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1. 发明授权

US06890304B1 Device for diagnosing physiological state and device for controlling the same 有权
公开(公告)号：US06890304B1
公开(公告)日：2005-05-10
申请号：US09587049
申请日：2000-06-02
申请人： Kazuhiko Amano , Kazuo Uebaba , Hitoshi Ishiyama
发明人： Kazuhiko Amano , Kazuo Uebaba , Hitoshi Ishiyama
IPC分类号： A61B5/0245 , A61B5/00 , A61B5/02 , A61B5/024 , A61B5/18 , A61M5/172 , A61N1/30 , G06F19/00 , G06Q50/00
CPC分类号： A61B5/02416 , A61B5/02 , A61B5/02007 , A61B5/024 , A61B5/02438 , A61B5/18 , A61B5/4854 , A61B5/6806 , A61B5/681 , A61B5/6821 , A61B5/6822 , A61B5/7257 , A61M5/1723 , G06F19/00
摘要： The present invention relates to a device for diagnosing physiological state based on blood pulse waves detected in the body. It is the objective of the present invention to provide a device which correctly diagnoses the current physiological state based on changes in physiological state measured over a specified period of time in the past while taking into consideration the cyclical variation exhibited in physiological state. In order to realize this objective, the device according to the present invention has as its main components: blood pulse wave detector 381 and stroke-volume-per-beat measurer 382 which respectively detect blood pulse wave and stroke volume in the body; blood pulse wave extraction memory 386 which extracts characteristic information from the detected blood pulse wave; memory 383 in which the physiological state calculated from the stroke volume and this characteristic information is stored; output portion 385 which outputs an alarm; and microcomputer 387 which controls each part inside the device. The microcomputer calculates the circulatory parameters based on characteristic information obtained from the waveform extraction memory, and stores the parameters in memory at specified time intervals. At these times, microcomputer 387 calculates the circulatory parameters from the stroke volume per beat and the characteristic information of the blood pulse wave at specified time intervals, and stores the parameters in memory 383. Further, microcomputer 387 reads out from memory 383 the circulatory parameters from a specified time interval in the past, and calculates the average value and standard deviation. Microcomputer 387 then determines whether or not the current circulatory parameters are within a specified range determined by their average value and standard deviation. When the circulatory parameters are determined to be outside this range, microcomputer 387 controls output portion 385 to sound an alarm.

2. 发明授权

US06554763B1 Relaxation guidance device and biofeedback guidance device 有权
标题翻译：放松引导装置和生物反馈引导装置
公开(公告)号：US06554763B1
公开(公告)日：2003-04-29
申请号：US09542789
申请日：2000-04-04
申请人： Kazuhiko Amano , Kazuo Uebaba , Hitoshi Ishiyama
发明人： Kazuhiko Amano , Kazuo Uebaba , Hitoshi Ishiyama
IPC分类号： A61B500
CPC分类号： A61M21/00 , A61B5/486 , A61B5/726 , A61M2021/0016 , A61M2021/0022 , A61M2021/0044 , A61M2021/005 , A61M2230/04 , A61M2230/005
摘要： In order to enable a user to easily and quickly ascertain his body's state of relaxation, the device is provided with: a physiological information extractor 101 for extracting an indicator expressing physiological state from user Y; a storage member 102 for storing the extracted indicator; a judging member 103 for analyzing the change over time in the stored indicator, and determining whether or not the user's condition has improved toward a state of greater relaxation based on the indicator; and a notifying member 104 for providing notice that the body has moved toward a state of greater relaxation, if the results of the aforementioned determination are affirmative.
摘要翻译：为了使用户能够容易且快速地确定其身体的放松状态，该装置设置有：用于从用户Y提取表示生理状态的指示符的生理信息提取器101; 用于存储提取的指示符的存储构件102; 用于分析所存储的指示符中的随时间的变化的判断部件103，并且基于指示器判断用户的状况是否改善到更大松弛的状态; 以及如果上述确定的结果是肯定的，通知构件104用于提供身体已经朝向较大放松状态移动的通知。

