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1. 发明授权

US08486722B1 Sensing method for biopolymers and sensing device therefor 有权
标题翻译：生物聚合物的传感方法及其感测装置
公开(公告)号：US08486722B1
公开(公告)日：2013-07-16
申请号：US13713643
申请日：2012-12-13
申请人： Saburo Tanaka , Shinji Katsura , Noriyuki Ohnishi , Kageaki Matsui
发明人： Saburo Tanaka , Shinji Katsura , Noriyuki Ohnishi , Kageaki Matsui
IPC分类号： G01N33/553 , G01N33/543
CPC分类号： G01N33/5434
摘要： A sensing method for biopolymers by detecting the magnetic signal generated from a labeled biopolymer under AC magnetic field with thermo-responsive magnetic nano particles as label having a critical solution temperature across which the particles have the ability to aggregate or disperse with cooling or heating.
摘要翻译：通过检测在交流磁场下由标记的生物聚合物产生的磁信号的热敏磁性纳米颗粒作为具有临界溶解温度的标签的生物聚合物的感测方法，通过该临界溶液温度，颗粒具有通过冷却或加热而聚集或分散的能力。

2. 发明授权

US08372659B2 Sensing method for biopolymers and sensing device therefor 有权
标题翻译：生物聚合物的传感方法及其感测装置
公开(公告)号：US08372659B2
公开(公告)日：2013-02-12
申请号：US11686025
申请日：2007-03-14
申请人： Saburo Tanaka , Shinji Katsura , Noriyuki Ohnishi , Kageaki Matsui
发明人： Saburo Tanaka , Shinji Katsura , Noriyuki Ohnishi , Kageaki Matsui
IPC分类号： G01N33/553 , G01N1/26
CPC分类号： G01N33/5434
摘要： The present invention provides a highly sensitive sensing device for biopolymers which detects the magnetic signal generated from a labeled biopolymer under AC magnetic field using thermo-responsive magnetic nano particles as a probe.
摘要翻译：本发明提供了一种用于生物聚合物的高灵敏度感测装置，其使用热响应磁性纳米颗粒作为探针在AC磁场下检测由标记的生物聚合物产生的磁信号。

3. 发明申请

US20100062433A1 KIT FOR DETECTION/QUANTIFICATION OF ANALYTE, AND METHOD FOR DETECTION/QUANTIFICATION OF ANALYTE 有权
标题翻译：用于检测/分析分析物的试剂盒，以及分析物的检测/定量方法
公开(公告)号：US20100062433A1
公开(公告)日：2010-03-11
申请号：US12306178
申请日：2007-06-28
申请人： Hirokazu Nagaoka , Noriyuki Ohnishi , Kageaki Matsui , Satoru Sugita
发明人： Hirokazu Nagaoka , Noriyuki Ohnishi , Kageaki Matsui , Satoru Sugita
IPC分类号： C12Q1/68
CPC分类号： G01N33/54313 , G01N33/54333
摘要： Disclosed are a detection/quantification kit and a detection/quantification method for detecting/quantifying an analyte rapidly at a low cost and in a simple manner. Specifically, disclosed is a kit for detecting an analyte in a sample, comprising a first conjugate and a second conjugate, wherein the first conjugate comprises a first substance comprising a stimuli-responsive polymer and a first affinity substance having affinity for the analyte and bound to the first substance, and the second conjugate comprises a second substance carrying an electrical charge and a second affinity substance having affinity for the analyte and bound to the second substance. The first and second affinity substances can bind to different sites on the analyte simultaneously.
摘要翻译：公开了一种用于以低成本和简单的方式快速检测/定量分析物的检测/定量试剂盒和检测/定量方法。具体地，公开了一种用于检测样品中的分析物的试剂盒，其包含第一缀合物和第二缀合物，其中第一缀合物包含包含刺激响应性聚合物的第一物质和对分析物具有亲和力并结合到第一物质和第二共轭物包含携带电荷的第二物质和对分析物具有亲和力并与第二物质结合的第二亲和物质。第一和第二亲和物质可以同时结合到分析物上的不同部位。

