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    • 5. 发明申请
    • NOVEL USE OF PANDURATIN A OR DERIVATIVES THEREOF
    • 潘德拉汀A或其衍生物的新用途
    • WO2008023966A1
    • 2008-02-28
    • PCT/KR2007/004109
    • 2007-08-27
    • Industry-Academic Cooperation Foundation, Yonsei UniversityHWANG, Jae-KwanKIM, Mi-KyungSONG, Min-SooSHIM, Jae-SeokYOON, Ji-Hoon
    • HWANG, Jae-KwanKIM, Mi-KyungSONG, Min-SooSHIM, Jae-SeokYOON, Ji-Hoon
    • A61K31/122
    • A61K31/122
    • The present invention relates to the novel use of a panduratin A compound, derivative thereof or an extract of Kaempferia pandurata. More particularly, it relates to the use for the antibacterial activities and acne treatment of a panduratin A compound represented by Formula 1, a panduratin A derivative represented by Formula 2 or an extract of Kaempferia pandurata. The above panduratin A compound, derivative thereof or extract of Kaempferia pandurata has excellent antibacterial activity of inhibiting the growth of bacteria selected from the group consisting of Propionibacterium acnes, Staphylococcus epidermidis, Micrococcus luteus, Staphylococcus aureus, Staphylococcus warneri, Staphylococcus haemolyticus, Staphylococcus xylosus, Staphylococcus hominis and Staphylococcus saprophyticus. Accordingly, the inventive compounds or extract may be very useful as an antibacterial composition or a composition for treating acne against the above bacteria.
    • 本发明涉及一种潘多蛋白A化合物,其衍生物或山茶皮提取物的新用途。 更具体地说,涉及用式1表示的潘多蛋白A化合物,式2表示的潘多汀A衍生物或白头翁提取物的抗菌活性和痤疮治疗用途。 上述潘多蛋白A化合物,其衍生物或山茶皮提取物具有优异的抗菌活性,其抑制选自以下的细菌的生长:丙酸杆菌属,表皮葡萄球菌,藤黄微球菌,金黄色葡萄球菌,葡萄球菌,溶血葡萄球菌,葡萄球菌, 人类葡萄球菌和腐生葡萄球菌。 因此,本发明化合物或提取物可以作为抗菌组合物或用于治疗针对上述细菌的痤疮的组合物非常有用。