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1. 发明申请

WO2011049894A2 MICROFABRICATED THERMAL MODULATOR FOR COMPREHENSIVE 2D GAS CHROMATOGRAPHY 审中-公开
标题翻译：用于全面2D气相色谱的微晶热调制器
公开(公告)号：WO2011049894A2
公开(公告)日：2011-04-28
申请号：PCT/US2010/053109
申请日：2010-10-19
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , KIM, Sung Jin , KURABAYASHI, Katsuo , WISE, Kensall, D. , ZELLERS, Edward, T. , BLOCK, Bruce, P.
发明人： KIM, Sung Jin , KURABAYASHI, Katsuo , WISE, Kensall, D. , ZELLERS, Edward, T. , BLOCK, Bruce, P.
IPC分类号： G01N30/30 , G01N30/02
CPC分类号： G01N30/463 , G01N30/465 , G01N30/6095
摘要： A two-dimensional gas chromatography system having first and second separation columns, a thermal modulator disposed between the first and second columns and having a plurality of stage channels, and a micro heater monolithically integrated in the thermal modulator. The thermal modulator is operable to trap and focus gas/vapor species within the plurality of stage channels upon cooling and release the gas/vapor species to the second column upon heating by the micro heater.
摘要翻译：具有第一和第二分离柱的二维气相色谱系统，设置在第一和第二列之间并具有多个级通道的热调节器和单片集成在热调制器中的微加热器。热调节器可操作以在冷却时捕获和聚焦多个级通道内的气体/蒸汽物质，并且通过微加热器加热将气体/蒸汽物质释放到第二塔。

2. 发明申请

WO2003008937A3 GAS-FOCUSING FLOW CYTOMETER CELL AND FLOW CYTOMETER DETECTION SYSTEM WITH WAVEGUIDE OPTICS 审中-公开
公开(公告)号：WO2003008937A3
公开(公告)日：2003-01-30
申请号：PCT/US2002/022903
申请日：2002-07-18
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , KURABAYASHI, Katsuo , TAKAYAMA, Shuichi , SKERLOS, Steven, J. , HUH, Dongeun , GROTBERG, James, B. , TUNG, Yi-Chung
发明人： KURABAYASHI, Katsuo , TAKAYAMA, Shuichi , SKERLOS, Steven, J. , HUH, Dongeun , GROTBERG, James, B. , TUNG, Yi-Chung
IPC分类号： G01N15/14
摘要： A gas-focusing flow cytometer cell (10) comprises a liquid sample inlet (23) in fluid communication with a liquid sample channel (12) and at least one focusing gas inlet (21, 22) in fluid communication with a focusing gas channel (11, 13), a convergent focusing zone (15) in fluid communication with said liquid sample channel and said focusing gas channel and narrowing to form an interrogation zone (27) through which sample liquid enveloped by gas flows, wherein said liquid sample channel and said focusing gas channels meet at an angle of less than 90° and wherein at least said focusing zone and said interrogation zone have hydrophobic surfaces. A flow cytometer comprising said gas-focusing cytometer cell or a conventional liquid-focusing cytometer cell comprises a light source, preferably at least one laser diode or LED, and a detector, preferably a semiconductor detector, connected to the flow cellvia fiber optical light paths.

