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1. 发明授权

US08951974B2 Self-assembling peptide and peptide gel with high strength 有权
标题翻译：自组装肽和肽凝胶具有高强度
公开(公告)号：US08951974B2
公开(公告)日：2015-02-10
申请号：US14226341
申请日：2014-03-26
申请人： Yusuke Nagai , Hidenori Yokoi , Koji Uesugi , Keiji Naruse
发明人： Yusuke Nagai , Hidenori Yokoi , Koji Uesugi , Keiji Naruse
IPC分类号： A61K38/10 , C07K7/08 , A61K8/64 , A61K9/06 , B01J20/28
CPC分类号： C07K7/08 , A61K8/64 , A61K9/0048 , A61K9/06 , A61K38/10 , A61K47/42 , A61L15/60 , A61L27/227 , A61L27/52 , A61L29/145 , A61L31/10 , A61L31/145 , A61Q5/00 , A61Q19/00 , B01J20/28047 , C10M173/02 , C12N5/0068 , C12N5/0656 , C12N5/0658 , C12N2533/50
摘要： Provide are a peptide gel with practically sufficient mechanical strength and a self-assembling peptide capable of forming the peptide gel. The self-assembling peptide is formed of the following amino acid sequence: a1b1c1b2a2b3 db4a3b5c2b6a4 where: a1 to a4 each represent a basic amino acid residue; b1 to b6 each represent an uncharged polar amino acid residue and/or a hydrophobic amino acid residue, provided that at least five thereof each represent a hydrophobic amino acid residue; c1 and c2 each represent an acidic amino acid residue; and d represents a hydrophobic amino acid residue.
摘要翻译：提供具有实际足够的机械强度的肽凝胶和能够形成肽凝胶的自组装肽。自组装肽由以下氨基酸序列形成：a1b1c1b2a2b3 db4a3b5c2b6a4其中：a1至a4各自表示碱性氨基酸残基; b1至b6各自表示不带电极性氨基酸残基和/或疏水性氨基酸残基，条件是其至少5个各自表示疏水性氨基酸残基; c1和c2各自表示酸性氨基酸残基; d表示疏水性氨基酸残基。

2. 发明申请

US20140286888A1 SELF-ASSEMBLING PEPTIDE AND PEPTIDE GEL WITH HIGH STRENGTH 有权
标题翻译：自组装肽和肽凝胶高强度
公开(公告)号：US20140286888A1
公开(公告)日：2014-09-25
申请号：US14226341
申请日：2014-03-26
申请人： Yusuke NAGAI , Hidenori Yokoi , Koji Uesugi , Keiji Naruse
发明人： Yusuke NAGAI , Hidenori Yokoi , Koji Uesugi , Keiji Naruse
IPC分类号： C07K7/08 , A61K9/06 , B01J20/28 , A61K8/64
CPC分类号： C07K7/08 , A61K8/64 , A61K9/0048 , A61K9/06 , A61K38/10 , A61K47/42 , A61L15/60 , A61L27/227 , A61L27/52 , A61L29/145 , A61L31/10 , A61L31/145 , A61Q5/00 , A61Q19/00 , B01J20/28047 , C10M173/02 , C12N5/0068 , C12N5/0656 , C12N5/0658 , C12N2533/50
摘要： Provide are a peptide gel with practically sufficient mechanical strength and a self-assembling peptide capable of forming the peptide gel. The self-assembling peptide is formed of the following amino acid sequence: a1b1c1b2a2b3 db4a3b5c2b6a4 where: a1 to a4 each represent a basic amino acid residue; b1 to b6 each represent an uncharged polar amino acid residue and/or a hydrophobic amino acid residue, provided that at least five thereof each represent a hydrophobic amino acid residue; c1 and c2 each represent an acidic amino acid residue; and d represents a hydrophobic amino acid residue.
摘要翻译：提供具有实际足够的机械强度的肽凝胶和能够形成肽凝胶的自组装肽。自组装肽由以下氨基酸序列形成：a1b1c1b2a2b3 db4a3b5c2b6a4其中：a1至a4各自表示碱性氨基酸残基; b1至b6各自表示不带电极性氨基酸残基和/或疏水性氨基酸残基，条件是其至少5个各自表示疏水性氨基酸残基; c1和c2各自表示酸性氨基酸残基; d表示疏水性氨基酸残基。

