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    • 10. 发明申请
    • EPHA2 AND NON-NEOPLASTIC HYPERPROLIFERATIVE CELL DISORDERS
    • EPHA2和非神经性高增殖性细胞病变
    • WO2004091375A3
    • 2005-07-14
    • PCT/US2004011482
    • 2004-04-12
    • MEDIMMUNE INCKIENER PETER AKINCH MICHAEL SLANGERMANN SOLOMONREED JENNIFER L
    • KIENER PETER AKINCH MICHAEL SLANGERMANN SOLOMONREED JENNIFER L
    • A61B20060101A61K39/00A61K39/395A61K49/00C07K16/28C07K16/32
    • C07K16/28A61K2039/505C07K16/32
    • The present invention relates to methods and compositions designed for the treatment, management, or prevention of a non-neoplastic hyperproliferative cell or excessive cell accumulation disorders, particularly those involving hyperproliferation of epithelial or endothelial cells. In one embodiment, the methods of the invention comprise the administration of an effective amount of one or more EphA2 agonistic agents that bind to EphA2 and increase EphA2 cytoplasmic tail phosphorylation and/or increase EphA2 autophosphorylation. in cells which EphA2 has been agonized. In another embodiment, the methods of the invention comprise the administration of an effective amount of one or more EphA2 agonistic agents that bind to EphA2 and reduce EphA2 activity (other than autophosphorylation). In another embodiment, the methods of the invention comprise administration of an effective amount of one or more EphA2 agonistic agents that bind to EphA2 and decrease a pathology-causing cell phenotype (e.g., a pathology-causing epithelial cell phenotype or a pathology-causing endothelial cell phenotype). In another embodiment, the methods of the invention comprise the administration of an effective amount. of one or more EphA2 agonistic agents that are EphA2 antibodies that bind to EphA2 with a very low Koff rate. In prefer-red embodiments, agents of the invention are inonoclonal antibodies. The invention also provides pharmaceutical compositions comprising one or more EphA2 agonistic agents of the invention either alone or in combination with one or more other agents useful in therapy for non-neoplastic hyperproliferative cell or excessive cell accumulation disorders.
    • 本发明涉及设计用于治疗,管理或预防非肿瘤性过度增殖性细胞或过度细胞累积障碍,特别是涉及上皮细胞或内皮细胞过度增殖的方法和组合物。 在一个实施方案中,本发明的方法包括施用有效量的一种或多种结合EphA2并增加EphA2细胞质尾磷酸化和/或增加EphA2自磷酸化的EphA2激动剂。 在EphA2被激活的细胞中。 在另一个实施方案中,本发明的方法包括施用有效量的一种或多种EphA2激动剂,其结合EphA2并降低EphA2活性(除了自磷酸化)。 在另一个实施方案中,本发明的方法包括施用有效量的一种或多种结合EphA2的EphA2激动剂并减少病理学引起的细胞表型(例如,导致病理的上皮细胞表型或致病性病因的内皮 细胞表型)。 在另一个实施方案中,本发明的方法包括施用有效量。 的一种或多种EphA2激动剂,其是以非常低的Koff率与EphA2结合的EphA2抗体。 在优选的实施方案中,本发明的试剂是异源抗体。 本发明还提供包含本发明的一种或多种EphA2激动剂的药物组合物,其单独或与一种或多种其它可用于治疗非肿瘤性过度增殖性细胞或过度细胞累积障碍的其它药物组合。