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1. 发明授权

US09436088B2 Un-supported polymeric film with embedded microbeads 有权
标题翻译：具有嵌入微珠的未负载的聚合物膜
公开(公告)号：US09436088B2
公开(公告)日：2016-09-06
申请号：US11761789
申请日：2007-06-12
申请人： Michael Seul , Sukanta Banerjee , Kairali Podual , Ye Hong
发明人： Michael Seul , Sukanta Banerjee , Kairali Podual , Ye Hong
IPC分类号： G01N33/553 , G03F7/16 , G03F7/004
CPC分类号： C08J3/075 , C08J3/28 , C08J2333/26 , C08J2425/06 , C12Q1/6837 , G01N33/5005 , G01N33/545 , G03F7/0047 , G03F7/164 , Y10T428/249952 , Y10T428/25
摘要： The present invention relates to polymer-bead composites having a single layer planar, crystalline assembly of encoded beads embedded in a hydrophilic polymeric matrix. The composite may be unattached to a solid support. The encoded beads have different biomolecules attached to their surfaces, and the encoding permits distinguishing beads having different biomolecules attached thereto. The present invention also relates to a systematic process for the creation of functionally organized, spatially patterned assemblies of polymer-microparticle composites, including the AC electric field-mediated assembly of patterned, self-supporting organic (polymeric) films and organic-polymer-microparticle composites of tailored composition and morphology. The present invention also relates to the application of such functional assemblies in materials science and biology. Additional areas of application include sensors, catalysts, membranes, and micro-reactors, and miniaturized format for generation of multifunctional thin films.
摘要翻译：本发明涉及具有嵌入亲水性聚合物基质中的编码珠粒的单层平面结晶组合物的聚合物 - 珠复合物。复合材料可能不附着在固体支撑物上。编码的珠粒具有连接到其表面的不同生物分子，并且编码允许区分附着有不同生物分子的珠粒。本发明还涉及一种用于创建聚合物 - 微粒复合材料的功能组织的空间图案化组件的系统方法，包括图案化的自支撑有机（聚合物）膜和有机 - 聚合物 - 微粒的AC电场介导装配定制组合和形态的复合材料。本发明还涉及这种功能组件在材料科学和生物学中的应用。其他应用领域包括传感器，催化剂，膜和微反应器以及用于产生多功能薄膜的小型化形式。

2. 发明申请

US20060068447A1 Directed assembly of functional heterostructures 失效
标题翻译：定向组装功能异质结构
公开(公告)号：US20060068447A1
公开(公告)日：2006-03-30
申请号：US11253452
申请日：2005-10-19
申请人： Sukanta Banerjee , Kairali Podual , Michael Seul
发明人： Sukanta Banerjee , Kairali Podual , Michael Seul
IPC分类号： G01N33/567 , G01N33/53 , B05D3/00
CPC分类号： C08J3/075 , C08J3/28 , C08J2333/26 , C08J2425/06 , C12Q1/6837 , G01N33/5005 , G01N33/545 , G03F7/0047 , G03F7/164 , Y10T428/249952 , Y10T428/25
摘要： The present invention relates to a systematic process for the creation of functionally organized, spatially patterned assemblies polymer-microparticle composites including the AC electric field-mediated assembly of patterned, self supporting organic (polymeric) films and organic (polymeric)-microparticle composite films of tailored composition and morphology; the present invention further relates to the incorporation of said assemblies into other structures. The present invention. also relates to the application of such functional assemblies in materials science and biology. Additional areas of application include sensors, catalysts, membranes, micro-reactors, smart materials. Miniaturized format for generation of multifunctional thin films. Provides a simple set-up to synthesize thin films of tailored composition and morphology.
摘要翻译：本发明涉及一种用于产生功能组织的空间图案化聚合物 - 聚合物 - 微粒复合材料的系统方法，其包括图案化的自支撑有机（聚合物）膜和有机（聚合） - 微粒复合膜的交流电场介导组装定制组合和形态; 本发明还涉及将所述组件结合到其它结构中。本发明。还涉及这种功能组件在材料科学和生物学中的应用。其他应用领域包括传感器，催化剂，膜，微反应器，智能材料。用于生成多功能薄膜的小型化格式。提供简单的设置来合成定制组合和形态的薄膜。

