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1. 发明专利

AU6514096A A new achiral linker reagent for the incorporation of multiple amino groups into oligonucleotides 未知
公开(公告)号：AU6514096A
公开(公告)日：1997-02-26
申请号：AU6514096
申请日：1996-07-26
申请人： CARSTEN BEHRENS , KENNETH H PETERSEN , MICHAEL EGHOLM , JOHN NIELSEN , OTTO DAHL
发明人： BEHRENS CARSTEN , PETERSEN KENNETH H , EGHOLM MICHAEL , NIELSEN JOHN , DAHL OTTO
IPC分类号： C07F9/24 , C07F9/6561 , C07H21/00 , G01N33/543 , C07F9/141 , C12Q1/68

2. 发明申请

US20110229975A1 Hybridization Compositions and Methods 审中-公开
标题翻译：杂交组合和方法
公开(公告)号：US20110229975A1
公开(公告)日：2011-09-22
申请号：US12994492
申请日：2009-05-27
申请人： Steen Hauge Matthiesen , Kenneth H. Petersen , Tim Svenstrup Poulsen , Charles M. Hansen
发明人： Steen Hauge Matthiesen , Kenneth H. Petersen , Tim Svenstrup Poulsen , Charles M. Hansen
IPC分类号： G01N33/50 , C07H1/00
CPC分类号： C12Q1/6832 , C12Q1/6841 , Y10T436/143333 , C12Q2527/125
摘要： The invention provides methods and compositions for hybridizing at least one molecule to a target. The invention may, for example, eliminate the use of or reduce the dependence on formamide in hybridization. Compositions for use in the invention include an aqueous composition comprising at least one nucleic acid sequence and at least one polar aprotic solvent in an amount effective to denature double-stranded nucleotide sequences.
摘要翻译：本发明提供了用于将至少一种分子与目标物杂交的方法和组合物。例如，本发明可以消除在杂交中使用或减少甲酰胺的依赖性。用于本发明的组合物包括水性组合物，其包含至少一种核酸序列和至少一种极性非质子溶剂，其量有效使双链核苷酸序列变性。

3. 发明申请

US20090136935A1 Dye Compounds 有权
标题翻译：染料化合物
公开(公告)号：US20090136935A1
公开(公告)日：2009-05-28
申请号：US12095163
申请日：2006-11-24
申请人： Kenneth H. Petersen
发明人： Kenneth H. Petersen
IPC分类号： C12Q1/68 , C12P17/16 , G01N33/566 , G01N33/58 , G01N33/533 , C09B23/08
CPC分类号： G01N33/581 , C09B23/06 , C09B23/083
摘要： The present disclosure provides compounds that may be used as chromogens, fluorochromes, or as both. Said compounds may further be used as substrate for at least one enzyme, wherein said enzyme is capable of processing an aromatic amine group (—NH2), an aromatic hydroxyl group (—OH), or an aromatic phosphate group (—PO4). Furthermore, the present disclosure also provides methods for precipitating said compounds as well as methods for detecting a target using said compounds. Even further, kits comprising said compounds are disclosed. Said compounds may be used in any method utilizing a fluorochrome, a chromogen, or both.
摘要翻译：本公开提供可用作色素，荧光色素或两者的化合物。所述化合物还可用作至少一种酶的底物，其中所述酶能够加工芳族胺基（-NH 2），芳族羟基（-OH）或芳族磷酸酯基（-PO 4）。此外，本公开还提供了沉淀所述化合物的方法以及使用所述化合物检测靶的方法。更进一步地，公开了包含所述化合物的试剂盒。所述化合物可以以使用荧光染料，色原或两者的任何方法使用。

4. 发明授权

US09297035B2 Compositions and methods for detection of chromosomal aberrations with novel hybridization buffers 有权
标题翻译：用新型杂交缓冲液检测染色体畸变的组合物和方法
公开(公告)号：US09297035B2
公开(公告)日：2016-03-29
申请号：US12994495
申请日：2009-05-27
申请人： Steen Hauge Matthiesen , Kenneth H. Petersen , Tim Svenstrup Poulsen
发明人： Steen Hauge Matthiesen , Kenneth H. Petersen , Tim Svenstrup Poulsen
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6832 , C12Q1/6841 , Y10T436/143333 , C12Q2527/125
摘要： The present invention provides compositions and methods for the detection of nucleic acid sequences associated with chromosomal aberrations. The invention may, for example, eliminate the use of or reduce the dependence on formamide in hybridization. Compositions for use in the invention include an aqueous composition comprising at least one nucleic acid sequence and at least one polar aprotic solvent in an amount effective to denature double-stranded nucleotide sequences.
摘要翻译：本发明提供了用于检测与染色体畸变相关的核酸序列的组合物和方法。例如，本发明可以消除在杂交中使用或减少甲酰胺的依赖性。用于本发明的组合物包括水性组合物，其包含至少一种核酸序列和至少一种极性非质子溶剂，其量有效使双链核苷酸序列变性。

