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1. 发明授权

US06939887B2 Benzimidazolidinone derivatives 失效
标题翻译：苯并咪唑烷酮衍生物
公开(公告)号：US06939887B2
公开(公告)日：2005-09-06
申请号：US10470813
申请日：2002-01-30
申请人： Kazuhiko Okazaki , Yasuyuki Ueki
发明人： Kazuhiko Okazaki , Yasuyuki Ueki
IPC分类号： A61P5/02 , C07D235/26 , C07D405/06 , A61K31/4184
CPC分类号： C07D235/26 , C07D405/06
摘要： The present invention can provide novel compounds useful as orally administrable growth hormone releaser, more specifically a benzimidazolidinone derivative of formula (1) or a pharmaceutically acceptable salt thereof: (1) wherein R1 is optionally substituted alkyl or the like; R2, R3 and R4 are each hydrogen, optionally substituted alkyl, or the like; R5 is optionally substituted aryl; q is 0 or 1; and W1 is a group represented by formula (2): (2) n is 1, 2 or 3; m is 0, 1, 2 or 3; R6 and R7 are each hydrogen, optionally substituted alkyl, or the like; and R8 and R9 are each hydrogen, optionally substituted alkyl, or the like.
摘要翻译：本发明可以提供用作可口服给药的生长激素释放剂，更具体地是式（1）的苯并咪唑啉酮衍生物或其药学上可接受的盐的新化合物：（1）其中R 1是任选取代的烷基或类似; R 2，R 3和R 4各自为氢，任选取代的烷基等; R 5是任选取代的芳基; q为0或1; 和W 1是由式（2）表示的基团：（2）n是1,2或3; m为0,1,2或3; R 6和R 7各自为氢，任选取代的烷基等; R 8和R 9各自为氢，任选取代的烷基等。

2. 发明授权

US06576656B1 Oxindole derivative 失效
标题翻译：羟吲哚衍生物
公开(公告)号：US06576656B1
公开(公告)日：2003-06-10
申请号：US09763241
申请日：2001-03-22
申请人： Teruhisa Tokunaga , Takashi Umezome , W. Ewan Hume , Ryu Nagata , Kazuhiko Okazaki , Yasuyuki Ueki , Kazuo Kumagai
发明人： Teruhisa Tokunaga , Takashi Umezome , W. Ewan Hume , Ryu Nagata , Kazuhiko Okazaki , Yasuyuki Ueki , Kazuo Kumagai
IPC分类号： A61K3140
CPC分类号： C07D401/04 , C07D209/38 , C07D209/40 , C07D403/06 , C07D405/04 , C07D409/04 , C07D413/06 , C07D417/04
摘要： An oxindole of Formula 1 or a prodrug thereof, or a pharmaceutically acceptable salt thereof is useful for growth hormone releaser: wherein R1, R2, R3 and R4 are independently hydrogen, optionally substituted alkyl etc; R5 is optionally substituted aryl or optionally substituted heteroaryl; Z is —O— or —NH—; one of W1 and W2 is hydrogen, alkyl or —Y—CON(R10)R11; the other of W1 and W2 is n is 1, 2 or 3; m is 0, 1, 2 or 3; Y is single bond or C1-C3 alkylene; R6 and R7 are independently hydrogen, optionally substituted alkyl etc; R8 and R9 are independently hydrogen, optionally substituted alkyl etc; R10 and R11 are independently hydrogen, alkyl etc.
摘要翻译：式1的羟吲哚或其前药或其药学上可接受的盐可用于生长激素释放剂：其中R 1，R 2，R 3和R 4独立地为氢，任选取代的烷基等; R 5为任选取代的芳基或任选取代的杂芳基; Z 是-O-或-NH-; W1和W2之一是氢，烷基或-Y-CON（R10）R11; W1和W2中的另一个是1,2或3; m是0,1,2或3; Y是单键或C1-C3亚烷基; R6和R7独立地是氢，任选取代的烷基等; R 8和R 9独立地是氢，任选取代的烷基等; R 10和R 11独立地是氢，烷基等

3. 发明授权

US06655760B1 Cold storage 失效
标题翻译：冷库
公开(公告)号：US06655760B1
公开(公告)日：2003-12-02
申请号：US09582506
申请日：2000-06-26
申请人： Yasushi Sakata , Yasuhide Watanabe , Kazuhiko Okazaki , Toshimi Hosokawa
发明人： Yasushi Sakata , Yasuhide Watanabe , Kazuhiko Okazaki , Toshimi Hosokawa
IPC分类号： A47F304
CPC分类号： A47F3/043 , A47F3/0434 , E06B3/4609 , E06B3/5892 , E06B3/725 , E06B5/11 , F25D23/021
摘要： There is disclosed a cold storage which improves a door insulating performance, and which is preferable particularly for low-temperature insulation of chemicals, and the like. A low-temperature insulating showcase is formed by openably closing a storage chamber opening constituted in an insulation box by a door, the door is constituted of a transparent panel and a see-through composite layer glass, and a panel is detachably attached to the storage chamber side of the composite layer glass.
摘要翻译：公开了一种提高门绝缘性能的冷库，特别适用于化学品的低温绝缘等。一个低温绝缘陈列柜是通过可开闭地关闭由门构成在绝缘箱中的存储室开口形成的，门由透明板和透明复合层玻璃构成，并且面板可拆卸地附接到储存器复合层玻璃的室侧。

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