3. 发明授权

US07892854B2 Multianalyte molecular analysis using application-specific random particle arrays 有权
标题翻译：使用应用特异性随机粒子阵列进行多分析分析
公开(公告)号：US07892854B2
公开(公告)日：2011-02-22
申请号：US10204799
申请日：2001-06-21
申请人： Sukanta Banerjee , Michael Seul , Alice X. Li , Kairali Podual , Chiu W. Chau
发明人： Sukanta Banerjee , Michael Seul , Alice X. Li , Kairali Podual , Chiu W. Chau
IPC分类号： G01N33/553 , C12Q1/68
CPC分类号： C12Q1/6813 , B01J19/0046 , B01J2219/00286 , B01J2219/00315 , B01J2219/00497 , B01J2219/005 , B01J2219/00527 , B01J2219/00545 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00644 , B01J2219/00648 , B01J2219/00653 , B01J2219/00722 , B01J2219/00725 , C12Q1/6837 , C12Q1/6876 , G01N27/745 , G01N33/5434 , G01N33/54346 , G01N33/587 , G01N2035/00564 , G01N2035/00762 , G01N2446/20 , G01N2446/64 , Y10T436/11 , C12Q2565/513 , C12Q2563/143 , C12Q2563/107 , C12Q2563/155
摘要： The present invention provides methods and apparatus for the application of a particle array in bioassay format to perform qualitative and/or quantitative molecular interaction analysis between two classes of molecules (an analyte and a binding agent). The methods and apparatus disclosed herein permit the determination of the presence or absence of association, the strength of association, and/or the rate of association and dissociation governing the binding interactions between the binding agents and the analyte molecules. The present invention is especially useful for performing multiplexed (parallel) assays for qualitative and/or quantitative analysis of binding interactions of a number of analyte molecules in a sample.
摘要翻译：本发明提供了用于以生物测定形式应用颗粒阵列以在两类分子（分析物和结合剂）之间进行定性和/或定量分子相互作用分析的方法和装置。本文公开的方法和装置允许确定结合剂和分析物分子之间的结合相互作用的存在或不存在，缔合的强度，和/或缔合速率和解离速率。本发明特别可用于进行多个（并行）测定以定性和/或定量分析样品中许多分析物分子的结合相互作用。

4. 发明授权

US07262063B2 Directed assembly of functional heterostructures 有权
标题翻译：定向组装功能异质结构
公开(公告)号：US07262063B2
公开(公告)日：2007-08-28
申请号：US10034727
申请日：2001-12-26
申请人： Sukanta Banerjee , Kairali Podual , Michael Seul
发明人： Sukanta Banerjee , Kairali Podual , Michael Seul
IPC分类号： G01N33/551
CPC分类号： C08J3/075 , C08J3/28 , C08J2333/26 , C08J2425/06 , C12Q1/6837 , G01N33/5005 , G01N33/545 , G03F7/0047 , G03F7/164 , Y10T428/249952 , Y10T428/25
摘要： The present invention relates to a systematic process for the creation of functionally organized, spatially patterned assemblies polymer-microparticle composites including the AC electric field-mediated assembly of patterned, self supporting organic (polymeric) films and organic (polymeric)—microparticle composite films of tailored composition and morphology; the present invention further relates to the incorporation of said assemblies into other structures. The present invention. also relates to the application of such functional assemblies in materials science and biology. Additional areas of application include sensors, catalysts, membranes, micro-reactors, smart materials. Miniaturized format for generation of multifunctional thin films. Provides a simple set-up to synthesize thin films of tailored composition and morphology:
摘要翻译：本发明涉及一种用于产生功能组织的空间图案化聚合物 - 聚合物 - 微粒复合材料的系统方法，其包括图案化的自支撑有机（聚合物）膜和有机（聚合） - 微粒复合膜的交流电场介导组装定制组合和形态; 本发明还涉及将所述组件结合到其它结构中。本发明。还涉及这种功能组件在材料科学和生物学中的应用。其他应用领域包括传感器，催化剂，膜，微反应器，智能材料。用于生成多功能薄膜的小型化格式。提供简单的设置来合成定制组合和形态的薄膜：

