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1. 发明申请

WO2006071091A1 HUMANIZED ANTIBODY SPECIFIC FOR TUMOR NECROSIS FACTOR-ALPHA 审中-公开
标题翻译：人肿瘤坏死因子-ATPHA的人体抗体特异性
公开(公告)号：WO2006071091A1
公开(公告)日：2006-07-06
申请号：PCT/KR2005/004634
申请日：2005-12-29
申请人： YUHAN CORPORATION , YOO, Tae Hyoung , SONG, Moo Young , KIM, Chang Seok , PARK, Sang Koo , NA, Kang In , LEE, Byung Kyu , KANG, Heui Il
发明人： YOO, Tae Hyoung , SONG, Moo Young , KIM, Chang Seok , PARK, Sang Koo , NA, Kang In , LEE, Byung Kyu , KANG, Heui Il
IPC分类号： C07K16/24 , A61K39/395 , A61P29/00
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Humanized antibodies specifically binding to hTNF-α are prepared from a mouse monoclonal antibody by the CDR (complementarity determining region) grafting method, and they show an antigen binding affinity similar to the origninal mouse monoclonal antibody and significantly low immunogenicity. Therefore, the humanized antibodies can be effectively used for treating a hTNF-α-related disease such as rheumatoid arthritis, Crohn's disease, psoriatic arthritis, psoriasis, septicemia, asthma, Wegener's granulomatosis, inflammation, and ankylosing spondylitis.
摘要翻译：通过CDR（互补决定区）接枝方法由小鼠单克隆抗体制备与hTNF-a特异性结合的人源化抗体，它们显示出与正义小鼠单克隆抗体相似的抗原结合亲和力，并具有显着低的免疫原性。因此，人源化抗体可以有效地用于治疗hTNF-a相关疾病如类风湿性关节炎，克罗恩病，牛皮癣关节炎，银屑病，败血病，哮喘，韦格纳肉芽肿病，炎症和强直性脊柱炎。

2. 发明申请

WO2011105693A3 OPTICAL INTERCONNECTION METHOD FOR A PLANAR LIGHTWAVE CIRCUIT DEVICE 审中-公开
标题翻译：一种用于平面照明电路设备的光学互连方法
公开(公告)号：WO2011105693A3
公开(公告)日：2011-11-24
申请号：PCT/KR2010009635
申请日：2010-12-31
申请人： PUSAN NAT UNIV IND COOP FOUND , JEONG MYUNG YUNG , KIM CHANG SEOK , RYU JIN HWA , OH SEUNG HUN , LEE TAE HO , CHO SANG UK
发明人： JEONG MYUNG YUNG , KIM CHANG SEOK , RYU JIN HWA , OH SEUNG HUN , LEE TAE HO , CHO SANG UK
IPC分类号： G02B6/13 , G02B6/42
CPC分类号： G02B6/30
摘要： The present invention relates to an optical interconnection method for a planar lightwave circuit (PLC) device, which simultaneously forms the PLC device and grooves for the insertion of optical fibers using a single imprint mold during the manufacture of the PLC device, and optically interconnects the PLC device and the grooves. The method comprises the following steps: forming a first pattern duplicating an original pattern using an original silicon master, and forming a second pattern duplicating an original pattern using the first pattern duplicating an original pattern; forming a lower clad using the second pattern duplicating an original pattern; forming a core layer on a channel cavity of the lower clad, and stacking an upper clad to form a PLC device chip; cutting an input end and an output end of the first pattern duplicating an original pattern, and arranging optical fibers in the grooves; and aligning the grooves having the optical fibers arranged therein with the PLC device chip, and optically interconnecting the grooves and the PLC device chip.
摘要翻译：本发明涉及一种用于平面光波电路（PLC）装置的光互连方法，其同时形成PLC装置和用于在PLC装置的制造期间使用单个压印模插入光纤的槽，并且将 PLC设备和槽。该方法包括以下步骤：使用原始硅母版形成复制原始图案的第一图案，以及使用复制原始图案的第一图案形成复制原始图案的第二图案; 使用复制原始图案的第二图案形成下包层; 在下包层的通道腔上形成芯层，堆叠上包层以形成PLC器件芯片; 切割复制原始图案的第一图案的输入端和输出端，以及将光纤布置在凹槽中; 并将其中布置有光纤的槽与PLC器件芯片对准，并将沟槽和PLC器件芯片光学互连。

3. 发明申请

WO2004013278A2 EXPRESSION VECTORS 审中-公开
标题翻译：表达向量
公开(公告)号：WO2004013278A2
公开(公告)日：2004-02-12
申请号：PCT/KR2003/001555
申请日：2003-08-01
申请人： YUHAN CORPORATION , LEE, Jong-Wook , KO, In-Young , SONG, Moo-Young , KIM, Chang-Seok , LEE, Jae-Sun , YOO, Tae-Hyoung , KIM, Ji-Min , PARK, Sang-Koo
发明人： LEE, Jong-Wook , KO, In-Young , SONG, Moo-Young , KIM, Chang-Seok , LEE, Jae-Sun , YOO, Tae-Hyoung , KIM, Ji-Min , PARK, Sang-Koo
IPC分类号： C12N
CPC分类号： C07K16/00
摘要： Provided is an expression vector for a heavy chain variable region, a lambda (λ ) light chain variable region, or a kappa (κ ) light chain variable region of an antibody. The expression vector includes a restriction site which commonly exists in joining regions of genes encoding antibody variable regions; and a gene encoding an antibody constant region.
摘要翻译：提供了抗体的重链可变区，λ（λ）轻链可变区或kappa（κ）轻链可变区的表达载体。表达载体包含通常存在于编码抗体可变区的基因的连接区的限制性位点; 和编码抗体恒定区的基因。

