专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20130058447A1 NUCLEAR REACTOR POWER MONITOR 有权
标题翻译：核反应堆电力监控
公开(公告)号：US20130058447A1
公开(公告)日：2013-03-07
申请号：US13697950
申请日：2011-05-11
申请人： Yutaka Takeuchi , Hiroshi Ono , Kazuki Yano
发明人： Yutaka Takeuchi , Hiroshi Ono , Kazuki Yano
IPC分类号： G21C7/00
CPC分类号： G21C17/00 , G21C17/10 , G21D3/001 , G21D2003/005 , Y02E30/40
摘要： Provide a nuclear reactor power monitoring technology for enhancing the monitoring accuracy and reliability in nuclear thermal hydraulic stability.A power monitor 30 includes a first calculation unit 42,52 configured to calculate a first stability index based on time series data indicating power oscillation in nuclear instrumentation signals outputted from a plurality of nuclear instrumentation detectors 31; a first determination unit 44,53 configured to compare the first stability index and a first reference value and determine whether nuclear thermal hydraulic stability of the reactor core is stable or deteriorated; a second calculation unit 46,54 configured to calculate a second stability index of the reactor core based on the time series data when the deteriorated state is determined in the first determination unit 44,53; and a second determination unit 47,55 configured to compare the second stability index and a second reference value and determine whether to perform suppressing operation of the power oscillation.
摘要翻译：提供核反应堆功率监测技术，提高核热液压稳定性的监测精度和可靠性。功率监视器30包括第一计算单元42,52，其被配置为基于表示从多个核仪器检测器31输出的核仪器信号中的功率振荡的时间序列数据来计算第一稳定性指标; 第一确定单元44,53，被配置为比较第一稳定性指数和第一参考值，并确定反应堆堆芯的核热液压稳定性是否稳定或劣化; 第二计算单元46,54，被配置为当在第一确定单元44,53中确定恶化状态时，基于时间序列数据计算反应堆堆芯的第二稳定性指数; 以及第二确定单元47,55，被配置为比较第二稳定性指标和第二参考值，并确定是否执行功率振荡的抑制操作。

2. 发明申请

US20130013282A1 APPARATUS, METHOD AND PROGRAM FOR MONITORING NUCLEAR THERMAL HYDRAULIC STABILITY OF NUCLEAR REACTOR 有权
标题翻译：用于监测核反应堆核热液压稳定性的装置，方法和程序
公开(公告)号：US20130013282A1
公开(公告)日：2013-01-10
申请号：US13542911
申请日：2012-07-06
申请人： Yutaka TAKEUCHI , Hiroyuki TAKEUCHI , Kazuki YANO
发明人： Yutaka TAKEUCHI , Hiroyuki TAKEUCHI , Kazuki YANO
IPC分类号： G06G7/54
CPC分类号： G21C17/00 , G21C17/108 , G21D3/001 , G21D2003/005 , Y02E30/39
摘要： An apparatus for monitoring nuclear thermal hydraulic stability of a nuclear reactor, contains: a calculation unit configured to calculate a stability index of a nuclear thermal hydraulic phenomenon based on nuclear instrumentation signals, the signals being outputted by a plurality of nuclear instrumentation detectors placed at regular intervals in a reactor core; a simulation unit configured to simulate the nuclear thermal hydraulic phenomenon based on a physical model by using information on an operating state of the nuclear reactor as an input condition; a limit value updating unit configured to update a limit value of the nuclear thermal hydraulic phenomenon based on a result of the simulation; and a determination unit configured to determine, based on the stability index and the limit value, whether or not to activate a power oscillation suppressing device.
摘要翻译：一种用于监测核反应堆的核热液压稳定性的装置，包括：计算单元，被配置为基于核仪表信号计算核热液压现象的稳定性指标，所述信号由放置在规则的多个核仪器检测器输出反应堆核心间隔; 模拟单元，被配置为通过使用关于核反应堆的操作状态的信息作为输入条件来模拟基于物理模型的核热液压现象; 限制值更新单元，被配置为基于模拟结果来更新核热液压现象的极限值; 以及确定单元，其被配置为基于所述稳定性指标和所述极限值来确定是否激活功率振荡抑制装置。

