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1. 发明公开

EP0655913A1 NOVEL METALLOCENES AS ANTI-TUMOR DRUGS 失效
标题翻译：新的金属茂抗肿瘤药物。
公开(公告)号：EP0655913A1
公开(公告)日：1995-06-07
申请号：EP94908077.0
申请日：1993-08-19
申请人： KEINAN, Ehud
发明人： KEINAN, Ehud
IPC分类号： A61K33 , A61K31 , A61P35 , C07F7 , C07F17
CPC分类号： C07F17/00
摘要： The invention relates to novel titanocene derivatives possessing chemotherapeutic activity and method for their preparation. These compounds possess two cyclopentadiene rings linked to titanium as a central atom and bound covalently to two phenoxy groups which possess a substituent R selected from the group consisting of: COOCH3, COOC2H5, H, COOCH2CH2OCH2CH2OCH3 and are free from amino groups, nitro, chloride and fluoride. The novel compounds represent a compromise between the main properties for an antitumor agent, i.e. electrophilicity and stability, being water soluble. Cytotoxicity measurements of these compounds showed significant growth inhibition properties, expressed in terms of IC50[M] values.

2. 发明公开

EP0655913A4 NOVEL METALLOCENES AS ANTI-TUMOR DRUGS. 失效
标题翻译：新的金属茂抗肿瘤药物。
公开(公告)号：EP0655913A4
公开(公告)日：1995-08-16
申请号：EP94908077
申请日：1993-08-19
申请人： KEINAN EHUD
发明人： KEINAN EHUD
IPC分类号： A61K33/24 , A61K31/28 , A61P35/00 , C07F7/28 , C07F17/00
CPC分类号： C07F17/00
摘要： The invention relates to novel titanocene derivatives possessing chemotherapeutic activity and method for their preparation. These compounds possess two cyclopentadiene rings linked to titanium as a central atom and bound covalently to two phenoxy groups which possess a substituent R selected from the group consisting of: COOCH3, COOC2H5, H, COOCH2CH2OCH2CH2OCH3 and are free from amino groups, nitro, chloride and fluoride. The novel compounds represent a compromise between the main properties for an antitumor agent, i.e. electrophilicity and stability, being water soluble. Cytotoxicity measurements of these compounds showed significant growth inhibition properties, expressed in terms of IC50(M) values.

3. 发明申请

WO2008096360A3 FRICTIONLESS MOLECULAR ROTARY MOTORS 审中-公开
标题翻译：无摩擦分子旋转电机
公开(公告)号：WO2008096360A3
公开(公告)日：2008-09-25
申请号：PCT/IL2008000167
申请日：2008-02-06
申请人： TECHNION RES & DEV FOUNDATION , KEINAN EHUD
发明人： KEINAN EHUD
IPC分类号： B01L3/00 , B82B1/00 , B82B3/00 , C07D487/22
CPC分类号： C07D487/22
摘要： A rotaxane consisting of a cucurbituril and an uncharged guest molecule, having low or null affinity therebetween is provided as well as processes for providing the same. Various uses as energy converters ("frictionless" molecular motors), biochips and biosensors using the same are also provided.
摘要翻译：提供了由葫芦脲和不带电的客体分子组成的轮烷，其具有低亲合力或无亲合力的亲合分子，以及提供它们的方法。还提供了作为能量转换器（“无摩擦”分子马达）的各种用途，使用其的生物芯片和生物传感器。

