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1. 发明授权

US5770622A Method of preserving materials using 4-methylene-2-amino-cyclopentane-1-carboxylic acids 失效
标题翻译：使用4-亚甲基-2-氨基 - 环戊烷-1-羧酸保存材料的方法
公开(公告)号：US5770622A
公开(公告)日：1998-06-23
申请号：US709073
申请日：1996-09-06
申请人： Joachim Mittendorf , Franz Kunisch , Michael Matzke , Hans-Christian Militzer , Rainer Endermann , Karl Georg Metzger , Klaus-Dieter Bremm , Manfred Plempel
发明人： Joachim Mittendorf , Franz Kunisch , Michael Matzke , Hans-Christian Militzer , Rainer Endermann , Karl Georg Metzger , Klaus-Dieter Bremm , Manfred Plempel
IPC分类号： C07C61/15 , C07C61/20 , C07C61/35 , C07C61/39 , C07C61/40 , C07C69/74 , C07C69/753 , C07C69/757 , C07C229/48 , C07C237/04 , C07C251/42 , C07C271/22 , C07C271/24 , C07C271/34 , C07C271/36 , C07D265/12 , C07D307/93 , A01N37/00
CPC分类号： C07C251/42 , C07C229/48 , C07C237/04 , C07C271/22 , C07C271/24 , C07C271/34 , C07C271/36 , C07C61/15 , C07C61/20 , C07C61/35 , C07C61/39 , C07C61/40 , C07C69/74 , C07C69/753 , C07C69/757 , C07D265/12 , C07D307/93 , C07C2101/08 , C07C2101/10 , C07C2103/18
摘要： The invention relates to cyclopentane- and -pentene-.beta.-amino acids, processes for their preparation and their use as medicaments, and to prevent contamination of materials such as wood and leather.
摘要翻译：本发明涉及环戊烷和戊烯-β-氨基酸，其制备方法及其作为药物的用途，并且防止木材和皮革等材料的污染。

2. 发明授权

US5739339A 7-isoindolinyl-quinolone derivatives and 7-isoindolinyl-naphthyridone derivatives 失效
标题翻译： 7-异吲哚啉基 - 喹诺酮衍生物和7-异吲哚啉基 - 萘啶酮衍生物
公开(公告)号：US5739339A
公开(公告)日：1998-04-14
申请号：US649380
申请日：1996-05-17
申请人： Thomas Philipps , Stephan Bartel , Andreas Krebs , Uwe Petersen , Thomas Schenke , Klaus-Dieter Bremm , Rainer Endermann , Karl Georg Metzger , Burkhard Mielke
发明人： Thomas Philipps , Stephan Bartel , Andreas Krebs , Uwe Petersen , Thomas Schenke , Klaus-Dieter Bremm , Rainer Endermann , Karl Georg Metzger , Burkhard Mielke
IPC分类号： A61K31/435 , A61K31/4035 , A61K31/4375 , A61K31/47 , A61K31/4709 , A61K31/535 , A61K31/5383 , A61K31/54 , A61K31/55 , A61P31/04 , C07D209/44 , C07D215/56 , C07D401/04 , C07D405/04 , C07D405/06 , C07D405/14 , C07D471/04 , C07D471/06 , C07D491/18 , C07D491/20 , C07D495/04 , C07D498/06 , C07D498/08 , C07D513/04 , C07D513/06 , C07D513/16 , C07D519/00
CPC分类号： C07D401/04 , C07D209/44 , C07D471/04 , C07D513/06
摘要： The invention relates to novel quinolone derivatives and naphthyridone derivatives which are substituted in the 7-position by a partially hydrogenated isoindolinyl ring, to processes for their preparation and to antibacterial agents and feed additives containing them.
摘要翻译：本发明涉及通过部分氢化的异吲哚啉基环在7-位被取代的新型喹诺酮衍生物和萘啶酮衍生物，其制备方法以及含有它们的抗菌剂和饲料添加剂。