4. 发明申请

WO2012018195A3 OPTICAL COHERENCE TOMOGRAPHY USING ACTIVE MODE-LOCKING FIBER LASER 审中-公开
标题翻译：采用主动式锁模光纤激光器的光学相干层析成像
公开(公告)号：WO2012018195A3
公开(公告)日：2012-05-10
申请号：PCT/KR2011005571
申请日：2011-07-28
申请人： PUSAN NAT UNIV IND COOP FOUND , KIM CHANG SEOK , JEONG MYUNG YUNG , LEE HWI DON
发明人： KIM CHANG SEOK , JEONG MYUNG YUNG , LEE HWI DON
IPC分类号： G01B9/02 , G01N21/17
CPC分类号： G01B9/02091 , G01B9/02004 , G01N21/31 , G01N21/4795 , H01S3/067 , H01S3/06791 , H01S3/1112 , H01S3/2383
摘要： An optical coherence tomography (OCT) uses an active mode-locking fiber laser in order to obtain image information of a sample. An imaging device of the present invention comprises: a light source unit that emits light having a central wavelength which is periodically changed by a modulation signal received from the inside of a resonator; a light separation unit that separates the light having a single path, which is emitted from the light source unit, into a first light and a second light having different paths; a reference unit that is disposed on a path through which the first light separated by the light separation unit progresses, and reflects said first light; a diagnostic unit that has a sample mounted thereon, is disposed on a path of the second light separated by the light separation unit, and the second light is delayed more than the first light for a certain time to reflect the delayed light; a light coupling unit that couples the first light and the second light, which are progressed in different paths through the reference unit and the diagnostic unit and in which mutual interference is generated therefrom; and a signal processing unit that detects and images data of the light received from the light coupling unit. Thus, since the imaging device of the present invention removes a high-priced variable filter which has mechanical restrictions by directly delivering a modulation signal to a light source unit, the invention can overcome mechanical restrictions and reduce costs.
摘要翻译：光学相干断层扫描（OCT）使用主动模式锁定光纤激光器以获得样本的图像信息。本发明的成像装置包括：光源单元，其发射具有由从谐振器内部接收的调制信号周期性改变的中心波长的光; 分光单元，其将从所述光源单元发射的具有单一路径的光分成具有不同路径的第一光和第二光; 基准单元，所述基准单元设置在由所述光分离单元分离的所述第一光进行前进的路径上，并反射所述第一光; 其上安装有样本的诊断单元设置在由光分离单元分离的第二光的路径上，并且第二光在一定时间内延迟超过第一光以反映延迟光; 光耦合单元，所述光耦合单元将在不同路径中前进通过所述参考单元和所述诊断单元并且其中产生相互干扰的所述第一光和所述第二光耦合; 以及信号处理单元，其检测并且成像从光耦合单元接收的光的数据。因此，由于本发明的成像装置通过将调制信号直接传递给光源单元而去除了具有机械限制的高价可变滤光器，本发明可克服机械限制并降低成本。

5. 发明申请

WO2004013278A3 EXPRESSION VECTORS 审中-公开
标题翻译：表达载体
公开(公告)号：WO2004013278A3
公开(公告)日：2004-06-24
申请号：PCT/KR0301555
申请日：2003-08-01
申请人： YUHAN CORP , LEE JONG-WOOK , KO IN-YOUNG , SONG MOO-YOUNG , KIM CHANG-SEOK , LEE JAE-SUN , YOO TAE-HYOUNG , KIM JI-MIN , PARK SANG-KOO
发明人： LEE JONG-WOOK , KO IN-YOUNG , SONG MOO-YOUNG , KIM CHANG-SEOK , LEE JAE-SUN , YOO TAE-HYOUNG , KIM JI-MIN , PARK SANG-KOO
IPC分类号： C07K16/00 , C12N15/12
CPC分类号： C07K16/00
摘要： Provided is an expression vector for a heavy chain variable region, a lambda (lambda ) light chain variable region, or a kappa (kappa ) light chain variable region of an antibody. The expression vector includes a restriction site which commonly exists in joining regions of genes encoding antibody variable regions; and a gene encoding an antibody constant region.
摘要翻译：提供了用于抗体的重链可变区，λ（λ）轻链可变区或κ（κ）轻链可变区的表达载体。表达载体包括通常存在于编码抗体可变区的基因的连接区中的限制性位点; 和编码抗体恒定区的基因。

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