3. 发明申请

US20050026253A1 Novel protein and processes for producing the same 审中-公开
标题翻译：新型蛋白质及其生产方法
公开(公告)号：US20050026253A1
公开(公告)日：2005-02-03
申请号：US10900423
申请日：2004-07-28
申请人： Masaaki Goto , Akihiro Tomoyasu , Kazuki Yano , Fumie Kobayashi , Nobuaki Nakagawa , Hisataka Yasuda , Kyoji Yamaguchi , Masahiko Kinosaki , Shin-ichi Mochizuki , Tadashi Nakakarumai , Tomonori Morinaga , Eisuke Tsuda , Kanji Higashio
发明人： Masaaki Goto , Akihiro Tomoyasu , Kazuki Yano , Fumie Kobayashi , Nobuaki Nakagawa , Hisataka Yasuda , Kyoji Yamaguchi , Masahiko Kinosaki , Shin-ichi Mochizuki , Tadashi Nakakarumai , Tomonori Morinaga , Eisuke Tsuda , Kanji Higashio
IPC分类号： A61K38/00 , C07K14/47 , C12N5/08 , C07H21/04
CPC分类号： C07K14/47 , A61K38/00
摘要： A novel protein and a process of producing the protein is provided. The protein is a glycoprotein having activity of suppressing the differentiation and/or maturation of adipocyte, having a molecular weight of about 45 kD under non-reducing conditions and about 28 kD and/or 23 kD under reducing conditions, and exhibiting affinity to heparin. A process of producing the protein comprising culturing human fibroblasts and purifying the culture broth by chromatography using an ion exchange column, affinity column, and reverse phase column. A cDNA encoding the protein and a process of producing the protein using the cDNA are also provided. The protein of the present invention is useful as a pharmaceutical composition for preventing or treating obesity or as an antigen for establishing immunological diagnosis, etc.,
摘要翻译：提供了一种新的蛋白质和产生该蛋白质的方法。蛋白质是具有抑制脂肪细胞分化和/或成熟的活性的糖蛋白，在还原条件下，分子量约为45kD，在还原条件下具有约28kD和/或23kD，并且对肝素具有亲和力。一种生产蛋白质的方法，包括培养人成纤维细胞，并使用离子交换柱，亲和柱和反相柱通过色谱法纯化培养液。还提供了编码蛋白质的cDNA和使用cDNA产生蛋白质的方法。本发明的蛋白质可用作预防或治疗肥胖的药物组合物或用作建立免疫诊断等的抗原，

