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1. 发明授权

US07530461B2 Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy 有权
公开(公告)号：US07530461B2
公开(公告)日：2009-05-12
申请号：US10818917
申请日：2004-04-05
申请人： Karl E. Gierskcky , Johan Moan , Qian Peng , Harald Steen , Trond Warloe , Alf Bjørseth
发明人： Karl E. Gierskcky , Johan Moan , Qian Peng , Harald Steen , Trond Warloe , Alf Bjørseth
IPC分类号： B65D69/00 , A61K31/22 , C07C229/00
CPC分类号： A61K41/0061 , A61K49/0021 , C07C229/22
摘要： The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2-CH2CO—OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R2 represents a hydrogen atom or a group R1, and both R2 groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.

2. 发明授权

US07850008B2 Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy 有权
标题翻译： 5-氨基乙酰丙酸的酯类作为光化学疗法中的光敏剂
公开(公告)号：US07850008B2
公开(公告)日：2010-12-14
申请号：US12437444
申请日：2009-05-07
申请人： Karl E. Gierskcky , Johan Moan , Qian Peng , Harald Steen , Trond Warloe , Alf Bjørseth
发明人： Karl E. Gierskcky , Johan Moan , Qian Peng , Harald Steen , Trond Warloe , Alf Bjørseth
IPC分类号： B65D69/00 , A61K31/22 , C07C229/00
CPC分类号： A61K41/0061 , A61K49/0021 , C07C229/22
摘要： The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2-CH2CO—OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R2 represents a hydrogen atom or a group R1, and both R2 groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.
摘要翻译：本发明涉及作为5-氨基乙酰丙酸的酯或其药学上可接受的盐的化合物，包括式（I）R 22 N-CH 2 COCH 2 -CH 2 CO-OR 1的化合物（其中R 1可以表示任选被羟基，烷氧基，酰氧基，烷氧基羰基氧基，氨基，芳基，氧代或氟基团，并且任选地被氧，氮，硫或磷原子间隔;并且R 2表示氢原子或基团R 1，并且两个R 2基团可以相同或不同），以及它们在诊断和身体的外表面或内表面的紊乱或异常的光化学疗法，以及用于实施本发明的产品和试剂盒。

3. 发明授权

US6034267A Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy 失效
标题翻译： 5-氨基乙酰丙酸的酯类作为光化学疗法中的光敏剂
公开(公告)号：US6034267A
公开(公告)日：2000-03-07
申请号：US913257
申请日：1997-12-05
申请人： Karl E. Gierskcky , Johan Moan , Qian Peng , Harald Steen , Trond Warloe , Alf Bjorseth
发明人： Karl E. Gierskcky , Johan Moan , Qian Peng , Harald Steen , Trond Warloe , Alf Bjorseth
IPC分类号： G01N33/50 , A61K31/215 , A61K41/00 , A61K49/00 , A61P35/00 , C07C227/18 , C07C229/22 , G01N33/15 , G01N33/58 , C07C229/00 , A61K31/195
CPC分类号： A61K49/0021 , A61K41/0061 , A61K49/0017 , C07C229/22 , Y10T436/145555
摘要： The invention provides a pharmaceutical compositions comprising a compound of formula I:R.sub.2.sup.2 N--CH.sub.2 COCH.sub.2 --CH.sub.2 CO--OR.sup.1(I)wherein, R.sup.1 and R.sup.2 have any of the values defined in the specification; or a salt thereof; and a pharmaceutically acceptable carrier or excipient. The invention also provides a method for the diagnosis or photochemotherapeutic treatment of disorders or abnormalities of external or internal surfaces of the body using such compounds or salts.
摘要翻译： PCT No.PCT / GB96 / 00553 Sec。 371 1997年12月5日第 102（e）日期1997年12月5日PCT 1996年3月8日PCT公布。 WO96 / 28412 PCT出版物日本1996年9月19日本发明提供包含式I化合物：R 22 N-CH 2 COCH 2 -CH 2 CO-OR 1（I）的药物组合物，其中R1和R2具有说明书中定义的任何值; 或其盐; 和药学上可接受的载体或赋形剂。本发明还提供了一种用于使用这些化合物或盐对身体的外表面或内表面的病症或异常进行诊断或光化学治疗性治疗的方法。