3. 发明授权

US06293915B1 Pulse wave examination apparatus, blood pressure monitor, pulse waveform monitor, and pharmacological action monitor 有权
标题翻译：脉搏检测仪，血压计，脉搏波形监测仪，药理作用监测仪
公开(公告)号：US06293915B1
公开(公告)日：2001-09-25
申请号：US09341787
申请日：1999-07-16
申请人： Kazuhiko Amano , Kazuo Uebaba , Hitoshi Ishiyama , Hiroshi Kasahara
发明人： Kazuhiko Amano , Kazuo Uebaba , Hitoshi Ishiyama , Hiroshi Kasahara
IPC分类号： A61B502
CPC分类号： A61B5/4854 , A61B5/021 , A61B5/02116 , A61B5/11 , A61B5/681 , A61B5/6814 , A61B5/6816 , A61B5/6822 , A61B5/6826 , A61B5/6828 , A61B5/6838 , A61B5/721 , A61B5/7239 , A61B5/7257 , A61B5/726
摘要： An FFT treating section (40) carries out the frequency analysis of a pulse waveform MHj excluding a body movement component to yield pulse wave analysis data MKD and then a tidal wave-character extracting section (50) and a dicrotic wave-character extracting section (60) yield a tidal wave-character data (TWD) and a dicrotic wave-character data (DWD) showing the characteristics of a tidal wave and dicrotic wave respectively. Then, a pulse condition judging section (70) yields pulse condition data (ZD) on the basis of this data (TWD, DWD) and in succession a notifying section (80) advises of the pulse condition of a subject.
摘要翻译： FFT处理部（40）进行不包括体动成分的脉搏波形MHj的频率分析，得到脉波分析数据MKD，然后是潮汐波字符提取部（50）和重博波字符提取部 60）分别产生潮汐波字符数据（TWD）和显示潮波和重博波特征的重博波字符数据（DWD）。然后，脉冲条件判定部70基于该数据（TWD，DWD）生成脉冲条件数据（ZD），并且连续地通知被检体的脉搏状态。

4. 发明授权

US6162185A Touch detecting device, touch notifying device, information inputting device, touch replicating device, touch transmission system, pulse diagnostic device, pulse diagnosis training device, and pulse diagnostic information transmission device 有权
标题翻译：触摸检测装置，触摸通知装置，信息输入装置，触摸复制装置，触摸传输系统，脉冲诊断装置，脉冲诊断训练装置和脉冲诊断信息传输装置
公开(公告)号：US6162185A
公开(公告)日：2000-12-19
申请号：US194698
申请日：1998-11-30
申请人： Kazuhiko Amano , Kazuo Uebaba , Hitoshi Ishiyama
发明人： Kazuhiko Amano , Kazuo Uebaba , Hitoshi Ishiyama
IPC分类号： A61B5/021 , A61B5/026 , A61B19/00
CPC分类号： A61B5/681 , A61B5/021 , A61B5/0261 , A61B5/4854 , A61B5/6826 , A61B5/6838
摘要： The test subject attaches pulse wave detectors 1 to his fingertips, and presses down on pressure sensor 110. As a result, CPU 4 determines the DC component of the received light signal LS, and stores this in calibration table 50 in association with the pressure level. Subsequently, CPU 4 calculates threshold values, which can be used for grading the touch sensation, based on maximum value Pmax of the pressure level and calibration table 50, and stores this result in threshold table 51. When the subject grips an object with his fingers, the blood flow volume is detected by pulse wave detector 1 as received light signal LS. CPU 4 calculates the DC component of received light signal LS, compares this result to the threshold values stored in threshold value table 51, generates touch information SJ, and displays this on LCD 108. Accordingly, in this case, pulse diagnosis can be easily performed by expressing the degree of pressure in the pulse diagnosis as touch information SJ.
摘要翻译： PCT No.PCT / JP98 / 01396 Sec。 371日期：1998年11月30日 102（e）1998年11月30日日期PCT 1998年3月27日PCT PCT。公开号WO98 / 43538 日期1998年10月8日测试对象将脉波检测器1附着在指尖上，并按压压力传感器110.结果，CPU4确定接收到的光信号LS的DC分量，并将其存储在校准表50中与压力水平相关联。随后，CPU4基于压力水平和校准表50的最大值Pmax计算可用于对触摸感觉进行分级的阈值，并将该结果存储在阈值表51中。当对象用手指握住对象时血流量由脉波检测器1检测为接收光信号LS。 CPU4计算接收光信号LS的DC分量，将该结果与存储在阈值表51中的阈值进行比较，生成触摸信息SJ，并将其显示在LCD108上。因此，在这种情况下，可以容易地执行脉冲诊断通过将脉冲诊断中的压力的程度表示为触摸信息SJ。

