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1. 发明申请

US20070196454A1 Crosslinked gels comprising polyalkyleneimines, and their uses as medical devices 有权
公开(公告)号：US20070196454A1
公开(公告)日：2007-08-23
申请号：US11653433
申请日：2007-01-11
申请人： Kenneth Stockman , Michael Carnahan , Keith D'Alessio , Mark Grinstaff
发明人： Kenneth Stockman , Michael Carnahan , Keith D'Alessio , Mark Grinstaff
IPC分类号： A61K31/785 , A61K31/787
CPC分类号： A61L26/0019 , A61B2017/0065 , A61B2017/00951 , A61K31/785 , A61K31/787 , A61K51/1279 , A61L24/0031 , A61L24/0036 , A61L24/043 , A61L24/046 , A61L26/0052 , A61L26/008 , A61L26/0085 , A61L27/18 , A61L27/26 , A61L27/52 , A61L27/56 , C08L79/02
摘要： One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneamine. In a preferred embodiment, the polyalkyleneamine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer. In certain instances, the polyethyleneimine is mixed with a second polymer, such as a polyethylene glycol containing nucleophilic groups. In certain instances, the compositions used to seal the wound or tissue plane are formed by reacting a polyalkyleneamine bearing electrophilic groups with a cross-linking reagent containing nucleophilic groups. In certain instances, the electrophilic groups on the polyalkyleneamine are activated esters, such as N-hydroxy succinimide ester. In certain instances, the compositions used to seal the wound or tissue plane are formed by reacting a polyalkyleneamine bearing photopolymerizable groups with ultraviolet or visibile light. Compositions used to seal the wound which contain PEI or a derivative of PEI are found to adhere tightly to the tissue. Other aspects of the present invention relate to methods of filling a void of a patient or adhering tissue. In certain instances, the methods use a polyalkyleneamine. In a preferred embodiment, the polyalkyleneamine is polyethyleneimine. Another aspect of the present invention relates to a polymeric composition formed by exposing a polyalkyleneamine to an activated polyalkylene glycol. In certain instances, the composition is attached to mammalian tissue.

2. 发明申请

US20050196431A1 Adhesive applicator tip with a polymerization initiator, polymerization rate modifier, and/or bioactive material 审中-公开
标题翻译：具有聚合引发剂，聚合速率调节剂和/或生物活性材料的粘合剂施用头
公开(公告)号：US20050196431A1
公开(公告)日：2005-09-08
申请号：US11119992
申请日：2005-05-02
申请人： Upvan Narang , William Nicholson , Daniel Hedgpeth , Gabriel Szabo , Ibraheem Badejo , Joe Barefoot , William Cotter , Keith D'Alessio , Anthony Sherbondy
发明人： Upvan Narang , William Nicholson , Daniel Hedgpeth , Gabriel Szabo , Ibraheem Badejo , Joe Barefoot , William Cotter , Keith D'Alessio , Anthony Sherbondy
IPC分类号： A61B17/00 , A61L24/00 , A61L24/06 , A61M35/00 , A61L15/16
CPC分类号： A61B17/00491 , A61L24/0015 , A61L24/06 , C08L35/04
摘要： An applicator tip for an applicator for applying a polymerizable monomeric adhesive composition can include a bioactive material, a flavorant, a polymerization initiator, and/or a polymerization rate modifier.
摘要翻译：用于施加可聚合单体粘合剂组合物的施用器的施用器尖端可以包括生物活性材料，调味剂，聚合引发剂和/或聚合速率调节剂。

3. 发明申请

US20060049203A1 Applicators, dispensers and methods for mixing, dispensing and applying adhesive or sealant material and another material 有权
公开(公告)号：US20060049203A1
公开(公告)日：2006-03-09
申请号：US10933463
申请日：2004-09-03
申请人： Eric Boone , Keith D'Alessio , John Goodman , Scott Keplinger , Anthony Voiers , Daniel Tomko , William Johnson
发明人： Eric Boone , Keith D'Alessio , John Goodman , Scott Keplinger , Anthony Voiers , Daniel Tomko , William Johnson
IPC分类号： B67D5/00
CPC分类号： A61B17/00491 , A61B17/0057 , A61B2017/00495 , A61B2017/0065 , A61B2017/00654
摘要： An applicator/dispenser for dispensing, mixing and/or applying a polymerizable monomeric adhesive or sealant material comprises: a body portion; an actuator movable relative to the body portion; a cavity in the body portion; and a piercing or breaking portion on the actuator. Movement of the actuator relative to the body portion moves the piercing or breaking portion into the cavity. When a container of adhesive or sealant material is at least partially disposed within the cavity, movement of the actuator relative to the body portion moves the piercing or breaking portion to rupture the container for mixing, dispensing and/or applying the adhesive or sealant material.

