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1. 发明授权

US09844656B2 Localization of agents at a target site with a composition and an energy source 有权
公开(公告)号：US09844656B2
公开(公告)日：2017-12-19
申请号：US13581274
申请日：2011-03-01
申请人： Katherine W. Ferrara , Azedah Kheirolomoom
发明人： Katherine W. Ferrara , Azedah Kheirolomoom
IPC分类号： A61K9/127 , A61M37/00 , A61K9/00 , A61K9/107 , A61K31/704 , A61K33/34 , A61K41/00 , A61K45/06
CPC分类号： A61M37/0092 , A61K9/0009 , A61K9/0019 , A61K9/107 , A61K9/127 , A61K9/1271 , A61K9/1273 , A61K9/1277 , A61K31/704 , A61K33/34 , A61K41/0028 , A61K45/06 , A61K2300/00
摘要： A method for localizing delivery of an agent to a target site in a subject is provided. The method allows accumulation and/or release of the agent at the target site in the subject through the use of an energy source.

2. 发明申请

US20100068260A1 Methods, Compositions and Device for Directed and Controlled Heating and Release of Agents 审中-公开
标题翻译：用于定向和控制加热和释放试剂的方法，组合物和装置
公开(公告)号：US20100068260A1
公开(公告)日：2010-03-18
申请号：US12508076
申请日：2009-07-23
申请人： Dustin E. Kruse , Claude Meares , Katherine W. Ferrara , Eric Paoli , Douglas N. Stephens , Jeffrey Day
发明人： Dustin E. Kruse , Claude Meares , Katherine W. Ferrara , Eric Paoli , Douglas N. Stephens , Jeffrey Day
IPC分类号： A61K9/127 , A61N7/02
CPC分类号： A61K38/55 , A61K9/1272 , A61K9/1277 , A61K9/5073 , A61K41/0028 , A61K45/06 , A61K47/6911 , A61K2300/00
摘要： A composition coupled to an agent with a cleavable linker is provided. Specifically, the composition is used for releasing the agent through a temperature-sensitive mechanism at a targeted location in a subject with heat. It is advantageous to applications where there is a need to accurately deploy an agent in a targeted location to reduce adverse side effects or increase efficacy of the agent. A device and method for providing heat at the targeted location in the subject is also provided. The device and method allows release of the agents in a targeted manner and prevents overheating of the targeted location or the tissue surrounding the targeted location. It is advantageous to applications where there is a need to accurately control the temperature in a targeted location in a biological body, for instance, to deploy an agent in the targeted location.
摘要翻译：提供了与具有可切割连接子的试剂偶联的组合物。具体地说，该组合物用于通过热量在受试者的目标位置通过温度敏感性机构释放药剂。需要在目标位置准确地部署试剂以减少不良副作用或增加试剂功效的应用是有利的。还提供了一种用于在受试者的目标位置提供热量的装置和方法。该装置和方法允许以有针对性的方式释放试剂，并防止目标位置或围绕目标位置的组织过热。对于需要精确地控制生物体内的目标位置的温度的应用，例如在目标位置部署试剂是有利的。