3. 发明申请

US20120145563A1 pH OR CONCENTRATION MEASURING DEVICE AND pH OR CONCENTRATION MEASURING METHOD 有权
标题翻译： pH或浓度测量装置和pH或浓度测量方法
公开(公告)号：US20120145563A1
公开(公告)日：2012-06-14
申请号：US13391746
申请日：2010-08-24
申请人： Akira Yamada , Michihiro Nakamura , Satoshi Mohri , Keiji Naruse
发明人： Akira Yamada , Michihiro Nakamura , Satoshi Mohri , Keiji Naruse
IPC分类号： G01N27/414
CPC分类号： G01N27/4167 , G01N27/414 , H01L2924/13073
摘要： Disclosed are a pH or concentration measuring device and a pH or concentration measuring method which enable measurement in the shortest possible time even in an object to be measured having low buffer capacity. Specifically disclosed are a pH or concentration measuring device and measuring method for measuring the pH or concentration of a sample solution that is an object to be measured, the device being provided with first and second sensors that each output a signal corresponding to the pH or concentration of a solution, an inspection tube that is provided with a first room in which the first sensor is disposed and a second room in which the second sensor is disposed, a feeding means that feeds a baseline solution into the inspection tube, and an injecting means which injects the sample solution into the first room of the inspection tube and brings the sample solution into contact with the first sensor, wherein a vibration means which vibrates the interface between the sample solution stored in the first room and the baseline solution is provided.
摘要翻译：公开了一种pH或浓度测量装置和pH或浓度测量方法，即使在具有低缓冲容量的被测量物体中也能够在最短的时间内进行测量。具体公开的是用于测量作为被测量对象物的样品溶液的pH或浓度的pH或浓度测量装置和测量方法，该装置设置有第一和第二传感器，每个传感器输出对应于pH或浓度的信号解决方案的检查管，设置有设置有第一传感器的第一房间和设置有第二传感器的第二房间的检查管，将基线溶液供给到检查管中的供给单元，以及注入单元其将样品溶液注入检查管的第一房间，并使样品溶液与第一传感器接触，其中提供振动装置，其振动存储在第一房间中的样品溶液与基线溶液之间的界面。

4. 发明申请

US20070178584A1 Culture device 审中-公开
标题翻译：文化装置
公开(公告)号：US20070178584A1
公开(公告)日：2007-08-02
申请号：US10598780
申请日：2005-03-09
申请人： Keiji Naruse , Norio Ishida
发明人： Keiji Naruse , Norio Ishida
IPC分类号： C12M3/00
CPC分类号： C12M23/26 , C12M25/02 , C12M35/04
摘要： A culture device to apply uniform stress to cells is proposed. A culture device is formed in a rectangular box shape from a deformable material, comprising a bottom membrane and side walls upstanding from the entire periphery of said bottom membrane, wherein an engaging member is formed in opposing side walls on a line extended from a peripheral edge of said bottom membrane. By providing the latching member in the culture membrane so as to latch the cells to the latching member, the slippage between the bottom membrane and sample cells is forestalled upon the extension of the culture membrane.
摘要翻译：提出了对细胞施加均匀应力的培养装置。培养装置由可变形材料形成为矩形盒状，包括底膜和从所述底膜的整个周边直立的侧壁，其中，接合构件形成在从周缘延伸的线上的相对侧壁中的所述底膜。通过在培养膜中设置闩锁构件以将细胞锁定到闩锁构件，在培养膜延伸时防止底部膜和样品池之间的滑动。

5. 发明授权

US06653089B2 Differential treatment of selected parts of a single cell with different fluid components 有权
公开(公告)号：US06653089B2
公开(公告)日：2003-11-25
申请号：US09954978
申请日：2001-09-18
申请人： Shuichi Takayama , Emanuele Ostuni , Philip LeDuc , Keiji Naruse , Donald E. Ingber , George M. Whitesides
发明人： Shuichi Takayama , Emanuele Ostuni , Philip LeDuc , Keiji Naruse , Donald E. Ingber , George M. Whitesides
IPC分类号： G01N3353
CPC分类号： G01N33/5011 , A61K35/12 , C12N5/00 , C12N5/069 , C12N2501/48 , C12N2501/58 , C12N2503/00 , C12N2503/02 , C12N2510/00 , G01N33/5008 , G01N33/502 , G01N33/5035 , G01N33/5076 , G01N33/5079 , G01N33/528 , G01N2800/52
摘要： The present invention is directed, in certain embodiments, to improved, small scale systems and methods able to selectively treat parts of a single cell, including, in certain embodiments, portions of a main body portion of a single cell, and able, in certain embodiments, to establish long-term gradients of active substances within subcellular regions of a single cell. The present invention provides, in some embodiments, techniques for selectively contacting a portion of the surface of a biological cell with a fluid or fluid component carrying a particular potential for a biophysical or biochemical interaction with the cell, and simultaneously contacting a different portion of the surface of the cell with another fluid or fluid component having a different potential for the biophysical or biochemical interaction with the cell.

