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1. 发明申请

WO2007081943A2 METHHODS AND COMPOSITIONS FOR PROMOTING ATTACHMENT OF CELLS OF ENDOTHELIAL CELL LINEAGE TO MEDICAL DEVICES 审中-公开
标题翻译：用于促进内皮细胞系细胞连接到医疗器械的甲基和组合物
公开(公告)号：WO2007081943A2
公开(公告)日：2007-07-19
申请号：PCT/US2007000518
申请日：2007-01-09
申请人： AFFINERGY INC , KENAN DANIEL , HAMILTON PAUL
发明人： KENAN DANIEL , HAMILTON PAUL
IPC分类号： A61F2/02 , C07H21/04 , C07K14/705 , C12P21/06
CPC分类号： C07K14/705 , A61K38/00 , A61L27/34 , A61L31/10 , C07K7/06 , C07K7/08
摘要： The present invention provides compositions and methods for an improved coating for medical devices. Provided is a biofunctional coating composition comprising at least one binding domain that has binding specificity for a surface material of a medical device, and at least one binding domain that has binding specificity for cells of endothelial cell lineage. Methods for coating a surface of a medical device, and for manufacturing of a medical device, comprise contacting the surface to be coated with the biofunctional coating material in an amount effective to form a coating, and may further comprise contacting the coated surface with cells of endothelial cell lineage to bind the cells of endothelial cell lineage to the coated surface.
摘要翻译：本发明提供用于医疗装置的改进涂层的组合物和方法。提供了一种生物功能性涂料组合物，其包含至少一个对医疗器械的表面材料具有结合特异性的结合结构域和至少一个对内皮细胞谱系的细胞具有结合特异性的结合结构域。用于涂覆医疗装置的表面和用于制造医疗装置的方法包括以有效形成涂层的量使待涂覆的表面与生物功能性涂层材料接触，并且还可以包括使被涂覆的表面与内皮细胞谱系将内皮细胞谱系的细胞与涂层表面结合。

2. 发明申请

WO2003072542A2 INTERFACIAL BIOMATERIALS 审中-公开
标题翻译：界面生物材料
公开(公告)号：WO2003072542A2
公开(公告)日：2003-09-04
申请号：PCT/US2002/037414
申请日：2002-11-20
申请人： DUKE UNIVERSITY , GRINSTAFF, Mark, W. , KENAN, Daniel, J. , WALSH, Elisabeth, B. , MIDDLETON, Crystan
发明人： GRINSTAFF, Mark, W. , KENAN, Daniel, J. , WALSH, Elisabeth, B. , MIDDLETON, Crystan
IPC分类号： C07D
CPC分类号： G01N33/543 , A61L27/227 , A61L27/34 , C08L89/00
摘要： An interfacial biomaterial prepared using a plurality of binding agents, each binding agent including a first ligand that specifically binds a nonbiological substrate and a second ligand that specifically binds a biological substrate. Also provided is an interfacial biomaterial prepared using a plurality of binding agents, each binding agent including a ligand that specifically binds a non-biological substrate and a non-binding domain that shows substantially no binding to a biological substrate. Also provided are methods for preparing a binding agent, methods for preparing an interfacial biomaterial, and methods for using interfacial biomaterials.
摘要翻译：使用多种结合剂制备的界面生物材料，每种结合剂包括特异性结合非生物底物的第一配体和特异性结合生物底物的第二配体。还提供了使用多种结合剂制备的界面生物材料，每种结合剂包括特异性结合非生物底物的配体和基本上不与生物底物结合的非结合结构域。还提供了制备粘合剂的方法，制备界面生物材料的方法以及使用界面生物材料的方法。

3. 发明申请

WO2005113037A3 FILTRATION DEVICE AND METHOD FOR REMOVING SELECTED MATERIALS FROM BIOLOGICAL FLUIDS 审中-公开
标题翻译：用于从生物流体中去除选择的材料的过滤装置和方法
公开(公告)号：WO2005113037A3
公开(公告)日：2006-03-09
申请号：PCT/US2005012540
申请日：2005-04-14
申请人： AFFINERGY INC , CHRISTENSEN DALE J , GRINSTAFF MARK W , KENAN DANIEL J
发明人： CHRISTENSEN DALE J , GRINSTAFF MARK W , KENAN DANIEL J
IPC分类号： A61M1/36
CPC分类号： A61M1/3633 , Y10T436/25375
摘要： A filter and method for removing selected materials from a biological fluid sample are provided. The filter comprises an outer housing, inlet, and outlet. A plurality of filter surfaces are provided within the outer housing, and at least one coating is applied to the filter surfaces. The at least one coating comprises at least two binding modules that are in turn selectively bound to one another. One binding module is selectively bound to the filter surfaces and another binding module is configured to bind selectively to the selected materials that are to be removed from the fluid sample. As the fluid sample is allowed to pass through the inlet, outer housing, and outlet, the selected materials are selectively bound to the filter surfaces via the coating, thus producing a filtered product at the outlet.
摘要翻译：提供了用于从生物流体样品中去除所选材料的过滤器和方法。过滤器包括外壳，入口和出口。多个过滤器表面设置在外壳体内，并且至少一个涂层被施加到过滤器表面。所述至少一个涂层包括至少两个结合模块，所述至少两个结合模块又选择性地彼此结合。一个装订模块选择性地结合到过滤器表面，另一个装订模块被配置成选择性地结合待从流体样品中移除的所选择的材料。当流体样品被允许通过入口，外壳体和出口时，所选择的材料通过涂层选择性地结合到过滤器表面，从而在出口处产生过滤产物。

