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1. 发明授权

US09903863B2 Method for analyzing, sample analysis tool, method for preventing flow of sample solution in undesired direction, and method for preventing increase in background 有权
公开(公告)号：US09903863B2
公开(公告)日：2018-02-27
申请号：US13263725
申请日：2010-04-05
申请人： Kazuhiro Ohmiya
发明人： Kazuhiro Ohmiya
IPC分类号： G01N33/558
CPC分类号： G01N33/558
摘要： Provided is an analysis method in which increase in a background can be prevented in a simple manner without cost. The analysis method of the present invention is carried out using a sample analysis tool 10 including a development member 11 in which a developing solution supply portion 12, a sample supply portion 13, and a detection portion 14 in which a substance 17 that specifically binds to an analyte 16 in a sample is immobilized are provided in this order from upstream to downstream along the flow of a developing solution. A sample solution is supplied to the sample supply portion 13, and a developing solution is supplied to the developing solution supply portion 12 simultaneously with the supply of the sample solution or prior to the supply of the sample solution. By the development of the developing solution in the development member 11 in the presence of a labeled specifically binding substance 15, the sample solution is introduced to the detection portion 14. In the detection portion 14, a complex 18 of the immobilized specifically binding substance 17, the analyte 16, and the labeled specifically binding substance 15 is formed. The analyte 16 is analyzed by detecting a label 19 in the complex 18.

2. 发明申请

US20120031206A1 ANALYSIS METHOD, SAMPLE ANALYSIS TOOL, METHOD FOR PREVENTING BACK-FLOW OF SAMPLE SOLUTION, AND METHOD FOR PREVENTING INCREASE IN BACKGROUND 有权
标题翻译：分析方法，样品分析工具，用于防止样品溶液回流的方法和用于在背景中预防增加的方法
公开(公告)号：US20120031206A1
公开(公告)日：2012-02-09
申请号：US13263725
申请日：2010-04-05
申请人： Kazuhiro Ohmiya
发明人： Kazuhiro Ohmiya
IPC分类号： G01N1/00
CPC分类号： G01N33/558
摘要： Provided is an analysis method in which increase in a background can be prevented in a simple manner without cost. The analysis method of the present invention is carried out using a sample analysis tool 10 including a development member 11 in which a developing solution supply portion 12, a sample supply portion 13, and a detection portion 14 in which a substance 17 that specifically binds to an analyte 16 in a sample is immobilized are provided in this order from upstream to downstream along the flow of a developing solution. A sample solution is supplied to the sample supply portion 13, and a developing solution is supplied to the developing solution supply portion 12 simultaneously with the supply of the sample solution or prior to the supply of the sample solution. By the development of the developing solution in the development member 11 in the presence of a labeled specifically binding substance 15, the sample solution is introduced to the detection portion 14. In the detection portion 14, a complex 18 of the immobilized specifically binding substance 17, the analyte 16, and the labeled specifically binding substance 15 is formed. The analyte 16 is analyzed by detecting a label 19 in the complex 18.
摘要翻译：提供了一种分析方法，其中可以以简单的方式避免成本增加背景。本发明的分析方法使用样品分析工具10进行，该样品分析工具10包括显影液供给部12，样品供给部13和检测部14，显影液供给部12，沿着显影液的流动从上游到下游依次提供固定样品中的分析物16。将样品溶液供给到样品供给部13，并且在供给样品溶液的同时或在供给样品溶液之前将显影液同时供给到显影液供给部12。通过在标记的特异性结合物质15的存在下开发显影液11中的显影溶液，将样品溶液引入检测部分14.在检测部分14中，将固定化的特异性结合物质17 ，分析物16和标记的特异性结合物质15形成。通过检测复合物18中的标签19来分析分析物16。

