专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO0143691A3 FRAGMENTS AND ANTAGONISTS OF HEAT SHOCK PROTEIN 60 审中-公开
标题翻译：热休克蛋白的片段和拮抗剂60
公开(公告)号：WO0143691A3
公开(公告)日：2002-01-10
申请号：PCT/IL0000833
申请日：2000-12-14
申请人： PEPTOR LTD , KOLB HUBERT , ELIAS DANA
发明人： KOLB HUBERT , ELIAS DANA
IPC分类号： G01N33/50 , A01N63/00 , A61K20060101 , A61K38/00 , A61K39/00 , A61K45/00 , A61P1/00 , A61P1/02 , A61P1/04 , A61P3/10 , A61P7/02 , A61P9/10 , A61P19/02 , A61P21/04 , A61P25/00 , A61P29/00 , A61P31/00 , A61P37/02 , A61P37/08 , C07K14/47 , C12Q1/02 , G01N33/15
CPC分类号： C07K14/47 , A61K38/00
摘要： The invention identifies fragments of hsp60 which retain the capability of inducing a pro-inflammatory immune response of cells of the innate immune system. It is further disclosed the unexpectedfinding that smaller peptides derived from these fragments of hsp60 are capable of acting as antagonists of hsp60 insofar as they have the ability to reduce or even prevent the induction of a pro-inflammatory immune response by hsp60 in cells of the innate immune system. It further discloses variants, derivatives and analogs of such peptides, which are capable of acting as antagonists of hsp60 insofar as they have the ability to reduce or prevent the induction of a pro-inflammatory immune response by hsp60 in cells of the immune system. The invention also discloses pharmaceutical compositions comprising such peptide fragments or variants, derivatives and analogs thereof, and their use to prevent or ameliorate inflammatory diseases or disorders.
摘要翻译：本发明鉴定hsp60的片段，其保留诱导先天免疫系统细胞的促炎免疫应答的能力。进一步公开了意想不到的是，从hsp60的这些片段衍生的较小的肽能够作为hsp60的拮抗剂，只要它们具有降低甚至预防hsp60在先天细胞中诱导促炎免疫应答的能力免疫系统。它进一步公开了这样的肽的变体，衍生物和类似物，其能够充当hsp60的拮抗剂，只要它们具有降低或预防免疫系统细胞中hsp60诱导促炎免疫应答的能力。本发明还公开了包含这样的肽片段或变体，其衍生物和类似物的药物组合物及其用于预防或改善炎性疾病或病症的用途。

2. 发明申请

WO2004098489A3 COMPOSITIONS AND METHODS FOR MODULATION OF SPECIFIC EPITOPES OF HSP60 审中-公开
标题翻译： HSP60特异性抗原决定簇的组成和方法
公开(公告)号：WO2004098489A3
公开(公告)日：2006-09-14
申请号：PCT/IL2004000404
申请日：2004-05-12
申请人： PEPTOR LTD , KOLB HUBERT
发明人： KOLB HUBERT
IPC分类号： C07K16/00 , A61K20060101 , A61K38/00 , A61K38/04 , A61K39/395
CPC分类号： A61K38/1709 , C07K16/18 , C07K2317/76
摘要： Distinct epitopes of HSP60 are identified to modulate binding and activation of macrophages. One epitope, localized to residues 335-366, and more specifically to residues 254-265, of human HSP60 binds LPS and by presenting it to toll receptor-4 complex immunostimulates the cells, and a second epitope, localized to residues 481-500 of HSP60, is responsible for binding to the macrophage cell surface. The present invention relates to novel compounds, capable of inhibiting the binding of those peptidic regions to LPS or to macrophages. The present invention further relates to pharmaceutical compositions comprising these novel compounds, useful for prevention or treatment of inflammatory and autoimmune diseases and disorders.
摘要翻译：鉴定HSP60的不同表位，以调节巨噬细胞的结合和活化。定位于人HSP60的残基335-366，更具体地说残基254-265的一个表位结合LPS并通过将其呈递给收费受体-4复合物免疫刺激细胞，并将第二表位定位于残基481-500 HSP60，负责结合巨噬细胞表面。本发明涉及能够抑制那些肽区域与LPS或巨噬细胞结合的新型化合物。本发明还涉及包含这些新化合物的药物组合物，其可用于预防或治疗炎性和自身免疫疾病和病症。

3. 发明申请

WO2004098489A2 COMPOSITIONS AND METHODS FOR MODULATION OF SPECIFIC EPITOPES OF HSP60 审中-公开
标题翻译： HSP60特异性抗原决定簇的组成和方法
公开(公告)号：WO2004098489A2
公开(公告)日：2004-11-18
申请号：PCT/IL2004/000404
申请日：2004-05-12
申请人： PEPTOR LTD. , KOLB, Hubert
发明人： KOLB, Hubert
IPC分类号： A61K
CPC分类号： A61K38/1709 , C07K16/18 , C07K2317/76
摘要： Distinct epitopes of HSP60 are identified to modulate binding and activation of macrophages. One epitope, localized to residues 335-366, and more specifically to residues 254-265, of human HSP60 binds LPS and by presenting it to toll receptor-4 complex immunostimulates the cells, and a second epitope, localized to residues 481-500 of HSP60, is responsible for binding to the macrophage cell surface. The present invention relates to novel compounds, capable of inhibiting the binding of those peptidic regions to LPS or to macrophages. The present invention further relates to pharmaceutical compositions comprising these novel compounds, useful for prevention or treatment of inflammatory and autoimmune diseases and disorders.
摘要翻译：鉴定HSP60的不同表位调节巨噬细胞的结合和活化。定位于人HSP60的残基335-366，更具体地说残基254-265的一个表位与LPS结合并通过将其呈递给受体受体-4复合物来免疫刺激细胞，并将第二表位定位于残基481-500 HSP60负责结合巨噬细胞表面。本发明涉及能够抑制那些肽区域与LPS或巨噬细胞结合的新型化合物。本发明还涉及包含这些新化合物的药物组合物，其可用于预防或治疗炎性和自身免疫性疾病和病症。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式