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1. 发明授权

US5457192A Method of manufacturing D-allosan 失效
标题翻译：制造D-异黄酮的方法
公开(公告)号：US5457192A
公开(公告)日：1995-10-10
申请号：US937847
申请日：1992-10-21
申请人： Katsuya Matsumoto , Takashi Ebata , Hajime Matsushita
发明人： Katsuya Matsumoto , Takashi Ebata , Hajime Matsushita
IPC分类号： C07H1/00 , C07H3/10 , C07H3/02
CPC分类号： C07H3/10 , Y02P20/55
摘要： The carbonyl group at the 2-position of levoglucosenone is reduced to obtain a hydroxyl group having a .beta.-configuration. The hydroxyl group having a .beta.-configuration is reversed to an .alpha.-configuration, and hydroxyl groups are added at the 3- and 4-positions in a cis-.alpha. form. Finally, the protective group of the hydroxyl group at the 2-position is eliminated. The reduction of the carbonyl group at the 2-position can be performed such that the levoglucosenone is reacted with aluminum lithium hydride or sodium boron hydride in an appropriate solvent. Reversion of the hydroxyl group having a .beta.-configuration can be performed by the Mitsunobu method or a method having a mesylation step and a step using cesium acetate. The addition of the hydroxyl groups to the 3-and 4-positions in the cis form can be performed by oxidizing the double bond across the 3- and 4-positions with an appropriate oxidizing agent. The elimination of the protective group of the hydroxyl group at the 2-position can be performed under basic conditions in accordance with normal methods. According to the method of the present invention, D-allosan can be obtained stereoselectively in high yield via a smaller number of steps than that of the conventional synthesis method.
摘要翻译： PCT No.PCT / JP92 / 00170 Sec。 371日期：1992年10月21日 102（e）日期1992年10月21日PCT提交1992年2月19日PCT公布。第WO92 / 14744号公报日期：1992年9月3日。将左旋葡萄糖酮酮2位上的羰基还原，得到具有β-构型的羟基。具有β-构型的羟基被逆转成α构型，羟基在顺式-α形式的3-和4-位加入。最后，消除了2-位羟基的保护基。可以进行2-位上的羰基的还原，使得左旋葡萄糖酮与氢化铝锂或硼氢化钠在合适的溶剂中反应。具有β-构型的羟基的反转可以通过Mitsunobu方法或具有甲磺酰化步骤的方法和使用乙酸铯的步骤进行。以顺式形式向3-和4-位加入羟基可以通过用合适的氧化剂氧化穿过3-和4-位的双键来进行。可以在碱性条件下按照常规方法在2-位上除去羟基的保护基。根据本发明的方法，可以通过比常规合成方法更少的步骤以高产率立体选择性地获得D-异亮唾液酸。

2. 发明授权

US5322955A Method of manufacturing 3-DPA-lactone 失效
标题翻译：制备3-DPA-内酯的方法
公开(公告)号：US5322955A
公开(公告)日：1994-06-21
申请号：US938238
申请日：1992-10-22
申请人： Katsuya Matsumoto , Takashi Ebata , Hiroshi Kawakami , Koshi Koseki , Hajime Matsushita
发明人： Katsuya Matsumoto , Takashi Ebata , Hiroshi Kawakami , Koshi Koseki , Hajime Matsushita
IPC分类号： C07D307/33 , C07D233/00
CPC分类号： C07D307/33 , Y02P20/55
摘要： In the method of the present invention for manufacturing 3-DPA-lactone, a protective group is introduced in the first step into the hydroxyl group at 4-position of .gamma.-ribonolactone by an ordinary method. Then, an acid anhydride or an acid chloride is added in the presence of a tertiary amine compound so as to conduct a .beta.-elimination of the hydroxyl group at the 3-position. As a result, a double bond is formed between the 2- and 3-positions and, at the same time, the hydroxyl group at the 2-position is acylated. The double bond between the 2- and 3-positions is reduced in the next step by means of a catalytic hydrogenation. Finally, the protective group of the hydroxyl group is eliminated by an ordinary method. The particular method permits using readily available raw materials, decreasing the number of manufacturing steps, and easily and selectively synthesizing the desired 3-DPA-lactone, which is hardly obtained from nature in a large amount, in high yield, compared with the conventional method.
摘要翻译： PCT No.PCT / JP92 / 00186 Sec。 371日期：1992年10月22日 102（e）日期1992年10月22日PCT提交1992年2月21日PCT公布。第WO92 / 14721号公报日本9月3日。在本发明的制备3-DPA-内酯的方法中，通过常规方法，将第一步中的保护基引入γ-内酯的4-位的羟基。然后，在叔胺化合物的存在下加入酸酐或酰氯，以在3-位进行羟基的β-烯丙基化。结果，在2-位和3-位之间形成双键，并且同时将2-位的羟基酰化。通过催化氢化，在下一步骤中2-和3-位之间的双键被还原。最后，通过常规方法除去羟基的保护基。该特定方法与常规方法相比，允许使用容易获得的原料，减少制造步骤的数量，并且容易且有选择地合成从大量难以获得的大量难以获得的所需3-DPA-内酯。