3. 发明授权

US5723627A Preparation of 7-(3-amino- and 3-amino-methyl-1-pyrrolidinyl)-3-quinolonecarboxylic acids and -naphthridonecarboxylic acids 失效
标题翻译： 7-（3-氨基 - 和3-氨基 - 甲基-1-吡咯烷基）-3-喹诺酮羧酸和萘啶酮羧酸的制备
公开(公告)号：US5723627A
公开(公告)日：1998-03-03
申请号：US803479
申请日：1997-02-20
申请人： Uwe Petersen , Andreas Krebs , Thomas Schenke , Klaus Grohe , Michael Schriewer , Ingo Haller , Karl Georg Metzger , Rainer Endermann , Hans-Joachim Zeiler
发明人： Uwe Petersen , Andreas Krebs , Thomas Schenke , Klaus Grohe , Michael Schriewer , Ingo Haller , Karl Georg Metzger , Rainer Endermann , Hans-Joachim Zeiler
IPC分类号： C07D227/04 , A61K31/397 , A61K31/435 , A61K31/47 , A61P31/00 , C07D205/04 , C07D207/09 , C07D207/14 , C07D227/10 , C07D401/04 , C07D405/12 , C07D471/04 , C07D498/06 , C07D513/06 , C07D211/56
CPC分类号： C07D401/04 , C07D207/14 , C07D471/04 , Y02P20/55
摘要： Process for the preparation of antibacterial compounds of the formula ##STR1## comprises condensing an oxo compound of the formula ##STR2## with an amino compound of the formula ##STR3## to produce a compound of the formula ##STR4## reacting the compound of the formula (III) with a compound of the formula ##STR5## to give a compound of the formula ##STR6## and then eliminating the amino-protective group ##STR7##
摘要翻译：用于制备式（I）的抗菌化合物的方法包括将式IMA的（V）的氧代化合物与式VI的氨基化合物缩合以产生式（III）使式（III）的化合物与式（II）的化合物反应，得到式（IV）的化合物，然后除去氨基保护基

4. 发明授权

US5371090A Naphthyridonecarboxylic acid derivatives 失效
标题翻译：萘啶酮酸衍生物
公开(公告)号：US5371090A
公开(公告)日：1994-12-06
申请号：US199371
申请日：1994-02-18
申请人： Uwe Petersen , Andreas Krebs , Thomas Schenke , Klaus Grohe , Klaus-Dieter Bremm , Rainer Endermann , Karl-Georg Metzger , Hans-Joachim Zeiler
发明人： Uwe Petersen , Andreas Krebs , Thomas Schenke , Klaus Grohe , Klaus-Dieter Bremm , Rainer Endermann , Karl-Georg Metzger , Hans-Joachim Zeiler
IPC分类号： A61K31/435 , A61K31/44 , A61K31/47 , A61K31/535 , A61P31/04 , C07D239/26 , C07D241/12 , C07D471/04 , C07D487/04 , C07D519/00 , C07D471/02
CPC分类号： C07D239/26 , C07D241/12 , C07D471/04 , C07D487/04
摘要： The invention relates to naphthyridonecarboxylic acid derivatives which are substituted in the 7-position by an optionally partially hydrogenated azaisoindolinyl ring, to processes for their preparation, and to antibacterial agents and feed additives containing them.
摘要翻译：本发明涉及通过任选的部分氢化的氮杂吲哚啉基环在7-位上被取代的萘啶酮羧酸衍生物，其制备方法以及含有它们的抗菌剂和饲料添加剂。

5. 发明授权

US5312823A 7-azaisoindolinyl-quinolone-carboxylic acid derivatives 失效
标题翻译： 7-氮杂吲哚啉基 - 喹诺酮 - 羧酸衍生物
公开(公告)号：US5312823A
公开(公告)日：1994-05-17
申请号：US901056
申请日：1992-06-19
申请人： Uwe Petersen , Andreas Krebs , Thomas Schenke , Klaus Grohe , Klaus-Dieter Bremm , Rainer Endermann , Karl-Georg Metzger , Hans-Joachim Zeiler
发明人： Uwe Petersen , Andreas Krebs , Thomas Schenke , Klaus Grohe , Klaus-Dieter Bremm , Rainer Endermann , Karl-Georg Metzger , Hans-Joachim Zeiler
IPC分类号： A61K31/435 , A61K31/44 , A61K31/47 , A61K31/535 , A61P31/04 , C07D239/26 , C07D241/12 , C07D471/04 , C07D487/04 , C07D519/00 , A61K31/55
CPC分类号： C07D239/26 , C07D241/12 , C07D471/04 , C07D487/04
摘要： The invention relates to new quinolonecarboxylic acid derivatives which are substituted in the 7-position by an optionally partially hydrogenated azaisoindolinyl ring, to processes for their preparation, and to antibacterial agents and feed additives containing them.
摘要翻译：本发明涉及通过任选的部分氢化的氮杂吲哚啉基环在7-位上被取代的新的喹诺酮羧酸衍生物，其制备方法以及含有它们的抗菌剂和饲料添加剂。