4. 发明授权

US07335684B2 Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy 有权
标题翻译： 5-氨基乙酰丙酸的酯类作为光化学疗法中的光敏剂
公开(公告)号：US07335684B2
公开(公告)日：2008-02-26
申请号：US11290275
申请日：2005-11-29
申请人： Karl E. Gierskcky , Johan Moan , Qian Peng , Harald Steen , Trond Warloe , Alf Bjorseth
发明人： Karl E. Gierskcky , Johan Moan , Qian Peng , Harald Steen , Trond Warloe , Alf Bjorseth
IPC分类号： A61K31/22 , C07C229/00
CPC分类号： A61K49/0021 , A61K31/22 , A61K41/0061 , C07C229/22 , Y10S514/863 , Y10S514/947
摘要： The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2-CH2CO—OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R2 represents a hydrogen atom or a group R1, and both R2 groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.
摘要翻译：本发明涉及作为5-氨基乙酰丙酸的酯或其药学上可接受的盐的化合物，包括式（I）R 22 N-CH 2 COCH 2 -CH 2 CO-OR 1的化合物（其中R 1可以表示任选被羟基，烷氧基，酰氧基，烷氧基羰基氧基，氨基，芳基，氧代或氟基团，并且任选地被氧，氮，硫或磷原子间隔;并且R 2表示氢原子或基团R 1，并且两个R 2基团可以相同或不同），以及它们在诊断和身体的外表面或内表面的紊乱或异常的光化学疗法，以及用于实施本发明的产品和试剂盒。

5. 发明授权

US07287646B2 Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy 有权
标题翻译： 5-氨基乙酰丙酸的酯及其在光化学疗法中作为光敏化合物的用途
公开(公告)号：US07287646B2
公开(公告)日：2007-10-30
申请号：US10966408
申请日：2004-10-14
申请人： Karl E Gierskcky , Johan Moan , Qian Peng , Harald Steen , Trond Warloe , Alf Bjorseth , Jo Klaveness , Nils Nilsen , Jon Erik Braenden , Aslak Godal
发明人： Karl E Gierskcky , Johan Moan , Qian Peng , Harald Steen , Trond Warloe , Alf Bjorseth , Jo Klaveness , Nils Nilsen , Jon Erik Braenden , Aslak Godal
IPC分类号： B65D69/00 , A61K31/22 , C07C69/66
CPC分类号： C07C229/22 , A61K41/0061 , A61K49/0021 , A61K49/0052
摘要： The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2—CH2CO—OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R2 represents a hydrogen atom or a group R1, and both R2 groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.
摘要翻译：本发明涉及作为5-氨基乙酰丙酸的酯或其药学上可接受的盐的化合物，包括式（I）的化合物R 2 N 2 CH 2 其中R 1可以表示任选取代的烷基，其中R 1表示任选被取代的烷基，羟基，烷氧基，酰氧基，烷氧基羰基氧基，氨基，芳基，氧代或氟基团，且任选被氧，氮，硫或磷原子间隔; R 2表示氢原子或基团R > 1 ，并且两个R 2个基团可以相同或不同），以及它们在诊断和光化学治疗身体的外部或内部表面的障碍或异常中的用途，以及产品和用于执行本发明的试剂盒。

