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1. 发明申请

WO2011107807A3 COLLAGEN GEL FOR BONDING POROUS COLLAGEN- BASED MATERIALS WITH NON- POROUS COLLAGEN- BASED MATERIALS 审中-公开
标题翻译：胶原蛋白凝胶与多孔胶原蛋白基材料粘结多孔胶原蛋白
公开(公告)号：WO2011107807A3
公开(公告)日：2011-11-17
申请号：PCT/GB2011050439
申请日：2011-03-07
申请人： TIGENIX LTD , KEW SIMON , MEAD TIM , RUSHTON NEIL
发明人： KEW SIMON , MEAD TIM , RUSHTON NEIL
IPC分类号： C09J189/06 , A61L24/04 , A61L24/10 , A61L27/38
CPC分类号： A61F2/02 , A61F2013/00357 , A61L27/24 , A61L27/26 , A61L27/46 , A61L27/52 , A61L31/044 , A61L2400/18 , C08L2666/26 , C09J189/06 , C08L89/06
摘要： The invention discloses a process for fabricating a biomaterial, comprising: a) joining a porous collagen based-material with a non-porous collagen based- material by applying a controlled amount of a bonding layer of a gel comprising collagen to a bonding surface of the non-porous collagen based-material, and contacting a surface of the porous collagen based-material with the gel applied to the bonding surface to partially hydrate a section of the porous material at the interface between the materials; b)drying the gel to dry to bond the materials together; and c)cross-linking the collagens in the bonding layer. Also disclosed are biomaterials and implants produced using the fabrication process.
摘要翻译：本发明公开了一种用于制造生物材料的方法，包括：a）通过将受控量的包含胶原蛋白的凝胶粘合层施加到所述多孔胶原基材料的粘合表面上，使多孔胶原基材料的表面与施加到接合表面上的凝胶接触，以在材料之间的界面部分地水合多孔材料的一部分; b）干燥凝胶以将材料粘合在一起; 和c）交联粘合层中的胶原。还公开了使用制造工艺生产的生物材料和植入物。

2. 发明申请

WO2007039717A1 USE OF HOLOGRAPHIC SENSORS 审中-公开
标题翻译：全息传感器的使用
公开(公告)号：WO2007039717A1
公开(公告)日：2007-04-12
申请号：PCT/GB2006/003645
申请日：2006-09-29
申请人： SMART HOLOGRAMS LIMITED , MARHSALL, Alexander, James , KEW, Simon
发明人： MARHSALL, Alexander, James , KEW, Simon
IPC分类号： G01N21/47 , G01N21/05 , G01N21/75
CPC分类号： G01N21/4788 , G01N21/05 , G01N21/75 , G01N2021/0346 , Y10T436/144444
摘要： A method of measuring the amount of an analyte in a sample, comprises (a) passing the sample through a flow channel in or on a holographic sensor, wherein the analyte interacts with and is retained by the sensor and wherein the interaction of the analyte changes an optical property of the sensor, and (b) monitoring analyte interaction, wherein the distance along the flow channel at which analyte interaction occurs or the area of the channel over which analyte interaction occurs, indicates the amount of analyte in the sample. Further, a method of detecting an analyte in a sample, comprises (a) passing the sample through a flow channel in or on a holographic sensor, wherein the analyte interacts with the sensor, thereby changing an optical property of the sensor, and wherein the flow channel defines a symbol; and (b) detecting the analyte by observing the appearance, disappearance or change in appearance of the symbol.
摘要翻译：测量样品中分析物的量的方法包括（a）使样品通过全息传感器中或其上的流动通道，其中分析物与传感器相互作用并由传感器保留，并且其中分析物的相互作用改变传感器的光学特性，和（b）监测分析物相互作用，其中发生分析物相互作用的沿着流动通道的距离或发生分析物相互作用的通道的面积指示样品中分析物的量。此外，检测样品中的分析物的方法包括（a）使样品通过全息传感器中或全息传感器上的流动通道，其中分析物与传感器相互作用，从而改变传感器的光学性质，并且其中流通道定义符号; 和（b）通过观察符号的外观，消失或外观变化来检测分析物。