4. 发明申请

US20050003457A1 Antibodies to OCIF-binding molecules 有权
标题翻译： OCIF结合分子的抗体
公开(公告)号：US20050003457A1
公开(公告)日：2005-01-06
申请号：US10854300
申请日：2004-05-27
申请人： Kyoji Yamaguchi , Hisataka Yasuda , Nobuaki Nakagawa , Nobuyuki Shima , Masahiko Kinosaki , Eisuke Tsuda , Masaaki Goto , Kazuki Yano , Akihiro Tomoyasu , Fumie Kobayashi , Naohiro Washida , Ken Takahashi , Tomonori Morinaga , Kanji Higashio
发明人： Kyoji Yamaguchi , Hisataka Yasuda , Nobuaki Nakagawa , Nobuyuki Shima , Masahiko Kinosaki , Eisuke Tsuda , Masaaki Goto , Kazuki Yano , Akihiro Tomoyasu , Fumie Kobayashi , Naohiro Washida , Ken Takahashi , Tomonori Morinaga , Kanji Higashio
IPC分类号： C07K14/715 , A61K20060101 , A61K38/00 , A61K39/395 , A61K45/00 , A61P3/14 , A61P19/00 , A61P19/02 , A61P19/08 , A61P19/10 , A61P29/00 , B01J20/281 , C07K20060101 , C07K1/22 , C07K14/47 , C07K14/525 , C07K14/705 , C07K16/18 , C07K16/28 , C12N20060101 , C12N5/10 , C12N5/20 , C12N15/02 , C12N15/09 , C12N15/12 , C12P20060101 , C12P21/02 , C12P21/08 , C12Q20060101 , G01N20060101 , G01N30/88 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/566 , G01N33/577 , G01N33/567 , C12Q1/68
CPC分类号： C07K16/2875 , A61K38/00 , A61K2039/505 , C07K14/525 , C07K14/705 , C07K14/70578 , C07K16/28 , C07K16/2878 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/566 , G01N2333/525 , G01N2333/70578 , G01N2800/108
摘要： A novel protein which binds to Osteoclastogenesis Inhibitory Factor (OCIF-binding molecule; OBM), a process for preparing the same, DNA encoding said protein, a protein having an amino acid sequence encoded by this DNA, a method for producing said protein by genetic engineering technique, and a pharmaceutical composition containing said protein. Screening methods for a substance for controlling expression of said protein using said protein and the DNA, a substance which inhibits or modulates the biological activity of said protein, or a receptor which transmits the action of said protein through binding to said protein, the substance obtained by the screening methods, and a pharmaceutical composition which contains this substance. An antibody for said protein, a process for preparing the same, a measuring method of said protein using the antibody, and a medicine comprising this antibody.
摘要翻译：结合破骨细胞发生抑制因子（OCIF-结合分子; OBM）的新型蛋白质，其制备方法，编码所述蛋白质的DNA，由该DNA编码的氨基酸序列的蛋白质，通过遗传学生产所述蛋白质的方法工程技术和含有该蛋白质的药物组合物。使用所述蛋白质和DNA控制所述蛋白质的表达的物质的筛选方法，抑制或调节所述蛋白质的生物活性的物质，或通过与所述蛋白质结合而转移所述蛋白质的作用的受体，获得的物质通过筛选方法和含有该物质的药物组合物。所述蛋白质的抗体，其制备方法，使用该抗体的所述蛋白质的测定方法，以及包含该抗体的药物。

5. 发明申请

US20080187540A9 Antibodies to OCIF-binding molecules 审中-公开
标题翻译： OCIF结合分子的抗体
公开(公告)号：US20080187540A9
公开(公告)日：2008-08-07
申请号：US11513178
申请日：2006-08-31
申请人： Kyoji Yamaguchi , Hisataka Yasuda , Nobuaki Nakagawa , Nobuyuki Shima , Masahiko Kinosaki , Eisuke Tsuda , Masaaki Goto , Kazuki Yano , Akihiro Tomoyasu , Fumie Kobayashi , Naohiro Washida , Ken Takahashi , Tomonori Morinaga , Kanji Higashio
发明人： Kyoji Yamaguchi , Hisataka Yasuda , Nobuaki Nakagawa , Nobuyuki Shima , Masahiko Kinosaki , Eisuke Tsuda , Masaaki Goto , Kazuki Yano , Akihiro Tomoyasu , Fumie Kobayashi , Naohiro Washida , Ken Takahashi , Tomonori Morinaga , Kanji Higashio
IPC分类号： C12Q1/68 , G01N33/567 , C07H21/04 , C12P21/06 , A61K39/395 , C07K14/705 , C07K16/28
CPC分类号： C07K16/2875 , A61K38/00 , A61K2039/505 , C07K14/525 , C07K14/705 , C07K14/70578 , C07K16/28 , C07K16/2878 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/566 , G01N2333/525 , G01N2333/70578 , G01N2800/108
摘要： A novel protein which binds to Osteoclastogenesis Inhibitory Factor (OCIF-binding molecule; OBM), a process for preparing the same, DNA encoding said protein, a protein having an amino acid sequence encoded by this DNA, a method for producing said protein by genetic engineering technique, and a pharmaceutical composition containing said protein. Screening methods for a substance for controlling expression of said protein using said protein and the DNA, a substance which inhibits or modulates the biological activity of said protein, or a receptor which transmits the action of said protein through binding to said protein, the substance obtained by the screening methods, and a pharmaceutical composition which contains this substance. An antibody for said protein, a process for preparing the same, a measuring method of said protein using the antibody, and a medicine comprising this antibody.
摘要翻译：结合破骨细胞发生抑制因子（OCIF-结合分子; OBM）的新型蛋白质，其制备方法，编码所述蛋白质的DNA，由该DNA编码的氨基酸序列的蛋白质，通过遗传学生产所述蛋白质的方法工程技术和含有该蛋白质的药物组合物。使用所述蛋白质和DNA控制所述蛋白质的表达的物质的筛选方法，抑制或调节所述蛋白质的生物活性的物质，或通过与所述蛋白质结合而转移所述蛋白质的作用的受体，获得的物质通过筛选方法和含有该物质的药物组合物。所述蛋白质的抗体，其制备方法，使用该抗体的所述蛋白质的测定方法，以及包含该抗体的药物。