4. 发明授权

US5702656A Process for making polymeric articles 失效
标题翻译：制造聚合物制品的方法
公开(公告)号：US5702656A
公开(公告)日：1997-12-30
申请号：US473186
申请日：1995-06-07
申请人： David Sarver , Keith D'Alessio , Raymond A. D'Alessio
发明人： David Sarver , Keith D'Alessio , Raymond A. D'Alessio
IPC分类号： B29C31/04 , B29C39/24 , B29C39/42 , B29C47/28 , B29C43/56 , B29C55/24
CPC分类号： B29C31/041 , B29C39/24 , B29C39/42 , B29C47/0023 , B29C47/0033 , B29C47/0054 , B29C47/0076 , B29C47/0876 , B29C47/28 , B29C47/0016 , B29C47/0026 , B29C47/20 , B29K2995/006 , B29L2031/06
摘要： Processes for fabricating substantially void-free polymeric articles are provided. In one embodiment, a polymer melt is formed followed by extrusion through a die to form a polymeric extrudate. The polymeric extrudate is directly discharged vertically upward into an open-ended mold the open-ended mold having a longitudinal axis oriented substantially vertically. The polymeric article is cooled and removed from the mold. In a further embodiment, a mold is loaded with polymeric particles. The mold is oriented such that its longitudinal axis is substantially vertical. A vacuum is drawn on the loaded mold followed by heating the loaded mold above the melting point of the polymeric particles. After the polymeric particles are melted, the loaded mold is charged with an inert gas to above ambient pressure to collapse any remaining voids. The loaded mold is slowly cooled to form a polymeric article. Oriented polymeric bioabsorbable cannulated surgical articles and a method of making same are provided. Also provided are methods and articles having polymeric material which has been oriented radially and optionally further oriented axially.
摘要翻译：提供了制造基本上无空隙的聚合物制品的方法。在一个实施方案中，形成聚合物熔体，然后通过模头挤出以形成聚合物挤出物。将聚合物挤出物直接排放到开口模具中，该开口模具具有基本垂直取向的纵向轴线。将聚合物制品冷却并从模具中取出。在另一个实施方案中，模具装载有聚合物颗粒。模具被定向成使得其纵向轴线基本垂直。在加载的模具上抽真空，然后将加载的模具加热到聚合物颗粒的熔点之上。在聚合物颗粒熔融后，将负载的模具装入惰性气体至高于环境压力以折叠任何剩余的空隙。将加载的模具缓慢冷却以形成聚合物制品。提供了定向聚合物生物可吸收插管式外科用品及其制备方法。还提供了具有聚合材料的方法和制品，其已被径向定向并任选地进一步轴向取向。

5. 发明授权

US5674286A Bioabsorbable medical implants 失效
标题翻译：生物可吸收医用植入物
公开(公告)号：US5674286A
公开(公告)日：1997-10-07
申请号：US914437
申请日：1992-07-15
申请人： Keith D'Alessio , Donald S. Kaplan , Ross R. Muth , John Kennedy
发明人： Keith D'Alessio , Donald S. Kaplan , Ross R. Muth , John Kennedy
IPC分类号： A61B17/00 , A61B17/80 , A61F2/30 , A61L27/48 , A61L27/58 , A61L31/12 , A61L31/14 , C08L67/04 , A61F2/02 , A61F2/06 , A61F2/28
CPC分类号： A61L31/148 , A61B17/80 , A61L27/48 , A61L27/58 , A61L31/129 , C08L67/04 , A61B2017/00004 , A61F2/30965
摘要： A completely bioabsorbable reinforced composite material for use in medical implants and a method for making same. The composite material comprises a hybrid yarn of intimately co-mingled reinforcement fibers of a crystalline polymer and matrix fibers of a polymer having a glass transition temperature below the melting point of the crystalline polymer. The hybrid yarn is heated under pressure to a processing temperature between the glass transition temperature of the matrix fibers and the melting point of the crystalline polymer to form a continuous matrix with reinforcing fibers of crystalline polymer. The composite material may be formed by a two step consolidation process.
摘要翻译：用于医疗植入物的完全生物可吸收增强复合材料及其制造方法。该复合材料包括结晶聚合物的紧密共混增强纤维和玻璃化转变温度低于结晶聚合物熔点的聚合物的基质纤维的混合纱线。将混合纱线在压力下加热到基质纤维的玻璃化转变温度和结晶聚合物的熔点之间的加工温度，以形成具有结晶聚合物的增强纤维的连续基质。复合材料可以通过两步固结方法形成。

6. 发明授权

US5358677A Methods of forming bioabsorbable objects from polyvinyl alcohol 失效
标题翻译：从聚乙烯醇形成生物可吸收物体的方法
公开(公告)号：US5358677A
公开(公告)日：1994-10-25
申请号：US852964
申请日：1992-03-17
申请人： Ross R. Muth , Nagabhushanam Totakura , Keith D'Alessio
发明人： Ross R. Muth , Nagabhushanam Totakura , Keith D'Alessio
IPC分类号： A61B17/00 , A61B17/06 , A61B17/064 , A61B17/08 , A61B17/122 , A61B17/16 , A61B17/68 , A61B17/80 , A61B17/86 , A61F2/00 , A61F2/02 , A61F2/24 , A61F2/28 , A61F2/30 , A61F2/82 , A61L27/16 , A61L27/34 , A61L31/04 , A61L31/10 , B29C43/00 , B29C43/14 , B29C51/00 , B29C67/24 , B29C69/02 , B29B11/12 , B29C43/56
CPC分类号： B29C69/02 , A61L27/16 , A61L27/34 , A61L31/048 , A61L31/10 , B29C43/003 , B29C43/14 , B29C67/24 , A61B17/06066 , A61B17/064 , A61B17/08 , A61B17/122 , A61B17/16 , A61B17/68 , A61B17/80 , A61B17/86 , A61B2017/00004 , A61F2/0077 , A61F2/24 , A61F2/28 , A61F2/30767 , A61F2/82 , A61F2002/30062 , A61F2210/0004 , B29C2791/001 , B29C51/00 , B29K2003/00 , B29K2029/04
摘要： Method for forming polyvinyl alcohol (PVA) into surgical elements include forming a mixture of PVA and water into a film by vacuum pressing with a first force, heating, applying a second force two to two hundred times the firs force, drying the film to remove water to a content of less than about 10% by weight based on the weight of the film, and molding the film into a desired shape.
摘要翻译：将聚乙烯醇（PVA）形成手术元件的方法包括通过用第一力真空压制形成PVA和水的混合物，加热，施加第二次力的二至二倍的力，干燥该膜以除去水的含量基于膜的重量小于约10重量％，并将膜成型为期望的形状。

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