3. 发明授权

US4879039A Process for measuring stable-type glycated hemoglobin in a sample 失效
标题翻译：测定样品中稳定型糖化血红蛋白的方法
公开(公告)号：US4879039A
公开(公告)日：1989-11-07
申请号：US079435
申请日：1987-07-30
申请人： Hiroaki Takahashi , Haruo Okada , Katsuya Matsumoto , Masuo Umino
发明人： Hiroaki Takahashi , Haruo Okada , Katsuya Matsumoto , Masuo Umino
IPC分类号： G01N30/12 , G01N30/88 , G01N33/72
CPC分类号： G01N30/12 , G01N33/723 , Y10T436/25125 , Y10T436/255
摘要： A process for measuring the amount of stable-type glycated hemoglobin in a sample using high performance liquid chromatography, comprising heating a sample diluted with a hemolysis agent containing a reagent for the removal of unstable-type glycated hemoglobin to achieve the removal of the unstable-type glycated hemoglobin, and analyzing the sample by high performance liquid chromatography.
摘要翻译：使用高效液相色谱法测定样品中稳定型糖化血红蛋白量的方法，包括加热用含有用于除去不稳定型糖化血红蛋白的试剂的溶血剂稀释的样品，以除去不稳定型糖化血红蛋白，型糖化血红蛋白，并通过高效液相色谱分析样品。

4. 发明授权

US5416204A Method for preparing 2'-3'-dideoxy-.beta.-nucleosides using 2,2-dideoxy-di(organothio)-pentofuranose intermediates 失效
标题翻译：使用2,2-二脱氧 - 二（有机硫） - 呋喃糖苷中间体制备2'-3'-二脱氧-β-核苷的方法
公开(公告)号：US5416204A
公开(公告)日：1995-05-16
申请号：US971768
申请日：1993-02-12
申请人： Hiroshi Kawakami , Katsuya Matsumoto , Koshi Koseki , Takashi Ebata , Hajime Matsushita , Kazuo Itoh , Yoshitake Naoi
发明人： Hiroshi Kawakami , Katsuya Matsumoto , Koshi Koseki , Takashi Ebata , Hajime Matsushita , Kazuo Itoh , Yoshitake Naoi
IPC分类号： C07D405/04 , C07F7/18 , C07H19/06 , C07H19/073 , C07H1/00
CPC分类号： C07D405/04 , C07F7/1856 , C07H19/06 , Y02P20/55
摘要： 2,3-Dideoxy-2,2-di(organothio)-B-D-pentofuranosyl-pyrimidines are disclosed as intermediates in the synthesis of 2', 3'-dideoxynucleosides and have the structure shown below. ##STR1## wherein R.sup.4 is a hydroxyl protecting group;X is oxygen or nitrogen, said nitrogen being bonded to a hydrogen atom, an alkyl or acyl group;Y is hydrogen, halogen, alkyl, haloalkyl or haloalkenyl; andR.sup.5 is alkyl, aralkyl, or aryl wherein aralkkyl or aryl is substituted with hydrogen, halogen, nitro or alkoxy.2', 3'-Dideoxynucleosides, products of the above intermediates, are useful as antiviral agents.
摘要翻译： PCT No.PCT / JP92 / 00752 Sec。 371日期：1993年2月12日 102（e）日期1993年2月12日PCT提交1992年6月12日PCT公布。公开号WO92 / 22548 1992年12月23日的日期.2,3-二脱氧-2,2-二（有机硫）-B-D-呋喃鸟糖基 - 嘧啶作为2'，3'-双脱氧核苷合成中的中间体被公开，具有如下结构。其中R 4是羟基保护基; X是氧或氮，所说的氮键合到氢原子，烷基或酰基上; Y是氢，卤素，烷基，卤代烷基或卤代烯基; R 5为烷基，芳烷基或芳基，其中芳烷基或芳基被氢，卤素，硝基或烷氧基取代。 2'，3'-双脱氧核苷，上述中间体的产物可用作抗病毒剂。