5. 发明申请

WO2008111077A3 SELF-ASSEMBLED POLYHEDRAL MULTIMERIC CHEMICAL STRUCTURES 审中-公开
标题翻译：自组装多晶硅多化学结构
公开(公告)号：WO2008111077A3
公开(公告)日：2008-11-20
申请号：PCT/IL2008000353
申请日：2008-03-13
申请人： TECHNION RES & DEV FOUNDATION , OLSON ARTHUR , KEINAN EHUD
发明人： OLSON ARTHUR , KEINAN EHUD
IPC分类号： C07D401/04 , C07D403/04 , C07D403/08 , C07D471/04
CPC分类号： C07D401/08 , C07D403/04 , C07D403/08 , C07D471/04
摘要： Self-assembled, closed and hollow chemical multimer structures having a dodecahedral morphology, composed of chemical monomers having a structurally symmetric core which posses a 5-fold rotational symmetry, are provided. Also provided are methods of creating such chemical monomers, methods of creating such chemical multimer structures and compositions comprising these chemical multimer structures. Also provided are uses of these chemical multimer structures in applications such as drug delivery, imaging, immunization, formation of plastic crystals and nanopaticle matrices and other medical and material science applications.
摘要翻译：提供具有十二面体形态的自组装，封闭和中空的化学多聚体结构，其由具有5重旋转对称性的结构对称核心的化学单体组成。还提供了产生这种化学单体的方法，产生这种化学多聚体结构的方法和包含这些化学多聚体结构的组合物。还提供了这些化学多聚体结构在诸如药物递送，成像，免疫，塑性晶体和纳米颗粒基质形成以及其他医学和材料科学应用等应用中的用途。

6. 发明申请

WO0115656A9 TRICYCLIC COMPOUNDS AND THEIR USES AS ANTIARRHYTHMIC ANTIFIBRILLATORY AND DEFIBRILLATORY AGENTS 审中-公开
标题翻译：三聚体化合物及其作为抗微生物剂和抗菌剂的用途
公开(公告)号：WO0115656A9
公开(公告)日：2002-04-18
申请号：PCT/IL0000510
申请日：2000-08-27
申请人： TECHNION RES & DEV FOUNDATION , EREZ MORDECHAI , LEVY OFRA , KEINAN EHUD
发明人： EREZ MORDECHAI , LEVY OFRA , KEINAN EHUD
IPC分类号： C07D221/28 , C07D243/38 , C07D405/06 , A61K31/55 , A61P9/00 , A61P9/10 , C07D223/18 , C07D243/10
CPC分类号： C07D405/06 , C07D221/28 , C07D243/38
摘要： A compound having a general formula (II) wherein R1 is saturated or unsaturated alkyl, amino-alcohol, diamino, cycloalkyl, and C(=O)(CH2)nNR'R'', (CH2)nCHOHCH2NR'R'', wherein n is an integer; RQ, RT, R', and R'' are each independently a hydrogen, halogen, hydroxyl, saturated, unsaturated, aliphatic, or branched alkyl, substituted or unsubstituted (CH2)m-(hetero)aryl, and sulfonylamide; q and t are each an integer independently selected from 1-4; and pharmaceutically acceptable salts thereof, and the new therapeutic uses thereof and similar compounds as defibrillating, and/or anti-fibrillatory, and/or anti-arrhythmic and/or anti-ischemic drugs.
摘要翻译：具有通式（II）的化合物，其中R1是饱和或不饱和的烷基，氨基醇，二氨基，环烷基和C（= O）（CH2）nNR'R“，（CH2）nCHOHCH2NR'R”，其中 n 是整数; RQ，RT，R'和R“各自独立地为氢，卤素，羟基，饱和，不饱和，脂族或支链烷基，取代或未取代的（CH 2）m - （杂）芳基和磺酰胺; q i和t i都是独立地选自1-4的整数; 和其药学上可接受的盐，以及其新的治疗用途和类似化合物作为去纤维化，和/或抗纤维化和/或抗心律失常和/或抗缺血药物。

