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1. 发明授权

US5694196A Experimental instrument for examining permeability of a flowing cornea and an experimental unit using said experimental instrument 失效
标题翻译：用于检查流动角膜的渗透性和使用所述实验仪器的实验单元的实验仪器
公开(公告)号：US5694196A
公开(公告)日：1997-12-02
申请号：US408024
申请日：1995-03-21
申请人： Yoshiaki Hirai , Kakuji Tojo
发明人： Yoshiaki Hirai , Kakuji Tojo
IPC分类号： G01N13/04 , B01F13/08 , G01N13/00 , G01N15/08 , A61B3/00 , F04B17/00
CPC分类号： G01N13/00 , B01F13/0818
摘要： An experimental instrument for examining permeability of a flowing cornea is used for imitating a lacrimal layer in the front part of a cornea or the back part of the cornea (an aqueous humor) by means of storing a various kinds of solutions comprises a cell body including a stirring part of a cylindrical wall and a bottom surface at a bottom part thereof, a constant temperature tank which surrounds the cell body all around a sample membrane setting part which is protrusively arranged at an outer surface of the call body and can set a sample membrane such as a contact lens used as a cornea or a corneal model, an outflow tube which is protrusively arranged at an outer surface of the stirring part and makes a solution in the cell body discharge, an inflow tube which is protrusively arranged at an upper part of the cell body and makes the solution flow inside of the cell body, a magnet rotator which is arranged inside the stirring part of the cell body, and a magnet stirrer which makes the magnet rotator inside the cell body rotate by means of magnetic force.
摘要翻译：用于检查流动角膜的渗透性的实验仪器用于通过存储各种溶液来模拟角膜前部或角膜后部（房水）中的泪液层，其包括细胞体，包括一个圆筒壁的搅拌部分和一个底部的底面，一个恒温罐，围绕一个试样膜设置部分围绕着电池体，该样品膜设置部分突出地布置在呼叫体的外表面，并可以设置样品诸如用作角膜或角膜模型的隐形眼镜的膜，突出地布置在搅拌部分的外表面并使细胞体排出的溶液的流出管，突出地布置在上部的流入管电池体的一部分，使溶液流入电池体内部，配置在电池体的搅拌部内的磁铁旋转体，使磁铁搅拌器电池体内的磁铁旋转体通过磁力旋转。

2. 发明授权

US5866141A Patch preparations for treating plants 失效
标题翻译：用于处理植物的补片制剂
公开(公告)号：US5866141A
公开(公告)日：1999-02-02
申请号：US610789
申请日：1996-03-11
申请人： Kakuji Tojo , Yuzuru Wada , Yuichi Otsu , Kunihiro Isono , Shinzaburo Sone , Katsuhiko Hanaki
发明人： Kakuji Tojo , Yuzuru Wada , Yuichi Otsu , Kunihiro Isono , Shinzaburo Sone , Katsuhiko Hanaki
IPC分类号： A01G7/06 , A01M1/20 , A01M7/00 , A01N25/34 , A01N43/40 , A61K9/70
CPC分类号： A01N25/34
摘要： The following invention introduces a patch preparation for treating plants, whereas the patch preparations comprise a chemical layer composed of at least one agrochemically active compound, at least one adhesive and optionally, one or more additives. The components are dispersed in a matrix state on a substrate which are then introduced on the roots of the plant to be treated.
摘要翻译：以下发明引入了用于处理植物的贴片制剂，而贴片制剂包括由至少一种农业化学活性化合物，至少一种粘合剂和任选的一种或多种添加剂组成的化学层。组分以基质状分散在基质上，然后将其引入待处理植物的根部。