6. 发明授权

US4199572A N-Substituted amino glycoside compounds, their production, and their use as medicaments 失效
标题翻译： N-取代氨基糖苷化合物，其生产及其作为药物的用途
公开(公告)号：US4199572A
公开(公告)日：1980-04-22
申请号：US881263
申请日：1978-02-24
申请人： Theo Schroder , Karl-Georg Metzger
发明人： Theo Schroder , Karl-Georg Metzger
IPC分类号： A23K20/195 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07H15/234 , C07H15/236 , A61K31/71 , C07H15/22
CPC分类号： C07H15/234
摘要： The invention relates to new derivatives, substituted on one or more nitrogen atoms, of 4,6-di-(amino-glycosyl)-1,3-diamino-cyclitols, which include the gentamycins, sisomicin, verdamycin, tobramycin, the kanamycins, the antibiotics G-418, 66-40 B, 66-40 D, JI-20 B, JI-20 B and G-52, and the 5-epi-, 5-epi-amino-5-deoxy and 5-epi-azido-5-deoxy derivatives of these antibiotics and the metamycins, and furthermore to processes for the preparation of these derivatives and to pharmaceutical compositions which contain the derivatives of the above mentioned 4,6-di-(amino-glycosyl)-1,3-diamino-cyclitols or their pharmaceutically acceptable acid addition salts, and to their use as antibacterial agents.
摘要翻译：本发明涉及由一个或多个氮原子取代的4,6-二 - （氨基 - 糖基）-1,3-二氨基 - 环醇的新衍生物，其包括：万古霉素，西索米星，维尔霉素，妥布霉素，卡那霉素，抗生素G-418,66-40B，66-40D，JI-20B，JI-20B和G-52，以及5表位，5-表氨基-5-脱氧和5-epi - 氨基-5-脱氧衍生物，以及这些衍生物的制备方法，以及含有上述4,6-二（氨基 - 糖基）-1的衍生物的药物组合物， 3-二氨基 - 环状醇或其药学上可接受的酸加成盐，以及它们作为抗菌剂的用途。

7. 发明授权

US4009272A Penicillins 失效
公开(公告)号：US4009272A
公开(公告)日：1977-02-22
申请号：US605742
申请日：1975-08-18
申请人： Hans-Bodo Konig , Wilfried Schrock , Karl-Georg Metzger
发明人： Hans-Bodo Konig , Wilfried Schrock , Karl-Georg Metzger
IPC分类号： C07D499/00 , A61K31/505
CPC分类号： C07D499/00
摘要： Penicillins of the formula ##STR1## or pharmaceutically acceptable non-toxic salts thereof, wherein C* is a carbon atom constituting a center of chirality;A is a moiety of the formula ##STR2## wherein X is ##STR3## Y is ##STR4## WHEREIN Aryl is an aryl moiety; Z is ##STR5## Q.sub.1 is ##STR6## Q.sub.2 is ##STR7## R is straight-chain or branched alkyl of 1 to 5 carbon atoms; R.sub.1 is alkyl of 1 to 10 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, alkenyl of 2 to 10 carbon atoms, cycloalkenyl of 3 to 10 carbon atoms, vinyl, arylvinyl, mono-, di-, or tri-halo-lower alkyl, H.sub.2 N--, R--NH--, (R).sub.2 N--, aryl--NH--, aryl-lower alkylamino, alkoxy of 1 to 8 carbon atoms, aralkoxy of 1 to 8 carbon atoms in the alkoxy portion, cycloalkoxy of 3 to 7 carbon atoms, aryloxy, R--O--V--, R--S--V--, N=C--V--, R--O--CO--V--, H.sub.2 N--CO--V--, R--NH--CO--V--, R--O--CO--NH--, R--SO.sub.2 --NH--, (R).sub.2 N--CO--V--, wherein R is as above defined, ##STR8## provided that when X is --SO.sub.2 --, R.sub.1 is not alkoxy, aralkoxy, cycloalkoxy or aryloxy, and further provided that R.sub.1 can also be hydrogen when X is --CO--;V is a divalent organic radical of 1 to 3 carbon atoms;n is 0, 1 or 2;R.sub.2 and R.sub.3 are the same or different and are each hydrogen, alkyl of 1 to 8 carbon atoms, alkenyl of 2 to 8 carbon atoms, vinyl, allyl, propenyl, cycloalkyl of 3 to 6 carbon atoms, cycloalkenyl of 3 to 6 carbon atoms, mono-, di- or tri-halo lower alkyl or aryl;R.sub.4, r.sub.5 and R.sub.6 are the same or different and are each hydrogen, nitro, cyano, (R).sub.2 N--, (R).sub.2 N--CO--, R--CO--NH--, R--O--CO--, R--CO--O--, R--, R--O--, wherein R is as above defined, H.sub.2 N--SO.sub.2 --, chlorine, bromine, iodine, fluorine, or trifluoromethyl;G is hydrogen or straight or branched chain alkyl of 1 to 5 carbon atoms; andB is a moiety of the formula ##STR9## wherein R.sub.7, R.sub.8 and R.sub.9 are the same or different and are each hydrogen, halogen, nitro, hydroxy, R--, R--O--, R--S--, R--SO--, R--SO.sub.2 --, (R).sub.2 N--, R--CO--NH--, or R--CO--O--, wherein R is as above defined;the arrow in the divalent linking group Q.sub.2 means that the linkage of two atoms by the free valencies of this group must take place as indicated by the arrow;exhibit activity against both Gram-positive and Gram-negative bacteria.This is a division of Ser. No. 502,956, filed Sept. 3, 1974, now U.S. Pat. No. 3,974,142, which in turn is continuation-in-part of our then copending but now abandoned applications Ser. Nos. 299,246 and 300,776, each of which was filed Oct. 20, 1972.

