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1. 发明申请

WO1998000400A1 TETRAHYDROBENZINDOLE COMPOUNDS 审中-公开
标题翻译：四氢化萘化合物
公开(公告)号：WO1998000400A1
公开(公告)日：1998-01-08
申请号：PCT/JP1997002226
申请日：1997-06-27
申请人： MEIJI SEIKA KAISHA, LTD. , KOYAMA, Masao , KIKUCHI, Chika , USHIRODA, Osamu , ANDO, Takashi , NAGASO, Hiroshi , FUJI, Kazuyuki , OKUNO, Masayo , HIRANUMA, Toyokazu
发明人： MEIJI SEIKA KAISHA, LTD.
IPC分类号： C07D209/92
CPC分类号： C07D401/06 , C07D209/92 , C07D401/12 , C07D403/12
摘要： Compounds represented by general formula (I) and pharmaceutically acceptable salts thereof which strongly inhibit [ H]-serotonin and [ H]-5-CT binding to the human serotonin 5-HT7 receptor subtype expressed in a cultured cell line and can provide medicinal compositions for treating or preventing mental diseases. In said formula (I) A represents N, CH, C having a double bond or CR ; B and Z independently represent each N, CH or CR , provided that A is N when B and/or Z is N; R represents hydrogen, halogeno, lower alkyl, cyano, trihalomethyl, hydroxy, alkoxy, alkylthio, alkylsulfenyl, alkylsulfonyl, alkoxycarbonyl, sulfamoyl, optionally substituted amino, optionally alkylated carbamoyl, acyl or carboxy; R represents hydrogen or lower alkyl; R represents hydrogen, lower alkyl or aralkyl; R represents hydrogen, halogeno, lower alkyl, hydroxyl, alkoxy, acyl, alkoxycarbonyl, nitro, optionally substituted amino, optionally alkylated carbamoyl or acyloxy; R represents lower alkyl, cyano, carbamoyl, carboxy, acyl, acyloxy, alkoxy, alkoxycarbonyl, trihalomethyl or hydroxy; and n is an integer of from 2 to 6.
摘要翻译：由通式（I）表示的化合物及其药学上可接受的盐，其强力抑制在培养细胞中表达的人5-羟色胺5-HT7受体亚型的[3 H] - 血清素和[3 H] -5-CT结合可以提供用于治疗或预防精神疾病的药物组合物。在所述式（I）中，A表示具有双键或CR 5的N，CH，C; B和Z独立地表示每个N，CH或CR 1，条件是当B和/或Z为N时A为N; R 1表示氢，卤代，低级烷基，氰基，三卤代甲基，羟基，烷氧基，烷硫基，烷基亚磺酰基，烷基磺酰基，烷氧基羰基，氨磺酰基，任选取代的氨基，任选烷基化的氨基甲酰基，酰基或羧基; R 2表示氢或低级烷基; R 3表示氢，低级烷基或芳烷基; R 4表示氢，卤代，低级烷基，羟基，烷氧基，酰基，烷氧基羰基，硝基，任选取代的氨基，任选烷基化的氨基甲酰基或酰氧基; R 5代表低级烷基，氰基，氨基甲酰基，羧基，酰基，酰氧基，烷氧基，烷氧基羰基，三卤代甲基或羟基; n为2〜6的整数。

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