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1. 发明专利

IL241779A Method for producing protein 未知
公开(公告)号：IL241779A
公开(公告)日：2017-07-31
申请号：IL24177915
申请日：2015-09-21
申请人： NIPPI INCORPORATED , TOMONORI UENO , YUKI TAGA , KIYOKO GOTO , YUKO KAKU
发明人： TOMONORI UENO , YUKI TAGA , KIYOKO GOTO , YUKO KAKU
IPC分类号： A61K20060101 , A61P20060101 , C12N20060101 , C12P20060101
摘要： It has been believed that promoting the assembly of polysomes composed of many ribosomes attached to mRNA is very effective for highly efficient protein synthesis. However, the mechanism for p 180 protein's capability of promoting polysome formation has been yet to be elucidated.The inventors of the present application newly discovered SF3b4 protein as a protein that specifically interacts with the coiled-coil domain of p 180 protein, a responsible region for its capability of promoting polysome formation, and which is capable of promoting mRNA localization to an endoplasmic reticulum (ER). The inventors also found that, in cells capable of highly expressing both p180 protein and a protein promoting mRNA localization to an endoplasmic reticulum (ER) (e.g., SF3b4 protein), the mRNA localization to the endoplasmic reticulum can be significantly elevated so that the secretory capacity in cultured cells can be enhanced. Further, the inventors demonstrated that when a particular nucleotide sequence is inserted into an expression plasmid, SF3b4 protein exhibiting protein expression enhancing ability can be localized onto the endoplasmic reticulum membrane, and the mRNA distribution in polysomes can be shifted towards heavier fractions, whereby the secretory capacity in cells can be enhanced.

2. 发明专利

IL241779D0 Method for producing protein 未知
公开(公告)号：IL241779D0
公开(公告)日：2015-11-30
申请号：IL24177915
申请日：2015-09-21
申请人： NIPPI INC , TOMONORI UENO , YUKI TAGA , KIYOKO GOTO , YUKO KAKU
IPC分类号： C12N20060101
摘要： It has been believed that promoting the assembly of polysomes composed of many ribosomes attached to mRNA is very effective for highly efficient protein synthesis. However, the mechanism for p 180 protein's capability of promoting polysome formation has been yet to be elucidated.The inventors of the present application newly discovered SF3b4 protein as a protein that specifically interacts with the coiled-coil domain of p 180 protein, a responsible region for its capability of promoting polysome formation, and which is capable of promoting mRNA localization to an endoplasmic reticulum (ER). The inventors also found that, in cells capable of highly expressing both p180 protein and a protein promoting mRNA localization to an endoplasmic reticulum (ER) (e.g., SF3b4 protein), the mRNA localization to the endoplasmic reticulum can be significantly elevated so that the secretory capacity in cultured cells can be enhanced. Further, the inventors demonstrated that when a particular nucleotide sequence is inserted into an expression plasmid, SF3b4 protein exhibiting protein expression enhancing ability can be localized onto the endoplasmic reticulum membrane, and the mRNA distribution in polysomes can be shifted towards heavier fractions, whereby the secretory capacity in cells can be enhanced.

3. 发明专利

JP2010136811A Care-receiver supporting tool 有权
标题翻译：辅助接收器支持工具
公开(公告)号：JP2010136811A
公开(公告)日：2010-06-24
申请号：JP2008314430
申请日：2008-12-10
申请人： Kiyoko Goto , 清子後藤
发明人： GOTO KIYOKO
IPC分类号： A61G1/00 , A47D13/02
CPC分类号： A47D13/025
摘要： PROBLEM TO BE SOLVED: To provide a supporting tool of a care-receiver when a body of the care receiver is big, but a care giver can leave at least one hand unused for upholding the care receiver and moving. SOLUTION: An upper body of a care receiver is supported with a back pad section 12 while a shoulder belt 70 connected to the back pad section is hung down from a shoulder of a care giver, and the upper body of the care receiver is supported with it. At the same time, the lower body of the care receiver is supported by an annular belt 80 while the annular belt is hung down from the shoulder of the care giver. Then the care giver can leave one hand unused for supporting the lower body of the care receiver. The result is that the upper body and the lower body of the care receiver are hung down from the shoulder of the care giver through separate belts, and then the care giver can leave at least one hand unused for supporting the whole body of the care receiver. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：当护理人员的身体大时，提供护理者的支持工具，但护理人员可以至少留下一只手，以保持护理接收器和移动。解决方案：护理接收器的上身被后垫部分12支撑，而连接到背垫部分的肩带70从护理人员的肩膀上被挂起，护理接收器的上身被它支持。同时，护理接收器的下部由环形带80支撑，同时环形带从护理人员的肩部垂下。然后，护理人员可以不用一只手来支撑护理接收器的下身。结果是，护理接收器的上身和下身从护理人员的肩膀上通过分开的皮带挂起，然后护理人员可以至少留下一只手，以支持护理接收器的整个身体。版权所有（C）2010，JPO＆INPIT

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