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    • 1. 发明申请
    • NOVEL CEPHEM DERIVATIVES
    • 新CEPHEM衍生物
    • WO1998025935A1
    • 1998-06-18
    • PCT/JP1997004489
    • 1997-12-08
    • MEIJI SEIKA KAISHA, LTD.KOBAYASHI, KazukoUMEMURA, EijirouATSUMI, KunioIDA, Takashi
    • MEIJI SEIKA KAISHA, LTD.
    • C07D519/06
    • C07D519/00
    • Compounds represented by general formula (I). These compounds have broad and potent antibacterial activities on gram-positive bacteria including those producing beta -lactamase and gram-negative bacteria. In particular, these compounds are superior to the existing cephem derivatives of the onium salt type in the antibacterial activities on methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae (PRSP) and imipenem-resistant Pseudomonas aeruginosa, which makes them highly useful as remedies for infectious diseases caused by various pathogenic bacteria. In said formula, X represents CH or N; R represents hydrogen, optionally substituted C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl or cycloalkyl; one of R , R , R and R R NSO2NHC1-6 (wherein R and R may be the same or different from each other and each represents hydrogen or C1-6 alkyl); and n is 0 or 1.
    • 由通式(I)表示的化合物。 这些化合物对革兰氏阳性细菌具有广泛有效的抗菌活性,包括那些产生β-内酰胺酶和革兰氏阴性细菌的抗菌活性。 特别地,这些化合物优于现有的鎓盐型头孢烯衍生物对耐甲氧西林金黄色葡萄球菌(MRSA),青霉素耐药性肺炎链球菌(PRSP)和亚胺培南耐药铜绿假单胞菌的抗菌活性,使其高度 可用作各种病原菌引起的传染病的补救措施。 在所述式中,X表示CH或N; R 1表示氢,任选取代的C 1-6烷基,C 2-6烯基,C 2-6炔基或环烷基; R 2,R 3,R 4,R 5, 表示R 6> R 7 NSO 2 NHC 1-6(其中R 6和R 7可以相同或不同,各自表示氢或C 1-6烷基)。 n为0或1。
    • 9. 发明专利
    • FLOCCULATION DEVICE
    • JPH10277556A
    • 1998-10-20
    • JP10827297
    • 1997-04-10
    • KOBAYASHI KAZUKO
    • KOBAYASHI KAZUKO
    • C02F1/46C02F1/463C02F1/465
    • PROBLEM TO BE SOLVED: To remove impurities as high as a desired purification level in a short period of time by the polarization functions due to the action of electric field by providing the device with a treatment tank of closed construction having on its upper and lower ends an anode and a cathode, and an inlet and outlet ports for waste water, respectively, and disposing a dielectric plate horizontally in the tank so as not to come into contact with the anode and cathode. SOLUTION: Liquid to be treated flows into a treatment tank 1 from its inlet port 8 and flows out from an outlet port 9 via an S-shaped passage. At that moment, in a space defined by a dielectric plate 4 in the tank 1, if a predetermined voltage is applied between a cathode 2 and an anode 3, an electric field of a predetermined intensity is generated between the cathode and anode so that the plate 4 is polarized by the polarization action and the flocculation of impurities is accelerated by the catalytic action of the plate 4 and at the same time, a positive surface of the plate 4 emits metal ions, while a negative surface thereof emits minus electrons. And small bubbles of hydrogen are combined with suspended matters so as to be separated by a suspended matter removal device so that the deposition of the suspended matters from the liquid to be treated can be accelerated. And thereafter, the liquid to be treated is discharged from the tank 1 through a pipe on the side of the outlet port 9.