6. 发明授权

US08815078B2 pH or concentration measuring device and pH or concentration measuring method 有权
标题翻译： pH或浓度测量装置和pH或浓度测量方法
公开(公告)号：US08815078B2
公开(公告)日：2014-08-26
申请号：US13391746
申请日：2010-08-24
申请人： Akira Yamada , Michihiro Nakamura , Satoshi Mohri , Keiji Naruse
发明人： Akira Yamada , Michihiro Nakamura , Satoshi Mohri , Keiji Naruse
IPC分类号： G01N27/416
CPC分类号： G01N27/4167 , G01N27/414 , H01L2924/13073
摘要： Disclosed are a pH or concentration measuring device and a pH or concentration measuring method which enable measurement in the shortest possible time even in an object to be measured having low buffer capacity. Specifically disclosed are a pH or concentration measuring device and measuring method for measuring the pH or concentration of a sample solution that is an object to be measured, the device being provided with first and second sensors that each output a signal corresponding to the pH or concentration of a solution, an inspection tube that is provided with a first room in which the first sensor is disposed and a second room in which the second sensor is disposed, a feeding means that feeds a baseline solution into the inspection tube, and an injecting means which injects the sample solution into the first room of the inspection tube and brings the sample solution into contact with the first sensor, wherein a vibration means which vibrates the interface between the sample solution stored in the first room and the baseline solution is provided.
摘要翻译：公开了一种pH或浓度测量装置和pH或浓度测量方法，即使在具有低缓冲容量的被测量物体中也能够在最短的时间内进行测量。具体公开的是用于测量作为被测量对象物的样品溶液的pH或浓度的pH或浓度测量装置和测量方法，该装置设置有第一和第二传感器，每个传感器输出对应于pH或浓度的信号解决方案的检查管，设置有设置有第一传感器的第一房间和设置有第二传感器的第二房间的检查管，将基线溶液供给到检查管中的供给单元，以及注入单元其将样品溶液注入检查管的第一房间，并使样品溶液与第一传感器接触，其中提供振动装置，其振动存储在第一房间中的样品溶液与基线溶液之间的界面。

7. 发明申请

US20120058066A1 SELF-ASSEMBLING PEPTIDE AND PEPTIDE GEL WITH HIGH STRENGTH 有权
标题翻译：自组装肽和肽凝胶高强度
公开(公告)号：US20120058066A1
公开(公告)日：2012-03-08
申请号：US13255457
申请日：2010-02-12
申请人： Yusuke Nagai , Hidenori Yokoi , Koji Uesugi , Keiji Naruse
发明人： Yusuke Nagai , Hidenori Yokoi , Koji Uesugi , Keiji Naruse
IPC分类号： A61K8/64 , C12N5/071 , C12N5/04 , A61K47/42 , A61K38/10 , B05D7/24 , A61Q19/00 , A61P7/02 , C09K3/00 , A61L2/04 , B05D5/00 , C07K7/08 , A61Q5/00
CPC分类号： C07K7/08 , A61K8/64 , A61K9/0048 , A61K9/06 , A61K38/10 , A61K47/42 , A61L15/60 , A61L27/227 , A61L27/52 , A61L29/145 , A61L31/10 , A61L31/145 , A61Q5/00 , A61Q19/00 , B01J20/28047 , C10M173/02 , C12N5/0068 , C12N5/0656 , C12N5/0658 , C12N2533/50
摘要： Provide are a peptide gel with practically sufficient mechanical strength and a self-assembling peptide capable of forming the peptide gel. The self-assembling peptide is formed of the following amino acid sequence: a1b1c1b2a2b3db4a3b5c2b6a4 where: a1 to a4 each represent a basic amino acid residue; b1 to b6 each represent an uncharged polar amino acid residue and/or a hydrophobic amino acid residue, provided that at least five thereof each represent a hydrophobic amino acid residue; c1 and c2 each represent an acidic amino acid residue; and d represents a hydrophobic amino acid residue.
摘要翻译：提供具有实际足够的机械强度的肽凝胶和能够形成肽凝胶的自组装肽。自组装肽由以下氨基酸序列形成：a1b1c1b2a2b3db4a3b5c2b6a4其中：a1至a4各自表示碱性氨基酸残基; b1至b6各自表示不带电极性氨基酸残基和/或疏水性氨基酸残基，条件是其至少5个各自表示疏水性氨基酸残基; c1和c2各自表示酸性氨基酸残基; d表示疏水性氨基酸残基。

