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1. 发明申请

WO1997048382A2 MULTIPLE-UNIT TYPE PROLONGED ACTION DRUG PREPARATION 审中-公开
标题翻译：多种类型的长效药物制剂
公开(公告)号：WO1997048382A2
公开(公告)日：1997-12-24
申请号：PCT/JP1997001836
申请日：1997-05-29
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , MUKAI, Tadashi , KOIKE, Masami , NAKAMURA, Toshio , KIMURA, Yuzo
发明人： OTSUKA PHARMACEUTICAL CO., LTD.
IPC分类号： A61K09/16
CPC分类号： A61K31/4709 , A61K9/2054 , A61K9/4808
摘要： The present invention provides a multiple-unit type prolonged release action drug preparation which is characterized by containing at least 2 small tablets of sustained release type drug preparation obtained by formulating cilostazol with hydroxypropylmethylcellulose as the base material of the drug preparation. By formulating cilostazol as in the form of a multiple-unit type prolonged release action drug preparation of the present invention, side-effects, such as headache and other symptoms caused by high blood concentration of cilostazol due to the rapid absorption, can be reduced.
摘要翻译：本发明提供一种多单位型延长释放作用药物制剂，其特征在于含有至少2种缓释型药物制剂的小片剂，其配制西洛他唑与羟丙基甲基纤维素作为药物制剂的基质。通过以本发明的多单位型延长释放作用药物制剂的形式配制西洛他唑，可以减少由于快速吸收引起的西洛他唑高血药浓度引起的头痛等症状。

2. 发明申请

WO1996021448A1 RESIN PARTICLE, MEDICAL MATERIAL AND PHARMACEUTICAL PREPARATION CONTAINING SAID RESIN PARTICLE 审中-公开
标题翻译：树脂颗粒，含有树脂颗粒的医用材料和药物制剂
公开(公告)号：WO1996021448A1
公开(公告)日：1996-07-18
申请号：PCT/JP1996000004
申请日：1996-01-04
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , OTSUKA PHARMACEUTICAL FACTORY, INC. , IGUCHI, Seiichiro , HIGASHINO, Rika , YAMATO, Minoru , YAMAMOTO, Hiroaki , KIMURA, Yuzo , NAKAGAWA, Shinsuke , YAMADA, Keigo , NAKAMURA, Toshio
发明人： OTSUKA PHARMACEUTICAL CO., LTD. , OTSUKA PHARMACEUTICAL FACTORY, INC.
IPC分类号： A61K31/47
CPC分类号： A61K9/1694 , A61K9/1635 , A61K31/4709
摘要： A resin particle is provided which comprises an ethylene vinyl alcohol copolymer and 5 to 90 % by weight of cilostazol incorporated therein, and has a particle size of not greater than 2,000 mu m. The resin particle, upon being administered orally, allows the concentration of cilostazol in blood to be kept constant over an extended period of time and, therefore, remarkably alleviates side effects such as pain and headache which may otherwise be caused by rapid release of cilostazol into a body.
摘要翻译：提供了一种树脂颗粒，其包含乙烯乙烯醇共聚物和5至90重量％的西洛他唑，其粒径不大于2000微米。通过口服给药，树脂粒子能够使长时间保持血液中西洛他唑的浓度保持恒定，因此显着地减轻副作用，例如由于西洛他唑迅速释放引起的疼痛和头痛，身体。

3. 发明申请

WO9748382A3 MULTIPLE-UNIT TYPE PROLONGED ACTION DRUG PREPARATION 审中-公开
标题翻译：多种类型的长效药物制剂
公开(公告)号：WO9748382A3
公开(公告)日：1998-02-19
申请号：PCT/JP9701836
申请日：1997-05-29
申请人： OTSUKA PHARMA CO LTD , MUKAI TADASHI , KOIKE MASAMI , NAKAMURA TOSHIO , KIMURA YUZO
发明人： MUKAI TADASHI , KOIKE MASAMI , NAKAMURA TOSHIO , KIMURA YUZO
IPC分类号： A61K9/20 , A61K9/22 , A61K9/48 , A61K31/4709 , A61K9/16 , A61K31/47
CPC分类号： A61K31/4709 , A61K9/2054 , A61K9/4808
摘要： The present invention provides a multiple-unit type prolonged release action drug preparation which is characterized by containing at least 2 small tablets of sustained release type drug preparation obtained by formulating cilostazol with hydroxypropylmethylcellulose as the base material of the drug preparation. By formulating cilostazol as in the form of a multiple-unit type prolonged release action drug preparation of the present invention, side-effects, such as headache and other symptoms caused by high blood concentration of cilostazol due to the rapid absorption, can be reduced.
摘要翻译：本发明提供一种多单位型延长释放作用药物制剂，其特征在于含有至少2种缓释型药物制剂的小片剂，其配制西洛他唑与羟丙基甲基纤维素作为药物制剂的基质。通过以本发明的多单位型延长释放作用药物制剂的形式配制西洛他唑，可以减少由于快速吸收引起的西洛他唑高血药浓度引起的头痛等症状。