3. 发明申请

US20110065099A1 METHOD OF PRETREATING SPECIMEN AND IMMUNOASSAY USING THE SAME 有权
标题翻译：使用该方法预测样本和免疫测定方法
公开(公告)号：US20110065099A1
公开(公告)日：2011-03-17
申请号：US12949446
申请日：2010-11-18
申请人： Kyouichi OHSHIRO , Kazuhiro OHMIYA , Naoko IZUI
发明人： Kyouichi OHSHIRO , Kazuhiro OHMIYA , Naoko IZUI
IPC分类号： C12Q1/70 , G01N33/566
CPC分类号： G01N33/56983 , G01N33/5306 , G01N2333/11 , G01N2333/95
摘要： The present invention provides a method of pretreating a specimen, which allows measurement according to an immunoassay to be carried out on a specimen from nasal secretion while preventing non-specific reactions. According to this method, the specimen from nasal secretion is treated with a protease beforehand and then an immunoassay is performed. As the protease, it is preferable to use semi-alkaline protease (EC 3.4.21.63). Furthermore, it is preferable that a substance to be pretreated by the pretreatment method according to the present invention is an influenza virus contained in the specimen from nasal secretion. The immunoassay preferably is an immunoagglutination assay. Examples of the immunoagglutination assay include a turbidimetric immunoassay, a latex turbidimetric immunoassay, and a latex agglutination assay that is performed on a slide glass.
摘要翻译：本发明提供了一种预处理样品的方法，其允许根据免疫测定进行测量，以在防止非特异性反应的同时进行来自鼻分泌物的样品。根据该方法，预先用蛋白酶处理来自鼻分泌物的样品，然后进行免疫测定。作为蛋白酶，优选使用半碱性蛋白酶（EC 3.4.21.63）。此外，优选通过本发明的预处理方法进行预处理的物质是来自鼻分泌物的样品中含有的流感病毒。免疫测定优选是免疫凝集测定。免疫凝集测定的实例包括比浊免疫测定，胶乳比浊免疫测定和在载玻片上进行的胶乳凝集测定。

4. 发明授权

US08426125B2 Method of pretreating specimen and immunoassay using the same 有权
标题翻译：使用其进行样品预处理和免疫测定的方法
公开(公告)号：US08426125B2
公开(公告)日：2013-04-23
申请号：US12949446
申请日：2010-11-18
申请人： Kyouichi Ohshiro , Kazuhiro Ohmiya , Naoko Izui
发明人： Kyouichi Ohshiro , Kazuhiro Ohmiya , Naoko Izui
IPC分类号： C12Q1/70 , C12Q1/00
CPC分类号： G01N33/56983 , G01N33/5306 , G01N2333/11 , G01N2333/95
摘要： The present invention provides a method of pretreating a specimen, which allows measurement according to an immunoassay to be carried out on a specimen from nasal secretion while preventing non-specific reactions. According to this method, the specimen from nasal secretion is treated with a protease beforehand and then an immunoassay is performed. As the protease, it is preferable to use semi-alkaline protease (EC 3.4.21.63). Furthermore, it is preferable that a substance to be pretreated by the pretreatment method according to the present invention is an influenza virus contained in the specimen from nasal secretion. The immunoassay preferably is an immunoagglutination assay. Examples of the immunoagglutination assay include a turbidimetric immunoassay, a latex turbidimetric immunoassay, and a latex agglutination assay that is performed on a slide glass.
摘要翻译：本发明提供了一种预处理样品的方法，其允许根据免疫测定进行测量，以在防止非特异性反应的同时进行来自鼻分泌物的样品。根据该方法，预先用蛋白酶处理来自鼻分泌物的样品，然后进行免疫测定。作为蛋白酶，优选使用半碱性蛋白酶（EC 3.4.21.63）。此外，优选通过本发明的预处理方法进行预处理的物质是来自鼻分泌物的样品中含有的流感病毒。免疫测定优选是免疫凝集测定。免疫凝集测定的实例包括比浊免疫测定，胶乳比浊免疫测定和在载玻片上进行的胶乳凝集测定。