3. 发明授权

US5462059A Method for assessing and displaying vascular architecture using ultrasound 失效
标题翻译：使用超声波评估和显示血管结构的方法
公开(公告)号：US5462059A
公开(公告)日：1995-10-31
申请号：US248824
申请日：1994-05-25
申请人： Katherine W. Ferrara , V. Ralph Algazi
发明人： Katherine W. Ferrara , V. Ralph Algazi
IPC分类号： A61B8/08 , G01S15/58 , G01S15/89 , A61B8/06
CPC分类号： A61B8/06 , A61B8/08 , A61B8/483 , G01S15/8981 , A61B8/0833 , G01S15/584 , G01S15/8993
摘要： A method for assessing and displaying vasculature in a tissue mass using ultrasound and optimal velocity dependent data acquisition to differentiate between received signals from stationary tissue and received signals from slowly moving blood is disclosed herein. For a particular flow velocity, an optimal periodic or aperiodic signaling strategy is determined by matching the observation interval of any group of scatters to the correlated signal interval. Signals from moving blood cells are separated from signals from stationary tissue using a wall filter. Wall filtered signals from moving blood cells are further separated from signals from stationary tissue using a threshold filter. The resulting enhanced spatial and velocity resolution provides for identification of tumors by resistive index measurement, assessment of the percentage of vasculature in a section of tissue mass, and assessment of random structural characteristics, and further provides for three dimensional graphical display of vasculature within and surrounding a tissue mass.
摘要翻译：本文公开了一种使用超声波和最佳速度相关数据采集来评估和显示组织块中的脉管系统以区分来自静止组织的接收信号和来自缓慢移动的血液的接收信号的方法。对于特定的流速，通过将任何散射组的观测间隔与相关信号间隔进行匹配来确定最佳周期性或非周期性信令策略。来自移动血细胞的信号使用壁滤器与来自固定组织的信号分离。来自移动血细胞的壁滤波信号使用阈值滤波器进一步与来自固定组织的信号分离。所得到的增强的空间和速度分辨率通过阻力指数测量，组织块截面中脉管系统的百分比评估以及随机结构特征的评估来提供肿瘤的鉴别，并进一步提供血管内和周围的脉管系统的三维图形显示组织块

4. 发明申请

US20130090591A1 LOCALIZATION OF AGENTS AT A TARGET SITE WITH A COMPOSITION AND AN ENERGY SOURCE 有权
标题翻译：在具有组成和能量来源的目标站点上的代理商的本地化
公开(公告)号：US20130090591A1
公开(公告)日：2013-04-11
申请号：US13581274
申请日：2011-03-01
申请人： Katherine W. Ferrara , Azedah Kheirolomoom
发明人： Katherine W. Ferrara , Azedah Kheirolomoom
IPC分类号： A61M37/00 , A61K31/704 , A61K47/48 , A61K9/127
CPC分类号： A61M37/0092 , A61K9/0009 , A61K9/0019 , A61K9/107 , A61K9/127 , A61K9/1271 , A61K9/1273 , A61K9/1277 , A61K31/704 , A61K33/34 , A61K41/0028 , A61K45/06 , A61K2300/00
摘要： A method for localizing delivery of an agent to a target site in a subject is provided. The method allows accumulation and/or release of the agent at the target site in the subject through the use of an energy source.
摘要翻译：提供了一种用于将药剂递送到受试者中的靶位点的方法。该方法允许通过使用能量来在受试者的目标部位累积和/或释放药剂。

5. 发明授权

US07358226B2 Ultrasonic concentration of drug delivery capsules 有权
标题翻译：超声波浓缩药物输送胶囊
公开(公告)号：US07358226B2
公开(公告)日：2008-04-15
申请号：US10928648
申请日：2004-08-26
申请人： Paul Dayton , Katherine W. Ferrara , Michaelann Shortencarier , Susannah Bloch
发明人： Paul Dayton , Katherine W. Ferrara , Michaelann Shortencarier , Susannah Bloch
IPC分类号： A61B8/00 , A61K38/08 , A61K38/13 , A61K31/445 , A61K31/277 , A61K31/138 , A61K9/127 , A61K9/133
CPC分类号： A61K41/0028 , A61B8/00 , A61B8/0816 , A61B8/4483 , A61K9/0009 , A61K9/1272 , A61K31/337 , A61K47/6907 , A61K49/223 , A61K49/225 , A61K49/227 , A61K51/04 , A61K51/1227 , A61N7/00 , Y10S424/812
摘要： Methods, compositions and apparatus for localized delivery of compounds are provided. In certain embodiments, radiation force is used to direct carriers to a target site, and additional radiation is used to fragment the localized carriers, releasing associate compounds. Ultrasound radiation is preferred as the source for radiation force and for fragmentation. Also encompassed are embodiments in which targeting and fragmentations are combined with imaging of the treatment site. Alternate embodiments are disclosed in which compounds are locally delivered without use of carriers.
摘要翻译：提供了用于局部递送化合物的方法，组合物和装置。在某些实施方案中，使用辐射力将载体引导到靶位点，并且使用另外的辐射来分段本征载体，释放缔合化合物。超声辐射是辐射源和分裂源的首选。还包括其中靶向和碎裂与治疗部位的成像组合的实施方案。公开了其中化合物在不使用载体的情况下局部递送的替代实施方案。