5. 发明申请

US20050277128A1 Looped probe design to control hybridization stringency 审中-公开
标题翻译：环路探针设计，以控制杂交严格性
公开(公告)号：US20050277128A1
公开(公告)日：2005-12-15
申请号：US11018545
申请日：2004-12-21
申请人： Sukanta Banerjee , Michael Seul , Alice Li , Kairali Podual , Chiu Chau , Zhi Li
发明人： Sukanta Banerjee , Michael Seul , Alice Li , Kairali Podual , Chiu Chau , Zhi Li
IPC分类号： G01N21/64 , B01J19/00 , C12M1/34 , C12Q1/68 , C12Q1/6837 , G01N33/53 , G01N33/543 , G01N33/553 , G01N33/58 , G01N35/00
CPC分类号： C12Q1/6813 , B01J19/0046 , B01J2219/00286 , B01J2219/00315 , B01J2219/00497 , B01J2219/005 , B01J2219/00527 , B01J2219/00545 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00644 , B01J2219/00648 , B01J2219/00653 , B01J2219/00722 , B01J2219/00725 , C12Q1/6837 , C12Q1/6876 , G01N27/745 , G01N33/5434 , G01N33/54346 , G01N33/587 , G01N2035/00564 , G01N2035/00762 , G01N2446/20 , G01N2446/64 , Y10T436/11 , C12Q2565/513 , C12Q2563/143 , C12Q2563/107 , C12Q2563/155
摘要： The present invention provides a method for the generation of novel libraries of encoded magnetic particles from sub-libraries of by the generation of novel sub- libraries of magnetic nanoparticles and encoded particles. The sub-libraries are functionalized on demand are useful in the formation of arrays. The present invention is especially useful for performing multiplexed (parallel) assays for qualitative and/or quantitative analysis of binding interactions of a number of analyte molecules in a sample.
摘要翻译：本发明提供了一种用于通过产生磁性纳米颗粒和编码颗粒的新型亚文库从子文库产生编码磁性颗粒的新文库的方法。子库根据需要进行功能化在数组的形成中是有用的。本发明特别可用于进行多个（并行）测定以定性和/或定量分析样品中许多分析物分子的结合相互作用。

6. 发明授权

US06706163B2 On-chip analysis of particles and fractionation of particle mixtures using light-controlled electrokinetic assembly of particles near surfaces 有权
$On-chip analysis of particles and fractionation of particle mixtures using light-controlled electrokinetic assembly of particles near surfaces$
标题翻译：颗粒的片上分析和使用表面附近的颗粒的光控电动组装的颗粒混合物的分级
公开(公告)号：US06706163B2
公开(公告)日：2004-03-16
申请号：US09813571
申请日：2001-03-21
申请人： Michael Seul , Sukanta Banerjee , Kairali Podual
发明人： Michael Seul , Sukanta Banerjee , Kairali Podual
IPC分类号： B01D5702
CPC分类号： G01N15/0266 , B03C5/026 , C02F1/469 , G01N2015/0294
摘要： A method and apparatus for fractionation of a mixture of particles and for particle analysis are provided, in which LEAPS (“Light-controlled Electrokinetic Assembly of Particles near Surfaces”) is used to fractionate and analyze a plurality of particles suspended in an interface between an electrode and an electrolyte solution. A mixture of particles are fractionated according to their relaxation frequencies, which in turn reflect differences in size or surface composition of the particles. Particles may also be analyzed to determine their physical and chemical properties based on particle relaxation frequency and maximal velocity.
摘要翻译：提供了一种用于分级颗粒混合物和用于颗粒分析的方法和装置，其中使用LEAPS（“靠近表面的颗粒的光控电动组装”）分级分析悬浮在电极和电解质溶液。颗粒的混合物根据它们的松弛频率进行分级，这又反映了颗粒的尺寸或表面组成的差异。还可以分析颗粒以基于颗粒松弛频率和最大速度确定其物理和化学性质。