4. 发明申请

WO1997023239A1 DRY COMPOSITIONS 审中-公开
标题翻译：干燥组合物
公开(公告)号：WO1997023239A1
公开(公告)日：1997-07-03
申请号：PCT/JP1996003772
申请日：1996-12-25
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , YAMASHITA, Chikamasa , SAKATA, Kazuya , ISHIKAWA, Shinichi , KIMURA, Yuzo
发明人： OTSUKA PHARMACEUTICAL CO., LTD.
IPC分类号： A61K47/18
CPC分类号： A61K9/0019 , A61K9/0075 , A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1623 , A61K9/1658 , A61K9/19 , A61K47/183 , A61K47/26
摘要： The object of the present invention is to provide a dry composition having the following advantageous properties. That is, even when left in a highly humid environment, the dry composition of the present invention scarcely loses its pharmacological activity, does not deliquesce and retains its dry state over a long period of time. A dry composition of the present invention comprises at least one of active ingredients selected from the group consisting of pharmacologically active proteins and pharmacologically active polypeptides and as a stabilizer at least one of hydrophobic stabilizers selected from the group consisting of hydrophobic amino acids, hydrophobic dipeptides and hydrophobic tripeptides.
摘要翻译：本发明的目的是提供具有以下有利性质的干组合物。也就是说，即使在高度潮湿的环境下，本发明的干燥组合物几乎不会失去其药理活性，不会在长时间内潮解并保持其干燥状态。本发明的干组合物包含选自药理活性蛋白质和药理活性多肽的活性成分中的至少一种，作为稳定剂，至少一种疏水稳定剂选自疏水性氨基酸，疏水性二肽和疏水三肽。

5. 发明申请

WO1995003802A1 AQUEOUS COMPOSITION 审中-公开
标题翻译：水分组合物
公开(公告)号：WO1995003802A1
公开(公告)日：1995-02-09
申请号：PCT/JP1994001222
申请日：1994-07-25
申请人： OTSUKA PHARMACEUTICAL COMPANY, LIMITED , KIMURA, Yuzo , ISHIKAWA, Shinichi , MASUDA, Yoshito
发明人： OTSUKA PHARMACEUTICAL COMPANY, LIMITED
IPC分类号： A61K31/47
CPC分类号： A61K47/12 , A61K9/0019 , A61K31/47 , A61K31/4704
摘要： This invention provides an aqueous composition wherein a hardly water-soluble active compound, 6-[3-(3,4-dimethoxybenzyl)amino-2-hydroxypropoxy]carbostyril or a salt thereof is dissolved in water in an effective amount, particularly in an amount sufficient for exhibiting the pharmacological activities, by using as a solubilizer DL-lactic acid.
摘要翻译：本发明提供一种水性组合物，其中将几乎不溶于水的活性化合物6- [3-（3,4-二甲氧基苄基）氨基-2-羟基丙氧基]喹诺酮或其盐以有效量溶于水中，特别是在通过使用增溶剂DL-乳酸，足以显示药理活性的量。

6. 发明申请

WO1991014423A1 LIPOSOME PREPARATION 审中-公开
标题翻译：脂质体制备
公开(公告)号：WO1991014423A1
公开(公告)日：1991-10-03
申请号：PCT/JP1991000373
申请日：1991-03-20
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , MUKAI, Masashi , ISHIZUE, Yoshihiro , ISHIKAWA, Shinichi , KIMURA, Yuzo
发明人： OTSUKA PHARMACEUTICAL CO., LTD.
IPC分类号： A61K09/127
CPC分类号： A61K9/127
摘要： A liposome preparation comprising a basic drug incorporated in a liposome having a membrane constituent comprising an acidic phospholipid or a mixture of neutral and acidic phospholipids, which can trap the basic drug stably in a sufficient amount.
摘要翻译：一种脂质体制剂，其包含引入脂质体中的碱性药物，其具有包含酸性磷脂或中性和酸性磷脂的混合物的膜组分，其可以稳定地捕获足量的碱性药物。

7. 发明申请

WO1990005535A1 INTERFERON PREPARATION FOR NASAL ADMINISTRATION 审中-公开
标题翻译：海军管理干预准备
公开(公告)号：WO1990005535A1
公开(公告)日：1990-05-31
申请号：PCT/JP1989001156
申请日：1989-11-13
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , ISHIZUE, Yoshihiro , KIMURA, Yuzo , TODA, Masafumi , MASUDA, Yoshito
发明人： OTSUKA PHARMACEUTICAL CO., LTD.
IPC分类号： A61K37/66
CPC分类号： A61K47/26 , A61K9/0043 , A61K38/21 , A61K2300/00
摘要： The invention provides preparation for nasal administration which contains a pharmacologically effective amount of interferon and a fatty acid ester of sugar.