5. 发明授权

US6042549A Exercise intensity measuring device and exercise quantity measuring device 失效
标题翻译：运动强度测量装置和运动量测量装置
公开(公告)号：US6042549A
公开(公告)日：2000-03-28
申请号：US952943
申请日：1998-01-23
申请人： Kazuhiko Amano , Kazuo Uebaba , Hitoshi Ishiyama
发明人： Kazuhiko Amano , Kazuo Uebaba , Hitoshi Ishiyama
IPC分类号： A61B5/024 , A61B5/11 , A61B5/22 , A61B5/02
CPC分类号： A61B5/4854 , A61B5/02438 , A61B5/1118 , A61B5/222 , A61B5/7257 , A61B5/726 , A61B5/742 , A61B5/744
摘要： An exercise intensity and exercise quantity measuring device is disclosed, which is capable of measuring the exercise intensity, irrespective of the type, of exercise, and measuring the exercise quantity only when the user is carrying out exercise of suitable intensity. The user first estimates his Vo.sub.2max in advance by the conventional direct method, and inputs this value into the device. The device determines upper and lower limit values of pulse rate corresponding to this Vo.sub.2max. During the time of exercise when pulse rate is between the upper and lower limit values, CPU 308 increments the accumulated time stored in RAM 309, at intervals based on a clock pulse supplied by oscillation circuit 311 and frequency dividing circuit 312. At the same time, CPU 308 compares the pulse waveform during exercise and the pulse waveform at rest, and estimates the exercise intensity.
摘要翻译： PCT No.PCT / JP97 / 00928 Sec。 371日期1998年1月23日 102（e）日期1998年1月23日PCT 1997年3月21日PCT公布。第WO97 / 35514号公报日期1997年10月2日公开了运动强度和运动量测量装置，其能够仅在用户进行适当强度的运动时才能测量运动强度，而不考虑运动类型和运动量。用户首先通过传统的直接方法预先估计他的Vo2max，并将该值输入到设备中。该装置确定对应于该Vo2max的脉搏率的上限值和下限值。在运动期间，当脉搏率在上限和下限值之间时，CPU 308基于由振荡电路311和分频电路312提供的时钟脉冲以间隔递增存储在RAM 309中的累加时间。同时 CPU308比较运动时的脉搏波形和静止时的脉搏波形，并估计运动强度。

6. 发明授权

US06331159B1 Device for measuring physiological state 有权
公开(公告)号：US06331159B1
公开(公告)日：2001-12-18
申请号：US09636775
申请日：2000-08-11
申请人： Kazuhiko Amano , Kazuo Uebaba , Hitoshi Ishiyama
发明人： Kazuhiko Amano , Kazuo Uebaba , Hitoshi Ishiyama
IPC分类号： A61B500
CPC分类号： A61B5/681 , A61B5/02 , A61B5/021 , A61B5/02108 , A61B5/029 , G06F19/00
摘要： A non-invasive device for evaluating circulatory state parameters, and specifically, a pulsewave analysis device capable of evaluation by separating blood vessel compliance and blood vessel resistance into central and peripheral components of the arterial system is provided. Microcomputer 4 detects the waveform at a test subject's radius artery via pulsewave detector 1, and uptakes the stroke volume in the test subject which is measured by a stroke-volume measurer. Next, based on the measured stroke volume, microcomputer 4 adjusts the values of each element in a lumped five parameter model made up of an electrical circuit which models the arterial system from the center to the periphery of the body, so that the response waveform obtained when an electric signal corresponding to the pressure waveform at the proximal portion of the aorta in a test subject is provided to the electric circuit coincides with the waveform at the radius artery. Microcomputer 4 then outputs the thus-obtained values of each element as circulatory state parameters. In addition, microcomputer 4 calculates the diastolic pressure value, systolic pressure value and pulse waveform at the proximal portion of the aorta from the values of each element, and outputs the calculated result to output device 6.

