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1. 发明专利

JP2014188054A Medical composition 有权
标题翻译：医学成分
公开(公告)号：JP2014188054A
公开(公告)日：2014-10-06
申请号：JP2013064360
申请日：2013-03-26
申请人： Oita Univ , 国立大学法人大分大学 , Kaigen Pharma Co Ltd , カイゲンファーマ株式会社
发明人： KITANO MASATAKE , INOMATA MASASHI , ETO TSUYOSHI , SHIROSHITA HIDEFUMI , AKAGI TOMONORI , KUSANO TORU , SATO MASAHIRO , KAGAYA JUN
IPC分类号： A61L31/00 , A61K9/08 , A61K47/36 , C08L1/08
摘要： PROBLEM TO BE SOLVED: To provide a medical composition for submucosal infusion, which is inexpensive, has excellent ability to raise the mucosa, and preferably is easily discharged from a puncture needle for an endoscope.SOLUTION: Provided is a medical composition for submucosal infusion in endoscopic mucosal resection or endoscopic submucosal dissection. The composition comprises alginic acid with a weight average molecular weight of 200,000 or more or a medically acceptable salt thereof and a solvent, and is liquid. Preferably, in the composition, concentration of alginic acid or a medically acceptable salt thereof is 0.4 w/v% or more and 1.0 w/v% or less.
摘要翻译：要解决的问题：为了提供廉价的粘膜下输液用医药组合物，具有优异的升高粘膜的能力，优选容易从内窥镜用穿刺针排出。本发明提供一种粘膜下输液用医疗用组合物内窥镜粘膜切除或内窥镜粘膜下剥离。该组合物包含重均分子量为20万以上的藻酸或其医药上可接受的盐和溶剂，为液体。优选地，在组合物中，藻酸或其医学上可接受的盐的浓度为0.4w / v％以上且1.0w / v％以下。

2. 发明专利

JP2014136678A Moisturizing cosmetic material and production method thereof 审中-公开
标题翻译：保湿化妆品及其生产方法
公开(公告)号：JP2014136678A
公开(公告)日：2014-07-28
申请号：JP2013004658
申请日：2013-01-15
申请人： Kaigen Pharma Co Ltd , カイゲンファーマ株式会社
发明人： SATO HIRONORI , HARA KOZO
IPC分类号： A61K8/44 , A61K8/49 , A61K8/97 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide a method of producing a moisturizing cosmetic material by utilizing a natural material having high safety.SOLUTION: A moisturizing cosmetic material is produced by heat treatment of an extract from thalluses or rhizoids of tangle, preferably a hot water extract, using high-pressure closed vessel, and producing pyrrolidone carboxylic acid and/or salt thereof with glutamic acid and/or salt thereof in the extract. By using the high-pressure closed vessel, the extract from tangle is effectively heat-treated in a short time, and pyrrolidone carboxylic acid can be produced by cyclization of glutamic acid and/or salt thereof. Since the obtained pyrrolidone carboxylic acid and/or salt thereof has moisturizing ability and excellent moisturizing ability through synergistic effect with amino acids except glutamic acid, the obtained pyrrolidone carboxylic acid can be utilized for the production of a cosmetic as a moisturizing cosmetic material. By combination with other moisturizing agent, moisturizing ability can also be improved.
摘要翻译：要解决的问题：提供一种通过利用具有高安全性的天然材料制备保湿化妆品材料的方法。溶液：通过热处理来自沙棘或根茎的提取物，优选热水提取物来制备保湿化妆品使用高压密闭容器，并在提取物中与谷氨酸和/或其盐产生吡咯烷酮羧酸和/或其盐。通过使用高压密闭容器，短时间内有效地对缠结的提取物进行热处理，可以通过谷氨酸和/或其盐的环化来制备吡咯烷酮羧酸。由于得到的吡咯烷酮羧酸和/或其盐具有保湿能力和通过与除了谷氨酸以外的氨基酸的协同效应的优异的保湿能力，所得到的吡咯烷酮羧酸可用于生产作为保湿化妆品的化妆品。通过与其他保湿剂的组合，还可以提高保湿能力。