6. 发明授权

US07205397B2 Proteins and methods for producing the proteins 失效
标题翻译：用于生产蛋白质的蛋白质和方法
公开(公告)号：US07205397B2
公开(公告)日：2007-04-17
申请号：US09062113
申请日：1998-04-17
申请人： Masaaki Goto , Eisuke Tsuda , Shin′ichi Mochizuki , Kazuki Yano , Fumie Kobayashi , Nobuyuki Shima , Hisataka Yasuda , Nobuaki Nakagawa , Tomonori Morinaga , Masatsugu Ueda , Kanji Higashio
发明人： Masaaki Goto , Eisuke Tsuda , Shin′ichi Mochizuki , Kazuki Yano , Fumie Kobayashi , Nobuyuki Shima , Hisataka Yasuda , Nobuaki Nakagawa , Tomonori Morinaga , Masatsugu Ueda , Kanji Higashio
IPC分类号： C07H21/04 , C07K14/51
CPC分类号： C07K14/70578
摘要： A protein which inhibits osteoclast differentiation and/or maturation and a method for producing the protein. The protein is produced by human embryonic lung fibroblasts and has a molecular weight of about 60 kD and about 120 kD under non-reducing conditions and about 60 kD under reducing conditions on SDS-polyacrylamide gel electrophoresis. The protein can be isolated and purified from the culture medium of fibroblasts. Furthermore, the protein can be produced by gene engineering. The present invention includes cDNA for producing the protein by gene engineering, antibodies having specific affinity for the protein or a method for determining protein concentration using these antibodies.
摘要翻译：抑制破骨细胞分化和/或成熟的蛋白质和制备蛋白质的方法。该蛋白质由人类胚胎肺成纤维细胞产生，在非还原条件下分子量约为60kD，约120kD，SDS-聚丙烯酰胺凝胶电泳时还原条件下分子量约为60kD。蛋白质可以从成纤维细胞的培养基中分离和纯化。此外，蛋白质可以通过基因工程产生。本发明包括通过基因工程产生蛋白质的cDNA，对蛋白质具有特异性亲和性的抗体或使用这些抗体测定蛋白质浓度的方法。

7. 发明授权

US07125686B1 Proteins and methods for producing the proteins 失效
标题翻译：用于生产蛋白质的蛋白质和方法
公开(公告)号：US07125686B1
公开(公告)日：2006-10-24
申请号：US08915004
申请日：1997-08-20
申请人： Masaaki Goto , Eisuke Tsuda , Shin'ichi Mochizuki , Kazuki Yano , Fumie Kobayashi , Nobuyuki Shima , Hisataka Yasuda , Nobuaki Nakagawa , Tomonori Morinaga , Masatsugu Ueda , Kanji Higashio
发明人： Masaaki Goto , Eisuke Tsuda , Shin'ichi Mochizuki , Kazuki Yano , Fumie Kobayashi , Nobuyuki Shima , Hisataka Yasuda , Nobuaki Nakagawa , Tomonori Morinaga , Masatsugu Ueda , Kanji Higashio
IPC分类号： C07K14/00
CPC分类号： C07K14/70578
摘要： A protein which inhibits osteoclast differentiation and/or maturation and a method for producing the protein. The protein is produced by human embryonic lung fibroblasts and has a molecular weight of about 60 kD and about 120 kD under non-reducing conditions and about 60 kD under reducing conditions on SDS-polyacrylamide gel electrophoresis. The protein can be isolated and purified from the culture medium of fibroblasts. Furthermore, the protein can be produced by gene engineering. The present invention includes cDNA for producing the protein by gene engineering, antibodies having specific affinity for the protein or a method for determining protein concentration using these antibodies.
摘要翻译：抑制破骨细胞分化和/或成熟的蛋白质和制备蛋白质的方法。蛋白质由人类胚胎肺成纤维细胞产生，在非还原条件下分子量约为60kD，约120kD，SDS-聚丙烯酰胺凝胶电泳时还原条件下分子量约为60kD。蛋白质可以从成纤维细胞的培养基中分离和纯化。此外，蛋白质可以通过基因工程产生。本发明包括通过基因工程产生蛋白质的cDNA，对蛋白质具有特异性亲和性的抗体或使用这些抗体测定蛋白质浓度的方法。