7. 发明授权

US06241684B1 Exercise workout support device 失效
标题翻译：锻炼锻炼支援装置
公开(公告)号：US06241684B1
公开(公告)日：2001-06-05
申请号：US08973267
申请日：1998-02-02
申请人： Kazuhiko Amano , Kazuo Uebaba , Hitoshi Ishiyama
发明人： Kazuhiko Amano , Kazuo Uebaba , Hitoshi Ishiyama
IPC分类号： A61B500
CPC分类号： A61B5/1118 , A61B5/02416 , A61B5/02438 , A61B5/222 , A61B5/721 , A61B5/7257 , A61B5/726 , G06F19/00
摘要： A device is provided, which is capable of determining the maximum oxygen uptake quantity without the restriction of a large device or requiring troublesome operations to be carried out. The device displays the upper and lower limit values for the pulse rate corresponding to an appropriate exercise intensity, and realizes in a wireless manner by means of optical communications the sending and receiving of information such as pulse wave signals to and from an information processing device which processes pulse wave information. The device is provided with a pulse wave detector 101 for detecting the test subject s pulse waveform; an FFT processor 103 for determining the test subject s heartbeat rate from the pulse waveform; a body motion detector 104 for detecting body motion when the test subject is running; an FFT processor 106 for determining the pitch from body motion during running by the test subject; exercise intensity calculator 108 for determining pitch, the test subject s stride, and the exercise intensity from body motion during running; and a nomogram recorder 109 for recording the relationship indicated by an Astrand-Ryhming nomogram, and determining the maximum oxygen uptake quantity from the heart rate and exercise intensity. The obtained maximum oxygen uptake quantity is divided by the test subject s body weight, to calculate the maximum oxygen uptake quantity per unit body weight. Next, the maximum oxygen uptake quantity and pulse according to sex are determined, and the pulse rate is multiplied by the upper and lower limit value coefficients, to determine the upper limit value UL and the lower limit value LL for the pulse rate.
摘要翻译：提供了一种能够在不受大型装置的限制的情况下确定最大氧气吸收量或需要进行麻烦的操作的装置。该装置显示对应于适当的运动强度的脉搏速率的上下限值，并通过光通信以无线方式实现向信息处理装置和从信息处理装置发送和接收诸如脉搏波信号的信息处理脉波信息。该装置设置有用于检测受试者脉搏波形的脉搏波检测器101; FFT处理器103，用于根据脉搏波形确定测试对象的心跳速率; 身体运动检测器104，用于当测试对象运行时检测身体运动; FFT处理器106，用于在由测试对象运行期间确定身体运动的音调; 运动强度计算器108，用于确定运动中的俯仰，测试对象的步幅和运动的运动强度; 以及用于记录由Astrand-Ryhming列线图表示的关系并且从心率和运动强度确定最大氧摄取量的诺欧图记录器109。将获得的最大氧气摄取量除以受试者的体重，计算每单位体重的最大氧吸收量。接下来，确定最大氧摄取量和根据性别的脉冲，并且将脉搏率乘以上限值系数和下限值系数，以确定脉搏率的上限值UL和下限值LL。

8. 发明授权

US6095984A Arrhythmia detecting apparatus 失效
标题翻译：心律失常检测装置
公开(公告)号：US6095984A
公开(公告)日：2000-08-01
申请号：US981349
申请日：1998-04-06
申请人： Kazuhiko Amano , Kazuo Uebaba , Hitoshi Ishiyama
发明人： Kazuhiko Amano , Kazuo Uebaba , Hitoshi Ishiyama
IPC分类号： A61B5/024 , A61B5/04 , A61B5/02
CPC分类号： A61B5/721 , A61B5/02438 , A61B5/7253 , A61B5/7225 , A61B5/7257 , A61B5/726
摘要： The arrhythmia detecting apparatus of the present invention is provided with a pulse wave detecting means which non-invasively detects the pulse waveform, and an arrhythmia detecting means which detects arrhythmia by monitoring changes in the pulse waveform detected by the pulse wave detecting means. The arrhythmia detection means has a decision element which determines that arrhythmia has occurred when there is an interruption in the continuity of this change. Methods employed for investigating the continuity of change in the pulse waveform include a time domain method employing pulse wave interval values, and a frequency domain method in which frequency analysis (FFT or wavelet transformation) is carried out on the pulse waveform, with continuity studied based on the results of this analysis. As a result of this design, it is possible to detect arrhythmia by means of a simpler structure and easier operations as compared to an electrocardiogram and so on. Further, it is also acceptable to provide a body motion detecting means, and to determine continuity of change for a pulse wave component after the body motion component detected by the aforementioned means has been removed therefrom. In this case, since it is possible to remove the body motion component from the pulse waveform, arrhythmia can be detected even more accurately throughout the course of daily activities.
摘要翻译： PCT No.PCT / JP97 / 01322 Sec。 371日期：1998年4月6日 102（e）1998年4月6日PCT PCT 1997年4月17日PCT公布。出版物WO97 / 38626 日本1997年10月23日本发明的心律失常检测装置具有不侵入性地检测脉搏波形的脉波检测装置，以及通过监视由脉波检测出的脉搏波形的变化来检测心律失常的心律失常检测装置检测装置。心律失常检测装置具有确定当该变化的连续性中断时发生心律失常的判定元件。用于研究脉搏波形变化连续性的方法包括采用脉搏波间隔值的时域方法，以脉冲波形进行频率分析（FFT或小波变换）的频域方法，连续性研究为基础对此分析的结果。作为该设计的结果，与心电图等相比，可以通过更简单的结构和更容易的操作来检测心律失常。此外，还可以提供体动检测装置，并且在通过上述装置检测到的身体运动成分已被去除之后确定脉搏波分量的变化连续性。在这种情况下，由于可以从脉搏波形中去除身体运动成分，因此可以在日常活动的整个过程中更准确地检测到心律失常。