3. 发明专利

JP2014162750A Salivation-promoting compositions 审中-公开
标题翻译：消化促进组合物
公开(公告)号：JP2014162750A
公开(公告)日：2014-09-08
申请号：JP2013034956
申请日：2013-02-25
申请人： Kaigen Pharma Co Ltd , カイゲンファーマ株式会社
发明人： YAMAUCHI KOSUKE , YAMAMOTO ATSUKI , NASU REIJI , YOSHIHARA TAKAHIRO , TAKENAKA YASUTAKA
IPC分类号： A61K36/25 , A61K36/00 , A61K36/48 , A61K36/75 , A61P1/02 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a composition which expresses an excellent salivation promoting effect, has a large extent of administering compared with the existing agent, and has a sialogogic effective in patients with particularly drug-induced mouth dryness.SOLUTION: Provided is a salivation-promoting composition which contains ginseng radix and citrus unshiu peel as herbal medicines, and a composition which preferably contains 300-6000 mg of ginseng radix and 300-5000 mg of citrus unshiu peel by an original herbal medicine equivalent unit in a daily dose. The composition is preferably administered to patients with drug-induced mouth dryness caused by side effects of an antihistaminic agent.
摘要翻译：要解决的问题：为了提供表现出优异的唾液促进作用的组合物，与现有药剂相比具有较大程度的给药，并且在具有特别药物诱导的口腔干燥的患者中具有唾液酸化作用。解决方案：提供唾液含有人参和柑橘类未剥离作为草药的促进剂组合物，以及日剂量的原始草药当量单元优选含有300-6000mg人参和300-5000mg柑橘不透皮的组合物。该组合物优选施用于由抗组胺剂的副作用引起的药物引起的口干燥的患者。

4. 发明专利

JP2014114253A Analgesic antiinflammatory composition containing crude drug 审中-公开
标题翻译：含有原药的有毒抗炎组合物
公开(公告)号：JP2014114253A
公开(公告)日：2014-06-26
申请号：JP2012270713
申请日：2012-12-11
申请人： Kaigen Pharma Co Ltd , カイゲンファーマ株式会社
发明人： HAYASHI HIDEKI , ITO YUICHI , YAMAUCHI KOSUKE , YOSHIHARA TAKAHIRO , TAKENAKA YASUTAKA
IPC分类号： A61K36/48 , A61K31/192 , A61K36/71 , A61P25/04 , A61P29/00 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a useful analgesic antiinflammatory composition that has enhanced analgesic and antiinflammatory activities and decreased clinical adverse effects.SOLUTION: Provided is an analgesic antiinflammatory composition containing loxoprofen or its salt, peony root and licorice. The composition contains, in raw crude drug weight equivalent, 3.3-83.4 pts.wt. of peony root and 2.5-83.4 pts.wt. of licorice relative to 1 pt.wt. of loxoprofen, where the ratio of peony root to licorice in raw crude drug weight equivalent is from 2:50 to 100:3. The combined use of loxoprofen or its salt, peony root and licorice enhances analgesic antiinflammatory actions and further reduces the dose of loxoprofen or its salt, and therefore, an analgesic antiinflammatory composition with a decreased adverse effect can be provided.
摘要翻译：要解决的问题：提供有用的镇痛抗炎组合物，其具有增强的止痛和抗炎活性并降低临床不良反应。解决方案：提供含有洛索洛芬或其盐，牡丹和甘草的止痛抗炎组合物。该组合物含有原料药物重量当量为3.3-83.4重量份的牡丹根和2.5-83.4重量％的甘草相对于1重量级其中原始生物药物重量当量中芍药与甘草的比例为2:50至100:3。结合使用洛索洛芬或其盐，牡丹根和甘草可增强止痛抗炎作用，并进一步降低洛索洛芬或其盐的剂量，因此可以提供减少不良反应的镇痛抗炎组合物。

5. 发明专利

JP2014009179A Composition for preventing and/or treating colonic inflammatory disease 审中-公开
标题翻译：用于预防和/或治疗大肠炎性炎症疾病的组合物
公开(公告)号：JP2014009179A
公开(公告)日：2014-01-20
申请号：JP2012145626
申请日：2012-06-28
申请人： Kaigen Pharma Co Ltd , カイゲンファーマ株式会社
发明人： YAMAMOTO ATSUKI , NASU REIJI , ITO YUICHI
IPC分类号： A61K31/734 , A61P1/04 , A61P29/00
摘要： PROBLEM TO BE SOLVED: To provide a composition for oral administration to effectively prevent and/or treat inflammatory diseases occurring in the colon, with adverse effects, effectiveness, easy administration, and the like improved.SOLUTION: A composition for oral administration to prevent and/or treat colonic inflammatory diseases, particularly ulcerative colitis or Crohn's disease, contains an alginate as an effective component. The composition is used so that preferably 0.2 to 2.5 g/kg weight per day of the alginate is orally administered.
摘要翻译：要解决的问题：提供一种用于口服给药的组合物，以有效预防和/或治疗结肠中发生的炎性疾病，具有不良作用，有效性，易于施用等。改进的方法。一种用于口服给药的组合物，用于预防和/ /或治疗结肠炎性疾病，特别是溃疡性结肠炎或克罗恩病，含有藻酸盐作为有效成分。使用组合物，以使口服给药优选每天0.2〜2.5g / kg的藻酸盐。

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