8. 发明授权

US08729032B2 Self-assembling peptide and peptide gel with high strength 有权
标题翻译：自组装肽和肽凝胶具有高强度
公开(公告)号：US08729032B2
公开(公告)日：2014-05-20
申请号：US13255457
申请日：2010-02-12
申请人： Yusuke Nagai , Hidenori Yokoi , Koji Uesugi , Keiji Naruse
发明人： Yusuke Nagai , Hidenori Yokoi , Koji Uesugi , Keiji Naruse
IPC分类号： A61K38/10 , C07K7/08
CPC分类号： C07K7/08 , A61K8/64 , A61K9/0048 , A61K9/06 , A61K38/10 , A61K47/42 , A61L15/60 , A61L27/227 , A61L27/52 , A61L29/145 , A61L31/10 , A61L31/145 , A61Q5/00 , A61Q19/00 , B01J20/28047 , C10M173/02 , C12N5/0068 , C12N5/0656 , C12N5/0658 , C12N2533/50
摘要： Provide are a peptide gel with practically sufficient mechanical strength and a self-assembling peptide capable of forming the peptide gel. The self-assembling peptide is formed of the following amino acid sequence: a1b1c1b2a2b3db4a3b5c2b6a4 where: a1 to a4 each represent a basic amino acid residue; b1 to b6 each represent an uncharged polar amino acid residue and/or a hydrophobic amino acid residue, provided that at least five thereof each represent a hydrophobic amino acid residue; c1 and c2 each represent an acidic amino acid residue; and d represents a hydrophobic amino acid residue.
摘要翻译：提供具有实际足够的机械强度的肽凝胶和能够形成肽凝胶的自组装肽。自组装肽由以下氨基酸序列形成：a1b1c1b2a2b3db4a3b5c2b6a4其中：a1至a4各自表示碱性氨基酸残基; b1至b6各自表示不带电极性氨基酸残基和/或疏水性氨基酸残基，条件是其至少5个各自表示疏水性氨基酸残基; c1和c2各自表示酸性氨基酸残基; d表示疏水性氨基酸残基。

9. 发明申请

US20140113365A1 CELL CULTURING VESSEL 审中-公开
标题翻译：细胞培养血管
公开(公告)号：US20140113365A1
公开(公告)日：2014-04-24
申请号：US14114134
申请日：2012-04-26
申请人： Yusuke Nagai , Keiji Naruse , Ken Takahashi , Eijiro Tokuyama
发明人： Yusuke Nagai , Keiji Naruse , Ken Takahashi , Eijiro Tokuyama
IPC分类号： C12M1/00
CPC分类号： C12M23/26 , C12M23/04 , C12M23/34
摘要： A cell culture vessel supplies cells close to the center of gel and deeper down to the bottom with sufficient nutrients for attaining an enhanced survival rate of the cultivated cells. The cell culturing vessel comprises a culture tray capable of holding a liquid culture medium and a cell mixture container fixed to inner walls of the culture tray for retaining the cell mixture. Once the culture tray is filled with the liquid culture medium, the cell mixture retained in the cell mixture container has its opposite outer parts exposed to the liquid culture medium.
摘要翻译：细胞培养容器提供靠近凝胶中心的细胞，更深层次地向底部提供足够的营养物质，以达到提高培养细胞的存活率。细胞培养容器包括能够保持液体培养基的培养托盘和固定在培养托盘的内壁上的细胞混合物容器，用于保持细胞混合物。一旦培养皿填充有液体培养基，保留在细胞混合容器中的细胞混合物具有暴露于液体培养基的相对的外部部分。

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