7. 发明授权

US07625765B2 Directed assembly of functional heterostructures 失效
标题翻译：定向组装功能异质结构
公开(公告)号：US07625765B2
公开(公告)日：2009-12-01
申请号：US11253452
申请日：2005-10-19
申请人： Sukanta Banerjee , Kairali Podual , Michael Seul
发明人： Sukanta Banerjee , Kairali Podual , Michael Seul
IPC分类号： G01N33/551
CPC分类号： C08J3/075 , C08J3/28 , C08J2333/26 , C08J2425/06 , C12Q1/6837 , G01N33/5005 , G01N33/545 , G03F7/0047 , G03F7/164 , Y10T428/249952 , Y10T428/25
摘要： The present invention relates to a systematic process for the creation of functionally organized, spatially patterned assemblies polymer-microparticle composites including the AC electric field-mediated assembly of patterned, self supporting organic (polymeric) films and organic (polymeric)-microparticle composite films of tailored composition and morphology; the present invention further relates to the incorporation of said assemblies into other structures. The present invention also relates to the application of such functional assemblies in materials science and biology. Additional areas of application include sensors, catalysts, membranes, micro-reactors, smart materials. Miniaturized format for generation of multifunctional thin films. Provides a simple set-up to synthesize thin films of tailored composition and morphology.
摘要翻译：本发明涉及一种用于产生功能组织的空间图案化聚合物 - 聚合物 - 微粒复合材料的系统方法，其包括图案化的自支撑有机（聚合物）膜和有机（聚合） - 微粒复合膜的交流电场介导组装定制组合和形态; 本发明还涉及将所述组件结合到其它结构中。本发明还涉及这种功能组件在材料科学和生物学中的应用。其他应用领域包括传感器，催化剂，膜，微反应器，智能材料。用于生成多功能薄膜的小型化格式。提供简单的设置来合成定制组合和形态的薄膜。

8. 发明申请

US20070248993A1 Un-supported Polymeric Film with Embedded Microbeads 有权
标题翻译：不支持的嵌入式微珠聚合物薄膜
公开(公告)号：US20070248993A1
公开(公告)日：2007-10-25
申请号：US11761789
申请日：2007-06-12
申请人： Michael Seul , Sukanta Banerjee , Kairali Podual , Ye Hong
发明人： Michael Seul , Sukanta Banerjee , Kairali Podual , Ye Hong
IPC分类号： C25D9/02 , C25D7/00 , G01N33/50
CPC分类号： C08J3/075 , C08J3/28 , C08J2333/26 , C08J2425/06 , C12Q1/6837 , G01N33/5005 , G01N33/545 , G03F7/0047 , G03F7/164 , Y10T428/249952 , Y10T428/25
摘要： The present invention relates to a systematic process for the creation of functionally organized, spatially patterned assemblies polymer-microparticle composites including the AC electric field-mediated assembly of patterned, self supporting organic (polymeric) films and organic (polymeric)—microparticle composite films of tailored composition and morphology; the present invention further relates to the incorporation of said assemblies into other structures. The present invention also relates to the application of such functional assemblies in materials science and biology. Additional areas of application include sensors, catalysts, membranes, micro-reactors, smart materials. Miniaturized format for generation of multifunctional thin films. Provides a simple set-up to synthesize thin films of tailored composition and morphology:
摘要翻译：本发明涉及一种用于产生功能组织的空间图案化聚合物 - 聚合物 - 微粒复合材料的系统方法，其包括图案化的自支撑有机（聚合物）膜和有机（聚合） - 微粒复合膜的交流电场介导组装定制组合和形态; 本发明还涉及将所述组件结合到其它结构中。本发明还涉及这种功能组件在材料科学和生物学中的应用。其他应用领域包括传感器，催化剂，膜，微反应器，智能材料。用于生成多功能薄膜的小型化格式。提供简单的设置来合成定制组合和形态的薄膜：