9. 发明授权

US4761477A 13-propylberberine salts 失效
标题翻译： 13-丙基苦参碱盐
公开(公告)号：US4761477A
公开(公告)日：1988-08-02
申请号：US802447
申请日：1985-11-27
申请人： Tetsuro Ikekawa , Fumitake Shimada , Jong-Chol Cyong , Kazuo Uebaba
发明人： Tetsuro Ikekawa , Fumitake Shimada , Jong-Chol Cyong , Kazuo Uebaba
IPC分类号： A61K31/47 , A61P1/12 , C07D455/03
CPC分类号： C07D455/00
摘要： A 13-propylberberine salt, which is represented by the following general formula (I): ##STR1## wherein X.sup.- means HSO.sub.4 or H.sub.2 PO.sub.4, has strong inhibitory effect against secretion, good stability and high water solubility. Its effects are shown promptly after its oral administration.
摘要翻译：由以下通式（I）表示的13-丙基辛腈盐：其中X表示HSO 4或H 2 PO 4，具有对分泌的强抑制作用，良好的稳定性和高水溶性。口服后立即显示其作用。

10. 发明授权

US06361501B1 Pulse wave diagnosing device 失效
标题翻译：脉波诊断装置
公开(公告)号：US06361501B1
公开(公告)日：2002-03-26
申请号：US09284932
申请日：1999-06-21
申请人： Kazuhiko Amano , Kazuo Uebaba , Hitoshi Ishiyama
发明人： Kazuhiko Amano , Kazuo Uebaba , Hitoshi Ishiyama
IPC分类号： A61B500
CPC分类号： A61B5/0205 , A61B5/02028 , A61B5/021 , A61B5/02108 , A61B5/024 , A61B5/029 , A61B5/0295 , A61B5/4854 , A61B5/6814 , A61B5/721 , A61B5/7239 , A61B5/7257 , A61B5/726
摘要： When pulse waveform MH is detected by pulse wave detection sensor unit 130, wavelet transformer 10 performs wavelet transformation on pulse waveform MH and generates analyzed pulse wave data MKD. This analyzed pulse wave data MKD consists of a time region in which one heartbeat is divided into eighths, and the frequency region of 0-4 Hz which has been divided into eighths. Frequency corrector 11 generates corrected pulse wave data MKD′ by performing frequency correction on analyzed pulse wave data MKD. Pulse type data generator 12 compares corrected pulse wave data MKD′ over each frequency-time region, and generates pulse type data ZD indicating the type of pulse. Display 13 displays the pulse type for pulse waveform MH based on pulse type data ZD.
摘要翻译：当由脉波检测传感器单元130检测到脉搏波形MH时，小波变换器10对脉波波形MH进行小波变换，并生成分析脉波数据MKD。该分析的脉波数据MKD由一个心跳被分成八分之一的时间区域和分频为八分之一的0-4Hz的频率区域组成。频率校正器11通过对分析的脉波数据MKD执行频率校正来产生校正的脉搏波数据MKD'。脉冲型数据发生器12比较每个频率 - 时间区域上的经校正的脉搏波数据MKD'，并产生指示脉冲类型的脉冲类型数据ZD。显示器13基于脉冲类型数据ZD显示脉冲波形MH的脉冲类型。

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