3. 发明授权

US5599175A Micro flow controlling pump 失效
标题翻译：微流量控制泵
公开(公告)号：US5599175A
公开(公告)日：1997-02-04
申请号：US352379
申请日：1994-12-08
申请人： Kakuji Tojo , Yoshiaki Hirai
发明人： Kakuji Tojo , Yoshiaki Hirai
IPC分类号： F04B35/00 , F04D13/02 , F04D29/22 , F04B17/00
CPC分类号： F04D29/2211 , F04D13/024
摘要： A micro-flow controlling pump according to the present invention is used for controlling a micro-flow of a liquid in an experiment using a chemical agent for examining permeability of a membrane, reaction of a flow system, reflux of vital tissues, or the like. The micro-flow controlling pump includes: a pump body formed to have a cylindrical wall and a bottom surface, and be provided with an outflow tube formed at an outer surface of the cylindrical wall; a cover body formed to be detachably attached to the pump body and be provided with an inflow tube; a magnet rotator arranged inside the pulp body having criss-crossing blade parts; and a magnet stirrer arranged outside the pump body, having magnetic force by which the magnet rotator in the pump body can be rotated.
摘要翻译：根据本发明的微流量控制泵用于使用用于检查膜的渗透性，流动系统的反应，重要组织的回流等的化学试剂来控制液体的微流量。微流控制泵包括：形成为具有圆筒壁和底面的泵体，并且在该圆筒壁的外表面上设置有流出管; 盖体，其形成为可拆卸地附接到所述泵体并设置有流入管; 布置在纸浆本体内的具有十字交叉叶片部分的磁体旋转器; 以及设置在泵体外部的磁力搅拌器，其具有通过该磁力使得泵体中的磁体旋转体能够旋转的磁力。

4. 发明申请

US20100160293A1 Solid Ophthalmic Drug for External Use 审中-公开
标题翻译：固体眼用药物用于外用
公开(公告)号：US20100160293A1
公开(公告)日：2010-06-24
申请号：US11884392
申请日：2006-02-10
申请人： Kakuji Tojo , Chiharu Kimura
发明人： Kakuji Tojo , Chiharu Kimura
IPC分类号： A61K31/55 , A61K31/4535 , A61K31/195 , A61K31/4178 , A61K31/335 , A61P27/02 , C07D409/08 , C07C63/00 , C07D405/06 , C07D313/10 , C07D223/14
CPC分类号： A61K9/0048 , A61K9/0014 , A61K9/06 , A61K47/06 , A61K47/14 , A61K47/44
摘要： An ophthalmic solid pharmaceutical preparation for external use is disclosed which can be used to continuously administer with ease a pharmacologically active agent to ocular local tissues. The pharmaceutical preparation is a solid pharmaceutical preparation containing a pharmacologically active ingredient in a base, which may comprise an oily base, and designed to be applied by being rubbed on the surface of the skin including the surface of either of the eyelids to deliver, through the skin of the eyelids, the pharmacologically active ingredient to the local tissues of the eye located on the backside of the eyelids.
摘要翻译：公开了一种用于外用的眼用固体药物制剂，其可用于向眼部局部组织容易地连续施用药理活性剂。药物制剂是在基质中含有药理活性成分的固体药物制剂，其可以包含油性基质，并且被设计为通过在皮肤表面上包括其中任何一种眼皮的表面进行摩擦来施用，以通过眼皮的皮肤，药物活性成分到位于眼睑背面的眼睛的局部组织。

5. 发明授权

US4690683A Transdermal varapamil delivery device 失效
标题翻译：透皮诺帕米尔输送装置
公开(公告)号：US4690683A
公开(公告)日：1987-09-01
申请号：US751126
申请日：1985-07-02
申请人： Yie W. Chien , Kakuji Tojo
发明人： Yie W. Chien , Kakuji Tojo
IPC分类号： A61K9/00 , A61K9/70 , A61K31/275
CPC分类号： A61K9/7069 , A61K31/275 , A61K9/7084
摘要： A transdermal drug delivery device for administering 5-[(3,4-dimethoxyphenethyl) methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile comprising a permeable matrix of silicone elastomer or other bioacceptable lipophilic polymer material having an effective cardiovascular affecting amount of active drug and an effective drug release promoting amount of a transport enhancing agent dispersed therein. The back of the matrix is covered with an occlusive backing and the face of the matrix is covered with a biocompatible adhesive such as a silicone adhesive also having a transport enhancing agent dispersed therein. A supply of skin permeation enhancing agent may be provided adjacent the adhesive layer such that the skin of a patient to whom the device is applied is pretreated with permeation enhancing agent. Particularly preferred skin permeation and transport enhancing agents include N,N-diethyl-m-toluamide, isopropyl myristate and similar compounds.
摘要翻译：一种用于施用5 - [（3,4-二甲氧基苯乙基）甲基氨基] -2-（3,4-二甲氧基苯基）-2-异丙基戊腈的透皮药物递送装置，其包含有机硅弹性体的可渗透基质或其它具有有效心血管的生物可接受的亲脂性聚合物材料影响分散在其中的活性药物的量和有效的药物释放促进量的运输增强剂。基质的背面被闭塞背衬覆盖，并且基质的表面覆盖有生物相容性粘合剂，例如分散有运输增强剂的硅氧烷粘合剂。可以在粘合剂层附近提供皮肤渗透增强剂的供应，使得施用该装置的患者的皮肤用渗透增强剂预处理。特别优选的皮肤渗透和运输增强剂包括N，N-二乙基 - 间甲苯甲酰胺，肉豆蔻酸异丙酯和类似化合物。

