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1. 发明授权

US06140330A Thiazole derivative 失效
标题翻译：噻唑衍生物
公开(公告)号：US06140330A
公开(公告)日：2000-10-31
申请号：US43642
申请日：1998-03-24
申请人： Toyoki Mori , Michiaki Tominaga , Fujio Tabusa , Kazuyoshi Nagami , Kaoru Abe , Kenji Nakaya , Isao Takemura , Tomoichi Shinohara , Yoshihisa Tanada , Takahito Yamauchi
发明人： Toyoki Mori , Michiaki Tominaga , Fujio Tabusa , Kazuyoshi Nagami , Kaoru Abe , Kenji Nakaya , Isao Takemura , Tomoichi Shinohara , Yoshihisa Tanada , Takahito Yamauchi
IPC分类号： C07D277/46 , C07D277/82 , C07D317/64 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , A61K31/495 , A61K31/445 , C07D413/02
CPC分类号： C07D417/12 , C07D277/46 , C07D277/82 , C07D317/64 , C07D417/14 , C07D471/04 , C07D487/04
摘要： A thiazole compound of the formula: ##STR1## wherein T is lower alkylene; u is 0 or 1; R.sup.1 and R.sup.2 are the same or different and are each H, or lower alkyl, etc.; R.sup.3 is ##STR2## R.sup.4 is H or lower alkanoyloxy-lower alkyl, which shows inhibitory activity on protein kinase C (PKC, Ca.sup.2+ /phospholipid-depending serine/threonine protein phosphatase), and are useful as a protein kinase C inhibitor.
摘要翻译： PCT No.PCT / JP97 / 02609 Sec。 371日期：1998年3月24日 102（e）1998年3月24日PCT PCT 1997年7月29日PCT公布。第WO98 / 04536号公报日期：1998年2月5日A下式的噻唑化合物：其中T是低级亚烷基; 你是0或1; R1和R2相同或不同，各自为H或低级烷基等; R3是R4是H或低级烷酰氧基 - 低级烷基，它对蛋白激酶C（PKC，Ca2 + /磷脂依赖性丝氨酸/苏氨酸蛋白磷酸酶）具有抑制活性，可用作蛋白激酶C抑制剂。

2. 发明授权

US5358949A Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives 失效
标题翻译：卡波他汀衍生物及其盐和含有喹诺酮衍生物的抗心律不齐剂
公开(公告)号：US5358949A
公开(公告)日：1994-10-25
申请号：US666490
申请日：1991-03-06
申请人： Fujio Tabusa , Kazuyoshi Nagami , Hironori Tsutsui
发明人： Fujio Tabusa , Kazuyoshi Nagami , Hironori Tsutsui
IPC分类号： C07D215/38 , C07D215/40 , C07D215/42 , C07D215/48 , C07D215/54 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D471/08 , C07D487/04 , C07D521/00 , A61K31/54 , A01N43/04 , C07D401/00
CPC分类号： C07D249/08 , C07D215/38 , C07D215/40 , C07D215/42 , C07D215/48 , C07D215/54 , C07D231/12 , C07D233/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/06 , C07D413/10 , C07D471/08 , C07D487/04
摘要： Carbostyril derivatives or salt thereof, including novel compounds, having activities for curing and/or improving arrhythmia.Some carbostyril derivatives having similar chemical structural formula to those of carbostyril derivatives of the present invention are known in the prior art references, however, above-mentioned pharmacological activities have not been known yet.
摘要翻译：碳青霉烯衍生物或其盐，包括具有固化和/或改善心律失常活性的新化合物。具有与本发明的喹诺酮衍生物相似的化学结构式的一些喹诺酮衍生物在现有技术参考文献中是已知的，然而，上述药理学活性尚未知晓。

3. 发明授权

US4564619A Carbostyril derivative 失效
标题翻译：碳青霉烯衍生物
公开(公告)号：US4564619A
公开(公告)日：1986-01-14
申请号：US528887
申请日：1983-09-02
申请人： Tatsuyoshi Tanaka , Kazuyoshi Nagami , Shigeharu Tamada , Kazuyuki Nakagawa
发明人： Tatsuyoshi Tanaka , Kazuyoshi Nagami , Shigeharu Tamada , Kazuyuki Nakagawa
IPC分类号： C07D215/22 , C07D215/227 , C07D401/12 , A61K31/47
CPC分类号： C07D215/227 , C07D401/12
摘要： Carbostyril derivative or a pharmaceutically acceptable acid addition salt thereof, having excellent platelate aggregation inhibitory effect, calcium antagonism, hypotensive effect and phosphodiesterase inhibitory effect are useful as prophylactic or treating agents for thrombosis, circulation improving agents for coronary blood flow such as coronary vasodilators, hypotensive agents and phosphodiesterase inhibitors. Furthermore, the carbostyril derivatives are weak in heart rate increasing activity and also in cardiac muscle contraction increasing activity, and the carbostyril derivatives are useful agents for curing and treating heart diseases such as cardiac angina and myocardial infarction caused by hypercoagulability of the platelets. Processes are disclosed for preparation of the carbostyril derivatives.
摘要翻译：具有极好的铂性聚集抑制作用，钙拮抗作用，降血压作用和磷酸二酯酶抑制作用的卡波他特里尔衍生物或其药学上可接受的酸加成盐可用作血栓形成的预防或治疗剂，用于冠状动脉血管扩张剂的血液循环改善剂，降血压药剂和磷酸二酯酶抑制剂。此外，喹诺酮衍生物的心率增加活性弱，心肌收缩增加活性也较弱，而喹诺酮衍生物可用于治疗和治疗由心血管病和心肌梗塞引起的血小板高凝状态引起的心脏病。公开了制备喹诺酮衍生物的方法。