3. 发明申请

WO2009013505A1 PACKAGING SYSTEM 审中-公开
标题翻译：包装系统
公开(公告)号：WO2009013505A1
公开(公告)日：2009-01-29
申请号：PCT/GB2008/002544
申请日：2008-07-24
申请人： SMART HOLOGRAMS LIMITED , KEW, Simon , MARSHALL, Alexander, James , CREASEY, Christopher , CANE, Michael, Roger , CLEMENTS, Jeremy, Peter
发明人： KEW, Simon , MARSHALL, Alexander, James , CREASEY, Christopher , CANE, Michael, Roger , CLEMENTS, Jeremy, Peter
IPC分类号： B65D75/00 , B65D81/26 , B65D1/36 , B65D75/32
CPC分类号： B65D1/36 , B65D75/327 , B65D81/266 , B65D81/267 , B65D85/38 , B65D85/58
摘要： A storage unit (10) for water-sensitive sensors comprising: a support plate (11); a plurality of wells (12), each well attached to said support plate, and each well so sized as to be able to house, in use, a water-sensitive sensor; a piercable, water- impervious sheet (17), attachable to said support plate, to seal each well; and desiccant (19, 20), located in each well. Preferred embodiments of the invention have fins (14) to grip a desiccant tablet (19), desiccant coatings (20) within the wells and markings (21, 22) to indicate how to open the pack.
摘要翻译：一种用于水敏传感器的存储单元（10），包括：支撑板（11）;以及支撑板多个井（12），每个井都连接到所述支撑板上，并且每个井的尺寸被设计成能够在使用中容纳水敏传感器; 可附接到所述支撑板的可穿透不透水片（17），以密封每个孔; 和干燥剂（19,20），位于每个孔中。本发明的优选实施例具有抓住干燥剂片剂（19），孔内的干燥剂涂层（20）和标记（21,22）以指示如何打开包装的翅片（14）。

4. 发明申请

WO2011107807A2 FABRICATION PROCESS 审中-公开
标题翻译：制造工艺
公开(公告)号：WO2011107807A2
公开(公告)日：2011-09-09
申请号：PCT/GB2011/050439
申请日：2011-03-07
申请人： TIGENIX LIMITED , KEW, Simon , MEAD, Tim , RUSHTON, Neil
发明人： KEW, Simon , MEAD, Tim , RUSHTON, Neil
CPC分类号： A61F2/02 , A61F2013/00357 , A61L27/24 , A61L27/26 , A61L27/46 , A61L27/52 , A61L31/044 , A61L2400/18 , C08L2666/26 , C09J189/06 , C08L89/06
摘要： The invention discloses a process for fabricating a biomaterial, comprising: a) joining a porous collagen based-material with a non-porous collagen based- material by applying a controlled amount of a bonding layer of a gel comprising collagen to a bonding surface of the non-porous collagen based-material, and contacting a surface of the porous collagen based-material with the gel applied to the bonding surface to partially hydrate a section of the porous material at the interface between the materials; b)drying the gel to dry to bond the materials together; and c)cross-linking the collagens in the bonding layer. Also disclosed are biomaterials and implants produced using the fabrication process.
摘要翻译：本发明公开了一种用于制造生物材料的方法，包括：a）通过将受控量的包含胶原蛋白的凝胶粘合层施加到所述多孔胶原基材料的粘合表面上，使多孔胶原基材料的表面与施加到接合表面上的凝胶接触，以在材料之间的界面部分地水合多孔材料的一部分; b）干燥凝胶以将材料粘合在一起; 和c）交联粘合层中的胶原。还公开了使用制造工艺生产的生物材料和植入物。

5. 发明申请

WO2008129268A3 METHODS OF MAKING HOLOGRAPHIC DEVICES 审中-公开
标题翻译：制作全息装置的方法
公开(公告)号：WO2008129268A3
公开(公告)日：2009-03-05
申请号：PCT/GB2008001371
申请日：2008-04-17
申请人： SMART HOLOGRAMS LTD , HORGAN ADRIAN MARTIN , MARSHALL ALEXANDER JAMES , KEW SIMON
发明人： HORGAN ADRIAN MARTIN , MARSHALL ALEXANDER JAMES , KEW SIMON
IPC分类号： G03H1/02 , G03H1/18
CPC分类号： G03H1/02 , G01N21/4788 , G03H1/0005 , G03H1/30 , G03H2001/0033 , G03H2001/0044 , G03H2001/0432 , G03H2001/0497 , G03H2001/303 , G03H2210/63 , G03H2260/12 , G03H2260/30 , G03H2260/32
摘要： A method of making a holographic device (4) comprises the steps of: forming a heterogeneous support medium (2) having at least two regions (1 ) which are heterogeneous; placing the heterogeneous support medium under recording conditions, e.g. in a liquid X, which are selected to change one or more physical properties of the heterogeneous support medium, wherein the extent or nature of the change in the physical property or physical properties is different in at least two of the heterogeneous regions; recording a holographic image in the heterogeneous support medium while it is under recording conditions; and removing the heterogeneous support medium from recording conditions. Such a device can be used for security and authentication.
摘要翻译：制造全息装置（4）的方法包括以下步骤：形成具有异质的至少两个区域（1）的多相支撑介质（2）将异质支持介质置于记录条件下，例如在液体X中，其被选择以改变所述非均相载体介质的一种或多种物理性质，其中物理性质或物理性质的变化的程度或性质在至少两个异质区域中不同; 在异质支持介质处于记录条件下记录全息图像; 并从记录条件中去除异质支持介质。这样的设备可以用于安全和认证。

