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1. 发明专利

AU2002351757A1 A ROTOR BLADE FOR A WIND TURBINE AND A WIND TURBINE WITH SUCH ROTOR BLADE 未知
公开(公告)号：AU2002351757A1
公开(公告)日：2003-07-30
申请号：AU2002351757
申请日：2002-12-30
申请人： KINCH MICHAEL , NEG MICON AS , BONUS ENERGY AS , LM GLASFIBER AS , VESTAS WIND SYS AS , NORDEX ENERGY GMBH , THISTED JAN , GRABAU PETER , KAMUK MADSEN KLAVS
发明人： KINCH MICHAEL , THISTED JAN , GRABAU PETER , KAMUK-MADSEN KLAVS
IPC分类号： F03D11/00 , F03D80/00

2. 发明专利

AU2003239585A1 LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE (LMW-PTP) AS A DIAGNOSTIC AND THERAPEUTIC TARGET 未知
公开(公告)号：AU2003239585A1
公开(公告)日：2003-12-12
申请号：AU2003239585
申请日：2003-05-22
申请人： PURDUE RESEARCH FOUNDATION , KINCH MICHAEL S
发明人： KINCH MICHAEL S
IPC分类号： A61K38/00 , A61K38/17 , C12N9/16 , G01N33/50 , G01N33/574 , G01N33/53 , A61K39/00 , A61K39/395
摘要： Low molecular weight protein tyrosine phosphatase (LMW-PTP) is identified as a novel diagnostic and therapeutic target in cancer diagnosis, prognosis and treatment. The invention provides diagnostic and treatment methods useful in connection with cancers expressing LMW-PTP and, optionally, EphA2 receptor. Also provided is a screening method that utilizes changes in the amount and/or activity of LMW-PTP to identify candidate cancer therapeutic agents that effectively target the oncoprotein EphA2.

3. 发明专利

AU2002351757A8 A rotor blade for a wind turbine and a wind turbine with such rotor blade 未知
公开(公告)号：AU2002351757A8
公开(公告)日：2003-07-30
申请号：AU2002351757
申请日：2002-12-30
申请人： KINCH MICHAEL , LM GLASFIBER AS , BONUS ENERGY AS , VESTAS WIND SYS AS , GRABAU PETER , NORDEX ENERGY GMBH , NEG MICON AS , KAMUK MADSEN KLAVS , THISTED JAN
发明人： GRABAU PETER , KINCH MICHAEL , KAMUK-MADSEN KLAVS , THISTED JAN
IPC分类号： F03D11/00 , F03D80/00

4. 发明申请

WO2010128988A1 HUMAN FG01 GENE AND ITS APPLICATIONS 审中-公开
标题翻译：人类FG01基因及其应用
公开(公告)号：WO2010128988A1
公开(公告)日：2010-11-11
申请号：PCT/US2009/058334
申请日：2009-09-25
申请人： FUNCTIONAL GENETICS, INC. , LI, Wu-Bo , KINCH, Michael , GOLDBLATT, Michael
发明人： LI, Wu-Bo , KINCH, Michael , GOLDBLATT, Michael
IPC分类号： G01N33/53
CPC分类号： G01N33/6896 , C07K14/4711 , G01N2800/2821
摘要： A human gene, fg01, on chromosome 8, is identified. This gene, and its expression product, human fg01, shares a homology under 70% with the corresponding murine gene, which has been linked to presentation of the Alzheimer's phenotype of Aβ plaques and hyperphosphorylated tau tangles. Upregulation appears to suppress the Alzheimer's phenotype, which may be effective in preventing the onset of symptoms or progression of symptoms associated with AD. Screening methods are also set forth.
摘要翻译：鉴定出染色体8上的人类基因fg01。该基因及其表达产物人fg01与70％的同源性与相应的鼠基因共享，该基因已经与阿尔茨海默病的Aß噬斑表现和高磷酸化tau缠结呈现相关。上调似乎可以抑制阿尔茨海默病的表型，这可能有效预防与AD有关的症状或进展症状。还阐述了筛选方法。

