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1. 发明公开

EP2838989A2 A METHOD OF IMPROVING THE ACTIVITY OF CELLULASE ENZYME MIXTURES IN THE SACCHARIFICATION OF (LIGNO)CELLULOSIC MATERIAL 审中-公开
标题翻译：法提高CELLULASEENZYMMISCHUNGEN的影响IN A糖化（木素）纤维素材料
公开(公告)号：EP2838989A2
公开(公告)日：2015-02-25
申请号：EP13777788.4
申请日：2013-04-19
申请人： Dyadic International (USA), Inc. , Emalfarb, Mark Aaron , Sinitsyn, Arkady Panteleimonovich , Jundzil, Richard , Wery, Jan , Visser, Jacob , Joosten, Rob , Koetsier, Martijn
发明人： EMALFARB, Mark , SINITSYN, Arkady , JUNDZIL, Richard , WERY, Jan , VISSER, Jacob , JOOSTEN, Rob , KOETSIER, Martijn
IPC分类号： C12N1/15
CPC分类号： C12N9/2437 , C12N9/0006 , C12N15/80 , C12P19/14 , C12Y101/99018
摘要： The present invention relates to modified filamentous fungal organisms having improved activity profiles with respect to the conversion of complex carbohydrates into simple sugars from cellulosic materials, including fungal organisms belonging to a genus selected from the group consisting of: Chrysosporium, Thielavia, Talaromyces, Thermomyces, Thermoascus, Neurospora, Aureobasidium, Filibasidium, Piromyces, Corynascus, Cryplococcus, Acremonium, Tolypocladium, Scytalidium, Schizophyllum, Sporotrichum, Penicillium, Gibberella, Myceliophthora, Mucor, Aspergillus, Fusarium, Humicola, Trichoderma, and Talaromyces, plus anamorphs and teleomorphs thereof. Filamentous fungal organisms having improved activity profiles are obtained by modifying genes encoding enzymes involved in the production of cellobionolactone, cellobionic acid, gluconolactone, gluconic acid, and related products, by a variety of mutagenic methods, resulting in nucleotide substitutions, insertions, and deletions, increasing the level of saccharification in enzyme mixtures obtained from the modified organisms.

2. 发明公开

EP2838989A4 A METHOD OF IMPROVING THE ACTIVITY OF CELLULASE ENZYME MIXTURES IN THE SACCHARIFICATION OF (LIGNO)CELLULOSIC MATERIAL 审中-公开
标题翻译： VERFAHREN ZURERHÖHUNGDER WIRKUNG VON CELLULASEENZYMMISCHUNGEN BEI DER VERZUCKERUNG EINES（LIGNO-）CELLULOSEMATERIALS
公开(公告)号：EP2838989A4
公开(公告)日：2015-12-09
申请号：EP13777788
申请日：2013-04-19
申请人： DYADIC INTERNAT USA INC , EMALFARB MARK AARON , SINITSYN ARKADY PANTELEIMONOVICH , JUNDZIL RICHARD , WERY JAN , VISSER JACOB , JOOSTEN ROB , KOETSIER MARTIJN JOHANNES
发明人： EMALFARB MARK , SINITSYN ARKADY , JUNDZIL RICHARD , WERY JAN , VISSER JACOB , JOOSTEN ROB , KOETSIER MARTIJN JOHANNES
IPC分类号： C12N1/15 , C12N9/04
CPC分类号： C12N9/2437 , C12N9/0006 , C12N15/80 , C12P19/14 , C12Y101/99018
摘要： The present invention relates to modified filamentous fungal organisms having improved activity profiles with respect to the conversion of complex carbohydrates into simple sugars from cellulosic materials, including fungal organisms belonging to a genus selected from the group consisting of: Chrysosporium, Thielavia, Talaromyces, Thermomyces, Thermoascus, Neurospora, Aureobasidium, Filibasidium, Piromyces, Corynascus, Cryplococcus, Acremonium, Tolypocladium, Scytalidium, Schizophyllum, Sporotrichum, Penicillium, Gibberella, Myceliophthora, Mucor, Aspergillus, Fusarium, Humicola, Trichoderma, and Talaromyces, plus anamorphs and teleomorphs thereof. Filamentous fungal organisms having improved activity profiles are obtained by modifying genes encoding enzymes involved in the production of cellobionolactone, cellobionic acid, gluconolactone, gluconic acid, and related products, by a variety of mutagenic methods, resulting in nucleotide substitutions, insertions, and deletions, increasing the level of saccharification in enzyme mixtures obtained from the modified organisms.
摘要翻译：本发明涉及关于将复合碳水化合物转化为纤维素材料的简单糖的改进的活性曲线的改良的丝状真菌生物，包括属于选自以下的属的真菌生物：Chrysosporium，Thielavia，Talaromyces，Thermomyces，嗜热链球菌，脉孢菌属，银耳菌属，丝状芽孢杆菌属，白喉菌属，丝状芽孢杆菌属，尖顶菌属，柯氏球菌属，孢子菌属，裂殖酵母属，孢子菌属，青霉属，赤霉菌属，霉菌属，毛霉属，曲霉属，镰孢霉属，腐质霉属，木霉属和塔拉木霉，以及其变形和远视。通过多种诱变方法修饰参与生产纤维二糖内酯，纤维二糖酸，葡萄糖酸内酯，葡萄糖酸和相关产品的酶的基因，获得具有改善的活性谱的丝状真菌生物，得到核苷酸取代，插入和缺失，增加从改性生物获得的酶混合物中的糖化水平。