3. 发明申请

WO03008937A2 FLOW CYTOMETERS AND DETECTION SYSTEM OF LESSER SIZE 审中-公开
标题翻译：流量计和小型检测系统
公开(公告)号：WO03008937A2
公开(公告)日：2003-01-30
申请号：PCT/US0222903
申请日：2002-07-18
申请人： UNIV MICHIGAN , KURABAYASHI KATSUO , TAKAYAMA SHUICHI , SKERLOS STEVEN J , HUH DONGEUN , GROTBERG JAMES B , TUNG YI-CHUNG
发明人： KURABAYASHI KATSUO , TAKAYAMA SHUICHI , SKERLOS STEVEN J , HUH DONGEUN , GROTBERG JAMES B , TUNG YI-CHUNG
IPC分类号： G01N15/10 , G01N15/14 , G01N33/49
CPC分类号： G01N33/491 , G01N15/1404 , G01N15/1484 , G01N2015/1006 , G01N2015/1413 , G01N2015/149 , Y10T436/2575
摘要： A gas-focusing flow cytometer cell (10) comprises a liquid sample inlet (23) in fluid communication with a liquid sample channel (12) and at least one focusing gas inlet (21, 22) in fluid communication with a focusing gas channel (11, 13), a convergent focusing zone (15) in fluid communication with said liquid sample channel and said focusing gas channel and narrowing to form an interrogation zone (27) through which sample liquid enveloped by gas flows, wherein said liquid sample channel and said focusing gas channels meet at an angle of less than 90 DEG and wherein at least said focusing zone and said interrogation zone have hydrophobic surfaces. A flow cytometer comprising said gas-focusing cytometer cell or a conventional liquid-focusing cytometer cell comprises a light source, preferably at least one laser diode or LED, and a detector, preferably a semiconductor detector, connected to the flow cellvia fiber optical light paths.
摘要翻译：气体聚焦流式细胞仪细胞（10）包括与液体样品通道（12）流体连通的液体样品入口（23）和与聚焦气体通道流体连通的至少一个聚焦气体入口（21,22） 11，13），与所述液体样品通道和所述聚焦气体通道流体连通的收敛聚焦区（15）并变窄以形成询问区（27），通过气体包围的样品液体通过所述询问区流动，其中所述液体样品通道和所述聚焦气体通道以小于90°的角度相遇，并且其中至少所述聚焦区域和所述询问区域具有疏水表面。包括所述气体聚焦血细胞计数器细胞或常规液体聚焦细胞计数器细胞的流式细胞仪包括光源，优选至少一个激光二极管或LED，以及通过光纤光路连接到流动池的优选半导体检测器的检测器。

4. 发明申请

WO2012040473A3 SOLUTION MICROARRAYS AND USES THEREOF 审中-公开
标题翻译：微波解决方案及其应用
公开(公告)号：WO2012040473A3
公开(公告)日：2012-07-12
申请号：PCT/US2011052772
申请日：2011-09-22
申请人： UNIV MICHIGAN , TAKAYAMA SHUICHI , SIMON ARLYNE , HUANG NIEN-TSU , KURABAYASHI KATSUO
发明人： TAKAYAMA SHUICHI , SIMON ARLYNE , HUANG NIEN-TSU , KURABAYASHI KATSUO
IPC分类号： G01N33/53 , G01N33/52 , G01N35/08
CPC分类号： G01N33/536 , G01N33/54313 , G01N33/54393 , G01N33/6845
摘要： The present invention relates to solution microarrays. In particular, the present invention relates to an aqueous 2-phase system for solution microarrays and uses thereof. The present invention further relates to systems and methods for performing assays within the solution microarrays (e.g., diagnostic assays).
摘要翻译：本发明涉及溶液微阵列。特别地，本发明涉及用于溶液微阵列的水性二相体系及其应用。本发明还涉及用于在溶液微阵列内进行测定的系统和方法（例如，诊断测定）。

5. 发明申请

WO2011049894A3 MICROFABRICATED THERMAL MODULATOR FOR COMPREHENSIVE 2D GAS CHROMATOGRAPHY 审中-公开
标题翻译： MICROFABRICATED热调节器的全面二维气相色谱
公开(公告)号：WO2011049894A3
公开(公告)日：2011-06-23
申请号：PCT/US2010053109
申请日：2010-10-19
申请人： UNIV MICHIGAN , KIM SUNG JIN , KURABAYASHI KATSUO , WISE KENSALL D , ZELLERS EDWARD T , BLOCK BRUCE P
发明人： KIM SUNG JIN , KURABAYASHI KATSUO , WISE KENSALL D , ZELLERS EDWARD T , BLOCK BRUCE P
IPC分类号： G01N30/30 , G01N30/02
CPC分类号： G01N30/463 , G01N30/465 , G01N30/6095
摘要： A two-dimensional gas chromatography system having first and second separation columns, a thermal modulator disposed between the first and second columns and having a plurality of stage channels, and a micro heater monolithically integrated in the thermal modulator. The thermal modulator is operable to trap and focus gas/vapor species within the plurality of stage channels upon cooling and release the gas/vapor species to the second column upon heating by the micro heater.
摘要翻译：二维气相色谱系统具有第一和第二分离柱，设置在第一和第二柱之间并具有多个级通道的热调节器，以及单片集成在热调节器中的微型加热器。热调节器可操作以在冷却时将多个级通道内的气体/蒸气物质捕集和聚焦，并且在通过微型加热器加热时将气体/蒸气物质释放到第二塔。