5. 发明申请

WO2010080782A3 RANDOM HOMOZYGOUS GENE PERBURBATION (RHGP) WITH THERMAL ASSYMETRIC INTERLACED (TAIL)-PCR 审中-公开
公开(公告)号：WO2010080782A3
公开(公告)日：2010-07-15
申请号：PCT/US2010/020190
申请日：2010-01-06
申请人： FUNCTIONAL GENETICS, INC. , KINCH, Michael, S. , GOLDBLATT, Michael , LI, Wu-Bo , BAMBA, Douty , CHANG, Shaojing , CHEN, Huosheng , FESSEHA, Zenbework , KOHLI, Manu , MAO, Hanwen , UNG-MEDOFF, Heather Thi Thu , WENG, Ke
发明人： KINCH, Michael, S. , GOLDBLATT, Michael , LI, Wu-Bo , BAMBA, Douty , CHANG, Shaojing , CHEN, Huosheng , FESSEHA, Zenbework , KOHLI, Manu , MAO, Hanwen , UNG-MEDOFF, Heather Thi Thu , WENG, Ke
IPC分类号： C12Q1/68 , C12Q1/70 , C12P19/34
摘要： A method for identifying host genes and encoded proteins for potential targets for therapeutic intervention employs a Gene Search Vector that is either lentivirus or MMLV-based, and can be used to interrogate an entire cell genome without prior knowledge of the genomic sequence. This Random Homozygous Gene Perturbation (RUGP) technique is rapidly verifiable and is used to identify potential host targets for intervention for influenza, HIV and other viral infections. Using Thermal Assymetric Interlaced (TAIL) - PCR, the period for identification of promising targets is reduced from months to weeks or less. Specific targets including PTCH1, Robo1 and Nedd4 are reviewed in detail.

6. 发明申请

WO2009091435A3 METHODS OF INHIBITING VIRAL INFECTION 审中-公开
标题翻译：抑制病毒感染的方法
公开(公告)号：WO2009091435A3
公开(公告)日：2009-10-15
申请号：PCT/US2008081904
申请日：2008-10-31
申请人： FUNCTIONAL GENETICS INC , KINCH MICHAEL , GOLDBLATT MICHAEL
发明人： KINCH MICHAEL , GOLDBLATT MICHAEL
IPC分类号： A01N55/02
CPC分类号： C07D215/44
摘要： Compounds, pharmaceutical compositions and methods of inhibiting viral infection in a mammal in need of same, are provided, which employ compounds of formula (I); wherein each X is independently H or an electrodonating group, each Y is independently H, alkyl of 1 - 4 carbon atoms, hydroxy, alkoxy or methylene and wherein Substituent Z is a di-or-tri akly amino, or alkyl di or tri amino, optionally substituted with a halogen moiety. This family of compounds, designated FGI-104 herein, inhibits viral infection therapeutically and prophylactically.
摘要翻译：提供了需要相同的哺乳动物抑制病毒感染的化合物，药物组合物和方法，其使用式（I）化合物; 其中每个X独立地是H或电子基团，每个Y独立地是H，1-4个碳原子的烷基，羟基，烷氧基或亚甲基，并且其中取代基Z是二 - 或三氨基，或烷基二或三氨基任选地被卤素部分取代。本文命名为FGI-104的化合物家族在治疗和预防上抑制病毒感染。

7. 发明申请

WO2009091435A2 METHODS OF INHIBITING VIRAL INFECTION 审中-公开
标题翻译：抑制病毒感染的方法
公开(公告)号：WO2009091435A2
公开(公告)日：2009-07-23
申请号：PCT/US2008/081904
申请日：2008-10-31
申请人： FUNCTIONAL GENETICS, INC. , KINCH, Michael , GOLDBLATT, Michael
发明人： KINCH, Michael , GOLDBLATT, Michael
IPC分类号： A61K31/4706
CPC分类号： C07D215/44
摘要： Compounds, pharmaceutical compositions and methods of inhibiting viral infection in a mammal in need of same, are provided, which employ compounds of formula (I); wherein each X is independently H or an electrodonating group, each Y is independently H, alkyl of 1 - 4 carbon atoms, hydroxy, alkoxy or methylene and wherein Substituent Z is a di-or-tri akly amino, or alkyl di or tri amino, optionally substituted with a halogen moiety. This family of compounds, designated FGI-104 herein, inhibits viral infection therapeutically and prophylactically.
摘要翻译：提供了在需要的哺乳动物中抑制病毒感染的化合物，药物组合物和方法，其使用式（I）的化合物; 其中每个X独立地为H或电子化的基团，每个Y独立地为H，具有1-4个碳原子的烷基，羟基，烷氧基或亚甲基，并且其中取代基Z为二或三烷基氨基或烷基二或三氨基任选被卤素部分取代。本文命名为FGI-104的该化合物家族在治疗上和预防上抑制病毒感染。

8. 发明申请

WO2008064072A2 ANTI-TSG101 ANTIBODIES AND THEIR USES FOR TREATMENT OF VIRAL INFECTIONS 审中-公开
标题翻译： ANTI-TSG101抗体及其用于治疗病毒感染的用途
公开(公告)号：WO2008064072A2
公开(公告)日：2008-05-29
申请号：PCT/US2007084808
申请日：2007-11-15
申请人： FUNCTIONAL GENETICS INC , LI LIMIN , KINCH MICHAEL , GOLDBLATT MICHAEL
发明人： LI LIMIN , KINCH MICHAEL , GOLDBLATT MICHAEL
IPC分类号： A61K39/42
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/18 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/76
摘要： The present invention provides antibodies that bind to the C-terminal region of TSG101. The invention also provides methods of using the TSG101 antibodies for the treatment of viral infections, including HIV and Ebola virus infection.
摘要翻译：本发明提供了结合TSG101的C-末端区域的抗体。本发明还提供了使用TSG101抗体治疗病毒感染（包括HIV和埃博拉病毒感染）的方法。