6. 发明申请

WO2009013505A8 PACKAGING SYSTEM 审中-公开
标题翻译：包装系统
公开(公告)号：WO2009013505A8
公开(公告)日：2009-03-19
申请号：PCT/GB2008002544
申请日：2008-07-24
申请人： SMART HOLOGRAMS LTD , KEW SIMON , MARSHALL ALEXANDER JAMES , CREASEY CHRISTOPHER , CANE MICHAEL ROGER , CLEMENTS JEREMY PETER
发明人： KEW SIMON , MARSHALL ALEXANDER JAMES , CREASEY CHRISTOPHER , CANE MICHAEL ROGER , CLEMENTS JEREMY PETER
IPC分类号： B65D75/00 , B65D1/36 , B65D75/32 , B65D81/26
CPC分类号： B65D1/36 , B65D75/327 , B65D81/266 , B65D81/267 , B65D85/38 , B65D85/58
摘要： A storage unit (10) for water-sensitive sensors comprising: a support plate (11); a plurality of wells (12), each well attached to said support plate, and each well so sized as to be able to house, in use, a water-sensitive sensor; a piercable, water- impervious sheet (17), attachable to said support plate, to seal each well; and desiccant (19, 20), located in each well. Preferred embodiments of the invention have fins (14) to grip a desiccant tablet (19), desiccant coatings (20) within the wells and markings (21, 22) to indicate how to open the pack.
摘要翻译：一种用于水敏传感器的存储单元（10），包括：支撑板（11）; 多个井（12），每个井附接到所述支撑板，并且每个井的尺寸使得能够在使用中容纳水敏传感器; 可穿透的不透水片（17），可附接到所述支撑板，以密封每个孔; 和干燥剂（19,20），位于每个井中。本发明的优选实施例具有用于夹持干燥剂片剂（19），孔内的干燥剂涂层（20）和标记（21,22）的翅片（14），以指示如何打开包装。

7. 发明申请

WO2008119962A3 SENSOR HOUSING 审中-公开
公开(公告)号：WO2008119962A3
公开(公告)日：2008-10-09
申请号：PCT/GB2008/001083
申请日：2008-03-31
申请人： SMART HOLOGRAMS LIMITED , MARSHALL, Alexander, James , CREASEY, Christopher , KEW, Simon , CANE, Michael, Roger , CLEMENTS, Jeremy, Peter
发明人： MARSHALL, Alexander, James , CREASEY, Christopher , KEW, Simon , CANE, Michael, Roger , CLEMENTS, Jeremy, Peter
IPC分类号： G01N21/05 , G01N21/47
摘要： A housing (1) for an analyte-responsive sensor (8) with an inlet (4), outlet (6), and sensor-contacting (5 flow channels. Specific configurations of the housing include sensor-contacting channels of smaller cross-section than the inlet and/or outlet flow channels; arrangement whereby only a portion of a sensor is contacted by a test liquid; multiple inlet flow channels and support members to support a sensor.

8. 发明申请

WO2008117052A1 SAMPLING DEVICE 审中-公开
标题翻译：采样设备
公开(公告)号：WO2008117052A1
公开(公告)日：2008-10-02
申请号：PCT/GB2008/001049
申请日：2008-03-27
申请人： SMART HOLOGRAMS LIMITED , CREASEY, Christopher , KEW, Simon , COX, Tristram , GODFREY, Daniel, Peterson , MALINGE, David, Serge , WILLIS, Samuel, Gilbert
发明人： CREASEY, Christopher , KEW, Simon , COX, Tristram , GODFREY, Daniel, Peterson , MALINGE, David, Serge , WILLIS, Samuel, Gilbert
IPC分类号： G01N1/14
CPC分类号： G01N1/14 , G01N33/22 , G01N2001/1427
摘要： A device for sampling liquids, especially flammable hydrocarbon fuels, having a barrel with an inlet at one end; a plunger, sliding within the barrel and sealing against its inside wall; and a release mechanism to allow the plunder to be retracted under the action of a biasing means, such as a spring, to draw liquid into the barrel. The invention also provides that the barrel may have transparent and translucent portions to allow visualisation of the sampling, and to further incorporate a bubble trap and/or a liquid drip trap.
摘要翻译：用于对液体进行采样的装置，特别是易燃烃类燃料，其具有在一端具有入口的桶; 柱塞，在筒体内滑动并密封其内壁; 以及释放机构，以在掠过诸如弹簧的偏置装置的作用下使掠夺物件缩回以将液体吸入筒中。本发明还提供了镜筒可以具有透明和半透明部分，以允许取样的可视化，并且进一步结合气泡阱和/或液体滴漏阱。