4. 发明授权

US5034395A Novel dihydropyridine derivatives 失效
标题翻译：新型二氢吡啶衍生物
公开(公告)号：US5034395A
公开(公告)日：1991-07-23
申请号：US18836
申请日：1987-02-24
申请人： Shigeharu Tamada , Kazuyoshi Nagami , Shuji Teramoto , Tatsuyoshi Tanaka , Kazuyuki Nakagawa
发明人： Shigeharu Tamada , Kazuyoshi Nagami , Shuji Teramoto , Tatsuyoshi Tanaka , Kazuyuki Nakagawa
IPC分类号： C07D211/84 , A61K31/443 , A61K31/455 , A61P3/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P31/00 , A61P35/00 , A61P43/00 , C07C43/178 , C07C43/315 , C07C67/00 , C07C69/732 , C07C313/00 , C07C323/12 , C07C323/14 , C07D211/90 , C07D295/185 , C07D309/12 , C07D401/12 , C07D405/12 , C07D409/12
CPC分类号： C07D295/185 , C07C323/00 , C07C327/00 , C07C43/1787 , C07C43/315 , C07C67/283 , C07C67/293 , C07C67/307 , C07C67/31 , C07C67/343 , C07C67/46 , C07D211/90 , C07D309/12 , C07D401/12 , C07D405/12 , C07D409/12
摘要： Dihydropyridine derivatives and salts thereof represented by the general formula, ##STR1## which possess excellent calcium antagonist effect, hypotensive effect, platelets aggregation inhibitory effect, phosphodiesterase inhibitory effect, calmodulin inhibitory effect and peroxidized lipid lowering effect, and thus dihydropyridine derivatives and salts thereof are useful as a coronary blood flow improving agent such as coronary vasodilator, hypotensive agent, prophylaxis and treating agents for thrombosis, phophodiesterase inhibitory agent, peroxidized lipid metabolism lowering agent, anti-inflammatory agent and others.
摘要翻译：具有优异的钙拮抗剂作用，降血压作用，血小板聚集抑制作用，磷酸二酯酶抑制作用，钙调蛋白抑制作用和过氧化脂质降低作用的通式表示的二氢吡啶衍生物及其盐，因此具有二氢吡啶衍生物及其盐可用作冠状动脉血管扩张剂，降血压药，血栓形成预防和治疗剂，二磷酸酯酶抑制剂，过氧化脂质代谢降低剂，抗炎剂等冠状动脉血流改善剂。

5. 发明授权

US4760064A Carbostyril compounds, compositions containing same and processes for preparing same 失效
标题翻译：碳青霉烯化合物，含有它们的组合物及其制备方法
公开(公告)号：US4760064A
公开(公告)日：1988-07-26
申请号：US808420
申请日：1985-12-13
申请人： Michiaki Tominaga , Takafumi Fujioka , Kazuyoshi Nagami , Kazuyuki Nakagawa
发明人： Michiaki Tominaga , Takafumi Fujioka , Kazuyoshi Nagami , Kazuyuki Nakagawa
IPC分类号： C07D215/38 , A61K31/495 , C07D401/04
CPC分类号： C07D215/38
摘要： A carbostyril compound of the formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are as defined or its pharmaceutically acceptable salt, composition containing the compound and processes for preparing the same are disclosed.The compound is useful as a cardiotonic agent.
摘要翻译：公开了式（I）的喹诺酮化合物：其中R 1和R 2如上所定义或其药学上可接受的盐，含该化合物的组合物及其制备方法。该化合物可用作强心剂。

6. 发明授权

US5137889A Dihydropyridine derivatives and process for preparing the same 失效
标题翻译：二氢吡啶衍生物及其制备方法
公开(公告)号：US5137889A
公开(公告)日：1992-08-11
申请号：US704374
申请日：1991-05-23
申请人： Shigeharu Tamada , Kazuyoshi Nagami , Shuji Teramoto , Tatsuyoshi Tanaka , Kazuyuki Nakagawa
发明人： Shigeharu Tamada , Kazuyoshi Nagami , Shuji Teramoto , Tatsuyoshi Tanaka , Kazuyuki Nakagawa
IPC分类号： A61K31/44 , C07C43/178 , C07C43/315 , C07D211/90 , C07D295/185 , C07D309/12 , C07D401/12 , C07D405/12 , C07D409/12
CPC分类号： C07D295/185 , C07C323/00 , C07C327/00 , C07C43/1787 , C07C43/315 , C07D211/90 , C07D309/12 , C07D401/12 , C07D405/12 , C07D409/12
摘要： Dihydropyridine derivatives and salts thereof represented by the general formula, ##STR1## which possess excellent calcium antagonist effect, hypotensive effect, platelets aggregation inhibitory effect, phosphodiesterase inhibitory effect, calmodulin inhibitory effect and peroxidized lipid lowering effect, and thus dihydropyridine derivatives and salts thereof are useful as a coronary blood flow improving agent such as coronary vasodilator, hypotensive agent, prophylaxis and treating agents for thrombosis, phosphodiesterase inhibitory agent, peroxidized lipid metabolism lowering agent, anti-inflammatory agent and others.
摘要翻译：具有优异的钙拮抗剂作用，降血压作用，血小板聚集抑制作用，磷酸二酯酶抑制作用，钙调蛋白抑制作用和过氧化脂质降低作用的通式表示的二氢吡啶衍生物及其盐，因此具有二氢吡啶衍生物及其盐可用作冠状动脉血管扩张剂，降血压药，血栓形成预防和治疗剂，磷酸二酯酶抑制剂，过氧化脂质代谢降低剂，抗炎剂等冠状动脉血流改善剂。

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