6. 发明授权

US07850993B2 Drug-releasing system of biodegradable polymer type 有权
标题翻译：可生物降解聚合物类型的药物释放系统
公开(公告)号：US07850993B2
公开(公告)日：2010-12-14
申请号：US10468585
申请日：2002-02-21
申请人： Kakuji Tojo , Yoshiko Fujikawa
发明人： Kakuji Tojo , Yoshiko Fujikawa
IPC分类号： A61K9/14
CPC分类号： A61K47/34 , A61K9/0024 , A61K9/204 , A61K9/2095
摘要： A method for producing compression-melt molded product using polylactic acid powder is described. The method comprises the steps of: 1) heat-melting polylactic acid having a weight-average molecular weight of 3,000-40,000 at 140-220° C., 2) allowing the melted polylactic acid to cool down to solidify at an ordinary or a lower temperature, 3) pulverizing the solidified polylactic acid at an ordinary temperature into powder, and 4) compressing the powder or a mixture powder prepared by addition of another ingredient, e.g., a biologically active compound, to the carrier powder in a mold at an ordinary temperature to cause the polylactic acid to melt into a molded product of a predetermined shape.
摘要翻译：描述了使用聚乳酸粉末制造压缩 - 熔融模制产品的方法。该方法包括以下步骤：1）在140-220℃下将重均分子量为3,000-40,000的聚乳酸加热熔融，2）使熔融的聚乳酸冷却至常压或 3）将常温下固化的聚乳酸粉碎成粉末，4）将粉末或将其它成分例如生物活性化合物加入制备的混合粉末压制成模具中的载体粉末常温使聚乳酸熔化成预定形状的成型体。

7. 发明授权

US07052714B1 Ophthalmic adhesive preparations for percutaneous adsorption 有权
标题翻译：用于经皮吸附的眼用粘合剂
公开(公告)号：US07052714B1
公开(公告)日：2006-05-30
申请号：US10089431
申请日：2000-09-29
申请人： Kakuji Tojo , Akiharu Isowaki
发明人： Kakuji Tojo , Akiharu Isowaki
IPC分类号： A61K9/20 , A61K13/00
CPC分类号： A61K31/573 , A61K9/0048 , A61K9/0051 , A61K9/7053 , A61K9/7061 , A61K9/7069 , A61K31/18
摘要： Ophthalmic adhesive preparations for percutaneous absorption to be used in treating diseases in the posterior parts of eye characterized by having a drug-containing layer which contains a drug to be delivered to the posterior parts of eye including the crystalline lens, the vitreous body, the uvea and the retina, together with a percutaneous sorbefacient comprising polyoxyethylene oleyl ether and/or isopropyl myristate uniformly dispersed in a base matrix.
摘要翻译：用于经皮吸收的用于治疗眼后部疾病的眼用粘合剂制剂，其特征在于具有药物含有层，其含有待递送至眼后部的药物，包括晶状体，玻璃体，葡萄膜和视网膜，以及包含均匀分散在基质中的聚氧乙烯油基醚和/或肉豆蔻酸异丙酯的经皮吸收剂。

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