5. 发明授权

US5412111A Method of preparing (3R,4R)-3-hydroxy-4-hydroxymethyl-4-butanolide 失效
标题翻译：制备（3R，4R）-3-羟基-4-羟甲基-4-丁醇酯的方法
公开(公告)号：US5412111A
公开(公告)日：1995-05-02
申请号：US095182
申请日：1993-07-23
申请人： Katsuya Matsumoto , Takashi Ebata , Koshi Koseki , Koji Okano , Hiroshi Kawakami , Hajime Matsushita
发明人： Katsuya Matsumoto , Takashi Ebata , Koshi Koseki , Koji Okano , Hiroshi Kawakami , Hajime Matsushita
IPC分类号： C07D307/33 , C07D493/04 , C07D493/08 , C07D493/18 , C07H3/10
CPC分类号： C07D307/33 , C07D493/08 , C07H3/10
摘要： Providing a method of preparing (3R,4R)-3-hydroxy-4-hydroxymethyl-4-butanolide conveniently and selectively from a widely available raw material in a high yield. A carbonyl group of the 2-position of levoglucosenone is reduced to obtain a hydroxyl group of a .beta.-configuration. Then, an iodo-group of an .alpha.-configuration and an acyloxy ion of a .beta.-configuration are introduced regioselectively and stereoselectively to the double bond at the 4-position and the 3-position of the above-mentioned levoglucosenone, respectively, keeping a trans stereochemical relationship. An alkoxide is then formed, by hydrolysis and an oxirane ring of a .beta.-configuration is formed by removing an iodo-group by intramolecular nucleophilic displacement reaction of the alkoxide. After the hydroxyl group of the 2-position is oxidized to convert to a carbonyl group, the oxirane ring is reductively and selectively cleaved, thereby obtaining a chemical compound having no substituent at the 3-position and a hydroxyl group of a .beta.-configuration at the 4-position. Finally a lactone of 5-membered-ring is prepared by subjecting the above-obtained compound to Baeyer-Villigar oxidation.
摘要翻译：提供从广泛获得的原料中以高产率方便且有选择地制备（3R，4R）-3-羟基-4-羟甲基-4-丁醇的方法。缩合左旋葡萄糖酮的2-位的羰基，得到β-构型的羟基。然后，分别对上述左旋葡萄糖酮的4-位和3-位分别选择性且立体选择地引入α-构型的碘组和β-构型的酰氧基，保持反式立体化学关系。然后通过水解形成醇盐，通过醇盐的分子内亲核取代反应除去碘基形成β-构型的环氧乙烷环。在2-位的羟基被氧化转化成羰基之后，环氧乙烷环被还原和选择性地裂解，从而得到在3-位没有取代基的化合物和β-构型的羟基在 4位。最后通过将上述得到的化合物进行Baeyer-Villigar氧化来制备5元环的内酯。

6. 发明授权

US5410038A method of preparing D-altrose 失效
标题翻译：制备D-阿托糖的方法
公开(公告)号：US5410038A
公开(公告)日：1995-04-25
申请号：US849387
申请日：1992-05-12
申请人： Katsuya Matsumoto , Takashi Ebata , Hajime Matsushita
发明人： Katsuya Matsumoto , Takashi Ebata , Hajime Matsushita
IPC分类号： C07H3/02 , C07H3/10 , C07H1/00
CPC分类号： C07H3/10 , C07H3/02
摘要： Disclosed is a method of preparing D-altrose (4) from the starting material levo-glucosenon (1) in accordance with reactions denoted by reaction formulas (I), (II) and (III) given below: ##STR1##
摘要翻译： PCT No.PCT / JP91 / 01376 Sec。 371日期：1992年5月12日 102（e）日期1992年5月12日PCT 1991年10月9日PCT公布。出版物WO92 / 06986 日期：1992年4月3日。公开是根据由下列给出的反应式（I），（II）和（III）表示的反应从原料左旋葡萄糖酮（1）制备D-麦芽糖（4）的方法（图）（三）（三）