9. 发明申请

WO2007016612A3 METHOD OF OPERATING AN AVALANCHE PHOTODIODE FOR REDUCING GAIN NORMALIZED DARK CURRENT 审中-公开
公开(公告)号：WO2007016612A3
公开(公告)日：2007-02-08
申请号：PCT/US2006/030052
申请日：2006-08-02
申请人： DRS INFRARED TECHNOLOGIES, LP , BECK, Jeffrey, Don , MITRA, Pradip , WAN, Chang-Feng , KINCH, Michael, A.
发明人： BECK, Jeffrey, Don , MITRA, Pradip , WAN, Chang-Feng , KINCH, Michael, A.
IPC分类号： H01L31/00 , H01L31/0296
摘要： An avalanche photodiode is operated in avalanche mode at a selected reverse bias that achieves high gain and a reduced gain normalized dark current.

10. 发明申请

WO2004091375A3 EPHA2 AND NON-NEOPLASTIC HYPERPROLIFERATIVE CELL DISORDERS 审中-公开
标题翻译： EPHA2和非神经性高增殖性细胞病变
公开(公告)号：WO2004091375A3
公开(公告)日：2005-07-14
申请号：PCT/US2004011482
申请日：2004-04-12
申请人： MEDIMMUNE INC , KIENER PETER A , KINCH MICHAEL S , LANGERMANN SOLOMON , REED JENNIFER L
发明人： KIENER PETER A , KINCH MICHAEL S , LANGERMANN SOLOMON , REED JENNIFER L
IPC分类号： A61B20060101 , A61K39/00 , A61K39/395 , A61K49/00 , C07K16/28 , C07K16/32
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/32
摘要： The present invention relates to methods and compositions designed for the treatment, management, or prevention of a non-neoplastic hyperproliferative cell or excessive cell accumulation disorders, particularly those involving hyperproliferation of epithelial or endothelial cells. In one embodiment, the methods of the invention comprise the administration of an effective amount of one or more EphA2 agonistic agents that bind to EphA2 and increase EphA2 cytoplasmic tail phosphorylation and/or increase EphA2 autophosphorylation. in cells which EphA2 has been agonized. In another embodiment, the methods of the invention comprise the administration of an effective amount of one or more EphA2 agonistic agents that bind to EphA2 and reduce EphA2 activity (other than autophosphorylation). In another embodiment, the methods of the invention comprise administration of an effective amount of one or more EphA2 agonistic agents that bind to EphA2 and decrease a pathology-causing cell phenotype (e.g., a pathology-causing epithelial cell phenotype or a pathology-causing endothelial cell phenotype). In another embodiment, the methods of the invention comprise the administration of an effective amount. of one or more EphA2 agonistic agents that are EphA2 antibodies that bind to EphA2 with a very low Koff rate. In prefer-red embodiments, agents of the invention are inonoclonal antibodies. The invention also provides pharmaceutical compositions comprising one or more EphA2 agonistic agents of the invention either alone or in combination with one or more other agents useful in therapy for non-neoplastic hyperproliferative cell or excessive cell accumulation disorders.
摘要翻译：本发明涉及设计用于治疗，管理或预防非肿瘤性过度增殖性细胞或过度细胞累积障碍，特别是涉及上皮细胞或内皮细胞过度增殖的方法和组合物。在一个实施方案中，本发明的方法包括施用有效量的一种或多种结合EphA2并增加EphA2细胞质尾磷酸化和/或增加EphA2自磷酸化的EphA2激动剂。在EphA2被激活的细胞中。在另一个实施方案中，本发明的方法包括施用有效量的一种或多种EphA2激动剂，其结合EphA2并降低EphA2活性（除了自磷酸化）。在另一个实施方案中，本发明的方法包括施用有效量的一种或多种结合EphA2的EphA2激动剂并减少病理学引起的细胞表型（例如，导致病理的上皮细胞表型或致病性病因的内皮细胞表型）。在另一个实施方案中，本发明的方法包括施用有效量。的一种或多种EphA2激动剂，其是以非常低的Koff率与EphA2结合的EphA2抗体。在优选的实施方案中，本发明的试剂是异源抗体。本发明还提供包含本发明的一种或多种EphA2激动剂的药物组合物，其单独或与一种或多种其它可用于治疗非肿瘤性过度增殖性细胞或过度细胞累积障碍的其它药物组合。

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