5. 发明授权

US08277752B2 Optical measurement apparatus 有权
标题翻译：光学测量装置
公开(公告)号：US08277752B2
公开(公告)日：2012-10-02
申请号：US12517765
申请日：2008-11-20
申请人： Takashi Nakagawa , Shinya Nakajima , Tokuo Kasai , Kazuhiro Ohmiya
发明人： Takashi Nakagawa , Shinya Nakajima , Tokuo Kasai , Kazuhiro Ohmiya
IPC分类号： G01N31/22 , G01N21/75 , G01N21/00 , C12M1/36
CPC分类号： G01N21/8483
摘要： An optical measurement apparatus is provided for conducting a test by efficiently reading color development of a reagent after reaction by optical measurement.To the above end, an optical measurement apparatus is provided which is to be used with at least one test instrument mounted to the apparatus. The test instrument includes a carrier provided with at least one reagent retaining portion which retains a reagent, and a sample is applied to the carrier. The optical measurement apparatus includes a reader for reading color development of the reagent retaining portion, and a controller for performing driving control of the reader and determination. The controller performs the determination by utilizing data obtained by a reading operation P to read the color development of the reagent performed after the lapse of a reaction completion period Tr1-Tr6 from the mounting of the test instrument, and the reaction completion period depends on the reagent.
摘要翻译：提供一种光学测量装置，用于通过光学测量反应后有效地读取试剂的显色来进行测试。为了上述目的，提供了一种与安装在该装置上的至少一个测试仪一起使用的光学测量装置。测试仪器包括具有至少一个保留试剂的试剂保持部分的载体，并将样品施加到载体上。光学测量装置包括用于读取试剂保持部分的显色的读取器，以及用于执行读取器的驱动控制和确定的控制器。控制器通过利用读取操作P获得的数据，从安装测试仪器后读取反应完成期间Tr1〜Tr6经过后进行的试剂的显色，进行判定，反应完成时间取决于试剂。

6. 发明申请

US20120034140A1 SAMPLE ANALYSIS TOOL, METHOD FOR PRODUCING SAMPLE ANALYSIS TOOL, AND METHOD FOR INHIBITING DECREASE IN LIQUID PERMEABILITY OF DEVELOPMENT MEMBER 有权
标题翻译：样品分析工具，生产样品分析工具的方法和抑制开发成员液体渗透性降低的方法
公开(公告)号：US20120034140A1
公开(公告)日：2012-02-09
申请号：US13263729
申请日：2010-04-05
申请人： Kazuhiro Ohmiya , Tomoko Hirayama
发明人： Kazuhiro Ohmiya , Tomoko Hirayama
IPC分类号： B01L3/00 , B23P11/00
CPC分类号： G01N33/558 , G01N33/525 , Y10T29/49826
摘要： Provide is a sample analysis tool whose reactivity and reproducibility in analysis can be prevented from decreasing. The sample analysis tool 10 of the present invention includes a development member 11 and a plastic base 16, and at least part of the development member 11 is in contact with the plastic base 16. The sample analysis tool 10 further includes a hydrophilic component layer 15, and the hydrophilic component layer 15 is formed on part or the whole of at least one of a surface of the plastic base 16 and a surface of the development member 11. It is particularly preferable that the hydrophilic component layer 15 contains sucrose or N-methyl glucosamine. In the sample analysis tool 10 of the present invention, since the hydrophilic component layer 15 is formed on part or the whole of at least one of the surface of the plastic base 16 and the surface of the development member 11, it is possible to prevent the adhesion of a hydrophobic component(s) derived from the plastic base 16.
摘要翻译：提供是一种样品分析工具，可以防止其分析中的反应性和重现性降低。本发明的样品分析工具10包括显影构件11和塑料基底16，并且显影构件11的至少一部分与塑料基底16接触。样品分析工具10还包括亲水性组分层15 并且亲水性成分层15形成在塑料基体16的表面和显影体11的表面的至少一方的一部分或全部上。特别优选亲水性成分层15含有蔗糖或N- 甲基葡糖胺。在本发明的样品分析工具10中，由于亲水性成分层15形成在塑料基体16的表面和显影体11的表面中的至少一个的一部分或全部上，因此可以防止衍生自塑料基底16的疏水组分的粘附。