4. 发明申请

WO1994006934A1 METHOD FOR DERIVING EPITOPES 审中-公开
标题翻译：用于衍生外植体的方法
公开(公告)号：WO1994006934A1
公开(公告)日：1994-03-31
申请号：PCT/US1993008210
申请日：1993-08-31
申请人： DUKE UNIVERSITY , KEENE, Jack, D. , KENAN, Daniel, J. , TSAI, Donald, E.
发明人： DUKE UNIVERSITY
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6811 , G01N33/53 , G01N33/6854
摘要： A method of generating a nucleic acid species which are immunologically cross-reactive with non-nucleic acid immunogens is disclosed. The method comprises combining an antigen binding protein which binds said immunogen with a degenerate pool of nucleic acid species, and then recovering a nucleic acid species bound by said antigen binding protein from said degenerate pool. Also disclosed are the nucleic acid species so made, along with the use thereof for tagging molecules for immunological detection, for detecting antibodies to predetermined non-nucleic acid immunogens, for blocking complex formation between an antigen binding protein and a non-nucleic acid immunogen, and for inducing an immune response to the immunogen in a human or animal subject. Preferred immunogens are peptides and preferred antigen binding proteins are antibodies.
摘要翻译：公开了产生与非核酸免疫原具有免疫交叉反应性的核酸物质的方法。该方法包括将结合所述免疫原的抗原结合蛋白与核酸种类的简并库结合，然后从所述退化池中回收由所述抗原结合蛋白结合的核酸种类。还公开了如此制备的核酸种类及其用于标记用于免疫检测的分子的用途，用于检测预定的非核酸免疫原的抗体，用于阻断抗原结合蛋白和非核酸免疫原之间的复合物形成，并且用于在人或动物受试者中诱导免疫原的免疫应答。优选的免疫原是肽，优选的抗原结合蛋白是抗体。

5. 发明申请

WO2007081942A3 COMPOSITIONS AND METHODS FOR PROMOTING ATTACHMENT OF CELLS OF ENDOTHELIAL CELL LINEAGE TO MEDICAL DEVICES 审中-公开
标题翻译：促进内皮细胞系细胞连接到医疗器械的组合物和方法
公开(公告)号：WO2007081942A3
公开(公告)日：2008-03-20
申请号：PCT/US2007000517
申请日：2007-01-09
申请人： AFFINERGY INC , HAMILTON PAUL , KENAN DANIEL , SOLAN AMY
发明人： HAMILTON PAUL , KENAN DANIEL , SOLAN AMY
IPC分类号： A61F2/00 , A61L33/00
CPC分类号： C07K14/705 , A61K38/00 , A61L27/34 , A61L31/10 , C07K7/06 , C07K7/08 , C07K2319/00
摘要： The present invention provides compositions and methods for an improved coating for medical devices. Provided is a biofunctional coating composition comprising at least one binding domain that has binding specificity for a metallic surface material of a medical device, and at least one binding domain that has binding specificity for cells of endothelial cell lineage. Methods for coating a metallic surface of a medical device, and for manufacturing of a medical device, comprise contacting the metallic surface to be coated with the biofunctional coating material in an amount effective to form a coating, and may further comprise contacting the coated surface with cells of endothelial cell lineage to bind the cells of endothelial cell lineage to the coated surface.
摘要翻译：本发明提供用于医疗装置的改进涂层的组合物和方法。本发明提供一种生物功能性涂料组合物，其包含至少一个对医疗器械的金属表面材料具有结合特异性的结合结构域和至少一个对内皮细胞谱系细胞具有结合特异性的结合结构域。用于涂覆医疗装置的金属表面和用于制造医疗装置的方法包括以有效形成涂层的量使待涂覆的金属表面与生物功能性涂层接触，并且还可以包括使涂覆的表面与内皮细胞谱系的细胞将内皮细胞谱系的细胞结合到包被的表面。