7. 发明申请

WO0115656A2 TRICYCLIC COMPOUNDS AND THEIR USES AS ANTIARRHYTHMIC ANTIFIBRILLATORY AND DEFIBRILLATORY AGENTS 审中-公开
标题翻译：三环类化合物及其作为抗心律失常剂和除颤剂的用途
公开(公告)号：WO0115656A2
公开(公告)日：2001-03-08
申请号：PCT/IL0000510
申请日：2000-08-27
申请人： TECHNION RES & DEV FOUNDATION , EREZ MORDECHAI , LEVY OFRA , KEINAN EHUD
发明人： EREZ MORDECHAI , LEVY OFRA , KEINAN EHUD
IPC分类号： C07D221/28 , C07D243/38 , C07D405/06 , A61K
CPC分类号： C07D405/06 , C07D221/28 , C07D243/38
摘要： A compound having a general formula (II) wherein R1 is saturated or unsaturated alkyl, amino-alcohol, diamino, cycloalkyl, and C(=O)(CH2)nNR'R'', (CH2)nCHOHCH2NR'R'', wherein n is an integer; RQ, RT, R', and R'' are each independently a hydrogen, halogen, hydroxyl, saturated, unsaturated, aliphatic, or branched alkyl, substituted or unsubstituted (CH2)m-(hetero)aryl, and sulfonylamide; q and t are each an integer independently selected from 1-4; and pharmaceutically acceptable salts thereof, and the new therapeutic uses thereof and similar compounds as defibrillating, and/or anti-fibrillatory, and/or anti-arrhythmic and/or anti-ischemic drugs.
摘要翻译：其中R1为饱和或不饱和烷基，氨基醇，二氨基，环烷基和C（= O）（CH2）nNR'R“，（CH2）nCHOHCH2NR'R”的通式（II）是一个整数; RQ，RT，R'和R“各自独立地为氢，卤素，羟基，饱和，不饱和，脂肪族或支化烷基，取代或未取代的（CH2）m-（杂）芳基和磺酰胺基; q和t分别是独立选自1-4的整数; 及其药学上可接受的盐以及其新的治疗用途和作为除颤的类似化合物，和/或抗纤维化和/或抗心律失常和/或抗局部缺血药物。

8. 发明申请

WO1995004306A1 ORGANIC CHARGE TRANSFER COMPOUNDS WITH LIQUID CRYSTAL PROPERTIES 审中-公开
标题翻译：有机电荷传输具有液晶性质LINKS
公开(公告)号：WO1995004306A1
公开(公告)日：1995-02-09
申请号：PCT/EP1994002143
申请日：1994-06-30
申请人： BASF AKTIENGESELLSCHAFT , HAEUSSLING, Lukas , FUNHOFF, Dirk , SIEMENSMEYER, Karl , ETZBACH, Karl-Heinz , RINGSDORF, Helmut , SCHUHMACHER, Peter , KEINAN, Ehud
发明人： BASF AKTIENGESELLSCHAFT
IPC分类号： G03G05/06
CPC分类号： G03G5/0655 , C07D487/16 , C09K19/3472 , H01L51/0072 , H01L51/0076 , H01L2251/308 , Y02E10/549
摘要： Low molecular or polymer tricycloquinazolines with liquid crystal properties are used as organic charge transfer compounds. These charge transfer compounds are suitable for producing electrophotographic recording materials.
摘要翻译：本发明涉及使用具有低分子量或聚合的Tricyclochinazolinen作为有机电荷传输化合物的液晶性质。适合于制作电子照相记录材料的新型电荷传输化合物。