7. 发明授权

US09446402B2 Specimen supplying tool and specimen analysing instrument using the same 有权
标题翻译：样品供应工具和样品分析仪器使用该仪器
公开(公告)号：US09446402B2
公开(公告)日：2016-09-20
申请号：US12530146
申请日：2008-07-17
申请人： Kazuhiro Ohmiya , Kaori Ishizaki
发明人： Kazuhiro Ohmiya , Kaori Ishizaki
IPC分类号： G01N31/00 , B01L3/02 , G01N35/10 , B01L3/00
CPC分类号： B01L3/0262 , B01L3/0293 , B01L3/5088 , B01L2300/0819 , G01N35/1016 , G01N2035/1034
摘要： A specimen supplying tool in which structure is simple, and a liquid specimen and air bubbles do not remain within a through-bore for introduction of a specimen, is provided. The specimen supplying tool includes a substrate 11 and a through-bore 13 provided in the substrate 11. One opening of the through-bore 13 is a specimen inflow port, and the other opening of the through-bore 13 is a specimen outflow port. The specimen supplying tool further includes a projection portion 14 projecting from a part p of a marginal part of the specimen outflow port. A liquid specimen is introduced from the specimen inflow port to the through-bore 13. When the introduced liquid specimen is discharged from the specimen outflow port, and supplied to a specimen analyzing instrument, the liquid specimen is drawn to the projection portion 14, led by the projection portion 14, and supplied to the specimen analyzing instrument.
摘要翻译：提供一种结构简单的试样供给工具，并且液体试样和气泡不会残留在用于引入试样的通孔内。样本供给工具包括基板11和设置在基板11中的贯通孔13.贯通孔13的一个开口为试样流入口，通孔13的另一个开口为试样流出口。样本供给工具还包括从试样流出口的边缘部分的p部突出的突出部14。将液体样本从样本流入口引入通孔13.当引入的液体样本从样本流出口排出并提供给样本分析仪器时，液体样本被拉到突出部分14，被引导通过突出部分14被提供给样本分析仪器。

8. 发明申请

US20080166701A1 Immunoassay Method and Immunoassay Kit to Be Used Therein 审中-公开
标题翻译：免疫测定法和免疫测定试剂盒
公开(公告)号：US20080166701A1
公开(公告)日：2008-07-10
申请号：US11885131
申请日：2006-07-24
申请人： Kazuhiro Ohmiya , Kyouichi Ohshiro
发明人： Kazuhiro Ohmiya , Kyouichi Ohshiro
IPC分类号： C12Q1/70 , G01N33/566 , G01N33/569 , C07K16/00
CPC分类号： G01N33/5306 , C07K16/1018 , C07K16/1275 , G01N33/54313 , G01N33/54393
摘要： In an immunoassay method using an antibody sensitization particle, the occurrence of false positives is prevented. The immunoassay method of the present invention is an immunoassay method for detecting or quantifying an analyte in a specimen by mixing an antibody sensitization particle obtained by sensitizing a particle with an antibody that reacts with the analyte in the specimen with the specimen, and measuring agglutination of the antibody sensitization particle by an antigen-antibody reaction, and the method includes pre-treating the specimen by using a cation exchange material in advance of the mixing step. As the cation exchange material, for example, a cation exchange material having a sulfonic acid group or a carboxyl group as a functional group can be used, and a form thereof is not limited particularly, and may be, for example, a cation exchange filter, a cation exchange column or the like.
摘要翻译：在使用抗体致敏颗粒的免疫测定方法中，防止了假阳性的发生。本发明的免疫测定方法是通过将通过使颗粒敏化获得的抗体致敏颗粒与与样品中的分析物反应的抗体与样品混合来检测或定量样品中的分析物的免疫测定方法，通过抗原抗体反应的抗体致敏颗粒，并且该方法包括在混合步骤之前使用阳离子交换材料对样品进行预处理。作为阳离子交换材料，例如可以使用具有磺酸基或羧基作为官能团的阳离子交换材料，其形式没有特别限制，可以是例如阳离子交换过滤器，阳离子交换柱等。