8. 发明授权

US06998242B2 Method of diagnosing metabolic bone diseases 失效
标题翻译：诊断代谢性骨疾病的方法
公开(公告)号：US06998242B2
公开(公告)日：2006-02-14
申请号：US10641088
申请日：2003-08-15
申请人： Kazuki Yano , Fumie Kobayashi , Masaaki Goto , Naohiro Washida , Eisuke Tsuda , Kaoji Higashio , Yoshiji Yamada
发明人： Kazuki Yano , Fumie Kobayashi , Masaaki Goto , Naohiro Washida , Eisuke Tsuda , Kaoji Higashio , Yoshiji Yamada
IPC分类号： C12N15/00
CPC分类号： C07K16/24 , G01N33/6893 , G01N2800/108 , Y10S436/811 , Y10S530/809
摘要： A method of diagnosing metabolic bone diseases, especially osteoporosis and arthrosis characterized by determining the concentration of osteoclastgenesis inhibitory factor (OCIF) in humor. Monoclonal antibodies recognizing equally both of monomer type and dimer type of OCIF. Monoclonal antibodies recognizing selectively dimer type of OCIF. And to provide an assay kit for determination of OCIF concentration comprising the aforementioned two antibodies recognizing different epitope of OCIF and having high affinity showing dissociation constant of less than 2×10−7 M with antigen. It is useful for a method of diagnosing metabolic bone diseases, especially osteoporosis and arthrosis or for an assay reagent for research thereof.
摘要翻译：一种诊断代谢性骨疾病，特别是骨质疏松症和关节病的诊断方法，其特征在于确定破骨细胞发生抑制因子（OCIF）在幽默中的浓度。单克隆抗体同时识别单体类型和二聚体类型的OCIF。识别选择性二聚体型OCIF的单克隆抗体。并提供用于测定OCIF浓度的测定试剂盒，其包含上述识别OCIF不同表位的两种抗体，并且具有高亲和力，其显示具有抗原的小于2×10 -7 M的解离常数。用于诊断代谢性骨疾病，特别是骨质疏松症和关节病的方法或用于其研究的测定试剂是有用的。

