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1. 发明申请

WO2007103077A3 NEGATIVE INDEX MATERIAL WITH COMPENSATED LOSSES 审中-公开
标题翻译：负指数材料与补偿损失
公开(公告)号：WO2007103077A3
公开(公告)日：2008-05-15
申请号：PCT/US2007005152
申请日：2007-02-28
申请人： PURDUE RESEARCH FOUNDATION , SHALAEV VLADIMIR M , DRACHEV VLADIMIR P , KLAR THOMAS A , KILDISHEV ALEXANDER V
发明人： SHALAEV VLADIMIR M , DRACHEV VLADIMIR P , KLAR THOMAS A , KILDISHEV ALEXANDER V
IPC分类号： B82B1/00
CPC分类号： G01J3/02 , B82Y20/00 , G01J3/0256 , G01J3/0297 , G02B1/007 , G02B6/1225 , G02B6/1226 , H01S3/0632 , H01S3/1608 , H01S3/169
摘要： A composition of resonant passive metal-dielectric elements with gain medium results in a meta-material with an effective negative refractive index and compensated losses. To compensate for losses, additional energy is supplied using the stimulated emission from active elements made of a gain material. The overall objective is to overcome the fundamental threshold in resolution for conventional optical imaging limited to about a half-wavelength of incident light. The negative index material with compensated losses (NIMCOL) can be used in NIM-based optical imaging and sensing devices with enhanced sub-wavelength resolution. A lasing device based on overcompensating for the loss in NIM structures is disclosed as well.
摘要翻译：具有增益介质的谐振无源金属 - 介电元件的组成导致具有有效负折射率和补偿损耗的超常材料。为了补偿损耗，使用由增益材料制成的有源元件的受激发射来提供额外的能量。总体目标是克服限于约半波长的入射光的常规光学成像的分辨率的基本阈值。具有补偿损耗的负指数材料（NIMCOL）可用于具有增强的亚波长分辨率的基于NIM的光学成像和感测装置。还公开了一种基于对NIM结构的损耗进行过补偿的激光装置。

2. 发明申请

WO2012045688A1 EINEM BIOLOGISCHEN GEWEBE NACHGEBILDETE STRUKTUR UND VERFAHREN ZU DEREN HERSTELLUNG 审中-公开
标题翻译：用于生产生物组织模拟的结构和工艺
公开(公告)号：WO2012045688A1
公开(公告)日：2012-04-12
申请号：PCT/EP2011/067177
申请日：2011-09-30
申请人： TECHNISCHE UNIVERSITÄT ILMENAU , SCHOBER, Andreas , GEBINOGA, Michael , FERNEKORN, Uta , WEISE, Frank , HAMPL, Jörg , KATZMANN, Julia , KLAR, Thomas
发明人： SCHOBER, Andreas , GEBINOGA, Michael , FERNEKORN, Uta , WEISE, Frank , HAMPL, Jörg , KATZMANN, Julia , KLAR, Thomas
IPC分类号： G05B19/4099
CPC分类号： A61F2/02 , G05B19/4099 , G05B2219/49019 , G05B2219/49031 , G06F19/12 , G06F19/24
摘要： Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung einer einem biologischen Gewebe nachgebildeten Struktur. Dabei wird insbesondere eine extrazelluläre Matrix des biologischen Gewebes nachgebildet, sodass biologische Zellen in die nachgebildete extrazelluläre Matrix eingebracht werden können, um das gesamte biologische Gewebe nachbilden zu können. Im Weiteren betrifft die Erfindung eine mit dem erfindungsgemäßen Verfahren herstellbare Struktur, durch welche zumindest eine extrazelluläre Matrix eines biologischen Gewebes nachgebildet ist. In einem ersten Schritt des erfindungsgemäßen Verfahrens werden Daten bereitgestellt, welche einen strukturellen Aufbau zumindest von Komponenten der extrazellulären Matrix des biologischen Gewebes beschreiben. In einem weiteren Schritt wird ein Vorläufer eines Biopolymers bereitgestellt. Erfindungsgemäß erfolgt ein örtlich gezieltes Bestrahlen des Vorläufers mit einer elektromagnetischen Strahlung, wobei das Bestrahlen, insbesondere die Auswahl der zu bestrahlenden Bereiche, gemäß dem durch die Daten beschriebenen strukturellen Aufbau erfolgt. Dabei wird die elektromagnetische Strahlung so bemessen, dass in den bestrahlten Bereichen des Vorläufers eine Zwei- oder Multiphotonen-Absorption stattfindet, durch welche der Vorläufer in den bestrahlten Bereichen zu dem Biopolymer polymerisiert wird, sodass er dort zumindest teilweise verfestigt.
摘要翻译：本发明涉及一种用于制造一个模拟生物组织结构的方法。特别地，生物组织的胞外基质进行了模拟，使得生物细胞可以被引入到模拟细胞外基质以再现整个生物组织。此外，本发明通过至少一个生物组织的细胞外基质是模拟本发明的方法的结构涉及一种生产。在本发明方法的数据的第一步骤，提供其中描述结构设计，至少从生物组织的细胞外基质的组分。在进一步的步骤中，提供一种生物聚合物的前体。根据本发明，本地定位用电磁辐射，其中所述辐射，特别是区域的选择要被照射时，根据由数据所描述的结构配置中进行照射前体。的电磁辐射的尺寸使得在二维或多光子吸收的前驱体的照射区域发生时，通过该前体在被照射的区域聚合，生物聚合物，以便它至少部分固化那里。

