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1. 发明授权

US07820769B2 Polymer for use in conduits, medical devices and biomedical surface modification 有权
标题翻译：用于导管，医疗器械和生物医学表面改性的聚合物
公开(公告)号：US07820769B2
公开(公告)日：2010-10-26
申请号：US10586649
申请日：2005-01-20
申请人： Alexander Seifalian , Henryk Salacinski , Kaila Srai , Bala Ramesh , Arnold Darbyshire , Steve Hancock
发明人： Alexander Seifalian , Henryk Salacinski , Kaila Srai , Bala Ramesh , Arnold Darbyshire , Steve Hancock
IPC分类号： C08L83/10
CPC分类号： A61L27/18 , C08G18/3893 , C08G18/44 , C08L75/04
摘要： A copolymer comprising (a) one or more pendant group segments and (b) one or more polyol segments, each of said segments being linked to one or more further segments which may be the same or different,wherein said one or more pendant group segments are the same or different and are selected from: (i) siloxane segments; (ii) segments containing phosphoryl choline or a derivative or analogue thereof; (iii) segments containing a di- or trifluoromethyl group; (iv) heparin-like segments containing a group of formula (XII) D-N═N—Ar—SO3− (XII) wherein D is an aliphatic or aromatic group and Ar—SO3− comprises one or more linked aryl and/or heteroaryl groups, at least one of the aryl and/or heteroaryl groups having an SO3− substituent; and (v) segments containing a group of formula (I) [P]n′-[Lys]n-Lys-[Spacer]-Lys-[Al]x (I) wherein: [Al] is an inert amino acid; x is 0, 1, 2 or 3; [Spacer] is a fatty acid, amino acid, peptide or PEG; [P]n′-[Lys]n is a dendritic structure formed from n lysine groups and terminating in n′ groups P; n is an integer of from 1 to 15; n′ is zero or an integer of up to 16; and each P is the same or different and is an amino acid or a peptide having up to 25 amino acids, and wherein at least a part of each of said pendant group segment(s) is on a side chain of the copolymer. The copolymer is useful in the production of implantable devices such as vascular grafts.
摘要翻译：一种共聚物，其包含（a）一个或多个侧链基团区段和（b）一个或多个多元醇区段，每个所述区段与一个或多个可以相同或不同的其它区段连接，其中所述一个或多个侧链基团区段相同或不同，并且选自：（i）硅氧烷链段; （ii）含有磷酸胆碱或其衍生物或类似物的片段; （iii）含有二或三氟甲基的链段; （iv）含有式（XII）的基团的肝素样片段，其中D是脂族或芳族基团，Ar-SO 3 - 包含一个或多个连接的芳基和/或杂芳基，具有SO 3 - 取代基的芳基和/或杂芳基中的至少一个; 和（v）含有式（I）基团的片段[P] n' - [Lys] n-Lys- [间隔] -Lys- [Al] x（I）其中：[Al]是惰性氨基酸; x为0,1,2或3; [间隔]是脂肪酸，氨基酸，肽或PEG; [P] n' - [Lys] n是由n个赖氨酸基团形成并终止于n'基团P的树枝状结构; n为1〜15的整数， n'为零或最多16的整数; 并且每个P相同或不同，并且是具有至多25个氨基酸的氨基酸或肽，并且其中每个所述侧基基团的至少一部分在共聚物的侧链上。共聚物可用于生产可植入装置如血管移植物。

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