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1. 发明申请

WO2010045895A3 A PROCESS FOR PREPARING N-(HYDROCARBYL) PHOSPHORIC OR THIOPHOSPHORIC TRIAMIDES 审中-公开
标题翻译：制备N-（氢氯化）磷酸或硫代三聚氰胺的方法
公开(公告)号：WO2010045895A3
公开(公告)日：2010-06-17
申请号：PCT/CZ2009000114
申请日：2009-09-30
申请人： AGRA GROUP AS , KYSILKA VLADIMIR , KOPENEC JIRI , KREPELKA JIRI
发明人： KYSILKA VLADIMIR , KOPENEC JIRI , KREPELKA JIRI
IPC分类号： C07F9/22
CPC分类号： C07F9/224
摘要： The invention provides a process for preparing N-(hydrocarbyl)phosphoric or thiophosphoric triamides with substantially improved yields and purity. Two equivalents of hydrocarbylamine are used in the reaction with phosphoryl or thiophosphoryl chloride and then with ammonia in an aromatic solvent. The invention further relates to N-(hydrocarbyl)phosphopric or thiophosphoric triamides having the purity of at least 98 % wherein R is a hydrocarbyl group and X is O or S.
摘要翻译：本发明提供了一种以显着提高的产率和纯度制备N-（烃基）磷酸或硫代磷酸三酰胺的方法。在与磷酰基或硫代磷酰氯的反应中使用两当量的烃基胺，然后与氨在芳族溶剂中反应。本发明进一步涉及纯度至少为98％的N-（烃基）磷酸酯或硫代磷酸三酰胺，其中R是烃基，X是O或S.

2. 发明申请

WO2010045895A2 A PROCESS FOR PREPARING N-(HYDROCARBYL) PHOSPHORIC OR THIOPHOSPHORIC TRIAMIDES 审中-公开
标题翻译：制备N-（氢氯化）磷酸或硫代三聚氰胺的方法
公开(公告)号：WO2010045895A2
公开(公告)日：2010-04-29
申请号：PCT/CZ2009/000114
申请日：2009-09-30
申请人： AGRA GROUP, A.S. , KYSILKA, Vladimir , KOPENEC, Jiri , KREPELKA, Jiri
发明人： KYSILKA, Vladimir , KOPENEC, Jiri , KREPELKA, Jiri
IPC分类号： C07F9/22
CPC分类号： C07F9/224
摘要： The invention provides a process for preparing N-(hydrocarbyl)phosphoric or thiophosphoric triamides with substantially improved yields and purity. Two equivalents of hydrocarbylamine are used in the reaction with phosphoryl or thiophosphoryl chloride and then with ammonia in an aromatic solvent. The invention further relates to N-(hydrocarbyl)phosphopric or thiophosphoric triamides having the purity of at least 98 %.
摘要翻译：本发明提供了一种以显着提高的产率和纯度制备N-（烃基）磷酸或硫代磷酸三酰胺的方法。在与磷酰基或硫代磷酰氯的反应中使用两当量的烃基胺，然后与氨在芳族溶剂中反应。本发明还涉及纯度至少为98％的N-（烃基）磷酸酯或硫代磷酸三酰胺。

5. 发明专利

CS272922B1 METHOD OF 2-(BENZYL-SUBSTITUTED) AMINO-NITROBENZENE PREPARATION 未知
公开(公告)号：CS272922B1
公开(公告)日：1991-02-12
申请号：CS18289
申请日：1989-01-10
申请人： VEJDELEK ZDENEK , KMONICEK VOJTECH , KREPELKA JIRI
发明人： VEJDELEK ZDENEK ING CSC , KMONICEK VOJTECH ING , KREPELKA JIRI ING CSC
IPC分类号： C07C211/29
摘要： The invention concerns the method of preparation of 2-(benzyl-substituted)-amino-nitrobenzene of general formula I, where R represents an atom of hydrogen, halogen, the nitro group, one methoxyl group or two methoxyl groups, whereas these compounds are important intermediate products, for example in the synthesis of benzimidazole derivatives blocking periphery H1-receptors and used for the therapy of allergy illnesses, as shown by the case of astemizole (Hismanal Janssen).The new method of preparing substances of formula I is based on the fact that 2-nitraniline is allowed to react with benzylhalogenide of general formula VI, where Hal represents the atom of chlorine or bromine and R has the same meaning as in formula I. The reaction occurs in the heterogeneous environment of the solution system, whose first phase is formed by benzene, toluene or xylene and the second by free aqueous 45 to 50 % sodium or potassium hydroxide; whereas for 1 mol of 2-nitraniline 4.5 to 5.0 mol sodium or potassium hydroxide is used, quaternary ammonium salt is added as a catalyst of the phase transformation. The reaction mixture is heated while mixing for 10 - 12 hours to the temperature of backflow and, after the reaction stops, the solvent is distilled from the separated organic part and the substance is thus isolated. Triethylbenzyl ammonium chloride can be used as a catalyst. Yields fluctuate above 70 % of the required product of general formula I.

7. 发明专利

CS8902143A1 METHOD OF LYSINESALICYLATE PREPARATION 未知
公开(公告)号：CS8902143A1
公开(公告)日：1990-09-12
申请号：CS214389
申请日：1989-04-07
申请人： JANOUSEK VLADIMIR ING , PRCHLIK JAROSLAV ING CSC , STUCHLIK JIRI , GRIMOVA JAROSLAVA , KREPELKA JIRI
发明人： JANOUSEK VLADIMIR ING , PRCHLIK JAROSLAV ING CSC , STUCHLIK JIRI ING , GRIMOVA JAROSLAVA MUDR CSC , KREPELKA JIRI ING CSC
IPC分类号： C07C65/10

8. 发明专利

CS694288A1 METHOD OF 1-PHENYL-2-METHYLAMINO-PROPENE PRODUCTION 未知
公开(公告)号：CS694288A1
公开(公告)日：1990-05-14
申请号：CS694288
申请日：1988-10-20
申请人： HAJICEK JOSEF , HRBATA JIRI , STURC ANTONIN , PIHERA PAVEL , STROJIL LADISLAV , KREPELKA JIRI
发明人： HAJICEK JOSEF ING CSC , HRBATA JIRI PHARMDR , STURC ANTONIN ING , PIHERA PAVEL , STROJIL LADISLAV , KREPELKA JIRI
IPC分类号： C07C211/00 , C07C87/28

9. 发明专利

CS268893B1 ANTINEOPLASTICALLY ACTIVE HALOGEN DERIVATIVES OF 7-OXO-7H-BENZO (C) FLUORENE AND METHOD OF THEIR PREPARATION 未知
公开(公告)号：CS268893B1
公开(公告)日：1990-04-11
申请号：CS762888
申请日：1988-11-21
申请人： SANTRUCEK MILAN , KREPELKA JIRI , MELKA MILAN
发明人： SANTRUCEK MILAN , KREPELKA JIRI ING CSC , MELKA MILAN MUDR RNDR
IPC分类号： C07C225/18 , A61K31/138 , A61P35/00 , C07C93/14

10. 发明专利

CS268891B1 HALOGEN DERIVATIVES OF 5-ACETOXY-7-OXO-BENZO (C) FLUORENE AND METHOD OF THEIR PREPARATION 未知
公开(公告)号：CS268891B1
公开(公告)日：1990-04-11
申请号：CS762588
申请日：1988-11-21
申请人： SANTRUCEK MILAN , KREPELKA JIRI
发明人： SANTRUCEK MILAN , KREPELKA JIRI ING CSC
IPC分类号： C07C69/767

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