6. 发明授权

US06492420B2 Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy 失效
标题翻译： 5-氨基乙酰丙酸的酯类作为光化学疗法中的光敏剂
公开(公告)号：US06492420B2
公开(公告)日：2002-12-10
申请号：US09471620
申请日：1999-12-21
申请人： Karl E. Gierskcky , Johan Moan , Qian Peng , Harald Steen , Trond Warloe , Alf Bjorseth
发明人： Karl E. Gierskcky , Johan Moan , Qian Peng , Harald Steen , Trond Warloe , Alf Bjorseth
IPC分类号： A61K3744
CPC分类号： A61K49/0021 , A61K31/22 , A61K41/0061 , C07C229/22 , Y10S514/863 , Y10S514/947
摘要： The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2—CH2CO—OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R2 represents a hydrogen atom or a group R1, and both R2 groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.
摘要翻译：本发明涉及作为5-氨基乙酰丙酸的酯或其药学上可接受的盐的化合物，包括式（I）R 22 N-CH 2 COCH 2 -CH 2 CO-OR 1的化合物（其中R 1可以表示任选被羟基，烷氧基，酰氧基，烷氧基羰基氧基，氨基，芳基，氧代或氟基团，并且任选地被氧，氮，硫或磷原子间隔;并且R 2表示氢原子或基团R 1，并且两个R 2基团可以相同或不同），以及它们在诊断和身体的外表面或内表面的紊乱或异常的光化学疗法，以及用于实施本发明的产品和试剂盒。

7. 发明申请

US20090280061A1 ESTERS OF 5-AMINOLEVULINIC ACID AS PHOTOSENSITIZING AGENTS IN PHOTOCHEMOTHERAPY 有权
标题翻译： 5-氨基酸在光化学疗法中作为光敏剂使用
公开(公告)号：US20090280061A1
公开(公告)日：2009-11-12
申请号：US12437444
申请日：2009-05-07
申请人： Karl E. GIERSKCKY , Johan MOAN , Qian PENG , Harald STEEN , Trond WARLOE , Alf BJORSETH
发明人： Karl E. GIERSKCKY , Johan MOAN , Qian PENG , Harald STEEN , Trond WARLOE , Alf BJORSETH
IPC分类号： A61K49/00 , A61K31/195 , A61P35/00
CPC分类号： A61K41/0061 , A61K49/0021 , C07C229/22
摘要： The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2-CH2CO—OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R2 represents a hydrogen atom or a group R1, and both R2 groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.
摘要翻译：本发明涉及作为5-氨基乙酰丙酸的酯或其药学上可接受的盐的化合物，包括式（I）R 22 N-CH 2 COCH 2 -CH 2 CO-OR 1的化合物（其中R 1可以表示任选被羟基，烷氧基，酰氧基，烷氧基羰基氧基，氨基，芳基，氧代或氟基团，并且任选地被氧，氮，硫或磷原子间隔;并且R 2表示氢原子或基团R 1，并且两个R 2基团可以相同或不同），以及它们在诊断和身体的外表面或内表面的紊乱或异常的光化学疗法，以及用于实施本发明的产品和试剂盒。

8. 发明授权

US06992107B1 Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy 失效
公开(公告)号：US06992107B1
公开(公告)日：2006-01-31
申请号：US09655570
申请日：2000-09-06
申请人： Karl E. Gierskcky , Johan Moan , Qian Peng , Harald Steen , Trond Warloe , Alf Bjorseth
发明人： Karl E. Gierskcky , Johan Moan , Qian Peng , Harald Steen , Trond Warloe , Alf Bjorseth
IPC分类号： A61K31/22 , A61K31/21 , C07C229/00 , B65D71/00
CPC分类号： C07C229/22 , A61K41/0061 , A61K49/0021 , A61K49/0052
摘要： The present invention provides a compound of formula I; R22N—CH2COCH2—CH2CO—OR1 (I) wherein R1 represents (a) an optionally substituted branched C6-30 alkyl group, comprising a straight chain C4-29 alkyl group, branched by substitution with one or more C1-6 alkyl groups, wherein said site of substitution is at C2 or a higher C atom, (b) a non-heteroaromatic aryl substituted alkyl group, wherein said aryl group is substituted, or (c) an alkoxy substituted alkyl group, wherein said alkoxy group is substituted by a methoxy group or an alkoxy group substituted with an alkoxy group, wherein in (a) and (b) said substituents are selected from hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, nitro, oxo or fluoro groups, and said alkyl group is optionally interrupted or terminated by one or more —O—, NR3—, —S— or PR3— groups; R2, each of which may be the same or different, represents a hydrogen atom or a group R1, wherein R1 represents (a) an optionally substituted branched C5-30 alkyl group, comprising a straight chain C4-29 alkyl group, branched by substitution with one or more C1-6 alkyl groups, wherein said site of substitution is at C2 or a higher C atom, (b) a non-heteroaromatic aryl substituted alkyl group, wherein said aryl group is substituted, or (c) an alkoxy substituted alkyl group, wherein said alkoxy group is substituted by a methoxy group or an alkoxy group substituted with an alkoxy group, wherein in (a) and (b) said substituents are selected from hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, nitro, oxo or fluoro groups, and said alkyl group is optionally interrupted or terminated by one or more —O—, NR3—, —S— or PR3— groups; and R3 represents a hydrogen or C1-6 alkyl group, and salts thereof for use in photochemotherapy or diagnosis. Pharmaceutical compositions comprising said compound, methods of diagnosis or photochemotherapy using said compound and related compounds and compositions, and products and kits comprising said compounds are also provided.