7. 发明授权

US09138819B2 Plastic deformation tapping tool with inside diameter finishing edges 有权
标题翻译：塑料变形攻丝工具，内径精整边
公开(公告)号：US09138819B2
公开(公告)日：2015-09-22
申请号：US13521887
申请日：2010-01-13
申请人： Seiji Ohhashi , Katsuya Matsumoto , Yousuke Suzuki
发明人： Seiji Ohhashi , Katsuya Matsumoto , Yousuke Suzuki
IPC分类号： B23G7/02 , B23G5/20
CPC分类号： B23G7/02 , B23G5/20 , Y10T408/34
摘要： Flutes defining inside diameter finishing edges are formed in middle portions of relief parts arranged in three linear arrays which are located between a plurality of linear arrays of protruding parts in a chamfered end section, about an axis 0, and the inside diameter finishing edges are formed along one of opposite open-end edges of each flute which is located on an upstream side of the flute as seen in a tap rotating direction A, and are offset by a predetermined angle θ in the tap rotating direction A with respect to the protruding parts in the chamfered end section. Accordingly, all of the plurality of linear arrays of protruding parts in the chamfered end section can be used to form the internal thread by plastic deformation of an inner circumferential surface of a hole to be tapped.
摘要翻译：形成内径精整边缘的凹槽形成在排列成三个线性阵列的凸出部分的中间部分，该三个线性阵列位于倒角端部中的多个线状阵列之间，绕轴线0形成，并且形成内径精加工边缘沿着沿分接头旋转方向A观察的位于所述凹槽的上游侧的每个凹槽的相对的开口端边缘中的一个，并且被偏移预定角度; 在分接头旋转方向A上相对于倒角端部中的突出部分。因此，倒角端部的突出部的多个线状阵列的全部可以用于通过要被攻丝的孔的内周面的塑性变形而形成内螺纹。

8. 发明申请

US20120301236A1 PLASTIC DEFORMATION TAPPING TOOL WITH INSIDE DIAMETER FINISHING EDGES 有权
标题翻译：具有内径修整边缘的塑料变形起子工具
公开(公告)号：US20120301236A1
公开(公告)日：2012-11-29
申请号：US13521887
申请日：2010-01-13
申请人： Seiji Ohhashi , Katsuya Matsumoto , Yousuke Suzuki
发明人： Seiji Ohhashi , Katsuya Matsumoto , Yousuke Suzuki
IPC分类号： B23B51/08
CPC分类号： B23G7/02 , B23G5/20 , Y10T408/34
摘要： Flutes defining inside diameter finishing edges are formed in middle portions of relief parts arranged in three linear arrays which are located between a plurality of linear arrays of protruding parts in a chamfered end section, about an axis O, and the inside diameter finishing edges are formed along one of opposite open-end edges of each flute which is located on an upstream side of the flute as seen in a tap rotating direction A, and are offset by a predetermined angle θ in the tap rotating direction A with respect to the protruding parts in the chamfered end section. Accordingly, all of the plurality of linear arrays of protruding parts in the chamfered end section can be used to form the internal thread by plastic deformation of an inner circumferential surface of a hole to be tapped.
摘要翻译：限定内径精加工边缘的槽纹形成在排列成三个线性阵列的凸出部分的中间部分，该三个线性阵列位于倒角端部中的多个线状阵列之间，绕轴线O形成，并且形成内径精加工边缘沿着沿分接头旋转方向A观察的位于所述凹槽的上游侧的每个凹槽的相对的开口端边缘中的一个，并且被偏移预定角度; 在分接头旋转方向A上相对于倒角端部中的突出部分。因此，倒角端部的突出部的多个线状阵列的全部可以用于通过要被攻丝的孔的内周面的塑性变形而形成内螺纹。