6. 发明申请

WO2006098744A3 IFBM'S TO PROMOTE ATTACHMENT OF TARGET ANALYTES 审中-公开
标题翻译： IFBM致力于推动目标分析
公开(公告)号：WO2006098744A3
公开(公告)日：2006-11-30
申请号：PCT/US2005021270
申请日：2005-06-15
申请人： AFFINERGY INC , HAMILTON PAUL T , GRINSTAFF MARK W , KENAN DANIEL J , CHRISTENSEN DALE J , BEYER WAYNE FL JR , HYDE-DERUYSCHER ROBIN , BENSON RAY EDWARD
发明人： HAMILTON PAUL T , GRINSTAFF MARK W , KENAN DANIEL J , CHRISTENSEN DALE J , BEYER WAYNE FL JR , HYDE-DERUYSCHER ROBIN , BENSON RAY EDWARD
IPC分类号： A61L27/22 , A61L27/34 , G01N33/543
CPC分类号： A61L27/227 , A61K38/00 , A61L27/34 , A61L27/54 , A61L2300/404 , A61L2300/606 , C07K7/08 , C07K14/001 , C08L89/00
摘要： The present invention provides an improved coating for surfaces of medical implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related material ("implant module") and at least one binding module that selectively binds to a target analyte or that is designed to have a desired effect ("analyte module"). The modules are connected by a linker. In some embodiments, the IFBM coating acts to promote the recognition and attachment of target analytes to surface of the device. The IFBM coating improves the performance of implanted medical devices, for example, by promoting osteointegration of the implant.
摘要翻译：本发明提供了用于医疗植入物表面的改进的涂层。所述涂层包含至少一种界面生物材料（IFBM），所述至少一种界面生物材料（IFBM）由至少一个结合模块组成，所述至少一个结合模块结合植入物或植入物相关材料（“植入物模块”）的表面，以及至少一个结合模块，目标分析物或被设计为具有期望效果（“分析物模块”）。模块通过链接器连接。在一些实施方案中，IFBM涂层用于促进目标分析物识别和附着到装置的表面。 IFBM涂层改善植入医疗装置的性能，例如通过促进植入物的骨整合。

7. 发明申请

WO2006007368A2 BIOFUNCTIONAL COATINGS 审中-公开
标题翻译：生物功能涂料
公开(公告)号：WO2006007368A2
公开(公告)日：2006-01-19
申请号：PCT/US2005/021147
申请日：2005-06-15
申请人： AFFINERGY, INC. , HAMILTON, Paul, T. , GRINSTAFF, Mark, W. , KENAN, Daniel, J. , CHRISTENSEN, Dale, J. , BEYER, Wayne, F., Jr. , HYDE-DERUYSCHER, Robin , BENSON, Ray, Edward
发明人： HAMILTON, Paul, T. , GRINSTAFF, Mark, W. , KENAN, Daniel, J. , CHRISTENSEN, Dale, J. , BEYER, Wayne, F., Jr. , HYDE-DERUYSCHER, Robin , BENSON, Ray, Edward
IPC分类号： A61L31/00
CPC分类号： A61L27/227 , A61K38/00 , A61L27/34 , A61L27/54 , A61L2300/404 , A61L2300/606 , C07K7/08 , C07K14/001 , C08L89/00
摘要： The present invention provides compositions and methods for an improved coating for medical devices. The coating is an interfacial biomaterial (“IFBM”) which comprises at least one binding module that binds to the surface of a device (“surface-binding module”) and at least one binding module that performs another function (“affector module”) and which acts to inhibit biofilm formation.
摘要翻译：本发明提供用于医疗装置的改进涂层的组合物和方法。该涂层是界面生物材料（“IFBM”），其包括至少一个结合到装置的表面的结合模块（“表面结合模块”）和至少一个执行另一功能的装订模块（“影响模块”））并且其作用是抑制生物膜形成。