9. 发明授权

US08410172B2 Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy 失效
标题翻译： 5-氨基乙酰丙酸的酯类作为光化学疗法中的光敏剂
公开(公告)号：US08410172B2
公开(公告)日：2013-04-02
申请号：US12961420
申请日：2010-12-06
申请人： Karl E. Gierskcky , Johan Moan , Qian Peng , Harald Steen , Trond Warloe , Alf Bjørseth
发明人： Karl E. Gierskcky , Johan Moan , Qian Peng , Harald Steen , Trond Warloe , Alf Bjørseth
IPC分类号： A61K31/22 , C07C229/00
CPC分类号： A61K41/0061 , A61K49/0021 , C07C229/22
摘要： The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2—CH2CO—OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R2 represents a hydrogen atom or a group R1, and both R2 groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.
摘要翻译：本发明涉及作为5-氨基乙酰丙酸的酯或其药学上可接受的盐的化合物，包括式（I）R 22 N-CH 2 COCH 2 -CH 2 CO-OR 1的化合物（其中R 1可以表示任选被羟基，烷氧基，酰氧基，烷氧基羰基氧基，氨基，芳基，氧代或氟基团，并且任选地被氧，氮，硫或磷原子间隔;并且R 2表示氢原子或基团R 1，并且两个R 2基团可以相同或不同），以及它们在诊断和身体的外表面或内表面的紊乱或异常的光化学疗法，以及用于实施本发明的产品和试剂盒。

10. 发明申请

US20110086915A1 Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy 失效
标题翻译： 5-氨基乙酰丙酸的酯类作为光化学疗法中的光敏剂
公开(公告)号：US20110086915A1
公开(公告)日：2011-04-14
申请号：US12961420
申请日：2010-12-06
申请人： Karl E. GIERSKCKY , Johan Moan , Qian Peng , Harald Steen , Trond Warloe , Alf Bjørseth
发明人： Karl E. GIERSKCKY , Johan Moan , Qian Peng , Harald Steen , Trond Warloe , Alf Bjørseth
IPC分类号： A61K31/22 , C07C229/24 , A61P31/00 , A61P35/00 , A61P15/02
CPC分类号： A61K41/0061 , A61K49/0021 , C07C229/22
摘要： The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2—CH2CO—OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R2 represents a hydrogen atom or a group R1, and both R2 groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.
摘要翻译：本发明涉及作为5-氨基乙酰丙酸的酯或其药学上可接受的盐的化合物，包括式（I）R 22 N-CH 2 COCH 2 -CH 2 CO-OR 1的化合物（其中R 1可以表示任选被羟基，烷氧基，酰氧基，烷氧基羰基氧基，氨基，芳基，氧代或氟基团，并且任选地被氧，氮，硫或磷原子间隔;并且R 2表示氢原子或基团R 1，并且两个R 2基团可以相同或不同），以及它们在诊断和身体的外表面或内表面的紊乱或异常的光化学疗法，以及用于实施本发明的产品和试剂盒。

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