3. 发明申请

WO2008151931A1 PROCESS FOR DETECTING NUCLEIC ACIDS 审中-公开
标题翻译：检测核酸的方法
公开(公告)号：WO2008151931A1
公开(公告)日：2008-12-18
申请号：PCT/EP2008/056505
申请日：2008-05-27
申请人： LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN , STEHR, Joachim A. , KLAR, Thomas A. , FELDMANN, Jochen , HRELESCU, Calin , PARAK, Wolfgang , RASCHKE, Gunnar , SPERLING, Ralf , WUNDERLICH, Michael , KÜRZINGER, Konrad , HEINDL, Dieter , NICHTL, Alfons
发明人： STEHR, Joachim A. , KLAR, Thomas A. , FELDMANN, Jochen , HRELESCU, Calin , PARAK, Wolfgang , RASCHKE, Gunnar , SPERLING, Ralf , WUNDERLICH, Michael , KÜRZINGER, Konrad , HEINDL, Dieter , NICHTL, Alfons
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , Y10T436/143333 , C12Q2563/155 , C12Q2527/107
摘要： A process for detecting nucleic acids, having the following steps: providing at least one nanoparticle that is functionalised for the nucleic acid to be detected by means of at least one oligonucleotide that is bound to it and that is able to hybridize with at least one segment of a nucleic acid to be detected; bringing the functionalised nanoparticle into contact with a sample in which the nucleic acid is to be detected; and measuring a property that provides information about the degree of hybridization of the at least one oligonucleotide with the nucleic acid to be detected. In addition, the process includes the step of exciting the nanoparticles to generate heat, for example by means of a photothermal effect. The invention is suitable, in particular, for high-throughput DNA analysis.
摘要翻译：一种用于检测核酸的方法，具有以下步骤：提供至少一种纳米颗粒，所述至少一种纳米颗粒通过与其结合的至少一种寡核苷酸为要检测的核酸而被官能化，并且能够与至少一个区段杂交的待检测核酸; 使官能化的纳米颗粒与待检测核酸的样品接触; 并测量提供关于至少一种寡核苷酸与待检测核酸的杂交程度的信息的性质。此外，该方法包括激发纳米颗粒以产生热量的步骤，例如通过光热效应。本发明特别适用于高通量DNA分析。

