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1. 发明申请

US20130309203A1 GROWTH-REGULATED VIRAL VECTOR CONTAINING THE AURORA KINASE PROMOTER 审中-公开
标题翻译：包含AURORA KINASE PROMOTER的生长调节的病毒载体
公开(公告)号：US20130309203A1
公开(公告)日：2013-11-21
申请号：US13876916
申请日：2011-09-29
申请人： Ken-ichiro Kosai
发明人： Ken-ichiro Kosai
IPC分类号： C12N15/86
摘要： Disclosed is a vector, preferably a viral vector, containing a treatment factor and/or a nucleic acid encoding a cytotoxic factor under control of an Aurora kinase promoter. Also disclosed is a virus vector in which the promoter of a nucleic acid encoding a factor necessary to the replication or assembly of at least one virus is substituted by the Aurora kinase promoter. Also disclosed are a disease treatment agent, in particular a cancer treatment agent, which contains the aforementioned vector, and a clinical diagnostic agent, in particular a cancer diagnostic agent, which contains the vector containing the Aurora kinase promoter.
摘要翻译：公开了一种载体，优选病毒载体，其含有治疗因子和/或编码在极光激酶启动子控制下的细胞毒性因子的核酸。还公开了病毒载体，其中编码至少一种病毒的复制或组装必需的因子的核酸的启动子被Aurora激酶启动子取代。还公开了含有上述载体的疾病治疗剂，特别是癌症治疗剂，以及包含含有极光激酶启动子的载体的临床诊断剂，特别是癌症诊断剂。

2. 发明授权

US10905742B2 Application of heparin-binding epidermal growth factor-like growth factor for medical purposes 有权
公开(公告)号：US10905742B2
公开(公告)日：2021-02-02
申请号：US11992728
申请日：2006-09-28
申请人： Ken-ichiro Kosai , Cin Khai Ngin , Tomoyuki Takahashi
发明人： Ken-ichiro Kosai , Cin Khai Ngin , Tomoyuki Takahashi
IPC分类号： C12N15/86 , A61K38/18 , A61K48/00
摘要： The present invention provides an agent for protecting the liver and/or promoting liver regeneration, which contains a heparin-binding EGF-like growth factor-like growth factor (HB-EGF) or a partial peptide thereof, or a nucleic acid that encodes same, and an agent for the prophylaxis or treatment of liver diseases. The present invention further provides a method for producing a cell for liver protection and/or promoting liver regeneration, and for the prophylaxis/treatment of a liver disease, which includes introducing a nucleic acid that encodes HB-EGF or a partial peptide thereof into a cell collected from an animal.

3. 发明授权

US10738324B2 Growth-regulated viral vector containing the aurora kinase promoter 有权
公开(公告)号：US10738324B2
公开(公告)日：2020-08-11
申请号：US13876916
申请日：2011-09-29
申请人： Ken-ichiro Kosai
发明人： Ken-ichiro Kosai
IPC分类号： C12N15/86 , C12N7/00 , A61K35/76 , C12N9/12
摘要： Disclosed is a vector, preferably a viral vector, containing a treatment factor and/or a nucleic acid encoding a cytotoxic factor under control of an Aurora kinase promoter. Also disclosed is a virus vector in which the promoter of a nucleic acid encoding a factor necessary to the replication or assembly of at least one virus is substituted by the Aurora kinase promoter. Also disclosed are a disease treatment agent, in particular a cancer treatment agent, which contains the aforementioned vector, and a clinical diagnostic agent, in particular a cancer diagnostic agent, which contains the vector containing the Aurora kinase promoter.

4. 发明申请

US20090130062A1 Novel Application of Heparin-Binding Epidermal Growth Factor-Like Growth Factor for Medical Purposes 审中-公开
标题翻译：肝素结合表皮生长因子生长因子在医学上的新应用
公开(公告)号：US20090130062A1
公开(公告)日：2009-05-21
申请号：US11992728
申请日：2006-09-28
申请人： Ken-ichiro Kosai , Cin Khai Ngin , Tomoyuki Takahashi
发明人： Ken-ichiro Kosai , Cin Khai Ngin , Tomoyuki Takahashi
IPC分类号： A61K48/00 , A61K31/711 , A61K38/18 , A61P1/16
CPC分类号： A61K38/1808 , A61K48/005 , C12N15/86 , C12N2710/10332 , C12N2710/10343 , C12N2710/10371
摘要： The present invention provides an agent for protecting the liver and/or promoting liver regeneration, which contains a heparin-binding EGF-like growth factor-like growth factor (HB-EGF) or a partial peptide thereof, or a nucleic acid that encodes same, and an agent for the prophylaxis or treatment of liver diseases. The present invention further provides a method for producing a cell for liver protection and/or promoting liver regeneration, and for the prophylaxis/treatment of a liver disease, which includes introducing a nucleic acid that encodes HB-EGF or a partial peptide thereof into a cell collected from an animal.
摘要翻译：本发明提供一种用于保护肝脏和/或促进肝脏再生的药剂，其含有肝素结合的EGF样生长因子样生长因子（HB-EGF）或其部分肽，或编码其的核酸，以及预防或治疗肝脏疾病的药剂。本发明还提供了用于肝保护和/或促进肝再生的细胞的制备方法和用于预防/治疗肝脏疾病的方法，其包括将编码HB-EGF或其部分肽的核酸引入到从动物收集的细胞。

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