3. 发明申请

WO2012078741A2 NOVEL FUNGAL ESTERASES 审中-公开
标题翻译：新鲜真菌
公开(公告)号：WO2012078741A2
公开(公告)日：2012-06-14
申请号：PCT/US2011063716
申请日：2011-12-07
申请人： DYADIC INTERNAT USA INC , VISSER JOHANNES , HINZ SANDRA , WERIJ JAN , VISSER JACOB , JOOSTEN VIVI , KOETSIER MARTIJN , EMALFARB MARK
发明人： VISSER JOHANNES , HINZ SANDRA , WERIJ JAN , VISSER JACOB , JOOSTEN VIVI , KOETSIER MARTIJN , EMALFARB MARK
IPC分类号： C12N15/55 , C07K19/00 , C12N9/16 , C12N15/62 , C12N15/63
CPC分类号： C12N9/16 , C12Y301/01011 , C12Y301/01072 , C12Y301/01073 , C12Y301/01074 , C12Y301/01086
摘要： This invention relates to novel enzymes and novel methods for producing the same. More specifically this invention relates to a variety of fungal enzymes. Nucleic acid molecules encoding such enzymes, compositions, recombinant and genetically modified host cells, and methods of use are described. The invention also relates to a method to convert lignocellulosic biomass to fermentable sugars with enzymes that degrade the lignocellulosic material and novel combinations of enzymes, including those that provide a synergistic release of sugars from plant biomass. The invention also relates to a method to release cellular content by degradation of cell walls. The invention also relates to methods to use the novel enzymes and compositions of such enzymes to improve the digestability of animal feed and in a variety of other processes, including food and beverage processing, baking, washing of clothing, detergent processes, biorefining, deinking and biobleaching of paper and pulp, and treatment of waste streams.
摘要翻译：本发明涉及新型酶及其生产方法。更具体地，本发明涉及各种真菌酶。描述了编码这种酶，组合物，重组和遗传修饰的宿主细胞的核酸分子和使用方法。本发明还涉及将木质纤维素生物质转化为可发酵糖的方法，其中酶可降解木质纤维素材料和酶的新组合，包括提供来自植物生物质的糖的协同释放的酶。本发明还涉及通过细胞壁降解释放细胞内容物的方法。本发明还涉及使用新型酶和这些酶的组合物来提高动物饲料和各种其它方法的消化能力的方法，包括食品和饮料加工，烘烤，洗涤衣物，洗涤剂方法，生物精炼，脱墨和纸和纸浆的生物漂白以及废物流的处理。