9. 发明授权

US07211183B2 Analysis and fractionation of particles near surfaces 有权
$Analysis and fractionation of particles near surfaces$
标题翻译：表面附近颗粒的分析和分馏
公开(公告)号：US07211183B2
公开(公告)日：2007-05-01
申请号：US10658070
申请日：2003-09-09
申请人： Michael Seul , Sukanta Banerjee , Kairali Podual
发明人： Michael Seul , Sukanta Banerjee , Kairali Podual
IPC分类号： B01D57/02
CPC分类号： G01N15/0266 , B03C5/026 , C02F1/469 , G01N2015/0294
摘要： A method and apparatus for fractionation of a mixture of particles and for particle analysis are provided, in which LEAPS (“Light-controlled Electrokinetic Assembly of Particles near Surfaces”) is used to fractionate and analyze a plurality of particles suspended in an interface between an electrode and an electrolyte solution. A mixture of particles are fractionated according to their relaxation frequencies, which in turn reflect differences in size or surface composition of the particles. Particles may also be analyzed to determine their physical and chemical properties based on particle relaxation frequency and maximal velocity.
摘要翻译：提供了一种用于分级颗粒混合物和用于颗粒分析的方法和装置，其中使用LEAPS（“靠近表面的颗粒的光控电动组装”）分级分析悬浮在电极和电解质溶液。颗粒的混合物根据它们的松弛频率进行分级，这又反映了颗粒的尺寸或表面组成的差异。还可以分析颗粒以基于颗粒松弛频率和最大速度确定其物理和化学性质。

10. 发明授权

US07118900B2 Directed assembly of functional heterostructures 有权
标题翻译：定向组装功能异质结构
公开(公告)号：US07118900B2
公开(公告)日：2006-10-10
申请号：US10176551
申请日：2002-06-21
申请人： Michael Seul , Sukanta Banerjee , Kairali Podual , Ye Hong
发明人： Michael Seul , Sukanta Banerjee , Kairali Podual , Ye Hong
IPC分类号： C12N11/04
CPC分类号： C08J3/075 , C08J3/28 , C08J2333/26 , C08J2425/06 , C12Q1/6837 , G01N33/5005 , G01N33/545 , G03F7/0047 , G03F7/164 , Y10T428/249952 , Y10T428/25
摘要： The present invention relates to a systematic process for the creation of functionally organized, spatially patterned assemblies of polymer-microparticle composites including the AC electric field-mediated assembly of patterned, self-supporting organic (polymeric) films and organic-polymer-microparticle composites of tailored composition and morphology. The present invention further relates to the incorporation of said assemblies into other structures. The present invention also relates to the application of such functional assemblies in materials science and biology. Additional areas of application include sensors, catalysts, membranes, and micro-reactors, and miniaturized format for generation of multifunctional thin films. This invention also provides simple methods and apparatus for synthesizing thin films of tailored composition and morphology.
摘要翻译：本发明涉及一种用于创建聚合物 - 微粒复合材料的功能组织的，空间上图案化的组件的系统方法，其包括图案化的自支撑有机（聚合物）膜和有机 - 聚合物 - 微粒复合材料的AC电场介导组装定制组合和形态。本发明还涉及将所述组件结合到其它结构中。本发明还涉及这种功能组件在材料科学和生物学中的应用。其他应用领域包括传感器，催化剂，膜和微反应器以及用于产生多功能薄膜的小型化形式。本发明还提供用于合成定制组合物和形态的薄膜的简单方法和装置。

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