8. 发明申请

WO2005113037A2 FILTRATION DEVICE AND METHOD FOR REMOVING SELECTED MATERIALS FROM BIOLOGICAL FLUIDS 审中-公开
标题翻译：过滤装置和从生物流体中清除选定材料的方法
公开(公告)号：WO2005113037A2
公开(公告)日：2005-12-01
申请号：PCT/US2005/012540
申请日：2005-04-14
申请人： AFFINERGY, INC. , CHRISTENSEN, Dale, J. , GRINSTAFF, Mark, W. , KENAN, Daniel, J.
发明人： CHRISTENSEN, Dale, J. , GRINSTAFF, Mark, W. , KENAN, Daniel, J.
IPC分类号： A61M1/36
CPC分类号： A61M1/3633 , Y10T436/25375
摘要： A filter and method for removing selected materials from a biological fluid sample are provided. The filter comprises an outer housing, inlet, and outlet. A plurality of filter surfaces are provided within the outer housing, and at least one coating is applied to the filter surfaces. The at least one coating comprises at least two binding modules that are in turn selectively bound to one another. One binding module is selectively bound to the filter surfaces and another binding module is configured to bind selectively to the selected materials that are to be removed from the fluid sample. As the fluid sample is allowed to pass through the inlet, outer housing, and outlet, the selected materials are selectively bound to the filter surfaces via the coating, thus producing a filtered product at the outlet.
摘要翻译：提供了用于从生物流体样品中去除所选材料的过滤器和方法。过滤器包括外壳，入口和出口。多个过滤表面设置在外壳内，并且至少一个涂层被施加到过滤器表面。所述至少一个涂层包括至少两个粘合模块，所述至少两个粘合模块又选择性地结合到另一个上。一个装订模块选择性地结合到过滤器表面，另一个装订模块被配置成选择性地结合待从流体样品中去除的所选择的材料。当允许流体样品通过入口，外部壳体和出口时，所选择的材料通过涂层选择性地结合到过滤器表面，从而在出口处产生过滤产物。

9. 发明申请

WO2007081943A3 METHODS AND COMPOSITIONS FOR PROMOTING ATTACHMENT OF CELLS OF ENDOTHELIAL CELL LINEAGE TO MEDICAL DEVICES 审中-公开
公开(公告)号：WO2007081943A3
公开(公告)日：2007-07-19
申请号：PCT/US2007/000518
申请日：2007-01-09
申请人： AFFINERGY, INC. , KENAN, Daniel , HAMILTON, Paul
发明人： KENAN, Daniel , HAMILTON, Paul
IPC分类号： C07K14/705 , C12P21/06 , A61F2/02
摘要： The present invention provides compositions and methods for an improved coating for medical devices. Provided is a biofunctional coating composition comprising at least one binding domain that has binding specificity for a surface material of a medical device, and at least one binding domain that has binding specificity for cells of endothelial cell lineage. Methods for coating a surface of a medical device, and for manufacturing of a medical device, comprise contacting the surface to be coated with the biofunctional coating material in an amount effective to form a coating, and may further comprise contacting the coated surface with cells of endothelial cell lineage to bind the cells of endothelial cell lineage to the coated surface.

10. 发明申请

WO2007081942A2 COMPOSITIONS AND METHODS FOR PROMOTING ATTACHMENT OF CELLS OF ENDOTHELIAL CELL LINEAGE TO MEDICAL DEVICES 审中-公开
标题翻译：促进内皮细胞系细胞连接到医疗器械的组合物和方法
公开(公告)号：WO2007081942A2
公开(公告)日：2007-07-19
申请号：PCT/US2007/000517
申请日：2007-01-09
申请人： AFFINERGY, INC. , HAMILTON, Paul , KENAN, Daniel , SOLAN, Amy
发明人： HAMILTON, Paul , KENAN, Daniel , SOLAN, Amy
IPC分类号： A61F2/02 , C07K14/705 , C07H21/04 , C12P21/06
CPC分类号： C07K14/705 , A61K38/00 , A61L27/34 , A61L31/10 , C07K7/06 , C07K7/08 , C07K2319/00
摘要： The present invention provides compositions and methods for an improved coating for medical devices. Provided is a biofunctional coating composition comprising at least one binding domain that has binding specificity for a metallic surface material of a medical device, and at least one binding domain that has binding specificity for cells of endothelial cell lineage. Methods for coating a metallic surface of a medical device, and for manufacturing of a medical device, comprise contacting the metallic surface to be coated with the biofunctional coating material in an amount effective to form a coating, and may further comprise contacting the coated surface with cells of endothelial cell lineage to bind the cells of endothelial cell lineage to the coated surface.
摘要翻译：本发明提供用于医疗装置的改进涂层的组合物和方法。本发明提供一种生物功能性涂料组合物，其包含至少一个对医疗器械的金属表面材料具有结合特异性的结合结构域和至少一个对内皮细胞谱系细胞具有结合特异性的结合结构域。用于涂覆医疗装置的金属表面和用于制造医疗装置的方法包括以有效形成涂层的量使待涂覆的金属表面与生物功能性涂层接触，并且还可以包括使涂覆的表面与内皮细胞谱系的细胞将内皮细胞谱系的细胞结合到包被的表面。

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