4. 发明申请

WO2012048334A3 NOVEL FUNGAL PROTEASES 审中-公开
标题翻译：新的真菌蛋白
公开(公告)号：WO2012048334A3
公开(公告)日：2013-01-10
申请号：PCT/US2011055703
申请日：2011-10-11
申请人： DYADIC INTERNAT USA INC , VISSER JOHANNES , HINZ SANDRA , WERIJ JAN , VISSER JACOB , JOOSTEN VIVI , KOETSIER MARTIJN , EMALFARB MARK
发明人： VISSER JOHANNES , HINZ SANDRA , WERIJ JAN , VISSER JACOB , JOOSTEN VIVI , KOETSIER MARTIJN , EMALFARB MARK
IPC分类号： C12N9/58 , A23B4/20 , A23C19/032 , A61K38/48 , C11D3/386 , C12N15/57
CPC分类号： C12N9/58 , A23C19/0326 , A61K38/48 , C11D3/38609
摘要： This invention relates to novel enzymes and novel methods for producing the same. More specifically this invention relates to a variety of fungal enzymes. Nucleic acid molecules encoding such enzymes, compositions, recombinant and genetically modified host cells, and methods of use are described. The invention also relates to a method to the degradation of protein and novel combinations of enzymes, including those that provide a synergistic release of amino acids or lower molecular weight proteins. The invention also relates to methods to use the novel enzymes and compositions of such enzymes in a variety of other processes, including washing or treating of clothing or fabrics, detergent processes, cleaning of carpets, leather treatment, animal feed, food processing, baking, increasing the protein yield of food, modification of food taste, processing of proteins in protein production, processing of beverages, medical treatment, and cosmetic treatment, and bio fuels.
摘要翻译：本发明涉及新型酶及其生产方法。更具体地，本发明涉及各种真菌酶。描述了编码这种酶，组合物，重组和遗传修饰的宿主细胞的核酸分子和使用方法。本发明还涉及降解蛋白质和酶的新型组合的方法，包括提供氨基酸或低分子量蛋白质的协同释放的酶的方法。本发明还涉及在各种其它方法中使用新型酶和这些酶的组合物的方法，包括衣物或织物的洗涤或处理，洗涤剂方法，地毯的清洁，皮革处理，动物饲料，食品加工，烘烤，增加食物的蛋白质产量，改变食物味道，蛋白质生产中的蛋白质加工，饮料加工，医疗和美容处理以及生物燃料。

5. 发明申请

WO2012068236A3 NOVEL FUNGAL OXIDOREDUCTASES 审中-公开
公开(公告)号：WO2012068236A3
公开(公告)日：2012-05-24
申请号：PCT/US2011/060970
申请日：2011-11-16
申请人： DYADIC INTERNATIONAL (USA) INC. , VISSER, Johannes , HINZ, Sandra , WERIJ, Jan , VISSER, Jacob , JOOSTEN, Vivi , KOETSIER, Martijn , EMALFARB, Mark
发明人： VISSER, Johannes , HINZ, Sandra , WERIJ, Jan , VISSER, Jacob , JOOSTEN, Vivi , KOETSIER, Martijn , EMALFARB, Mark
IPC分类号： C12N15/53 , C07K14/37 , C07K19/00 , C07K16/14 , C12P7/04 , C02F3/00 , A61K38/44
摘要： This invention relates to novel enzymes and novel methods for producing the same. More specifically this invention relates to enzymes of fungal origin classified as oxidoreductases and produced by fungi. Nucleic acid molecules encoding such enzymes, compositions, recombinant and genetically modified host cells, and methods of use are described. The invention also relates to methods to use the novel enzymes and compositions of such enzymes in a variety of other processes, including disinfection food, deinking and biobleaching of flour, cotton, paper and pulp, and the treatment of pollution. The invention also relates to a method to aid in the conversion of lignocellulosic biomass to fermentable sugars with enzymes that degrade the lignocellulosic material and novel combinations of enzymes, including those that provide a synergistic release of sugars from plant biomass.

