , Kenji Maruhashi , Yasuo Fujiwara
发明人： Ichiro Kojima , Kenji Maruhashi , Yasuo Fujiwara
IPC分类号： C12N1/20 , C12P17/18 , C12R1/06 , C12P17/16
CPC分类号： C12R1/06 , C12P17/182 , Y10S435/83
摘要： In a process for producing coproporphyrin III which comprises cultivating a coproporphyrin III-producing microorganism of the genus Arthrobacter in a culture medium containing a carbon source, a nitrogen source and a mineral and recovering coproporphyrin III from the culture broth, the improvement wherein the culture medium contains at least 0.1 g, per liter of the culture medium, of L-cystine, at leas 0.5 g, per liter of the culture medium, of Mg.sup.++, or both; and coproporphyrin III-producing microoganisms.
摘要翻译：在制备卟啉III的方法中，其包括在含有碳源，氮源和矿物质的培养基中培养节杆菌脯氨酸III生产微生物并从培养液中回收cop in in III，其中培养基每升培养基中含有至少0.1g L-胱氨酸，每升培养基0.5g，或两者均为0.1g; 和脯氨酸III产生微生物。

4. 发明授权

US4383110A Process for purifying and separating vitamin B.sub.12 失效
标题翻译：维生素B12的纯化和分离方法
公开(公告)号：US4383110A
公开(公告)日：1983-05-10
申请号：US324633
申请日：1981-11-24
申请人： Tatsuo Kinoshita , Yutaka Oguchi , Kenji Maruhashi , Ichiro Kojima , Noboru Endoh , Tetsuo Satoh
发明人： Tatsuo Kinoshita , Yutaka Oguchi , Kenji Maruhashi , Ichiro Kojima , Noboru Endoh , Tetsuo Satoh
IPC分类号： C07H23/00 , C12P19/42 , C07H15/12
CPC分类号： C07H23/00 , C12P19/42
摘要： A process for separating vitamin B.sub.12 in pure form, which comprises bringing a vitamin B.sub.12 -containing liquid containing impurities into contact with a resin selected from the group consisting of (A) a divinylbenzene/styrene copolymer having a mode pore diameter of at least about 200 A and a total pore volume of more than 0.6 ml/g, and (B) a copolymer of divinylbenzene/styrene/an unsaturated alkyl ester of an aromatic polycarboxylic acid represented by the formula ##STR1## wherein R represents a C.sub.3 -C.sub.10 unsaturated alkyl moiety having a carbon-carbon double bond and n is 2 or 3, said copolymer (B) having a surface area of at least about 700 m.sup.2 /g, to cause vitamin B.sub.12 to be adsorbed to said resin, and eluting the vitamin B.sub.12 with an eluent, and collecting the active eluate.
摘要翻译：用于分离纯的维生素B12的方法，其包括使含有杂质的含维生素B12的液体与选自（A）模式孔径为至少约200的二乙烯基苯/苯乙烯共聚物的树脂接触 A和总孔体积大于0.6ml / g，和（B）二乙烯基苯/苯乙烯/由式IMAMA表示的芳族多元羧酸的不饱和烷基酯的共聚物，其中R表示C3-C10不饱和烷基具有碳 - 碳双键的部分和n为2或3，所述共聚物（B）具有至少约700m 2 / g的表面积，以使维生素B12吸附到所述树脂上，并用洗脱液，并收集活性洗脱液。

5. 发明授权

US4436663A Process for separating porphyrins 失效
标题翻译：分离卟啉的方法
公开(公告)号：US4436663A
公开(公告)日：1984-03-13
申请号：US404054
申请日：1982-08-02
申请人： Kenji Maruhashi , Ichiro Kojima , Yutaka Oguchi , Noboru Endoh , Tetsuo Satoh
发明人： Kenji Maruhashi , Ichiro Kojima , Yutaka Oguchi , Noboru Endoh , Tetsuo Satoh
IPC分类号： C12P17/06 , B01J20/26 , B01J20/34 , C07D487/22 , C12P17/18 , C12R1/06
CPC分类号： C12P17/182 , B01J20/26
摘要： A process for separating porphyrins, which comprises(1) adjusting the pH of the liquid phase of a culture broth containing at least two porphyrins to about 2.5 to about 4 and collecting the resulting solid containing the porphyrins,(2) either (a) preparing an acidic aqueous solution of said solid and adjusting the pH of its liquid phase left after removal of insoluble matter to about 6 to about 8 to form an aqueous solution containing the porphyrins, or (b) preparing an acid-containing lower alcohol solution of said solid, adjusting the pH of its liquid phase left after removal of insoluble matter, adding water in an amount at least twice the amount of the solution to precipitate lower alkyl esters of the porphyrins, collecting the precipitates and dissolving them in an organic solvent to form an organic solvent solution of the porphyrin esters,(3) contacting the solution obtained in (a) or (b) in step (2) with a copolymer having a surface area of at least about 700 m.sup.2 /g and derived from(i) divinylbenzene,(ii) styrene or its functional derivative,(iii) an alkenyl ester of a benzenepolycarboxylic acid represented by the following formula ##STR1## wherein R represents an alkenyl group having 3 to 10 carbon atoms, and n is 2 or 3,thereby permitting adsorption of the porphyrins or their esters to the copolymer, and(4) thereafter, eluting the copolymer to obtain fractions of the individual porphyrins or their esters; and an adsorbent for use in the above-mentioned process.
摘要翻译：一种分离卟啉的方法，其包括（1）将含有至少两个卟啉的培养液的液相pH调节至约2.5至约4并收集所得到的含有卟啉的固体，（2）制备将所述固体的酸性水溶液调节其去除不溶物后留下的液相的pH至约6至约8以形成含有卟啉的水溶液，或（b）制备所述含贱金属的低级醇溶液固体，调节去除不溶物后留下的液相的pH值，加入至少两倍于溶液量的水，以沉淀卟啉的低级烷基酯，收集沉淀物并将其溶解在有机溶剂中形成卟啉酯的有机溶剂溶液，（3）使步骤（2）中（a）或（b）中获得的溶液与表面积至少为约700m 2 / g的共聚物接触，得到（i）二乙烯基苯，（ii）苯乙烯或其官能衍生物，（iii）由下式表示的苯多羧酸的链烯基酯，其中R表示碳原子数3〜10的烯基，n为2 或3，从而允许将卟啉或其酯吸附到共聚物上，和（4）此后，将共聚物洗脱得到各个卟啉或其酯的部分; 和用于上述方法的吸附剂。

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