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1. 发明申请

US20080051598A1 Process for Production of Polysubstituted Cyclobutanes and Polysubstituted Cyclobutenes 审中-公开
标题翻译：多取代环丁烷和多取代环丁烯的制备方法
公开(公告)号：US20080051598A1
公开(公告)日：2008-02-28
申请号：US11571410
申请日：2004-07-22
申请人： Kiyosei Takasu , Masataka Ihara , Kazato Inenaga
发明人： Kiyosei Takasu , Masataka Ihara , Kazato Inenaga
IPC分类号： C07C69/74
CPC分类号： C07C67/343 , C07F7/1804 , C07C69/757
摘要： The prior art required specialized substrates or reaction conditions to be used to manufacture polysubstituted cyclobutane compounds and polysubstituted cyclobutene compounds, and the method had poor generality. The type or quantity of the catalyst or solvent used was also problematic in the industrial manufacture of polysubstituted cyclobutane compounds. The present invention provides a method for manufacturing a polysubstituted cyclobutane compound with high stereoselectivity that has low environmental load (is ecologically advantageous) and is applicable to industrial manufacturing from the standpoint of operation, substrate generality, catalyst, solvent, and efficiency. A polysubstituted cyclobutane, a cyclobutene, and a bicyclo[4.2.0]octane compound can be manufactured efficiently, stereoselectively, and in an ecologically advantageous manner by causing a Brønsted acid to act on a mixture of an enol ether compound or 2-siloxydiene compound with an alkene or alkyne compound in which a carbonyl group is substituted at the 1-position in a non-aqueous solvent or without a solvent.
摘要翻译：现有技术需要用于制备多取代环丁烷化合物和多取代环丁烯化合物的特殊底物或反应条件，并且该方法的普遍性差。所用的催化剂或溶剂的类型或数量在多取代环丁烷化合物的工业制造中也是有问题的。本发明提供一种具有低立体选择性的多取代环丁烷化合物的方法，其具有低的环境负荷（在生态上是有利的），并且从操作，基材通用性，催化剂，溶剂和效率的观点来看可应用于工业制造。多取代的环丁烷，环丁烯和双环[4.2.0]辛烷化合物可以有效地，立体选择性地并且以生态有利的方式通过使布朗斯台德酸作用于烯醇醚化合物或2-硅氧烷二烯化合物的混合物与在非水溶剂中或没有溶剂的1-位被羰基取代的烯烃或炔化合物。

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