9. 发明申请

US20050208580A1 Novel protein and method for producing the protein 审中-公开
标题翻译：新型蛋白质及其生产方法
公开(公告)号：US20050208580A1
公开(公告)日：2005-09-22
申请号：US11135521
申请日：2005-05-24
申请人： Kyoji Yamaguchi , Hisataka Yasuda , Nobuaki Nakagawa , Nobuyuki Shima , Masahiko Kinosaki , Eisuke Tsuda , Masaaki Goto , Kazuki Yano , Akihiro Tomoyasu , Fumie Kobayashi , Naohiro Washida , Ken Takahashi , Tomonori Morinaga , Kanji Higashio
发明人： Kyoji Yamaguchi , Hisataka Yasuda , Nobuaki Nakagawa , Nobuyuki Shima , Masahiko Kinosaki , Eisuke Tsuda , Masaaki Goto , Kazuki Yano , Akihiro Tomoyasu , Fumie Kobayashi , Naohiro Washida , Ken Takahashi , Tomonori Morinaga , Kanji Higashio
IPC分类号： C07K14/715 , A61K20060101 , A61K38/00 , A61K39/395 , A61K45/00 , A61P3/14 , A61P19/00 , A61P19/02 , A61P19/08 , A61P19/10 , A61P29/00 , B01J20/281 , C07K20060101 , C07K1/22 , C07K14/47 , C07K14/525 , C07K14/705 , C07K16/18 , C07K16/28 , C12N20060101 , C12N5/10 , C12N5/20 , C12N15/02 , C12N15/09 , C12N15/12 , C12P20060101 , C12P21/02 , C12P21/08 , C12Q20060101 , G01N20060101 , G01N30/88 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/566 , G01N33/577 , C12Q1/68 , C07H21/04
CPC分类号： C07K16/2875 , A61K38/00 , A61K2039/505 , C07K14/525 , C07K14/705 , C07K14/70578 , C07K16/28 , C07K16/2878 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/566 , G01N2333/525 , G01N2333/70578 , G01N2800/108
摘要： A novel protein which binds to Osteoclastogenesis Inhibitory Factor (OCIF-binding molecule; OBM), a process for preparing the same, DNA encoding said protein, a protein having an amino acid sequence encoded by this DNA, a method for producing said protein by genetic engineering technique, and a pharmaceutical composition containing said protein. Screening methods for a substance for controlling expression of said protein using said protein and the DNA, a substance which inhibits or modulates the biological activity of said protein, or a receptor which transmits the action of said protein through binding to said protein, the substance obtained by the screening methods, and a pharmaceutical composition which contains this substance. An antibody for said protein, a process for preparing the same, a measuring method of said protein using the antibody, and a medicine comprising this antibody.
摘要翻译：结合破骨细胞发生抑制因子（OCIF-结合分子; OBM）的新型蛋白质，其制备方法，编码所述蛋白质的DNA，由该DNA编码的氨基酸序列的蛋白质，通过遗传学生产所述蛋白质的方法工程技术和含有该蛋白质的药物组合物。使用所述蛋白质和DNA控制所述蛋白质的表达的物质的筛选方法，抑制或调节所述蛋白质的生物活性的物质，或通过与所述蛋白质结合而转移所述蛋白质的作用的受体，获得的物质通过筛选方法和含有该物质的药物组合物。所述蛋白质的抗体，其制备方法，使用该抗体的所述蛋白质的测定方法，以及包含该抗体的药物。

10. 发明申请

US20050026837A1 Novel proteins and methods for producing the proteins 失效
公开(公告)号：US20050026837A1
公开(公告)日：2005-02-03
申请号：US10929748
申请日：2004-08-31
申请人： Masaaki Goto , Eisuke Tsuda , Shin'ichi Mochizuki , Kazuki Yano , Fumie Kobayashi , Nobuyuki Shima , Hisataka Yasuda , Nobuaki Nakagawa , Tomonori Morinaga , Masatsuga Ueda , Kanji Higashio
发明人： Masaaki Goto , Eisuke Tsuda , Shin'ichi Mochizuki , Kazuki Yano , Fumie Kobayashi , Nobuyuki Shima , Hisataka Yasuda , Nobuaki Nakagawa , Tomonori Morinaga , Masatsuga Ueda , Kanji Higashio
IPC分类号： C07K14/52 , A61K38/19 , A61P19/10 , C07K14/705 , C07K16/24 , C12N1/21 , C12N5/08 , C12N15/12 , C12N15/19 , C12P21/02 , C12P21/08 , A61K38/18 , C07H21/04 , C07K14/475
CPC分类号： C07K14/70578
摘要： A protein which inhibits osteoclast differentiation and/or maturation and a method for producing the protein. The protein is produced by human embryonic lung fibroblasts and has a molecular weight of about 60 kD and about 120 kD under non-reducing conditions and about 60 kD under reducing conditions on SDS-polyacrylamide gel electrophoresis. The protein can be isolated and purified from the culture medium of fibroblasts. Furthermore, the protein can be produced by gene engineering. The present invention includes cDNA for producing the protein by gene engineering, antibodies having specific affinity for the protein or a method for determining protein concentration using these antibodies.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式