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    • 4. 发明申请
    • ANTIOBESITY COMPOSITION
    • 抗菌成分
    • WO2007040377A1
    • 2007-04-12
    • PCT/KR2006/004049
    • 2006-10-09
    • ANGIO-LAB., INC.KIM, Min-YoungLEE, Hee-SukKIM, Joon-SikHAHM, Jong-Cheon
    • KIM, Min-YoungLEE, Hee-SukKIM, Joon-SikHAHM, Jong-Cheon
    • A61K36/53A61K36/282A61K36/605A23L1/29A61P3/04
    • A61K36/82A23L33/105A23V2002/00A61K36/258A61K36/282A61K36/53A61K36/605A61K36/68A61K2300/00A23V2250/21A23V2250/5114A23V2250/5066
    • The present invention provides antiobesity composition comprising extract of Melissa as an active ingredient, use of Melissa extract, and a method for suppressing obesity using the composition. Also, the present invention provides an antiobesity composition comprising extract of Melissa and extract of Mori Folium as active ingredients, use of a mixture of Melissa extract and Mori Folium extract, and a method for suppressing obesity using the composition. Further, the present invention provides an antiobesity composition comprising extract of Melissa, extract of Artemisia and extract of Mori Folium as active ingredients, use of a mixture of Melissa extract, Artemisia extract and Mori Folium extract, and a method for suppressing obesity using the composition. When the present compositions are administrated into genetically obese mice or high fat diet-induced obese mice, the present compositions reduced body weight, body fat and gonadal fat, and reduce blood cholesterol level and obesity-related blood glucose level. Also, the present compositions suppress hypertrophy of adipocytes, and inhibit the accumulation of lipid in the liver by reducing the size and number of lipid vacuoles. Furthermore, in human clinial trial the present compositions show that body weight, PIBW, body fat, especially visceral fat, apolipoprotin B concentration, ratio of total cholesterol/HDL cholesterol and ratio of LDL cholesterol /HDL cholesterol are significantly decreased, and atherogenic index is improved and muscle mass is increased. Thus, the present compositions can be usefully applied as antiobesity composition for reduction of body weight and suppression of abdominal fat, particularly, visceral fat.
    • 本发明提供了包含Melissa的提取物作为活性成分的抗肥胖组合物,使用Melissa提取物,以及使用该组合物抑制肥胖症的方法。 另外,本发明提供一种抗肥胖组合物,其包含梅利莎提取物和森叶提取物作为活性成分,使用梅利莎提取物和山楂提取物的混合物,以及使用该组合物抑制肥胖的方法。 此外,本发明提供一种抗肥胖组合物,其包含梅利莎提取物,艾蒿提取物和森林提取物作为活性成分,使用梅利莎提取物,艾蒿提取物和山楂提取物的混合物,以及使用该组合物抑制肥胖的方法 。 当本发明组合物施用于遗传性肥胖小鼠或高脂饮食诱导的肥胖小鼠时,本发明的组合物降低体重,体脂肪和性腺脂肪,并降低血液胆固醇水平和肥胖相关的血糖水平。 此外,本发明的组合物抑制脂肪细胞的肥大,并通过减少脂质空泡的大小和数量来抑制脂质在肝脏中的积聚。 此外,在人体临床试验中,本发明的组合物显示,体重,PIBW,体脂肪,特别是内脏脂肪,载脂蛋白B浓度,总胆固醇/ HDL胆固醇的比例和LDL胆固醇/ HDL胆固醇的比例显着降低,而致动脉粥样化指数为 改善肌肉质量。 因此,本发明的组合物可有效地用作抗肥胖组合物,用于减轻体重和抑制腹部脂肪,特别是内脏脂肪。