8. 发明授权

US3985879A Antibacterial compositions containing a 4-amino-pyrimido-(4,5,b)-quinoxaline-5,10-dioxide and method of using same 失效
标题翻译：含有4-氨基 - 嘧啶并 - （4,5，b） - 喹喔啉-5,10-二氧化物的抗菌组合物及其使用方法
公开(公告)号：US3985879A
公开(公告)日：1976-10-12
申请号：US511175
申请日：1974-10-02
申请人： Florin Seng , Kurt Ley , Karl Georg Metzger
发明人： Florin Seng , Kurt Ley , Karl Georg Metzger
IPC分类号： A23K1/16 , A61K31/505
CPC分类号： A23K20/116
摘要： 4-amino-pyrimido-(4,5,b)-quinoxaline-5,10-dioxides of the formula: ##SPC1##WhereinR is hydrogen, a straight or branched chain saturated or partially unsaturated substituted or unsubstituted aliphatic moiety or a substituted or unsubstituted cycloaliphatic moiety, are produced by reacting quinoxaline-di-N-oxide of the formula: ##SPC2##With an amine of the general formula R--NH.sub.2, wherein R is as defined, above, in a diluent, at a temperature in the range of 20.degree. to 100.degree. C.These compounds are useful for their antimicrobial activity. They exhibit activity against both gram positive and gram negative bacteria.
摘要翻译： 4-氨基 - 嘧啶并 - （4,5，b） - 喹喔啉-5,10-二氧化物，其结构如下：

9. 发明授权

US3980792A Ureidoacetamido-penicillins 失效
公开(公告)号：US3980792A
公开(公告)日：1976-09-14
申请号：US568477
申请日：1975-04-16
申请人： Hans-Bodo Konig , Wilfried Schrock , Hans Disselnkotter , Karl Georg Metzger
发明人： Hans-Bodo Konig , Wilfried Schrock , Hans Disselnkotter , Karl Georg Metzger
IPC分类号： A61K31/43 , C07C275/60
CPC分类号： C07D499/64 , A61K31/43 , C07C275/60 , C07D499/68
摘要： 6-(.alpha.-3-Acyl-ureidoacetamido)-penicillanic acids and pharmaceutically acceptable non-toxic salts thereof in which the hydrogen atom of the nitrogen atom present in the 3-position is substituted, are effective against Gram-positive and Gram-negative infections, particularly Klebsiella aerobacter infections.

10. 发明授权

US3974142A Penicillins 失效
标题翻译：青霉素
公开(公告)号：US3974142A
公开(公告)日：1976-08-10
申请号：US502956
申请日：1974-09-03
申请人： Hans-Bodo Konig , Wilfried Schrock , Karl-Georg Metzger
发明人： Hans-Bodo Konig , Wilfried Schrock , Karl-Georg Metzger
IPC分类号： C07D233/38 , C07D275/02 , C07D333/34 , C07D499/00 , C07D499/64 , C07D499/46
CPC分类号： C07D275/02 , C07D233/38 , C07D333/34 , C07D499/00
摘要： Arylmethyl- and cyclohexenylmethyl- penicillins, substituted on the .alpha.carbon atom of the side chain by a 2,3-disubstituted imidazolidinylcarbamido or a 2,3-disubstituted imidazolidinylthiocarbamido group, or by the corresponding 2,3-disubstituted 1,3-diazacyclohexylcarbamido or thiocarbamido groups are anti-bacterial agents.
摘要翻译：通过2,3-二取代的咪唑烷基氨基甲酰基或2,3-二取代的咪唑烷基硫代氨基甲酰基取代在侧链的α碳原子上的芳基甲基 - 和环己烯基甲基 - 青霉素，或通过相应的2,3-二取代的1,3-二氮杂环己基氨基甲酰基或硫代氨基甲酰基是抗菌剂。

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