6. 发明申请

WO2012068236A2 NOVEL FUNGAL OXIDOREDUCTASES 审中-公开
标题翻译：新型真菌氧化剂
公开(公告)号：WO2012068236A2
公开(公告)日：2012-05-24
申请号：PCT/US2011060970
申请日：2011-11-16
申请人： DYADIC INTERNAT USA INC , VISSER JOHANNES , HINZ SANDRA , WERIJ JAN , VISSER JACOB , JOOSTEN VIVI , KOETSIER MARTIJN , EMALFARB MARK
发明人： VISSER JOHANNES , HINZ SANDRA , WERIJ JAN , VISSER JACOB , JOOSTEN VIVI , KOETSIER MARTIJN , EMALFARB MARK
IPC分类号： C12N15/53 , A61K38/44 , C02F3/00 , C07K14/37 , C07K16/14 , C07K19/00 , C12P7/04
CPC分类号： C07K14/37 , A61K38/00 , C12N9/0004 , C12P7/10 , C12P19/02 , C12P19/14 , C12P2203/00 , Y02E50/16
摘要： This invention relates to novel enzymes and novel methods for producing the same. More specifically this invention relates to enzymes of fungal origin classified as oxidoreductases and produced by fungi. Nucleic acid molecules encoding such enzymes, compositions, recombinant and genetically modified host cells, and methods of use are described. The invention also relates to methods to use the novel enzymes and compositions of such enzymes in a variety of other processes, including disinfection food, deinking and biobleaching of flour, cotton, paper and pulp, and the treatment of pollution. The invention also relates to a method to aid in the conversion of lignocellulosic biomass to fermentable sugars with enzymes that degrade the lignocellulosic material and novel combinations of enzymes, including those that provide a synergistic release of sugars from plant biomass.
摘要翻译：本发明涉及新型酶及其生产方法。更具体地，本发明涉及分类为氧化还原酶并由真菌产生的真菌来源的酶。描述了编码这种酶，组合物，重组和遗传修饰的宿主细胞的核酸分子和使用方法。本发明还涉及在各种其他方法中使用新型酶和这些酶的组合物的方法，包括消毒食品，面粉，棉花，纸和纸浆的脱墨和生物漂白以及污染的处理。本发明还涉及一种帮助将木质纤维素生物质转化为可发酵糖的方法，其中酶降解木质纤维素材料和酶的新型组合，包括提供来自植物生物质的糖的协同释放的酶。

7. 发明申请

WO2012021883A3 NOVEL FUNGAL ENZYMES 审中-公开
标题翻译：新型真菌酶
公开(公告)号：WO2012021883A3
公开(公告)日：2012-05-10
申请号：PCT/US2011047734
申请日：2011-08-15
申请人： DYADIC INTERNATIONAL INC , EMALFARB MARK , VISSER JOHANNES , HINZ SANDRA , WERIJ JAN , VISSER JACOB , JOOSTEN VIVI , KOETSIER MARTIJN
发明人： EMALFARB MARK , VISSER JOHANNES , HINZ SANDRA , WERIJ JAN , VISSER JACOB , JOOSTEN VIVI , KOETSIER MARTIJN
IPC分类号： C07H21/04 , C12N9/30 , C12N9/58
CPC分类号： C12N9/2402
摘要： This invention relates to novel fungal enzymes and methods for producing the same. Nucleic acid molecules encoding such enzymes, compositions, recombinant and genetically modified host cells, and methods of use are described. The invention also relates to a method to convert lignocellulosic biomass to fermentable sugars with enzymes that degrade the lignocellulosic material and novel combinations of enzymes promoting the synergistic release of sugars from plant biomass. The invention also relates to a method to release cellular content by degradation of cell walls. The invention also relates to methods to use the novel enzymes and compositions of such enzymes to improve digest ability of animal feed and in a variety of other processes, including food and beverage processing, baking, washing of clothing, detergent processes, biorefining, deinking and biobleaching of paper and pulp, and treatment of waste streams.
摘要翻译：本发明涉及新颖的真菌酶及其制备方法。描述了编码这种酶，组合物，重组和遗传修饰的宿主细胞的核酸分子和使用方法。本发明还涉及将木质纤维素生物质转化成可降解木质纤维素材料的酶和促进植物生物质中糖的协同释放的酶的新组合的可发酵糖的方法。本发明还涉及通过细胞壁降解释放细胞内容物的方法。本发明还涉及使用新型酶和这些酶的组合物来提高动物饲料的消化能力和各种其它方法的方法，包括食品和饮料加工，烘烤，洗涤衣物，洗涤剂方法，生物精炼，脱墨和纸和纸浆的生物漂白以及废物流的处理。

