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    • 1. 发明申请
    • SYSTEM FOR ENHANCED CARDIAC FUNCTION WITH COMBINED PESP/NES
    • 具有组合PESP / NES的增强心脏功能的系统
    • WO2006115774A2
    • 2006-11-02
    • PCT/US2006/013592
    • 2006-04-11
    • MEDTRONIC, INC.BURNES, John, E.MULLIGAN, Lawrence, J.KNOLL, Randall, L.
    • BURNES, John, E.MULLIGAN, Lawrence, J.KNOLL, Randall, L.
    • A61N1/362
    • A61N1/3627A61N1/36114A61N1/36564
    • In some embodiments, a method of applying stimulation pulse therapy to excitable tissue may include one or more of the following steps: (a) delivering a PESP stimulation therapy to the excitable tissue for a cardiac cycle, (b) delivering a NES stimulation therapy to the excitable tissue during certain cardiac cycles, (c) determining physiologic demand of the patient based on at least one physiologic measurement, (d) determining physiologic demand being placed on a heart based on at least one physiologic measurement, and ceasing the delivery of the NES and PESP stimulation therapy when physiologic demand returns to a base level, and (e) determining physiologic demand being placed on a heart based on at least one physiologic measurement, and modulating the ratio of the number of cardiac cycles in which the NES stimulation therapy is delivered to the number of cardiac cycles in which the PESP stimulation therapy is delivered based on physiologic demand.
    • 在一些实施方案中,将刺激脉冲治疗应用于可兴奋组织的方法可以包括以下步骤中的一个或多个:(a)将PESP刺激疗法递送至心脏周期的可兴奋组织,(b)将NES刺激疗法递送至 (c)基于至少一个生理测量来确定患者的生理需求,(d)基于至少一个生理测量来确定置于心脏上的生理需求,并且停止递送 NES和PESP刺激治疗,当生理需求恢复到基础水平时,以及(e)基于至少一个生理测量来确定置于心脏上的生理需求,以及调节NES刺激疗法的心脏周期数 基于生理需求被传递到其中递送PESP刺激疗法的心脏周期数。