9. 发明申请

US20110268922A1 BONDED PRODUCT AND MANUFACTURING METHOD AND MANUFACTURING DEVICE THEREFOR 审中-公开
标题翻译：捆绑产品和制造方法及其制造设备
公开(公告)号：US20110268922A1
公开(公告)日：2011-11-03
申请号：US13130872
申请日：2009-11-20
申请人： Katsuya Matsumoto , Sumitomo Watanabe , Mitsugu Kaneko , Toshihiro Murakawa , Takahiro Morita
发明人： Katsuya Matsumoto , Sumitomo Watanabe , Mitsugu Kaneko , Toshihiro Murakawa , Takahiro Morita
IPC分类号： B32B3/00 , B22D27/08 , B22D27/11 , B22D19/00 , B22C9/00
CPC分类号： B22D18/02 , B22D17/007 , B22D19/00 , Y10T428/24479
摘要： Disclosed are a bonded product, and a manufacturing method and manufacturing device therefor. To obtain a bonded product formed of a solidified material of a molten metal which has been poured into a forming mold with a workpiece, all or part of which is already held therein, or formed of a semi-solidified slurry which is contained in the forming mold together with the workpiece, the semi-solidified slurry or the molten metal is relatively made to flow on the end faces of the workpiece while friction sufficient to break the passive state existing at the surface of the molten metal or the semi-solidified slurry is generated between the workpiece and the semi-solidified slurry or the molten metal.
摘要翻译：公开了一种粘合产品及其制造方法和制造装置。为了获得由熔融金属凝固材料形成的粘合产品，该熔融金属已经被浇注到成型模具中，其全部或部分已经被保持在其中，或由包含在成型中的半固化浆料形成与工件一起模制，半固化浆料或熔融金属相对地制造成在工件的端面上流动，同时足以破坏熔融金属或半固化浆料表面存在的被动状态的摩擦是在工件和半固化浆料或熔融金属之间产生。

10. 发明申请

US20110210102A1 PLASMA WELDING TORCH, AND WELDING METHOD USING PLASMA WELDING TORCH 失效
标题翻译：等离子焊接机，以及使用等离子焊接焊机的焊接方法
公开(公告)号：US20110210102A1
公开(公告)日：2011-09-01
申请号：US13026558
申请日：2011-02-14
申请人： Katsuya Matsumoto , Jun Kitagawa , Keishi Setoda , Yusuke Muramatsu
发明人： Katsuya Matsumoto , Jun Kitagawa , Keishi Setoda , Yusuke Muramatsu
IPC分类号： B23K10/02
CPC分类号： B23K10/02 , H05H1/341 , H05H2001/3421
摘要： A plasma welding torch that can be reduced in size more than in conventional cases. When an inert gas G such as argon gas is supplied to an outer circumferential space around a non-consumable electrode 13, a portion of the inert gas G is used as plasma gas GP that forms a plasma arc PA between the non-consumable electrode 13 and a base material 2 via a plasma orifice 51. A plasma welding torch 1 moves, maintaining this state, in the direction of the arrow shown in FIG. 4. Meanwhile, a portion of the inert gas G supplied to a gas flowing part 21 is not used as the plasma gas GP but is used as shielding gas GS and is ejected onto the base material 2 ahead in the welding direction via a shielding orifice 52. The welding on the base material 2 is performed in a state where the plasma arc PA and the base material 2 are shielded from the air by this shielding gas.
摘要翻译：一种等离子焊枪，其尺寸可以比常规情况下减小。当诸如氩气的惰性气体G被供应到非消耗性电极13周围的外周空间时，惰性气体G的一部分被用作在非消耗性电极13之间形成等离子弧PA的等离子体气体GP 和等离子体喷嘴51的基材2.等离子体焊炬1沿图1所示的箭头方向移动，保持该状态。同时，供给到气体流通部21的惰性气体G的一部分不用作等离子体气体GP，而被用作保护气体GS，并且通过屏蔽孔向焊接方向前方喷射到基材2上在等离子弧PA和基材2被该保护气体与空气隔离的状态下，对基材2进行焊接。

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