6. 发明申请

WO2011053828A3 TARGETED DUAL-AXES CONFOCAL IMAGING APPARATUS WITH VERTICAL SCANNING CAPABILITIES 审中-公开
标题翻译：具有垂直扫描能力的目标双轴共焦成像装置
公开(公告)号：WO2011053828A3
公开(公告)日：2011-07-21
申请号：PCT/US2010054806
申请日：2010-10-29
申请人： UNIV MICHIGAN , WANG THOMAS D , KURABAYASHI KATSUO , OLDHAM KENN , QIU ZHEN
发明人： WANG THOMAS D , KURABAYASHI KATSUO , OLDHAM KENN , QIU ZHEN
IPC分类号： G02B21/00 , G01N21/84 , G02B26/10
CPC分类号： G02B26/101 , A61B5/0068 , A61B5/0073 , A61B5/4255 , A61B2503/40 , G01N21/6458 , G02B21/0028 , G02B21/0036 , G02B21/0076 , G02B26/0841
摘要： An optical device is described that may be used as a microscope system for realtime, three-dimensional optical imaging. The device includes a miniature, fiber optic, intravital probe microscope that uses a dual-axes confocal architecture to allow for vertical scanning perpendicular to a surface of the sample (e.g., a tissue surface). The optical device can use off-axis illumination and collection of light to achieve sub-cellular resolution with deep tissue penetration. The optical device may be used as part of an integrated molecular imaging strategy using fluorescence-labeled peptides to detect cell surface targets that are up-regulated by the epithelium and/or endothelium of colon and breast tumors in small animal models of cancer.
摘要翻译：描述了可用作实时三维光学成像的显微镜系统的光学装置。该装置包括微型光纤，活体探针显微镜，其使用双轴共焦结构来允许垂直于样品表面（例如，组织表面）的垂直扫描。光学装置可以使用离轴照明和光的收集来实现具有深层组织穿透的亚细胞分辨率。光学装置可以被用作使用荧光标记的肽来检测小癌动物模型中由结肠和乳腺肿瘤的上皮和/或内皮上调的细胞表面靶的整合分子成像策略的一部分。

7. 发明申请

WO02092496A2 HIGH-PERFORMANCE FULLY-COMPLIANT MICRO-MECHANISMS FOR FORCE/DISPLACEMENT AMPLIFICATION 审中-公开
标题翻译：高性能，完全兼容的微机械强度/位移放大
公开(公告)号：WO02092496A2
公开(公告)日：2002-11-21
申请号：PCT/US0215077
申请日：2002-05-13
申请人： UNIV MICHIGAN , JENSEN BRIAN D , FARINA MICHAEL , KURABAYASHI KATSUO
发明人： JENSEN BRIAN D , FARINA MICHAEL , KURABAYASHI KATSUO
IPC分类号： B81B3/00
CPC分类号： B81B3/0062 , B81B3/0037 , B81B2201/0235 , G01P15/00 , H01Q3/01 , H01Q9/14 , Y10T74/20006 , Y10T74/20207 , Y10T74/20305 , Y10T74/20329
摘要： A device for amplifying mechanical and geometrical advantage having a base structure, a first link member having a first end and a second end, and a first compliant flexural joint pivotally interconnects the first end of the first link member to the base structure. A second link member is also provided having a first end and a second end. A second compliant flexural joint pivotally interconnects the first end of the second link member to the base structure. Furthermore, a third link member is provided having a first end and a second end. A third compliant flexural joint pivotally interconnects the first end of the third link member to the second end of the first link member and a fourth compliant flexural joint pivotally interconnects the second end of the third link member to the second end of the second link member. The base structure, first link member, second link member, and third link member cooperate to define a four-bar linkage for receiving an input force and providing an amplified force or displacement output in response thereto.
摘要翻译：一种用于放大具有基座结构的机械和几何优点的装置，具有第一端和第二端的第一连杆构件以及第一柔性弯曲接头将第一连杆构件的第一端枢转地互连到基座结构。还提供了具有第一端和第二端的第二连杆构件。第二顺从弯曲接头将第二连杆构件的第一端枢转地互连到基部结构。此外，提供具有第一端和第二端的第三连杆构件。第三顺从弯曲接头将第三连杆构件的第一端枢转地互连到第一连杆构件的第二端，并且第四顺从弯曲接头将第三连杆构件的第二端枢转地互连到第二连杆构件的第二端。基座结构，第一连杆构件，第二连杆构件和第三连杆构件协作以限定用于接收输入力的四杆联动装置，并响应于此而提供放大的力或位移输出。