9. 发明申请

US20080008992A1 Method Of Pretreating Specimen And Immunoassay Using The Same 审中-公开
标题翻译：预处理样品和使用其的免疫测定法
公开(公告)号：US20080008992A1
公开(公告)日：2008-01-10
申请号：US11792990
申请日：2005-12-13
申请人： Kyouichi Ohshiro , Kazuhiro Ohmiya , Naoko Izui
发明人： Kyouichi Ohshiro , Kazuhiro Ohmiya , Naoko Izui
IPC分类号： G01N33/53 , C12N5/06 , C12N9/50 , C12Q1/70
CPC分类号： G01N33/56983 , G01N33/5306 , G01N2333/11 , G01N2333/95
摘要： The present invention provides a method of pretreating a specimen, which allows measurement according to an immunoassay to be carried out on a specimen from nasal secretion while preventing non-specific reactions. According to this method, the specimen from nasal secretion is treated with a protease beforehand and then an immunoassay is performed. As the protease, it is preferable to use semi-alkaline protease (EC 3.4.21.63). Furthermore, it is preferable that a substance to be pretreated by the pretreatment method according to the present invention is an influenza virus contained in the specimen from nasal secretion. The immunoassay preferably is an immunoagglutination assay. Examples of the immunoagglutination assay include a turbidimetric immunoassay, a latex turbidimetric immunoassay, and a latex agglutination assay that is performed on a slide glass.
摘要翻译：本发明提供了一种预处理样品的方法，其允许根据免疫测定进行测量，以在防止非特异性反应的同时进行来自鼻分泌物的样品。根据该方法，预先用蛋白酶处理来自鼻分泌物的样品，然后进行免疫测定。作为蛋白酶，优选使用半碱性蛋白酶（EC 3.4.21.63）。此外，优选通过本发明的预处理方法进行预处理的物质是来自鼻分泌物的样品中含有的流感病毒。免疫测定优选是免疫凝集测定。免疫凝集测定的实例包括比浊免疫测定，胶乳比浊免疫测定和在载玻片上进行的胶乳凝集测定。

10. 发明授权

US09903864B2 Sample analysis tool, method for producing sample analysis tool, and method for inhibiting decrease in liquid permeability of development member 有权
公开(公告)号：US09903864B2
公开(公告)日：2018-02-27
申请号：US13263729
申请日：2010-04-05
申请人： Kazuhiro Ohmiya , Tomoko Hirayama
发明人： Kazuhiro Ohmiya , Tomoko Hirayama
IPC分类号： B01L3/00 , B23P11/00 , G01N33/558 , G01N33/52
CPC分类号： G01N33/558 , G01N33/525 , Y10T29/49826
摘要： Provide is a sample analysis tool whose reactivity and reproducibility in analysis can be prevented from decreasing. The sample analysis tool 10 of the present invention includes a development member 11 and a plastic base 16, and at least part of the development member 11 is in contact with the plastic base 16. The sample analysis tool 10 further includes a hydrophilic component layer 15, and the hydrophilic component layer 15 is formed on part or the whole of at least one of a surface of the plastic base 16 and a surface of the development member 11. It is particularly preferable that the hydrophilic component layer 15 contains sucrose or N-methyl glucosamine. In the sample analysis tool 10 of the present invention, since the hydrophilic component layer 15 is formed on part or the whole of at least one of the surface of the plastic base 16 and the surface of the development member 11, it is possible to prevent the adhesion of a hydrophobic component(s) derived from the plastic base 16.

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