6. 发明授权

US06371917B1 Ultrasound bubble recognition imaging 失效
标题翻译：超声波气泡识别成像
公开(公告)号：US06371917B1
公开(公告)日：2002-04-16
申请号：US09485412
申请日：2000-08-31
申请人： Katherine W. Ferrara , Karen Elizabeth Morgan , Paul Dayton
发明人： Katherine W. Ferrara , Karen Elizabeth Morgan , Paul Dayton
IPC分类号： A61B814
CPC分类号： A61B8/4281 , A61B8/06 , G01S7/52036 , G01S15/8952
摘要： In a method of identifying gaseous bubbles in a liquid, an ultrasound contrast agent is introduced into the liquid so as to form gaseous bubbles in the liquid. A first ultrasound pulse centered at a first frequency is directed onto the bubbles so as to cause the bubbles to undergo a first oscillating size change and produce a first oscillating echo signal corresponding thereto. The first oscillating echo signal produced by the bubbles is detected, and the bubbles are identified based upon the detected first echo signal.
摘要翻译：在液体中鉴别气泡的方法中，将超声造影剂引入液体中，以在液体中形成气泡。将以第一频率为中心的第一超声波脉冲引导到气泡上，以使气泡经历第一振荡尺寸变化并产生与其对应的第一振荡回波信号。检测由气泡产生的第一振荡回波信号，并且基于检测到的第一回波信号来识别气泡。

7. 发明授权

US06547731B1 Method for assessing blood flow and apparatus thereof 有权
标题翻译：评估血流的方法及其装置
公开(公告)号：US06547731B1
公开(公告)日：2003-04-15
申请号：US09305593
申请日：1999-05-05
申请人： D. Jackson Coleman , Katherine W. Ferrara , Dustin E. Kruse , Ronald H. Silverman
发明人： D. Jackson Coleman , Katherine W. Ferrara , Dustin E. Kruse , Ronald H. Silverman
IPC分类号： A61B802
CPC分类号： G01S15/8981 , A61B8/06 , A61B8/10 , A61B8/13 , G01S15/8945 , G01S15/8956
摘要： A method for assessing blood flow in a tissue involving directing a beam through the tissue along overlapping lines of sight and then generating the blood flow data from where the ultrasonic beams overlap to evaluate blood flow in the tissue. More specifically, spatially overlapping beams are generated at a fixed temporal intervals. Spatial overlap allows the spatial distance between overlapping lines-of-sight to be ignored, while moving reflectors within any overlapping line-of-sight will cause detectable changes in range of the moving reflector from one line-of-sight to the next. The rate of motion is determined from the measured change in range and the known time interval between vectors. Processing of data includes alignment of data between lines-of-sight to suppress artifactual motion and a wall filter for isolation of flow-data from stationary structures. An apparatus for assessing blood flow includes a transmission system and a storage system. The transmission system generates a beam which is sequentially transmitted towards the tissue along a plurality of overlapping lines of sight and receives echo data from the transmission along each of the lines of sight. The storage system stores the echo data.
摘要翻译：一种用于评估组织中的血液流动的方法，包括将束穿过组织沿着重叠的视线引导，然后产生来自超声波束重叠的血流数据，以评估组织中的血流。更具体地，以固定的时间间隔产生空间重叠的光束。空间重叠允许重叠视线之间的空间距离被忽略，而在任何重叠的视线范围内移动反射器将导致移动反射器的范围从一个视线到下一个的可见变化。运动速率由测量的范围变化和向量之间的已知时间间隔确定。数据处理包括视线间的数据对齐以抑制人为运动，以及用于隔离静态结构的流量数据的壁式过滤器。用于评估血液流量的装置包括传输系统和存储系统。传输系统产生沿着多个重叠视线依次传送到组织的光束，并且沿着每条视线从传输接收回波数据。存储系统存储回波数据。

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