8. 发明申请

WO2012040473A2 SOLUTION MICROARRAYS AND USES THEREOF 审中-公开
标题翻译：解决方案微阵列及其用途
公开(公告)号：WO2012040473A2
公开(公告)日：2012-03-29
申请号：PCT/US2011/052772
申请日：2011-09-22
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , TAKAYAMA, Shuichi , SIMON, Arlyne , HUANG, Nien-Tsu , KURABAYASHI, Katsuo
发明人： TAKAYAMA, Shuichi , SIMON, Arlyne , HUANG, Nien-Tsu , KURABAYASHI, Katsuo
IPC分类号： G01N33/53 , G01N33/52 , G01N35/08
CPC分类号： G01N33/536 , G01N33/54313 , G01N33/54393 , G01N33/6845
摘要： The present invention relates to solution microarrays. In particular, the present invention relates to an aqueous 2-phase system for solution microarrays and uses thereof. The present invention further relates to systems and methods for performing assays within the solution microarrays (e.g., diagnostic assays).
摘要翻译：本发明涉及解决方案微阵列。具体而言，本发明涉及一种用于溶液微阵列的含水两相系统及其用途。本发明进一步涉及用于在溶液微阵列内进行测定的系统和方法（例如，诊断测定）。

9. 发明申请

WO2005033654A3 MICRO FLOW CYTOMETER WITH MULTIANGULAR WAVEGUIDE DETECTORS HAVING SPECTRAL CAPABILITIES 审中-公开
标题翻译：具有光谱能力的多波长检波器的微流量计
公开(公告)号：WO2005033654A3
公开(公告)日：2006-02-16
申请号：PCT/US2004028175
申请日：2004-08-30
申请人： UNIV MICHIGAN , TUNG YI-CHUNG , LIN CHIH-TING , KURABAYASHI KATSUO , SKERLOS STEVEN J , ZHANG MIN
发明人： TUNG YI-CHUNG , LIN CHIH-TING , KURABAYASHI KATSUO , SKERLOS STEVEN J , ZHANG MIN
IPC分类号： G01N15/14 , G02B6/00
CPC分类号： G01N15/1436 , G01N15/1484
摘要： A micro flow cytometer having the ability to distinguish light emanating from a particle in the interrogation zone (6) of the cytometer contains a plurality of optical waveguides (10, 11, 12, 13) for receiving emanating light, the optical waveguides (10, 11, 12, 13) positioned at different angles from the axis of the interrogation zone and in the same plane. Photodetectors measuring emanated light provide an electrical signal which is processable to reveal an angular dependence of wavelength with respect to the interrogation channel (6).
摘要翻译：具有区分在血细胞计数器的询问区（6）中发射的光的能力的微流式细胞计数器包含用于接收发射光的多个光波导（10,11,12,13），光波导（10， 11,12,13），其位于与询问区的轴线不同的角度并位于同一平面内。测量发射光的光电检测器提供电信号，其可以处理以显示相对于询问通道（6）的波长的角度依赖性。

10. 发明申请

WO2005033654A2 MICRO FLOW CYTOMETER WITH MULTIANGULAR WAVEGUIDE DETECTORS HAVING SPECTRAL CAPABILITIES 审中-公开
标题翻译：具有光谱能力的多波长检波器的微流量计
公开(公告)号：WO2005033654A2
公开(公告)日：2005-04-14
申请号：PCT/US2004/028175
申请日：2004-08-30
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , TUNG, Yi-Chung , LIN, Chih-Ting , KURABAYASHI, Katsuo , SKERLOS, Steven, J. , ZHANG, Min
发明人： TUNG, Yi-Chung , LIN, Chih-Ting , KURABAYASHI, Katsuo , SKERLOS, Steven, J. , ZHANG, Min
IPC分类号： G01N
CPC分类号： G01N15/1436 , G01N15/1484
摘要： A micro flow cytometer having the ability to distinguish light emanating from a particle in the interrogation zone of the cytometer contains a plurality of optical waveguides for receiving emanating light, the optical waveguides positioned at different angles from the axis of the interrogation zone and in the same plane. Photodetectors measuring emanated light provide an electrical signal which is processable to reveal an angular dependence of wavelength with respect to the interrogation channel.
摘要翻译：具有区分在血细胞计数器询问区域中的粒子发出的光的微流式细胞计数器包含多个用于接收发射光的光波导，该光波导位于与询问区的轴线不同的角度并且位于相同的位置平面。测量发光的光电检测器提供电信号，其可以处理以显示相对于询问通道的波长的角度依赖性。

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