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1. 发明申请

WO1997036946A1 POLYARYLENE SULFIDE AND A COMPOSITION THEREOF 审中-公开
标题翻译：聚磺酰亚胺及其组合物
公开(公告)号：WO1997036946A1
公开(公告)日：1997-10-09
申请号：PCT/JP1997001138
申请日：1997-04-02
申请人： TONEN CHEMICAL CORPORATION , TSUDA, Takashi , KOMIYAMA, Osamu
发明人： TONEN CHEMICAL CORPORATION
IPC分类号： C08G75/02
CPC分类号： C08G75/0254 , C08K5/54 , C08L81/02
摘要： Polyarylene sulfide (PAS) is disclosed, of which extract with methylene chloride is in an amount of not more than 0.7 % by weight, a melt viscosity V6 is 20 to 15,000 poises and a content of -SX groups is at least 15 micro moles/g, wherein X represents an alkali metal or a hydrogen atom. The PAS is prepared as follows: an alkali metal sulfide is reacted with a dihaloaromatic compound in an organic amide solvent, while a part of a gaseous phase in a reactor is condensed by cooling a gaseous phase part of the reactor to return the condensed liquid to a liquid phase; and the polyarylene sulfide thus prepared is washed with an organic solvent and then with water. The present invention also provides a composition comprising 100 parts by weight of (A) the aforesaid PAS and 0.01 to 5.0 parts by weight of (B) at least a silane compound selected from the group consisting of methacryloxysilane compounds, ureidosilane compounds and epoxy silane compounds.
摘要翻译：公开了聚芳硫醚（PAS），其中二氯甲烷的提取物的量不大于0.7重量％，熔体粘度V6为20至15,000泊，-SX基团的含量至少为15微摩尔/ g，其中X表示碱金属或氢原子。 PAS如下制备：将碱金属硫化物与二卤代芳族化合物在有机酰胺溶剂中反应，同时反应器中的一部分气相通过冷却反应器的气相部分而使冷凝的液体返回到液相; 将由此制备的聚芳硫醚用有机溶剂洗涤，然后用水洗涤。本发明还提供一种组合物，其包含100重量份的（A）上述PAS和0.01至5.0重量份的（B）至少一种选自甲基丙烯酰氧基硅烷化合物，脲基硅烷化合物和环氧硅烷化合物的硅烷化合物。

2. 发明申请

WO1997021726A1 AGENTS FOR PROMOTING BONE FORMATION 审中-公开
标题翻译：促进骨形成的药剂
公开(公告)号：WO1997021726A1
公开(公告)日：1997-06-19
申请号：PCT/EP1996005380
申请日：1996-12-06
申请人： ROUSSEL UCLAF , KITAMURA, Kazuyuki , KOMIYAMA, Osamu , INAZU, Mizuho , BARON, Roland , GADEK, Thomas , KNOLLE, Jochen , STILZ, Han-Ulrich , WEHNER, Volkmar , MCDOWELL, Robert, S.
发明人： ROUSSEL UCLAF
IPC分类号： C07K07/06
CPC分类号： C07K5/0821 , A61K38/04 , A61K38/05 , A61K38/07 , A61K38/12 , A61K38/1703 , A61K38/39 , C07C271/22 , C07C279/08 , C07C279/20 , C07K5/0202 , C07K5/0817 , C07K5/1019 , C07K5/1024 , C07K14/46 , C07K14/745 , C07K14/78
摘要： The object is to provide a promoting agent for bone formation, a therapeutic method for bone formation and a process for preparing a promoting agent for bone formation. A promoting agent for bone formation which comprises at least one of kistrin, echstatin, a peptide or polypeptide containing the amino acid sequence ArgGlyAsp in the molecule such as a peptide represented by Gly-Arg-Gly-Asp-Ser or a compound represented by general formula (IX) and so on, as well as a biologically acceptable salt thereof, wherein R16 represents -N(R20)2 (R20 represents a hydrogen atom or a C1-C4 alkyl group), R17 represents a hydrogen atom or a C1-C4 alkyl group, R18 represents a hydrogen atom, a C1-C4 alkyl group and so on, R19 represents OH, NH2 and so on, Y represents -NH-, -O- or a direct bond, a represents 1-3, b represents 1 or 2, c represents 0 or 1 and d represents 0 or 1.
摘要翻译：本发明提供骨形成促进剂，骨形成治疗方法及骨形成促进剂的制备方法。用于骨形成的促进剂，其包含分子中含有氨基酸序列ArgGlyAsp的丝氨酸蛋白酶，抑制素，肽或多肽中的至少一种，例如由Gly-Arg-Gly-Asp-Ser表示的肽或由通式式（IX）等，以及其生物可接受的盐，其中R 16表示-N（R 20）2（R 20表示氢原子或C 1 -C 4烷基），R 17表示氢原子或C1- C4烷基，R18表示氢原子，C1-C4烷基等，R19表示OH，NH2等，Y表示-NH-，-O-或直接键，a表示1-3，b 表示1或2，c表示0或1，d表示0或1。

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