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1. 发明申请

WO2010120866A2 MEDICAL INSTRUMENT FOR DELIVERY OF HIGH VOLTAGE PULSES AND METHOD OF DELIVERING THE SAME 审中-公开
标题翻译：用于输送高电压脉冲的医用仪器及其传送方法
公开(公告)号：WO2010120866A2
公开(公告)日：2010-10-21
申请号：PCT/US2010/031014
申请日：2010-04-14
申请人： OLD DOMINION UNIVERSITY RESEARCH FOUNDATION , KOLB, Juergen, F. , SCHOENBACH, Karl, H. , BEEBE, Stephen, P.
发明人： KOLB, Juergen, F. , SCHOENBACH, Karl, H. , BEEBE, Stephen, P.
IPC分类号： A61B18/12 , A61B18/14 , A61B18/18 , A61N1/05
CPC分类号： A61N1/325 , A61N1/0502 , A61N1/306 , A61N1/327
摘要： An instrument (10) for delivering a high voltage pulse to tissue is disclosed. The instrument (10) can include an outer support member (12) with a liquid reservoir (14) that has a liquid-contacting interior surface (16), an opening (18) at a distal end (20) of the outer support member (12), and a ground electrode (22) extending in a longitudinal direction and having a lower surface (23) proximate the opening (18). The instrument (10) can also include a working electrode (26) extending longitudinally from the liquid-contacting interior surface (16) with a needle-shaped distal portion (28) proximate the distal end (20), and an inlet port (31) and an outlet port (34) in liquid communication with the liquid reservoir (14). The working electrode (26) can be electrically isolated from the ground electrode (22) by an insulating portion (30) of the outer support member (12), and a direct path can exist through the liquid reservoir (14) between the ground electrode (22) and the working electrode (26).
摘要翻译：公开了一种用于将高电压脉冲传送给组织的仪器（10）。仪器（10）可以包括具有液体储存器（14）的外部支撑构件（12），该储存器具有液体接触内表面（16），在外部支撑构件的远端（20）处的开口（18）（12）和沿纵向方向延伸并具有靠近开口（18）的下表面（23）的接地电极（22）。仪器（10）还可以包括从液体接触内表面（16）纵向延伸的工作电极（26）与靠近远端（20）的针状远端部分（28）和入口端口（31））和与液体储存器（14）液体连通的出口（34）。工作电极（26）可以通过外部支撑构件（12）的绝缘部分（30）与接地电极（22）电隔离，并且通过液体存储器（14）可以在接地电极（22）和工作电极（26）。

2. 发明申请

WO2010120866A3 MEDICAL INSTRUMENT FOR DELIVERY OF HIGH VOLTAGE PULSES AND METHOD OF DELIVERING THE SAME 审中-公开
标题翻译：用于输送高电压脉冲的医用仪器及其传送方法
公开(公告)号：WO2010120866A3
公开(公告)日：2011-01-13
申请号：PCT/US2010031014
申请日：2010-04-14
申请人： OLD DOMINION UNIV RES FOUND , KOLB JUERGEN F , SCHOENBACH KARL H , BEEBE STEPHEN P
发明人： KOLB JUERGEN F , SCHOENBACH KARL H , BEEBE STEPHEN P
IPC分类号： A61B18/12 , A61B18/14 , A61B18/18 , A61N1/05
CPC分类号： A61N1/325 , A61N1/0502 , A61N1/306 , A61N1/327
摘要： An instrument (10) for delivering a high voltage pulse to tissue is disclosed. The instrument (10) can include an outer support member (12) with a liquid reservoir (14) that has a liquid-contacting interior surface (16), an opening (18) at a distal end (20) of the outer support member (12), and a ground electrode (22) extending in a longitudinal direction and having a lower surface (23) proximate the opening (18). The instrument (10) can also include a working electrode (26) extending longitudinally from the liquid-contacting interior surface (16) with a needle-shaped distal portion (28) proximate the distal end (20), and an inlet port (31) and an outlet port (34) in liquid communication with the liquid reservoir (14). The working electrode (26) can be electrically isolated from the ground electrode (22) by an insulating portion (30) of the outer support member (12), and a direct path can exist through the liquid reservoir (14) between the ground electrode (22) and the working electrode (26).
摘要翻译：公开了一种用于将高电压脉冲传送给组织的仪器（10）。仪器（10）可以包括具有液体储存器（14）的外部支撑构件（12），该储存器具有液体接触内表面（16），在外部支撑构件的远端（20）处的开口（18）（12）和沿纵向方向延伸并具有靠近开口（18）的下表面（23）的接地电极（22）。仪器（10）还可以包括从液体接触内表面（16）纵向延伸的工作电极（26）与靠近远端（20）的针状远端部分（28）和入口端口（31））和与液体储存器（14）液体连通的出口（34）。工作电极（26）可以通过外部支撑构件（12）的绝缘部分（30）与接地电极（22）电隔离，并且通过液体存储器（14）可以在接地电极（22）和工作电极（26）。

3. 发明申请

WO2010120847A1 SYSTEM AND METHOD FOR APPLYING PLASMA SPARKS TO TISSUE 审中-公开
标题翻译：用于将等离子体火花应用于组织的系统和方法
公开(公告)号：WO2010120847A1
公开(公告)日：2010-10-21
申请号：PCT/US2010/030988
申请日：2010-04-14
申请人： OLD DOMINION UNIVERSITY RESEARCH FOUNDATION , KOLB, Juergen, F. , SCHOENBACH, Karl, H. , PAITHANKAR, Dilip , SCULLY, Noah
发明人： KOLB, Juergen, F. , SCHOENBACH, Karl, H. , PAITHANKAR, Dilip , SCULLY, Noah
IPC分类号： A61B18/14
CPC分类号： A61B18/1477 , A61B18/1206 , A61B2018/00827 , A61B2018/00875 , A61B2018/00892 , A61B2018/1213 , A61B2018/122
摘要： A pulse delivery system (10) for producing a spark in tissue is disclosed. The system (10) can include at least two electrodes (14, 16) having sharp surface features (18), where the at least two electrodes (14, 16) are electrically isolated from one another. The sharp features (18) of the electrodes (14, 16) can be separated by a distance of about 2 to 20 mm. The system (10) can also include a pulse generator (20) for delivering pulsed voltage differences between the at least two electrodes (14, 16). The pulsed voltage differences can producing a voltage difference ranging from about 2.5 kV to about 35 IcV for a duration of about 50 ns to 3μs. The system (10) can include a controller (24) for determining whether the plurality of pulsed voltage differences produced a spark between the at least two electrodes (14, 16). A method of producing a spark in tissue for both therapeutic and non-therapeutic, i.e., cosmetic, applications is also disclosed.
摘要翻译：公开了一种用于在组织中产生火花的脉冲传送系统（10）。系统（10）可以包括具有尖锐表面特征（18）的至少两个电极（14,16），其中至少两个电极（14,16）彼此电隔离。电极（14,16）的尖锐特征（18）可以分开约2至20mm的距离。系统（10）还可以包括用于在至少两个电极（14,16）之间递送脉冲电压差的脉冲发生器（20）。脉冲电压差可以产生约2.5kV至约35 IcV的电压差，持续时间约为50ns至3μs。系统（10）可以包括用于确定多个脉冲电压差是否在至少两个电极（14,16）之间产生火花的控制器（24）。还公开了用于治疗和非治疗性即化妆品应用的组织中产生火花的方法。

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