8. 发明申请

WO1996031195A1 PACKAGE HOLDING A PROCATEROL HYDROCHLORIDE AQUEOUS SOLUTION FORMULATION, AND A PROCATEROL HYDROCHLORIDE AQUEOUS SOLUTION FORMULATION 审中-公开
标题翻译：包装方法控制氢氯酸盐水溶液配方，以及一种过氧化氢氢氯酸盐水溶液配方
公开(公告)号：WO1996031195A1
公开(公告)日：1996-10-10
申请号：PCT/JP1996000772
申请日：1996-03-25
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , KIMURA, Yuzo , ISHIKAWA, Shinichi , TODA, Masafumi , MATSUDA, Takakuni
发明人： OTSUKA PHARMACEUTICAL CO., LTD.
IPC分类号： A61K09/00
CPC分类号： A61K9/0048 , A61K31/4704
摘要： An object of the present invention is to impart long-term storage stability to a pharmaceutical composition comprising an aqueous solution of procaterol hydrochloride. This invention is directed to an aqueous solution of procaterol hydrochloride which assures that the procaterol hydrochloride is kept from decomposing in the aqueous solution due to its oxidation reaction.
摘要翻译：本发明的目的是赋予包含盐酸丙卡特罗水溶液的药物组合物的长期保存稳定性。本发明涉及盐酸丙卡特罗的水溶液，其确保盐酸丙卡特醇由于其氧化反应而在水溶液中不被分解。

9. 发明专利

JPH0327290A DECOMPOSITION OF ORGANIC SUBSTANCE SUCH AS PLASTIC WITH THERMOPHILIC BACTERIA 失效
公开(公告)号：JPH0327290A
公开(公告)日：1991-02-05
申请号：JP16359289
申请日：1989-06-26
申请人： KIMURA YUZO
发明人： KIMURA YUZO
IPC分类号： C12P1/04 , C12R1/01
摘要： PURPOSE:To perform economical treatment of industrial waste, etc., without causing environmental pollution by culturing a specific thermophilic microbial strain at a high temperature in a bouillon medium containing organic substance. CONSTITUTION:A metallic container 1 is covered with a heat-insulator 5 such as glass wool and wound with a heating element. A glass bottle 2 filled with a lignin-dissolving organic substance to be decomposed (e.g. nylon or other plastics) and bouillon 3 is placed in the metallic container 1 and hot water 4 is poured into the space between the bottle and the container to form a water- bath thermostat. A thermophilic strain separated from an organic material existing in natural environment or produced by artificial means is inoculated to the bottle 2. The strain is a gram-positive non-acid-fast brevibacillus free from pathogenicity to human body. The strain is cultured for >=10 days in the medium controlled to >=75 deg.C by a temperature-controlling power source 7. After the completion of culture, the organic substance is separated from the cultured product and the weight of the substance measured after the cultivation is compared with the original weight to determine the decomposed amount of the organic material such as plastics.

10. 发明专利

JP2002203033A SUPPLY MANAGEMENT DEVICE AND SUPPLY MANAGEMENT SYSTEM FOR SOIL IMPROVEMENT MATERIAL 失效
公开(公告)号：JP2002203033A
公开(公告)日：2002-07-19
申请号：JP2000401259
申请日：2000-12-28
申请人： KIMURA YUZO
发明人： KIMURA YUZO
IPC分类号： C09K17/00 , C09K101/00 , G06Q50/00 , G06Q50/02 , G06Q50/10 , G06F17/60
摘要： PROBLEM TO BE SOLVED: To provide a system that efficiently supplies a consumer with the soil improvement materials of sludge produced by water-purification, organic fertilizer and the like from a supply source. SOLUTION: A demand reception means 11 for receiving a request for the soil improvement material from a soil improvement material consumer A, a soil improvement material determination means 12 for determining the soil improvement material that is applicable to the land utilization pattern and the soil for the soil improvement material consumer A, a supply source determination means 13 for determining a soil improvement material supply source B that supplies the soil improvement material determined with the soil improvement material determination means 12 on the basis of a predetermined map, and a communication means 14 for communicating with the soil improvement material consumer A and the soil improvement material supply source B are provided in a supply management device 10, which is connected to the soil improvement material consumer A and the soil improvement material supply source B through a network.

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