4. 发明申请

US20070218567A1 SENSING METHOD FOR BIOPOLYMERS AND SENSING DEVICE THEREFOR 有权
标题翻译：用于生物聚合物的感测方法及其感测装置
公开(公告)号：US20070218567A1
公开(公告)日：2007-09-20
申请号：US11686025
申请日：2007-03-14
申请人： Saburo Tanaka , Shinji Katsura , Noriyuki Ohnishi , Kageaki Matsui
发明人： Saburo Tanaka , Shinji Katsura , Noriyuki Ohnishi , Kageaki Matsui
IPC分类号： G01N33/553
CPC分类号： G01N33/5434
摘要： The present invention provides a highly sensitive sensing method for biopolymers and a sensing devise therefor by amplifying the magnetic signal generated from a biopolymer reaction. The invention concerns a sensing method for biopolymers which detects the magnetic signal generated from a labeled biopolymer under AC magnetic field using thermo-responsive magnetic nano particles as a probe. The method is characterized by using the thermo-responsive magnetic nano particles having a critical solution temperature across which the particles have the ability to aggregate or disperse with cooling or heating, binding a ligand for the target biopolymer to the thermo-responsive magnetic nano particles, labeling the biopolymer in solution with these particles using biopolymer reaction, adding the ligand free thermo-responsive magnetic nano particles, keeping the solution temperature at which the thermo-responsive magnetic nano particles aggregate, applying AC magnetic field after aggregating the thermo-responsive magnetic nano particles and enlarging the aggregate of the thermo-responsive magnetic nano particles, and obtaining a larger magnetic signal at the time of measurement as compared with the magnetic signal obtained when the ligand free thermo-responsive magnetic nano particles is not added.
摘要翻译：本发明提供了用于生物聚合物的高灵敏度感测方法及其通过放大由生物聚合反应产生的磁信号的感测设备。本发明涉及一种用于生物聚合物的感测方法，其使用热响应磁性纳米颗粒作为探针在AC磁场下检测由标记的生物聚合物产生的磁信号。该方法的特征在于使用具有临界溶解温度的热响应磁性纳米颗粒，颗粒具有通过冷却或加热而聚集或分散的能力，将靶生物聚合物的配体结合到热响应磁性纳米颗粒上，使用生物聚合反应将这些颗粒的生物聚合物标记在溶液中，加入无配体的热响应磁性纳米颗粒，保持热敏磁性纳米颗粒聚集的溶液温度，聚集热敏磁性纳米颗粒后施加交流磁场颗粒并扩大热响应磁性纳米颗粒的聚集体，并且与不添加无配体的热敏磁性纳米颗粒时获得的磁信号相比，在测量时获得较大的磁信号。

5. 发明授权

US09297799B2 Method for measuring protozoan oocyst and detecting reagent 有权
标题翻译：测量原生动物卵囊和检测试剂的方法
公开(公告)号：US09297799B2
公开(公告)日：2016-03-29
申请号：US11813563
申请日：2006-01-11
申请人： Noriyuki Ohnishi , Hirotaka Furukawa , Hideyuki Hata , Kageaki Matsui , Takako Nogami , Hideo Nishizawa , Akihiko Kondo
发明人： Noriyuki Ohnishi , Hirotaka Furukawa , Hideyuki Hata , Kageaki Matsui , Takako Nogami , Hideo Nishizawa , Akihiko Kondo
IPC分类号： G01N33/553 , G01N33/543 , G01N33/569
CPC分类号： G01N33/54326 , G01N33/56905
摘要： The present invention provides a method for measuring oocyst of protozoa, such as Cryptosporidium, in an environment sample with high sensitivity at low cost within a short period of time; and a detecting reagent for use therein.Magnetic fine particles of 5 to 500 nm particle diameter having, immobilized thereto, binding factors for specific recognition of oocyst are added to an analyte containing a protozoan oocyst to form oocyst/binding factor/magnetic fine particle complexes by using a binding reaction to the oocyst, the formed complexes are recovered by a magnetic separation, and the protozoan oocysts contained in the complexes are assayed. Further, there is provided, for conducting the above method, a reagent for detecting protozoan oocysts comprising magnetic fine particles of 5 to 500 nm particle diameter having, immobilized thereto, antibodies against oocysts or binding factors for recognizing the antibodies.
摘要翻译：本发明提供了一种在短时间内以低成本在环境样品中测定原生动物如隐孢子虫的卵囊的方法，所述环境样品具有高灵敏度; 和其中使用的检测试剂。将固定有5〜500nm粒径的磁性细颗粒加入到含有原生动物卵囊的分析物中以形成卵囊/结合因子/磁性细颗粒复合物，通过使用与卵囊的结合反应通过磁分离回收形成的复合物，并测定复合物中所含的原生动物卵囊。此外，为了进行上述方法，提供了一种用于检测原生动物卵囊的试剂，其包括具有5至500nm粒径的磁性细颗粒，其固定有针对卵囊的抗体或用于识别抗体的结合因子。