8. 发明申请

WO2013159005A3 A METHOD OF IMPROVING THE ACTIVITY OF CELLULASE ENZYME MIXTURES IN THE SACCHARIFICATION OF (LIGNO)CELLULOSIC MATERIAL 审中-公开
标题翻译：改善（LIGNO）纤维素材料分离中纤维素酶酶混合物活性的方法
公开(公告)号：WO2013159005A3
公开(公告)日：2014-01-16
申请号：PCT/US2013037390
申请日：2013-04-19
申请人： DYADIC INTERNAT USA LTD , EMALFARB MARK , SINITSYN ARKADY , JUNDZIL RICHARD , WERY JAN , VISSER JACOB , JOOSTEN ROB , KOETSIER MARTIJN
发明人： EMALFARB MARK , SINITSYN ARKADY , JUNDZIL RICHARD , WERY JAN , VISSER JACOB , JOOSTEN ROB , KOETSIER MARTIJN
IPC分类号： C12N1/15
CPC分类号： C12N9/2437 , C12N9/0006 , C12N15/80 , C12P19/14 , C12Y101/99018
摘要： The present invention relates to modified filamentous fungal organisms having improved activity profiles with respect to the conversion of complex carbohydrates into simple sugars from cellulosic materials, including fungal organisms belonging to a genus selected from the group consisting of: Chrysosporium, Thielavia, Talaromyces, Thermomyces, Thermoascus, Neurospora, Aureobasidium, Filibasidium, Piromyces, Corynascus, Cryplococcus, Acremonium, Tolypocladium, Scytalidium, Schizophyllum, Sporotrichum, Penicillium, Gibberella, Myceliophthora, Mucor, Aspergillus, Fusarium, Humicola, Trichoderma, and Talaromyces, plus anamorphs and teleomorphs thereof. Filamentous fungal organisms having improved activity profiles are obtained by modifying genes encoding enzymes involved in the production of cellobionolactone, cellobionic acid, gluconolactone, gluconic acid, and related products, by a variety of mutagenic methods, resulting in nucleotide substitutions, insertions, and deletions, increasing the level of saccharification in enzyme mixtures obtained from the modified organisms.
摘要翻译：本发明涉及关于将复合碳水化合物转化为纤维素材料的简单糖的改进的活性谱的改良的丝状真菌生物，包括属于选自以下的属的真菌生物：Chrysosporium，Thielavia，Talaromyces，Thermomyces，嗜热链球菌，丝状芽孢杆菌，白喉菌，丝状菌属，丝状芽孢杆菌属，Corynascus，Cryplococcus，Acremonium，Tolypocladium，Scytalidium，Schizophyllum，Sporotrichum，Penicillium，Gibberella，Myceliophthora，Mucor，Aspergillus，Fusarium，Humicola，Trichoderma和Talaromyces，以及其变形和远视。通过各种诱变方法修饰参与生产纤维二糖内酯，纤维二糖酸，葡萄糖酸内酯，葡萄糖酸和相关产品的酶的基因，得到具有改善的活性谱的丝状真菌生物，得到核苷酸取代，插入和缺失，增加从改性生物获得的酶混合物中的糖化水平。