5. 发明授权

US07972789B2 Dye compounds 有权
标题翻译：染料化合物
公开(公告)号：US07972789B2
公开(公告)日：2011-07-05
申请号：US12095163
申请日：2006-11-24
申请人： Kenneth H. Petersen
发明人： Kenneth H. Petersen
IPC分类号： C12Q1/68 , C07D221/18 , C07H21/00 , C07H21/02
CPC分类号： G01N33/581 , C09B23/06 , C09B23/083
摘要： The present disclosure provides compounds that may be used as chromogens, fluorochromes, or as both. Said compounds may further be used as substrate for at least one enzyme, wherein said enzyme is capable of processing an aromatic amine group (—NH2), an aromatic hydroxyl group (—OH), or an aromatic phosphate group (—PO4). Furthermore, the present disclosure also provides methods for precipitating said compounds as well as methods for detecting a target using said compounds. Even further, kits comprising said compounds are disclosed. Said compounds may be used in any method utilizing a fluorochrome, a chromogen, or both.
摘要翻译：本公开提供可用作色素，荧光色素或两者的化合物。所述化合物还可用作至少一种酶的底物，其中所述酶能够加工芳族胺基（-NH 2），芳族羟基（-OH）或芳族磷酸酯基（-PO 4）。此外，本公开还提供了沉淀所述化合物的方法以及使用所述化合物检测靶的方法。更进一步地，公开了包含所述化合物的试剂盒。所述化合物可以以使用荧光染料，色原或两者的任何方法使用。

6. 发明授权

US11118214B2 Hybridization compositions and methods 有权
公开(公告)号：US11118214B2
公开(公告)日：2021-09-14
申请号：US12994492
申请日：2009-05-27
申请人： Steen Hauge Matthiesen , Kenneth H. Petersen , Tim Svenstrup Poulsen , Charles M. Hansen
发明人： Steen Hauge Matthiesen , Kenneth H. Petersen , Tim Svenstrup Poulsen , Charles M. Hansen
IPC分类号： G01N33/50 , C12Q1/6832 , C12Q1/6841 , C07H1/00
摘要： The invention provides methods and compositions for hybridizing at least one molecule to a target. The invention may, for example, eliminate the use of or reduce the dependence on formamide in hybridization. Compositions for use in the invention include an aqueous composition comprising at least one nucleic acid sequence and at least one polar aprotic solvent in an amount effective to denature double-stranded nucleotide sequences.

7. 发明申请

US20110230664A1 NEW DYE COMPOUNDS 审中-公开
标题翻译：新型染料化合物
公开(公告)号：US20110230664A1
公开(公告)日：2011-09-22
申请号：US13150488
申请日：2011-06-01
申请人： Kenneth H. Petersen
发明人： Kenneth H. Petersen
IPC分类号： C07D403/06
CPC分类号： G01N33/581 , C09B23/06 , C09B23/083
摘要： The present disclosure provides compounds that may be used as chromogens, fluorochromes, or as both. Said compounds may further be used as substrate for at least one enzyme, wherein said enzyme is capable of processing an aromatic amine group (—NH2), an aromatic hydroxyl group (—OH), or an aromatic phosphate group (—PO4). Furthermore, the present disclosure also provides methods for precipitating said compounds as well as methods for detecting a target using said compounds. Even further, kits comprising said compounds are disclosed. Said compounds may be used in any method utilizing a fluorochrome, a chromogen, or both.
摘要翻译：本公开提供可用作色素，荧光色素或两者的化合物。所述化合物还可用作至少一种酶的底物，其中所述酶能够加工芳族胺基（-NH 2），芳族羟基（-OH）或芳族磷酸酯基（-PO 4）。此外，本公开还提供了沉淀所述化合物的方法以及使用所述化合物检测靶的方法。更进一步地，公开了包含所述化合物的试剂盒。所述化合物可以以使用荧光染料，色原或两者的任何方法使用。

8. 发明申请

US20110281263A1 Compositions and Methods for Detection of Chromosomal Aberrations with Novel Hybridization Buffers 有权
标题翻译：用新型杂交缓冲液检测染色体畸变的组合物和方法
公开(公告)号：US20110281263A1
公开(公告)日：2011-11-17
申请号：US12994495
申请日：2009-05-27
申请人： Steen Hauge Matthiesen , Kenneth H. Petersen , Tim Svenstrup Poulsen
发明人： Steen Hauge Matthiesen , Kenneth H. Petersen , Tim Svenstrup Poulsen
IPC分类号： C12Q1/68 , G01N33/82 , G01N21/75 , G01N21/64 , G01N33/53 , G01N33/574
CPC分类号： C12Q1/6832 , C12Q1/6841 , Y10T436/143333 , C12Q2527/125
摘要： The present invention provides compositions and methods for the detection of nucleic acid sequences associated with chromosomal aberrations. The invention may, for example, eliminate the use of or reduce the dependence on formamide in hybridization. Compositions for use in the invention include an aqueous composition comprising at least one nucleic acid sequence and at least one polar aprotic solvent in an amount effective to denature double-stranded nucleotide sequences.
摘要翻译：本发明提供了用于检测与染色体畸变相关的核酸序列的组合物和方法。例如，本发明可以消除在杂交中使用或减少甲酰胺的依赖性。用于本发明的组合物包括水性组合物，其包含至少一种核酸序列和至少一种极性非质子溶剂，其量有效使双链核苷酸序列变性。

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