9. 发明申请

WO2004066912A3 ANTI-INFLAMMATORY COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：抗炎组合物及其用途
公开(公告)号：WO2004066912A3
公开(公告)日：2005-12-08
申请号：PCT/IL2004000096
申请日：2004-02-01
申请人： TECHNION RES & DEV FOUNDATION , KEINAN EHUD , ALT ARON
发明人： KEINAN EHUD , ALT ARON
IPC分类号： A61K20060101 , A61K6/00 , A61K31/015 , A61K31/33 , A61K
CPC分类号： A61K31/035 , A61K31/01 , A61K31/015 , A61K31/045 , A61K31/122 , A61K31/202 , A61K31/33 , A61K31/351 , A61K31/352 , A61K31/353 , A61K31/404 , A61K31/522 , A61K31/7048
摘要： Methods of treating medical conditions associated with inflammation employing compounds capable of inhibiting an activity and/or a formation of an oxidant associated with the inflammation, pharmaceutical composition and inhalation devices containing such compounds are provided. Further provided are methods of identifying drug candidates for treating inflammation-associated medical conditions by inhibiting an activity and/or a formation of an oxidant associated with the inflammation and methods of diagnosing such medical conditions.
摘要翻译：提供了使用能够抑制与炎症相关的活性和/或形成与氧化剂相关的化合物的化合物治疗与炎症相关的医学病症的方法，药物组合物和含有这些化合物的吸入装置。进一步提供的是通过抑制与炎症相关的氧化剂的活性和/或形成以及诊断这种疾病的方法来鉴定用于治疗炎症相关的医学病症的候选药物的方法。

10. 发明申请

WO2005023816A3 SYNTHETIC BINDING PAIRS COMPRISING CUCURBITURIL DERIVATIVES AND POLYAMMONIUM COMPOUDS AND USES THEREOF 审中-公开
标题翻译：合成结合对包含CURGBITURIL衍生物和聚氨酯组合物及其用途
公开(公告)号：WO2005023816A3
公开(公告)日：2005-07-14
申请号：PCT/IL2004000796
申请日：2004-09-05
申请人： TECHNION RES & DEV FOUNDATION , KEINAN EHUD
发明人： KEINAN EHUD
IPC分类号： C07D487/22 , C07D519/00 , C08G61/12 , C08G73/00 , C08G73/06 , G01N33/00
CPC分类号： C12Q1/6841 , C07D487/22 , C08G61/123 , C08G73/06 , C08G73/0677 , G01N33/531 , G01N33/54306 , G01N33/54353 , Y10T436/13
摘要： Derivatized cucurbiturils can be efficiently prepared and utilized for forming cucurbituril assemblies. These cucurbituril assemblies, in turn, can form affinity binding pairs with polyamines structures that are designed capable of binding to these assemblies. The resulting affinity pairs are, highly advantageous over the presently known affinity pairs and therefore can be efficiently utilized in a myriad of application. Thus, according to one aspect of the present invention there is provided a cucurbituril comprising at least one functional group covalently attached thereto, whereby the at least one functional group being for forming an assembly of at least two cucurbiturils. According to further features in preferred embodiments of the invention described below, the cucurbituril is selected from thé group consisting of CB[5], CB[6], CB[7], CB[8] and CB[n], wherein n is an integer that equals to or is lower' than 20. Preferably the cucurbituril is selected from the group consisting of CB[5J, CB[6], CB[7] and CB[8]. According to still further features in the described preferred embodiments the assembly is, selected from 'the group consisting of a dimer, a trimer, a polymer, an oligómer, a dendrimer and a cluster of the cucurbituril.
摘要翻译：衍生的葫芦素可以有效地制备并用于形成葫芦素组合物。这些葫芦巴组件又可以与设计成能够结合这些组件的多胺结构形成亲和力结合对。所得到的亲和力对比目前已知的亲和力对是非常有利的，因此可以在无数应用中有效地使用。因此，根据本发明的一个方面，提供了包含与其共价连接的至少一个官能团的葫芦巴，其中所述至少一个官能团用于形成至少两种葫芦素的组合。根据下述本发明的优选实施方案中的其它特征，葫芦素选自由CB [5]，CB [6]，CB [7]，CB [8]和CB [n]组成的组，其中n为优选地，葫芦素选自CB [5J，CB [6]，CB [7]和CB [8]。根据所述优选实施方案中的另外的特征，该组合选自“二聚体，三聚体，聚合物，寡聚体，树枝状聚合物和葫芦素簇。

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