9. 发明申请

WO2013159005A2 A METHOD OF IMPROVING THE ACTIVITY OF CELLULASE ENZYME MIXTURES IN THE SACCHARIFICATION OF (LIGNO)CELLULOSIC MATERIAL 审中-公开
标题翻译：改善（LIGNO）纤维素材料分离中纤维素酶酶混合物活性的方法
公开(公告)号：WO2013159005A2
公开(公告)日：2013-10-24
申请号：PCT/US2013/037390
申请日：2013-04-19
申请人： DYADIC INTERNATIONAL (USA) LTD. , EMALFARB, Mark , SINITSYN, Arkady , JUNDZIL, Richard , WERY, Jan , VISSER, Jacob , JOOSTEN, Rob , KOETSIER, Martijn
发明人： EMALFARB, Mark , SINITSYN, Arkady , JUNDZIL, Richard , WERY, Jan , VISSER, Jacob , JOOSTEN, Rob , KOETSIER, Martijn
IPC分类号： C12N9/24 , C12N15/80 , C12P19/14
CPC分类号： C12N9/2437 , C12N9/0006 , C12N15/80 , C12P19/14 , C12Y101/99018
摘要： The present invention relates to modified filamentous fungal organisms having improved activity profiles with respect to the conversion of complex carbohydrates into simple sugars from cellulosic materials, including fungal organisms belonging to a genus selected from the group consisting of: Chrysosporium, Thielavia, Talaromyces, Thermomyces, Thermoascus, Neurospora, Aureobasidium, Filibasidium, Piromyces, Corynascus, Cryplococcus, Acremonium, Tolypocladium, Scytalidium, Schizophyllum, Sporotrichum, Penicillium, Gibberella, Myceliophthora, Mucor, Aspergillus, Fusarium, Humicola, Trichoderma, and Talaromyces, plus anamorphs and teleomorphs thereof. Filamentous fungal organisms having improved activity profiles are obtained by modifying genes encoding enzymes involved in the production of cellobionolactone, cellobionic acid, gluconolactone, gluconic acid, and related products, by a variety of mutagenic methods, resulting in nucleotide substitutions, insertions, and deletions, increasing the level of saccharification in enzyme mixtures obtained from the modified organisms.
摘要翻译：本发明涉及关于将复合碳水化合物转化为纤维素材料的简单糖的改进的活性谱的改良的丝状真菌生物，包括属于选自以下的属的真菌生物：Chrysosporium，Thielavia，Talaromyces，Thermomyces，嗜热链球菌，丝状芽孢杆菌，白喉菌，丝状菌属，丝状芽孢杆菌属，Corynascus，Cryplococcus，Acremonium，Tolypocladium，Scytalidium，Schizophyllum，Sporotrichum，Penicillium，Gibberella，Myceliophthora，Mucor，Aspergillus，Fusarium，Humicola，Trichoderma和Talaromyces，以及其变形和远视。通过各种诱变方法修饰参与生产纤维二糖内酯，纤维二糖酸，葡萄糖酸内酯，葡萄糖酸和相关产品的酶的基因，得到具有改善的活性谱的丝状真菌生物，得到核苷酸取代，插入和缺失，增加从改性生物获得的酶混合物中的糖化水平。

10. 发明申请

WO2012078741A3 NOVEL FUNGAL ESTERASES 审中-公开
公开(公告)号：WO2012078741A3
公开(公告)日：2012-06-14
申请号：PCT/US2011/063716
申请日：2011-12-07
申请人： DYADIC INTERNATIONAL (USA) INC. , VISSER, Johannes , HINZ, Sandra , WERIJ, Jan , VISSER, Jacob , JOOSTEN, Vivi , KOETSIER, Martijn , EMALFARB, Mark
发明人： VISSER, Johannes , HINZ, Sandra , WERIJ, Jan , VISSER, Jacob , JOOSTEN, Vivi , KOETSIER, Martijn , EMALFARB, Mark
IPC分类号： C12N15/55 , C12N15/62 , C07K19/00 , C12N9/16 , C12N15/63
摘要： This invention relates to novel enzymes and novel methods for producing the same. More specifically this invention relates to a variety of fungal enzymes. Nucleic acid molecules encoding such enzymes, compositions, recombinant and genetically modified host cells, and methods of use are described. The invention also relates to a method to convert lignocellulosic biomass to fermentable sugars with enzymes that degrade the lignocellulosic material and novel combinations of enzymes, including those that provide a synergistic release of sugars from plant biomass. The invention also relates to a method to release cellular content by degradation of cell walls. The invention also relates to methods to use the novel enzymes and compositions of such enzymes to improve the digestability of animal feed and in a variety of other processes, including food and beverage processing, baking, washing of clothing, detergent processes, biorefining, deinking and biobleaching of paper and pulp, and treatment of waste streams.

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