4. 发明申请

WO2004042403A2 METHODS, DEVICE AND INSTRUMENT FOR DETECTION OF ANALYTES 审中-公开
标题翻译：用于检测分析仪的方法，装置和仪器
公开(公告)号：WO2004042403A2
公开(公告)日：2004-05-21
申请号：PCT/EP2003/012234
申请日：2003-11-03
申请人： LUDWIG-MAXIMILIAN-UNI VERSITÄT MÜNCHEN , ROCHE DIAGNOSTICS GMBH , FELDMANN, Jochen , FRANZL, Thomas , KLAR, Thomas , RASCHKE, Gunnar , SÖNNICHSEN, Carsten , KOWARIK, Stefan , NICHTL, Alfons , KÜRZINGER, Konrad
发明人： FELDMANN, Jochen , FRANZL, Thomas , KLAR, Thomas , RASCHKE, Gunnar , SÖNNICHSEN, Carsten , KOWARIK, Stefan , NICHTL, Alfons , KÜRZINGER, Konrad
IPC分类号： G01N33/58
CPC分类号： G01N33/54346 , G01N15/1468 , G01N21/554
摘要： The present invention relates to a method, a device and an instrument for the detection of an analyte (4) in a sample(6). Such method, device and instrument is used in clinical diagnostics, pharmacology, e.g. drug screening, environmental analysis as well as in other fields of analysis like chemistry or biochemistry. According to the present invention, the method for detection of an analyte (4) in a sample comprises the following steps of a) providing at least one particle structure (1) detectable by light scattering and coated with binding entities (2) for said analyte (4); b) contacting the at least one particle structure (1) with the sample (6), c) illuminating the at least one particle structure (1) and measuring the scattered light emitted by individual particle structures (1) at least twice and d) determining a change in the spectral signature of the scattered light as a measure of the presence and/or quantity of the analyte (4) in the sample (6). In order to detect more than one analyte (4) simultaneously particle structures (1) of different classes of particle structures maybe coated with different binding entities. Further, instead of coatig the particle structure (1) with binding entities specific for the analyte (4), the particle structure (1) may be coated with substances (21) competing with said analyte (4) for binding to specific binding entities (2). Any competitive and non-competitive assay format can be put into practice.
摘要翻译：本发明涉及用于检测样品（6）中的分析物（4）的方法，装置和仪器。这种方法，装置和仪器用于临床诊断，药理学，例如。药物筛选，环境分析以及化学或生物化学等其他分析领域。根据本发明，用于检测样品中的分析物（4）的方法包括以下步骤：a）提供至少一个可通过光散射检测的颗粒结构（1），并涂覆有用于所述分析物的结合实体（2）（4）; b）使所述至少一个颗粒结构（1）与所述样品（6）接触，c）照射所述至少一个颗粒结构（1）并且测量由各个颗粒结构（1）发射的散射光至少两次，以及d）确定散射光的光谱特征的变化，作为样品（6）中分析物（4）的存在和/或量的量度。为了检测多于一种分析物（4），不同类型的颗粒结构的颗粒结构（1）可以同时涂覆不同的结合实体。此外，代替用特定于分析物（4）的结合实体对颗粒结构（1）进行涂层，颗粒结构（1）可以涂覆与所述分析物（4）竞争的物质（21）以结合特异性结合实体（ 2）。任何竞争性和非竞争性的测定格式都可以付诸实践。

5. 发明申请

WO2007103077A2 NEGATIVE INDEX MATERIAL WITH COMPENSATED LOSSES 审中-公开
标题翻译：负指数材料与补偿损失
公开(公告)号：WO2007103077A2
公开(公告)日：2007-09-13
申请号：PCT/US2007/005152
申请日：2007-02-28
申请人： PURDUE RESEARCH FOUNDATION , SHALAEV, Vladimir, M. , DRACHEV, Vladimir, P. , KLAR, Thomas, A. , KILDISHEV, Alexander, V.
发明人： SHALAEV, Vladimir, M. , DRACHEV, Vladimir, P. , KLAR, Thomas, A. , KILDISHEV, Alexander, V.
IPC分类号： G01J3/28
CPC分类号： G01J3/02 , B82Y20/00 , G01J3/0256 , G01J3/0297 , G02B1/007 , G02B6/1225 , G02B6/1226 , H01S3/0632 , H01S3/1608 , H01S3/169
摘要： A composition of resonant passive metal-dielectric elements with gain medium results in a meta-material with an effective negative refractive index and compensated losses. To compensate for losses, additional energy is supplied using the stimulated emission from active elements made of a gain material. The overall objective is to overcome the fundamental threshold in resolution for conventional optical imaging limited to about a half-wavelength of incident light. The negative index material with compensated losses (NIMCOL) can be used in NIM-based optical imaging and sensing devices with enhanced sub-wavelength resolution. A lasing device based on overcompensating for the loss in NIM structures is disclosed as well.
摘要翻译：具有增益介质的谐振无源金属 - 介电元件的组成导致具有有效负折射率和补偿损耗的超常材料。为了补偿损耗，使用由增益材料制成的有源元件的受激发射来提供额外的能量。总体目标是克服限于约半波长的入射光的常规光学成像的分辨率的基本阈值。具有补偿损耗的负指数材料（NIMCOL）可用于具有增强的亚波长分辨率的基于NIM的光学成像和感测装置。还公开了一种基于对NIM结构的损耗进行过补偿的激光装置。