9. 发明申请

WO2008102149A1 HOLOGRAPHIC SENSORS 审中-公开
标题翻译：全息传感器
公开(公告)号：WO2008102149A1
公开(公告)日：2008-08-28
申请号：PCT/GB2008/000606
申请日：2008-02-21
申请人： SMART HOLOGRAMS LIMITED , MARSHALL, Alexander, James , KEW, Simon
发明人： MARSHALL, Alexander, James , KEW, Simon
IPC分类号： G01N21/47 , G01N21/78 , G01N33/28 , G01N33/487 , G07D7/00 , G03H1/04
CPC分类号： G01N21/4788 , G01N21/78 , G03H1/0005 , G03H1/02 , G03H1/0256 , G03H2001/0033 , G03H2250/39
摘要： A holographic sensor comprises a matrix having a hologram therein or thereon,, wherein the sensor is capable of interacting with atmospheric moisture to change a physical characteristic of the matrix, which results in a change in an optical characteristic of the sensor, characterised in that the sensor is coated with a coating material which has a Hildebrand solubility parameter of less than 30 MPa 1/2 and is soluble in at least one non-aqueous solvent. Coating materials can be selected from the group consisting of paraffin waxes, hydrocarbon waxes, petroleum jelly naturally extracted waxes, mineral spirits and mixtures thereof. The coating is preferably petroleum jelly with 10 to 30 % by weight mineral spirits.
摘要翻译：全息传感器包括在其中或其上具有全息图的矩阵，其中传感器能够与大气水分相互作用以改变矩阵的物理特性，这导致传感器的光学特性的变化，其特征在于，传感器涂覆有希尔德布兰德溶解度参数小于30MPa 1/2的涂层材料，并且可溶于至少一种非水溶剂。涂料可选自石蜡，烃蜡，凡士林天然提取的蜡，矿物油及其混合物。该涂层优选是具有10至30重量％矿物油精的凡士林。

10. 发明申请

WO2008129268A2 METHODS OF MAKING HOLOGRAPHIC DEVICES 审中-公开
标题翻译：制作全息装置的方法
公开(公告)号：WO2008129268A2
公开(公告)日：2008-10-30
申请号：PCT/GB2008/001371
申请日：2008-04-17
申请人： SMART HOLOGRAMS LIMITED , HORGAN, Adrian, Martin , MARSHALL, Alexander, James , KEW, Simon
发明人： HORGAN, Adrian, Martin , MARSHALL, Alexander, James , KEW, Simon
IPC分类号： G03H1/04 , G03H1/02
CPC分类号： G03H1/02 , G01N21/4788 , G03H1/0005 , G03H1/30 , G03H2001/0033 , G03H2001/0044 , G03H2001/0432 , G03H2001/0497 , G03H2001/303 , G03H2210/63 , G03H2260/12 , G03H2260/30 , G03H2260/32
摘要： A method of making a holographic device (4) comprises the steps of: forming a heterogeneous support medium (2) having at least two regions (1 ) which are heterogeneous; placing the heterogeneous support medium under recording conditions, e.g. in a liquid X, which are selected to change one or more physical properties of the heterogeneous support medium, wherein the extent or nature of the change in the physical property or physical properties is different in at least two of the heterogeneous regions; recording a holographic image in the heterogeneous support medium while it is under recording conditions; and removing the heterogeneous support medium from recording conditions. Such a device can be used for security and authentication.
摘要翻译：制造全息装置（4）的方法包括以下步骤：形成具有异质的至少两个区域（1）的多相支撑介质（2）将异质支持介质置于记录条件下，例如在液体X中，其被选择以改变所述非均相载体介质的一种或多种物理性质，其中物理性质或物理性质的变化的程度或性质在至少两个异质区域中不同; 在异质支持介质处于记录条件下记录全息图像; 并从记录条件中去除异质支持介质。这样的设备可以用于安全和认证。

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