6. 发明授权

US08815518B2 Kit for detection/quantification of analyte, and method for detection/quantification of analyte 有权
标题翻译：分析物检测/定量试剂盒，分析物检测/定量方法
公开(公告)号：US08815518B2
公开(公告)日：2014-08-26
申请号：US12306178
申请日：2007-06-28
申请人： Hirokazu Nagaoka , Noriyuki Ohnishi , Kageaki Matsui , Satoru Sugita
发明人： Hirokazu Nagaoka , Noriyuki Ohnishi , Kageaki Matsui , Satoru Sugita
IPC分类号： G01N33/53 , C12Q1/00 , G01N33/00 , B01L3/00 , G01N31/22 , G01N33/544 , G01N33/543
CPC分类号： G01N33/54313 , G01N33/54333
摘要： Disclosed are a detection/quantification kit and a detection/quantification method for detecting/quantifying an analyte rapidly at a low cost and in a simple manner. Specifically, disclosed is a kit for detecting an analyte in a sample, comprising a first conjugate and a second conjugate, wherein the first conjugate comprises a first substance comprising a stimuli-responsive polymer and a first affinity substance having affinity for the analyte and bound to the first substance, and the second conjugate comprises a second substance carrying an electrical charge and a second affinity substance having affinity for the analyte and bound to the second substance. The first and second affinity substances can bind to different sites on the analyte simultaneously.
摘要翻译：公开了一种用于以低成本和简单的方式快速检测/定量分析物的检测/定量试剂盒和检测/定量方法。具体地，公开了一种用于检测样品中的分析物的试剂盒，其包含第一缀合物和第二缀合物，其中第一缀合物包含包含刺激响应性聚合物的第一物质和对分析物具有亲和力并结合到第一物质和第二共轭物包含携带电荷的第二物质和对分析物具有亲和力并与第二物质结合的第二亲和物质。第一和第二亲和物质可以同时结合到分析物上的不同部位。

7. 发明申请

US20130164862A1 SENSING METHOD FOR BIOPOLYMERS AND SENSING DEVICE THEREFOR 有权
标题翻译：用于生物聚合物的感测方法及其感测装置
公开(公告)号：US20130164862A1
公开(公告)日：2013-06-27
申请号：US13713643
申请日：2012-12-13
申请人： Saburo TANAKA , Shinji Katsura , Noriyuki Ohnishi , Kageaki Matsui
发明人： Saburo TANAKA , Shinji Katsura , Noriyuki Ohnishi , Kageaki Matsui
IPC分类号： G01N27/72
CPC分类号： G01N33/5434
摘要： A sensing method for biopolymers by detecting the magnetic signal generated from a labeled biopolymer under AC magnetic field with thermo-responsive magnetic nano particles as label having a critical solution temperature across which the particles have the ability to aggregate or disperse with cooling or heating.
摘要翻译：通过检测在交流磁场下由标记的生物聚合物产生的磁信号的热敏磁性纳米颗粒作为具有临界溶解温度的标签的生物聚合物的感测方法，通过该临界溶液温度，颗粒具有通过冷却或加热而聚集或分散的能力。

8. 发明申请

US20080199884A1 Method For Measuring Protozoan Oocyst and Detecting Reagent 有权
标题翻译：测定原生动物卵囊和检测试剂的方法
公开(公告)号：US20080199884A1
公开(公告)日：2008-08-21
申请号：US11813563
申请日：2006-01-11
申请人： Noriyuki Ohnishi , Hirotaka Furukawa , Hideyuki Hata , Kageaki Matsui , Takako Nogami , Hideo Nishizawa , Akihiko Kondo
发明人： Noriyuki Ohnishi , Hirotaka Furukawa , Hideyuki Hata , Kageaki Matsui , Takako Nogami , Hideo Nishizawa , Akihiko Kondo
IPC分类号： G01N33/53
CPC分类号： G01N33/54326 , G01N33/56905
摘要： The present invention provides a method for measuring oocyst of protozoa, such as Cryptosporidium, in an environment sample with high sensitivity at low cost within a short period of time; and a detecting reagent for use therein.Magnetic fine particles of 5 to 500 nm particle diameter having, immobilized thereto, binding factors for specific recognition of oocyst are added to an analyte containing a protozoan oocyst to form oocyst/binding factor/magnetic fine particle complexes by using a binding reaction to the oocyst, the formed complexes are recovered by a magnetic separation, and the protozoan oocysts contained in the complexes are assayed. Further, there is provided, for conducting the above method, a reagent for detecting protozoan oocysts comprising magnetic fine particles of 5 to 500 nm particle diameter having, immobilized thereto, antibodies against oocysts or binding factors for recognizing the antibodies.
摘要翻译：本发明提供了一种在短时间内以低成本在环境样品中测定原生动物如隐孢子虫的卵囊的方法，所述环境样品具有高灵敏度; 和其中使用的检测试剂。将固定有5〜500nm粒径的磁性细颗粒加入到含有原生动物卵囊的分析物中以形成卵囊/结合因子/磁性细颗粒复合物，通过使用与卵囊的结合反应通过磁分离回收形成的复合物，并测定复合物中所含的原生动物卵囊。此外，为了进行上述方法，提供了一种用于检测原生动物卵囊的试剂，其包括具有5至500nm粒径的磁性细颗粒，其固定有针对卵囊的抗体或用于识别抗体的结合因子。

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