6. 发明申请

WO2004042403A3 METHODS, DEVICE AND INSTRUMENT FOR DETECTION OF ANALYTES 审中-公开
标题翻译：用于检测分析的方法，装置和仪器
公开(公告)号：WO2004042403A3
公开(公告)日：2004-07-29
申请号：PCT/EP0312234
申请日：2003-11-03
申请人： LUDWIG MAXIMILIAN UNI VERSITAE , ROCHE DIAGNOSTICS GMBH , FELDMANN JOCHEN , FRANZL THOMAS , KLAR THOMAS , RASCHKE GUNNAR , SOENNICHSEN CARSTEN , KOWARIK STEFAN , NICHTL ALFONS , KUERZINGER KONRAD
发明人： FELDMANN JOCHEN , FRANZL THOMAS , KLAR THOMAS , RASCHKE GUNNAR , SOENNICHSEN CARSTEN , KOWARIK STEFAN , NICHTL ALFONS , KUERZINGER KONRAD
IPC分类号： G01N15/14 , G01N33/543 , G01N33/547
CPC分类号： G01N33/54346 , G01N15/1468 , G01N21/554
摘要： The present invention relates to a method, a device and an instrument for the detection of an analyte (4) in a sample(6). Such method, device and instrument is used in clinical diagnostics, pharmacology, e.g. drug screening, environmental analysis as well as in other fields of analysis like chemistry or biochemistry. According to the present invention, the method for detection of an analyte (4) in a sample comprises the following steps of a) providing at least one particle structure (1) detectable by light scattering and coated with binding entities (2) for said analyte (4); b) contacting the at least one particle structure (1) with the sample (6), c) illuminating the at least one particle structure (1) and measuring the scattered light emitted by individual particle structures (1) at least twice and d) determining a change in the spectral signature of the scattered light as a measure of the presence and/or quantity of the analyte (4) in the sample (6). In order to detect more than one analyte (4) simultaneously particle structures (1) of different classes of particle structures maybe coated with different binding entities. Further, instead of coatig the particle structure (1) with binding entities specific for the analyte (4), the particle structure (1) may be coated with substances (21) competing with said analyte (4) for binding to specific binding entities (2). Any competitive and non-competitive assay format can be put into practice.
摘要翻译：本发明涉及用于检测样品（6）中的分析物（4）的方法，装置和仪器。这样的方法，装置和仪器用于临床诊断，药理学，例如，药物筛选，环境分析以及化学或生物化学等其他分析领域。根据本发明，用于检测样品中的分析物（4）的方法包括以下步骤：a）提供至少一种可通过光散射检测并且用结合实体（2）检测的用于所述分析物的颗粒结构（1）（4）; b）使所述至少一个颗粒结构（1）与所述样品（6）接触，c）照射所述至少一个颗粒结构（1）并且测量由各个颗粒结构（1）发射的散射光至少两次，以及d）确定散射光的光谱特征的变化，作为样品（6）中分析物（4）的存在和/或数量的量度。为了检测多于一种分析物（4），不同类别的粒子结构的粒子结构（1）可以同时用不同的结合实体涂覆。此外，可以用与所述分析物（4）竞争结合特定结合实体的物质（21）涂覆颗粒结构（1），而不是将颗粒结构（1）与分析物（4） 2）。任何竞争性和非竞争性测定形式都可以付诸实践。

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